Iimbalasane
Uphononongo lweklinikhi lubonise ukuba ukusetyenziswa (ukufakwa) kwedosi ephezulu ye-ascorbate (ivithamin C) inamandla okuphucula impilo yonke yomhlaza wobuchopho (GBM) izigulane ezine-prognosis embi. IVithamin C infusions (kwaye mhlawumbi izongezo) ezinikezelwe kunye nomgangatho wokhathalelo lwemitha kunye neTemozolomide yonyango lwengqondo. umhlaza ukwanakho ukuthoba iziphumo ebezingalindelekanga, ngaloo ndlela iphucula umgangatho wobomi besigulana.
Umhlaza weBongo - iGlioblastoma
IGlioblastoma (GBM) sesona sifo somhlaza wobuchopho siphambili. Umgangatho wonyango wokhathalelo lwe-GBM ubandakanya indibaniselwano yotyando lokuhlinzwa kwithumba lobuchopho elilandelwa yimitha efanayo (RT) kunye nonyango lwe-temozolomide (TMZ). Kwiimeko ezininzi, oku kulandelwa yimijikelezo eyongezelelekileyo yemitha yeposi ye-TMZ. Ngaphandle kokuphuhliswa kwamachiza omhlaza wenoveli kunye nayo yonke inkqubela phambili kunyango, isifo kwizigulana ze-GBM ziyaqhubeka nokuba mbi, sisaphila iinyanga ezili-14-16 kunye nokusinda kweminyaka emi-5 engaphantsi kwe-10%. (Stupp R okqhubekayo, ILancet Oncol., 2009; UGilbert MR okqhubekayo, Engl eNtsha. UJ Med., 2014)
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-Vitamin C / i-Ascorbic Acid Sebenzisa kwiCancer Brain
Izifundo zePreclinical kunye nolingo lweklinikhi kwezinye umhlaza Iimpawu zibonise isiphumo esiluncedo sokusebenzisa idosi ephezulu yeVithamin C ukuze ikhuseleke kwaye iphucule ukusebenza kunye netyhefu esezantsi xa isetyenziswa kunye nemitha kunye nonyango lwechemotherapy.
Okokuqala kufundo lweklinikhi lomntu lwenziwa kwizigulana ezili-11 ezisandula ukuxilongwa ze-GBM liSebe leRadiation Oncology kwisibhedlele seYunivesithi yase-Iowa, ukuvavanya ukhuseleko kunye nefuthe lokunyuswa kwe-pharmacological ascorbate, enikwa kunye nomgangatho wonyango lwe-GBM. (UAllen BG okqhubekayo, uMhlaza kwiCancer Res., 2019I-ascorbate yedosi ephezulu yafakwa kathathu ngeveki ngexesha lonyango lwe-RT / TMZ kwaye kabini ngeveki ngexesha lokujikeleza kwe-TMZ. Kwizifundo ze-3 kolu phononongo, i-11 yazo yayine-prognosis engalunganga esekwe kwimeko ye-enzyme ye-MGMT, into eyaziwayo yokuphendula okuphantsi kwi-TMZ. Idatha yezembali ibonisa ukuba abaguli be-GBM ngaphandle kwe-MGMT yokukhuthaza i-methylation banokusinda kwiinyanga ezili-8 kuphela ngelixa izifundo ezikolu phononongo ngaphandle kokukhuthaza i-MGMT methylation zazisinda kwiinyanga ezingama-12 nezifundo ezi-23 zisaphila. Iziphumo ezibi kuphela ezifunyenwe zezi zifundo yayingumlomo owomileyo kunye nokugodola okunxulunyaniswa nokunyuswa kwe-ascorbate, ngelixa ezinye iziphumo ebezingalindelekanga ezinamandla zokudinwa, isicaphucaphu kunye neziganeko ezichaseneyo zehematological ezinxulunyaniswa ne-TMZ kunye ne-RT zinciphile.
isiphelo
Olu pho nonongo lubonisa ukuba ukunyusa umthamo ophezulu we-Vitamin C okanye i-ascorbate kumhlaza wesifo somhlaza (GBM) izigulane eziphathwa nge-RT / TMZ zonyango imijikelezo inokukwazi ukuphucula ukusinda ngokubanzi, ngakumbi kwizifundo ezine-MGMT engabonakaliyo. . Uphononongo lubonisa ukuba ukunyuswa kwe-ascorbate infusion akunakuphucula kuphela ukunyamezelana nokunyanga kwe-RT kunye ne-TMZ, kodwa kunokubangela ukonyusa umgangatho wobomi bezigulana kunye nokunciphisa ityhefu yemitha kunye nonyango lwechemotherapy. Idosi ephezulu yovithamini C (ascorbate) ukumiliselwa ikwabonakalise isithembiso sokunciphisa ityhefu yee-chemotherapies ezinje nge-gemcitabine, i-carboplatin kunye ne-paclitaxel kwi-pancreatic kunye nee-ovarian cancer. (I-Welsh JL okqhubekayo, iCancer Chemother Pharmacol., 2013; Ma Y okqhubekayo, Sci. Guqula. IMed., 2014) Abaphandi bacetyisa ukuba iziphumo zophononongo lwabo kweli qela lincinci lezigulane zisathembisa ngokwaneleyo ukuba zifanele ukuphononongwa ngophando lwezonyango kwimpembelelo yeVithamin C kunye nezongezo kwingqondo. umhlaza.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.