Iimbalasane
Ukuthatha i-Vitamin C (i-ascorbic acid) ukutya okucebileyo / imithombo njengenxalenye yokutya / isondlo semihla ngemihla kunokunciphisa umngcipheko wee-cancer ezithile ezifana nomhlaza wemiphunga kunye ne-glioma. Izongezo ze-Vitamin C zikwafumaneka kunye ne-calcium ukunciphisa ubunzima bokwetyisa. I-Vitamin C, nayo, iphucula ukufunxwa kwe-calcium ngumzimba wethu. Ngokubhekiselele kunyango lomhlaza, ukunqongophala kokufunxwa ngokupheleleyo kweVithamin C kwizongezo zayo zomlomo kunye nokutya / imithombo ibe sisithintelo. Nangona kunjalo, izifundo ezahlukeneyo zibonisa izibonelelo zeVithamin C kwi-intravenous umhlaza kubandakanywa nokuphucula ukusebenza konyango, ukunciphisa ubuthi kunye nokuphucula umgangatho wobomi bezigulane ezinomhlaza.
I-Vitamin C, ekwabizwa ngokuba yi-ascorbic acid, yi-antioxidant eyomeleleyo kwaye yenye yezona zinto zisetyenziswa ekukhuthazeni ukhuseleko kwindalo. Ukuba yi-vitamin ebalulekileyo, ayivelwanga ngumzimba womntu kwaye ifunyanwa ngokutya okusempilweni. Ikwayenye yeevithamini eziqhelekileyo ezinyibilikayo emanzini ezikhoyo kwiziqhamo nakwimifuno. Ukunqongophala kokutya iVitamin C (ascorbic acid) ngokutya / ukutya ngaphezulu kweenyanga ezintathu kunokubangela ukunqongophala kweVitamin-C ebizwa ngokuba siscurvy.
Ukuthatha i-Vitamin C (ascorbic acid) ukutya okunotyebileyo kunezibonelelo ezininzi zempilo ngenxa ye-antioxidant, anti-inflammatory, anti-cancer kunye ne-immune-boosting properties. Inceda ekugcineni impilo kunye amajoni omzimba omeleleyo, izicwili ezinxibelelanayo, ukwehlisa uxinzelelo lwegazi kunye nokuphucula impilo yentliziyo. UVitamin C unceda umzimba ekwenzeni i-collagen encedisa ekunyangeni amanxeba. Iipropathi zokulwa ne-Vitamin C inceda ukukhusela iiseli zethu kumonakalo obangelwe ziiradicals simahla. Iiradicals simahla yimixube esebenzayo eveliswayo xa umzimba wethu udibanisa ukutya. Ezi zinto ziveliswa ngenxa yokuvezwa kwemeko-bume enjengokutshaya icuba, ungcoliseko lomoya okanye imitha yelanga.
Ukutya / Imithombo yeVitamin C (Ascorbic Acid)
Singazifumana ngokulula iimfuno zethu zemihla ngemihla zikaVitamin C ngokubandakanya iintlobo ezahlukeneyo zeVitamin C (ascorbic acid) iziqhamo kunye nemifuno etyebileyo ekutyeni kwethu. Ukutya okuphezulu / imithombo yeVitamin C (ascorbic acid) ibandakanya:
- Iziqhamo zeCitrus ezinje ngeeorenji, iilamuni, iidiliya, iipomelos, kunye neelime.
- guava
- Ipepile eluhlaza
- Ipelepele ebomvu
- Ierberberries
- Isiqhamo se-Kiwi
- Ipapaya
- Ipanapula
- Ijusi yetamatisi
- Iipatata
- Ibrokholi
- I-Cantaloupes
- Iklabishi ebomvu
- Ispinatshi
Vitamin C kunye neCalcium Absorption
I-Vitamin C xa ithathwa kunye ne-calcium, inokuphucula ukufakwa kwe-calcium. Isifundo ngo IMorcos SR okqhubekayo. ikwabonakalisile ukuba iVitamin C / ascorbic acid, iorenji kunye neepepusi ziyakunyusa ukufunxeka kwe-calcium yamathumbu. Xa zithathiwe kunye, iVitamin C kunye necalcium zinokwandisa amandla ethambo.
I-Vitamin C / ascorbic acid ine-asidi kwindalo. Ngenxa yoko, ukutya kakhulu ukutya okune-Vitamin C / imithombo okanye i-Vitamin C emsulwa kunokukhokelela kubunzima bokugaya ukutya. Yiyo loo nto kwintengiso, izongezo zeVitamin C zikwakhona kunye neCalcium, kwaye zithengiswa njengezongezo zecalcium ascorbate. Izongezo zeCalcium ascorbate ziqulathe ikhalsiyam carbonate enokuthomalalisa ukusebenza kweascorbic Acid / Vitamin C.
Isibonelelo seDiary C esicetyiswayo siyi-75 mg yabasetyhini abadala kunye ne-90 mg yamadoda amadala. Xa i-30-180 mg yeVitamin C ithathwa ngomlomo ngemini ngokutya kunye nezongezo, i-70-90% iyafunxwa. Nangona kunjalo, ukungena okungaphezulu kwe-1g / ngosuku, iqondo lokufunxa liwela ngaphantsi kwe-50% (URobert A. Jacob & Gity Sotoudeh, Isondlo kuKhathalelo lweKlinikhi, 2002).
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izibonelelo zokuthatha iVitamin C (Aascorbic Acid) Ukutya okuTyebileyo kuMhlaza
Ngenxa yokuxhamla kwezempilo, uninzi lweemvavanyo zeklinikhi ziphande ukutya okunotyebileyo kweVitamin C / imithombo yokufunda izibonelelo ezinokubakho kumhlaza. Izifundo ezininzi zenziwa ukuze kufundwe umbutho we Ukutya iVitamin C nomngcipheko womhlaza okanye ukufunda ifuthe lonyango kunyango.
I-Vitamin C kunye nomngcipheko womhlaza
1. Ukudibana nomngcipheko womhlaza wemiphunga
Kwisifundo esapapashwa ngo-2014, abaphandi baqhuba uhlalutyo lweemeta kwizifundo ezahlukeneyo ezavavanya umanyano lokutya iVitamin C (ascorbic acid) ukutya okutyebileyo okanye izongezo kunye nomngcipheko womhlaza wemiphunga. Ukuchonga izifundo, abaphandi baqhuba uphando kulwazi, ngakumbi uPapasho, uWan Fang Med kwi-Intanethi kunye neWebhu yoLwazi (ULuo J okqhubekayo, uSci Rep., 2014). Uhlalutyo lweemeta lubandakanya amanqaku ali-18 ahlukeneyo anike ingxelo ngezifundo ezingama-21 ezibandakanya iimeko ezingama-8938 zomhlaza wemiphunga. Kwezi, izifundo ezili-15 zenziwa eUnited States, zimbini eNetherlands, zimbini eChina, ziyi-2 eCanada zaza zali-2 eUruguay. I-1 yamanqaku e-1 asetyenziselwa uhlalutyo lweemeta-asekwe kulawulo lwamatyala / kwizifundo zeklinikhi kwaye i-6 isekwe kubemi / kwizifundo ezenziwa ngabantu abaninzi.
Iziphumo zohlalutyo zibonise ukuba i-vitamin C ephezulu yokutya yayinxulunyaniswa kakhulu nokwehla komngcipheko womhlaza wemiphunga, ngakumbi e-United States nakwizifundo zamaqela. Iziphumo azibonisanga mpembelelo iphambili kuVitamin C kwizifundo ezivela kulawulo lwe-6 lwamatyala / amanqaku ezonyango.
Okwangoku, abaphandi benze uhlalutyo lokuphendula ngethamo besebenzisa idatha kwizifundo ezili-14 kubandakanya iimeko ezingama-6607. Iziphumo zophando zibonise ukuba kuyo yonke i-100 mg / ngosuku ukonyuka kokutya iVitamin C, bekukho ukwehla nge-7% kumngcipheko wokuba nomhlaza wemiphunga. (ULuo J okqhubekayo, uSci Rep., 2014).
Ukuthatha izinto eziphambili:
Ezi ziphumo zibonisa ukuba ukutya okuphezulu kweVitamin C (ascorbic acid) ukutya okunesityebi kunokuba nakho ukunciphisa umngcipheko womhlaza wemiphunga.
2. Ukudibana noMngcipheko weCancer yeBrain (Glioma)
Kwisifundo esapapashwa ngo-2015, abaphandi benza uhlalutyo lweemeta kwizifundo ezahlukeneyo ezavavanya umanyano lweVitamin C yokutya kunye ne-glioma / umngcipheko womhlaza wobuchopho. Kwizifundo ezifanelekileyo, abaphandi baqhuba uphando kulwazi, ngakumbi uPapasho kunye neWebhu yoLwazi kude kube nguJuni 2014 (UZhou S okqhubekayo, Neuroepidemiology., 2015). Uhlalutyo lubandakanya amanqaku e-13 axele ngezifundo ezili-15 ezibandakanya iimeko ezingama-3409 ze-glioma ezivela e-United States, Australia, China nase-Jamani. Abaphandi bafumanisa ubudlelwane obukhuselayo kubemi baseMelika kunye nophando lolawulo lwamatyala.
Ukuthatha izinto eziphambili:
Iziphumo zophononongo zibonisa ukuba ukutya kwe-vitamin C kunokunciphisa umngcipheko we-glioma, ngakumbi kubantu baseMelika. Nangona kunjalo, izifundo ezongezelelweyo zeklinikhi ziyafuneka ukuseka okufanayo.
Impembelelo kunyango loMhlaza kunye noMgangatho woBomi
Uvavanyo lweklinikhi oluyilwe kakuhle ekusetyenzisweni kwezincedisi zomlomo zeVitamin C / imithombo yokutya ayifumananga zibonelelo kubantu abanomhlaza. Idosi ephezulu yeVitamin C evela emlonyeni nezongezo/ Ukutya akufunxwanga ngokufanelekileyo ukufezekisa ukugxila okuphezulu njengoko kufunyenwe nge-infravenous Vitamin C ukumnika kwaye kungoko kungakhange kubonise zibonelelo. I-Vitamin C enikezwe ngaphakathi ifunyenwe ibonakalisa ifuthe lokungafani nedosi kwifom yomlomo. I-Vitamin C infusions infusions yafunyanwa ikhona Khu selekile kwaye inokuphucula ukusebenza kunye nokuhla utyhefu xa isetyenziswa kunye nonyango lwemitha kunye nonyango ngamayeza. Zininzi izifundo zeklinikhi eziphanda izibonelelo zokusebenzisa idosi ephezulu yeVitamin C kwii-cancer ezahlukeneyo.
1. Izibonelelo kwiGlioblastoma (Umhlaza weBongo) Izigulana ezanyangwa ngeMitha okanye isiyobisi i-TMZ chemo
Uphononongo lweklinikhi olupapashwe ngo-2019 luvavanye ukhuseleko kunye nefuthe lokulawula i-pharmacological ascorbate (Vitamin C) kunye neRadiation okanye ichemotherapy TMZ kwizigulana zeglioblastoma (zomhlaza wobuchopho). Imitha kunye ne-TMZ zizinto ezimbini eziqhelekileyo zonyango lokhathalelo lwe-glioblastoma (umhlaza wengqondo). Uphononongo luvavanye idatha evela kwi-11 ingqondo umhlaza izigulane (UAllen BG okqhubekayo, uMhlaza kwiCancer Res., 2019).
Abaphandi bafumanise ukuba umthamo ophakamileyo we-Vitamin C / ascorbate infusions uphucule ukusinda kwezigulana ze-glioblastoma ukusuka kwiinyanga ezili-12.7 ukuya kwiinyanga ezingama-23, ngakumbi kwizifundo ezazinophawu olubi lokuxela kwangaphambili. Idosi ephezulu efakwa ngaphakathi kwi-Vitamin C / ascorbate infusions inciphise iziphumo ebezingalindelekanga ezinzima zokudinwa, isicaphucaphu kunye neziganeko ezichaseneyo zehematological ezinxulumene ne-TMZ kunye nonyango lwemitha. Iziphumo ezibi kuphela ezinxulunyaniswa nokunyuswa kwe-ascorbate / Vitamin C efunyanwa zizigulana imilomo eyomileyo kunye nokugodola.
Ukuthatha izinto eziphambili:
Iziphumo zibonisa ukuba ukulawulwa kwethamo eliphezulu le-Vitamin C / ascorbate infusions kunye nonyango lwe-Radiation okanye i-TMZ kwizigulana ze-Glioblastoma kunokukhuseleka kwaye kunyamezeleke. Idosi ephezulu efakwa ngaphakathi kuVitamin C inokuphucula nokusebenza konyango njengoko kubonisiwe kukuphucuka kokuphila kwezigulana.
2. Izibonelelo kubantu abadala abagula yi-Myeloid Leukemia abaguli baphathwa nge-arhente ye-hypomethylating (HMA)
Iiarhente ze-Hypomethylating agents (HMA) zisetyenziselwa unyango lwe-Acute Myeloid Leukemia kunye neMyelodysplastic Syndromes (MDS). Nangona kunjalo, inqanaba lokuphendula kwamachiza athile e-hypomethylating zihlala ziphantsi, kuphela malunga ne-35-45%. (UWelch JS okqhubekayo, Engl eNtsha. UJ Med., 2016)
Ku kutshanje isifundo olwenziwe e-China, abaphandi bavavanye ifuthe lokuhambisa idosi ephantsi ye-Vitamin C kunye ne-HMA ethile kwizigulana ezigugileyo ze-myeloid leukemia (AML). Abaphandi bahlalutye iziphumo zeklinikhi zezigulana ezingama-73 zabantu abadala ze-AML ezifumene indibaniselwano yedosi ephantsi ye-Vitamin C kunye ne-HMA okanye i-HMA yodwa. (UZhao H et al, Leuk Res., 2018)
Abaphandi bafumanise ukuba abaguli abathathe le HMA ngokudibanisa neVitamin C babenenqanaba elipheleleyo lokuxolelwa nge-79.92% xa kuthelekiswa ne-44.11% kwabo bathathe i-HMA yodwa. Bafumanise ukuba ukusinda ngokubanzi (OS) yayiziinyanga ezili-15.3 kwiqela elithe lafumana iVitamin C kunye ne-HMA xa kuthelekiswa neenyanga eziyi-9.3 kwiqela elalifumene i-HMA kuphela. Bazimisele izizathu zesayensi ezibangelwe yimpembelelo elungileyo yeVitamin C kule mpendulo ye-HMA. Yiyo loo nto le yayingengomphumo nje.
Ukuthatha izinto eziphambili:
Ukuthatha idosi esezantsi ngaphakathi kwi-Vitamin C kunye neyeza elithile le-HMA kunokukhuseleka kwaye kusebenze kwizigulana ze-AML ezindala. Ukongeza, inokuphucula ukusinda ngokubanzi kunye nokuphendula kweklinikhi kwizigulana ze-AML eziphathwe nge-HMA. Ezi ziphumo zibonisa ukungqinelana kwe-Vitamin C efakwa ngaphakathi kunye nearhente yokuqhafaza kwizigulana ze-AML.
3. Impembelelo ekuDumbiseni kwizigulana ezinomhlaza
Isifundo esapapashwa kwi-2012 siphande ngefuthe ledosi ephezulu ye-Vitamin C yokuvuvukala kwizigulana ezinomhlaza. Uphononongo lubandakanya idatha evela kwizigulana ezingama-45 ezanyangwa kwikliniki yaseRiordan, eWichita, KS, United States. Aba baguli bafunyaniswe benomhlaza wedlala lobudoda, umhlaza webele, umhlaza wesinyi, umhlaza wepancreatic, umhlaza wemiphunga, umhlaza wedlala lengqula, umhlaza wolusu okanye iB-cell lymphoma. Baye babanjwa ngeedosi eziphezulu zeVitamin C bethumela unyango lwabo oluqhelekileyo. (UMikirova N et al, J Guqula iMed. 2012)
Ukuvuvukala kunye neeprotheyini ezisebenzayo ze-C-esebenzayo (i-CRP) zinxulunyaniswa nokungaxeli kakuhle kwaye kunciphise ukusinda kwiindidi ezininzi zomhlaza. (UMikirova N et al, J Guqula iMed. 2012Iziphumo zophononongo zibonise ukuba i-Vitamin C efakwa ngaphakathi inokuwanciphisa kakhulu amanqanaba amakishayo anyusa ukuvuvukala njenge-IL-1cy, IL-2, IL-8, TNF-α, chemokine eotaxin kunye neCRP. Abaphandi bafumanise ukuba ukwehla kwamanqanaba e-CRP ngexesha lonyango lwe-Vitamin C edityaniswa nokwehla kwamanqaku amancinci.
Ukuthatha izinto eziphambili:
Ezi ziphumo zibonisa ukuba unyango lwethamo eliphezulu lwe-Vitamin C lunokunciphisa ukudumba kwizigulana ezinomhlaza.
4. Impembelelo kuMgangatho woBomi beZigulana ezinomhlaza
Kuphononongo lokuqwalaselwa lwamaziko amaninzi, abaphandi bavavanya iziphumo zedosi ephezulu yeVithamin C kumgangatho wobomi umhlaza izigulane. Kuphononongo, abaphandi bavavanya idatha evela kwizigulana ezinomhlaza osandula kufunyaniswa ukuba zafumana idosi ephezulu yeVithamin C njengonyango lwe-adjuvant. Idatha evela kwizigulane ze-60 zifunyenwe kumaziko athatha inxaxheba eJapan phakathi kukaJuni noDisemba 2010. Uhlalutyo olukumgangatho wobomi lwenziwa kusetyenziswa idatha esekelwe kwi-questionnaire efunyenwe ngaphambili, kunye ne-2 kunye ne-4 yeeveki ze-dose ephezulu yonyango lwe-Vitamin C.
Izifundo zibonise ukuba ulawulo oluphezulu lwe-Vitamin C efakwe kwi-intravenous luyiphucule kakhulu impilo kunye nomgangatho wobomi bezigulana. Bafumene ukuphucuka komzimba, iimvakalelo, ukuqonda, kunye nokusebenza ekuhlaleni kwiiveki ezi-4 zolawulo lweVitamin C. Iziphumo zibonise ukukhululeka okukhulu kwiimpawu ezinje ngokudinwa, iintlungu, ukuqaqanjelwa sisisu kunye nokuqhinwa. (UHidenori Takahashi okqhubekayo, ubuGcisa boLuntu obuCwangcisiweyo, 2012).
Ukuthatha izinto eziphambili:
Ezi ziphumo zibonisa ukuba ulawulo oluphezulu lwe-Vitamin C olungena ngaphakathi lunokuphucula umgangatho wobomi bezigulana ezinomhlaza.
isiphelo
Isishwankathelo, ukutya kweVithamin C zi-antioxidants ezintle ezineenzuzo ezininzi zempilo kwaye kufuneka zibe yinxalenye yokutya kwethu kwemihla ngemihla. I-Vitamin C ikwaphucula ukufunxwa kwe-calcium ngumzimba wethu kwaye yonyusa amandla amathambo. Kwakhona kubonise amandla ekunciphiseni umngcipheko othile i cancer ezifana nomhlaza wemiphunga kunye neglioma. Xa kufikwa kunyango lomhlaza, iVithamin C yomlomo ayonelanga ngenxa yokufunxa okuncinci. Nangona kunjalo, i-intravenous Vitamin C infusions ibonise ukuphucula ukusebenza konyango kunye nokunyamezela kwamachiza athile e-chemotherapy. Ezi zikwabonise amandla okunyusa izigulane ' mgangatho wobomi kunye nokunciphisa ityhefu yemitha kunye neerejimeni zonyango zonyango. Idosi ephezulu ye-vitamin C (ascorbate) infusions ikwabonakalise ukubanakho ekunciphiseni ityhefu yee-chemotherapies ezithile kwiipancreatic kunye nee-ovarian cancer. (I-Welsh JL okqhubekayo, iCancer Chemother Pharmacol., 2013; Ma Y okqhubekayo, Sci. Guqula. IMed., 2014).
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) lolona nyango lwendalo olungcono lomhlaza kunye nokunxulumene nonyango imiphumela.