Iimbalasane
IVithamin E sisondlo se-antioxidant esisifumana kwimithombo yokutya okanye izongezo. Nangona kunjalo, ukuxhaswa kwe-Vitamin E kubonise impembelelo eyahlukileyo kwiintlobo ezahlukeneyo zomhlaza. I-Vitamin E ibonise umngcipheko owongeziweyo we-prostate kunye nomhlaza wobuchopho, akukho mpembelelo kumhlaza wemiphunga kunye neenzuzo kumhlaza we-Ovarian. Olu tshintsho lunokudityaniswa nokwahluka kofuzo kubantu ngokusekwe kwiiyantlukwano kwindlela i-Vitamin E icutshungulwa ngayo emzimbeni. Ukongezwa kwe-Vitamin E ngokugqithisileyo kunokubangela ingozi ngenxa yokopha kakhulu kunye ne-stroke. Ke ngoko, kungcono ukonyusa iVithamin E ngemithombo yokutya njengenxalenye yokutya okunempilo okanye isondlo umhlaza, kunokuba uthathe izongezo.
Ukongezwa kweVitamin E
Abantu abaninzi bakholelwa ukuba ukuthatha iivithamini kunye nezongezo kunokunceda ekunciphiseni umngcipheko weemeko zempilo ezingapheliyo kunye nokuphucula impilo yabo. Nangona kunjalo, zininzi izifundo zeklinikhi ezibonisa ukuba izibonelelo zeevithamini kunye nezongezo zizinto ezithile kwaye kwiimeko ezininzi aziboneleli sibonelelo kwaye zinokuba yingozi. I-Vitamin E sesinye sezakha mzimba esidume ngezibonelelo zempilo ezahlukileyo kwaye ngaphandle kokuba yinxalenye yokutya okuninzi esikutyayo njengenxalenye yokutya / isondlo, sithathwa njengesongezo sedosi eyongeziweyo kunye nesibonelelo. Siza kuvavanya imithombo, izibonelelo kunye nemingcipheko enxulunyaniswa nokuxhaswa kakhulu kweVitamin E kukutya komhlaza / kwisondlo.
I-Vitamin E liqela lamafutha ezinyibilikisi anetyhefu afumaneka kukutya okuninzi kwaye athathwe njengokongeza ngokwawo okanye inxenye yokongezwa kweevithamini ezininzi, kwizibonelelo zayo ezininzi zezempilo. I-Vitamin E ngokwenyani yenziwe ngamaqela amabini eekhemikhali: ii-tocopherols kunye ne-tocotrienols. Iipropathi zokulwa ne-Vitamin E zinceda ekukhuseleni iiseli zethu kumonakalo obangelwe kukungasebenzi kakuhle kwee-radicals kunye noxinzelelo lwe-oxidative. Ke, imithombo yokutya kunye nezongezo zeVitamin E zibonelela ngezibonelelo ezininzi zempilo ukusuka kukhathalelo lolusu ukuya kwimpilo yentliziyo kunye nengqondo.
Imithombo yeVitamin E
Imithombo yokutya etyebileyo kaVitamin E ibandakanya ioyile yombona, ioyile yemifuno, ioyile yesundu, iiamangile, iihazelnuts, iipinenuts, imbewu yejongilanga, ngaphandle kwezinye iziqhamo kunye nemifuno esiyityayo ekutyeni kwethu. IiTocopherol zezona mithombo ziphambili zeVitamin E ekudleni kwethu kunye nezongezo xa kuthelekiswa neetocotrienols. Ukutya okune-tocotrienol ephezulu yirayisi bran, i-oats, irye, irhasi kunye neoyile yesundu.
Umngcipheko-Uncedo lokudibana kweVitamin E noMhlaza
Iipropathi ze-Antioxidant ze-Vitamin E zinokunceda ekunciphiseni uxinzelelo oluyingozi lwe-oxidative kunye nomonakalo kwiiseli zethu. Ukwaluphala kubangela ukuncipha kwamandla e-antioxidant endalo emizimbeni yethu, ngenxa yoko iVithamin E inceda kwiziphumo zokuchasa ukuguga. Inxulunyaniswa nokunciphisa umngcipheko wokuphazamiseka okungapheliyo kunye nokwaluphala okunxulumene nentliziyo, isifo seswekile kunye nokuba nefuthe lokuchasa umhlaza. Izifundo kwi umhlaza iiseli kunye neemodeli zezilwanyana zibonise impembelelo enenzuzo yokuxhaswa kwe-Vitamin E ekuthinteleni umhlaza. Iimvavanyo ezininzi zeklinikhi ziye zavavanya umbutho wokusetyenziswa kwe-Vitamin E eyongezelelweyo kwizigulana ezinomhlaza kwaye zibonise iziphumo ezahlukeneyo ukusuka kwinzuzo, ngaphandle kwempembelelo, ukwenzakalisa, kwimihlaza eyahlukeneyo.
Kule bhulogi siza kushwankathela ezinye zezi zifundo zeklinikhi eziqaqambisa ukuba ukusetyenziswa kweVitamin E njengenxalenye yesondlo / ukutya kunceda kwezinye i-cancer ngelixa kunxulunyaniswa nefuthe elibi kwezinye iintlobo zomhlaza. Ke ngoko, izibonelelo ngokuchasene nomngcipheko wokusetyenziswa kwemithombo yeVitamin E kwisondlo somhlaza / isondlo kukuxhomekeka kwimeko kwaye kuyahluka ngohlobo lomhlaza kunye nonyango.
Izibonelelo zeVitamin E kwi-Ovarian Cancer
Ukuxilongwa komhlaza we-Ovarian kuhlala kwenzeka kamva, kwinqanaba eliphambili, kuba amanqanaba okuqala alo mhlaza kunqabile ukuba abangele naziphi na iimpawu. Ngexesha lamanqanaba okugqibela omhlaza we-ovari, iimpawu ezinje ngokuthoba ubunzima kunye nentlungu esiswini, ezo ngokungaqhelekanga, ziqala ukubonakalisa kwaye ezi zihlala zingaphakamisi kakhulu. Kungenxa yezi zizathu zokuba abasetyhini bafunyaniswe benomhlaza we-ovari kumanqanaba asemva kwexesha, ngenqanaba lokusinda leminyaka emihlanu le-47% (Umbutho waseMelika woMhlaza). Izigulana ezinomhlaza we-Ovarian ziphathwa ngonyango lwe-chemotherapy uninzi olungaziphenduliyo. Enye ye Olona nyango lujolise kuzo ikakhulu esetyenziselwa umhlaza we-ovari isebenza ngokulambisa iiseli zethumba ngokuthintela ukukhula kwemithambo yegazi emitsha ebalulekileyo ekuthuthweni kwezakhamzimba kwi-tumor ekhula ngokukhawuleza.
Kwimeko yomhlaza we-ovari, ivithamin E ikhompawundi tocotrienol ibonakalise izibonelelo xa isetyenziswa ngokudibanisa nomgangatho wokhathalelo (SOC) ichiza (humanized anti-VEGF monoclonal antibody) kwizigulana ezinganyangekiyo kunyango lwe-chemotherapy. Abaphandi kwiSebe le-Oncology kwisibhedlele iVejle, eDenmark, bafunde ngeziphumo zeqela le-tocotrienol le-Vitamin E ngokudibeneyo neyeza le-SOC kwizigulana ezinomhlaza we-ovari ezingaphendulanga kunyango lwe-chemotherapy. Olu pho nonongo lubandakanya izigulane ezingama-23. Umdibaniso we-tocotrienol kunye neziyobisi ze-SOC ubonakalise ubuthi obuphantsi kakhulu kwizigulana kwaye waba ne-70% yesilinganiso sozinzo. Ukusinda ngokubanzi okurekhodwe kweli nqanaba lesibini lalingaphezulu kakhulu xa kuthelekiswa noncwadi lwangoku. (I-Thomsen CB okqhubekayo, i-Pharmacol Res., 2019Olu phononongo luxhasa isiphumo sokulwa nomhlaza seqela le-delta-tocotrienol le-Vitamin E kumhlaza we-ovari omninzi, kodwa iyafana ayimiselwanga i-tocopherols.
Umngcipheko weVitamin E kuMhlaza weBongo
Isifundo esisekwe kwi-neuro oncology eyahlukeneyo kunye namasebe e-neurosurgery kwizibhedlele zase-US ahlalutya idatha yodliwanondlebe evela kwizigulana ezingama-470 ezenziwa emva kokuchongwa komhlaza wobuchopho i-glioblastoma multiforme (GBM). Iziphumo zibonise ukuba inani elikhulu lezi zigulana (iipesenti ezingama-77) zichaze ngokungacwangciswanga zisebenzisa uhlobo oluthile lonyango olongezelelekileyo njengeevithamini okanye izongezo zendalo. Okumangalisayo kukuba, abasebenzisi beVitamin E babenokufa okuphezulu xa kuthelekiswa nalawo angakhange asebenzise izongezo zeVitamin E. (UMulphur BH okqhubekayo, uNeurooncol Pract., 2015)
Kwesinye isifundo esivela kwiYunivesithi yaseUmea, eSweden kunye neCancer Registry yaseNorway, abaphandi bathatha indlela eyahlukileyo yokufumanisa umngcipheko womhlaza wobuchopho, i-glioblastoma. Bathathe iisampulu ze-serum ukuya kuthi ga kwiminyaka eyi-22 ngaphambi kokuchongwa kwe-glioblastoma kwaye bathelekisa ukugxilwa kweemetabolite zeesampulu zalabo bakhulisa umhlaza kwabo bangakhange benze njalo. Bafumene uxinzelelo oluphezulu kakhulu lwe-serum ye-Vitamin E isoform alpha-tocopherol kunye ne-gamma-tocopherol kumatyala aphuhlise i-glioblastoma. (UBjorkblom B okqhubekayo, Oncotarget, 2016)
Umngcipheko weVitamin E kwiCancer Prostate
I-Selenium enkulu kakhulu kunye novavanyo lwe-Vitamin E Cancer Prevention Trial (KHETHA) lwenziwe kwiindawo ezingama-427 e-United States, Canada nasePuerto Rico kumadoda angaphezu kwama-35,000 ukuvavanya ubungozi bokuncediswa nguVitamin E. Olu vavanyo lwenziwa kumadoda awayeneminyaka engama-50 okanye ngaphezulu kwaye enamaqondo aphantsi e-antigen (PSA) amanqanaba e-4.0 ng / ml okanye ngaphantsi. Xa kuthelekiswa nabo bangakhange bathathe izongezo zeVitamin E (i-Placebo okanye iqela lesalathiso), uphononongo lufumene ukonyuka okuthe ngqo kumngcipheko womhlaza wamadlala kwabo bathatha izongezo ze-vitamin E. Ke, ukongezwa kweVitamin E ekudleni / kwisondlo kunxulunyaniswa nomngcipheko okhulayo womhlaza wamadlala phakathi kwamadoda asempilweni. (UKlein EA okqhubekayo, JAMA, 2011)
Akukho siphumo seVitamin E kuMhlaza wemiphunga
Kwi-alpha-tocopherol, isifundo se-beta-carotene sokuthintela umhlaza esenziwe kubantu ababhemayo abangaphezu kweminyaka engama-50 ubudala, abafumananga kuncitshiswa kwimeko yomhlaza wemiphunga emva kweminyaka emihlanu ukuya kwesibhozo yokutya okune-alpha-tocopherol. (U-Engl J Med omtsha, ngo-1994)
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Isibonelelo / umngcipheko weVitamin E kuMhlaza unxulunyaniswa nokwahluka kwemfuzo
Uphononongo lwakutsha nje luhlalutye iimpembelelo ezahlukeneyo zeVitamin E kwiintsholongwane zomhlaza ezahlukeneyo, kwaye ibonakalise ukuba iziphumo zomhlaza zokukhusela imithombo yeVitamin E zahlukile kubantu ngenxa yomehluko kwi-enzyme eqhuba iVitamin E emzimbeni. ICatechol-o-methyltransferase (COMT) yi-enzyme eqhuba iVitamin E emzimbeni wethu. Umntu ngamnye unokuba nohlobo oluthile lwe-COMT, ngolunye uhlobo olunomsebenzi ophakamileyo kakhulu we-COMT, ngelixa olunye umahluko olunomsebenzi ophantsi kwaye abanye banokuba nekopi nganye kwaye ke banomsebenzi ophakathi we-COMT.
Uphononongo lufumanise ukuba ukusebenzisa imithombo yeVithamin E egqithisileyo kubantu abanolwahlulo oluphezulu lomsebenzi we-COMT kubabeka emngciphekweni wokufumana okuphezulu. umhlaza ingozi. Kubantu abanomsebenzi ophantsi we-COMT owathatha i-Vitamin E izongezelelo, ukuxhaswa kwe-Vitamin E kwakunenzuzo kwaye kwanciphisa umngcipheko wabo womhlaza nge-15% xa kuthelekiswa nabalingane babo abanomsebenzi ophantsi ofanayo we-COMT eyahlukileyo ongazange athathe i-Vitamin E yongezelela.
Yiyo loo nto, ngokolu hlalutyo, umahluko kuthintelo lomhlaza weVitamin E unokunxulunyaniswa ngakumbi nokwenziwa kofuzo lomntu ngokwendlela uVitamin E alungiswa ngayo emzimbeni. (IHolo, i-KT okqhubekayo, J iZiko loMhlaza weSizwe., 2019) Olu tshintsho olubizwa ngokuba yi-pharmacogenetics luyaziwa kakhulu kwiimpendulo zamachiza ahlukeneyo ngokusekelwe kwiinguqu zofuzo kubantu ngabanye. Oku kufunyenwe ngoku kusetyenzwa kwemithombo yeVithamin E kwaye inokufaneleka kweminye imithombo yezondlo esetyenziswa kuyo umhlaza isondlo / ukutya ngokunjalo..
Ngelixa ukungenisa uVitamin E kunokuba luncedo kunyango oluthile kwi-Ovarian Cancer, akunakunceda ukunciphisa umngcipheko wezinye iintlobo zomhlaza njengomhlaza weProstate.
Ukuqapha izakuthathwa
Idosi ecetyiswayo yemihla ngemihla yeVitamin E yi-15 mg. Ukugqitha kweli xabiso kungakhokelela kwiziphumo ebezingalindelekanga ezinzulu ezinjengokonyuka komngcipheko wokopha kunye nokubetha okuchaphazelayo, ngaphandle kwezinto ezinobungozi ezingentla ezinxulunyaniswa nomanyano olwandayo lomhlaza webele kunye ne-glioblastoma, njengoko kuchaziwe kwizifundo zeklinikhi.
Esinye isizathu sokuba i-Vitamin E eyongeziweyo ye-antioxidant supplementation ingaba yingozi kukuba inokuphazamisa ibhalansi efanelekileyo yokugcina inqanaba elifanelekileyo loxinzelelo lwe-oxidative kwindawo yethu yeselula. Uxinzelelo oluninzi lwe-oxidative lunokubangela ukufa kweeseli kunye nokuwohloka kodwa uxinzelelo oluncinci kakhulu lwe-oxidative lunokuphazamisana nomthamo we-antioxidant wendalo okhokelela kolunye utshintsho olulandelayo. Olunye olo tshintsho kukuncipha kwejini ephambili yokucinezela ithumba ebizwa ngokuba yiP53, ethathwa njengomgcini wegenome, ngaloo ndlela inyusa amathuba okukhula. umhlaza. (U-Sayin VI okqhubekayo, uSci uguqulela iMed., 2014)
Ke, ukongezwa okugqithileyo kweVitamin E (ngakumbi ekutyeni komhlaza wakho) kunokuba yinto entle kakhulu! Kungcono ukonyusa ukungenisa kwakho iVitamin E ngokutya kakhulu imithombo yokutya etyebileyo yeVitamin E kunokusebenzisa idosi ephezulu yokuncedisa iVitamin E, ngaphandle kokuba ucetyiswe ngugqirha wakho.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.