Iimbalasane
Le bhlog yingqokelela yezifundo zeklinikhi kunye neziphumo zokubonisa umanyano lwevithamini / i-multivitamin intake kunye nomngcipheko womhlaza kunye nolunye ulwazi olusisiseko malunga nemithombo yokutya yendalo yeevithamini ezahlukeneyo. Isiphetho esiphambili esivela kwizifundo ezahlukeneyo kukuba ukuthatha iivithamini kwimithombo yokutya yendalo kunenzuzo kuthi kwaye inokubandakanywa njengenxalenye yokutya / ukutya okunomsoco kwansuku zonke, ngelixa ukusetyenziswa kwe-multivitamin supplementation ayiloncedo kwaye ayifaki ixabiso elikhulu ekuboneleleni ngokuchasana- izibonelelo zempilo zomhlaza. Ukusetyenziswa ngokungaqhelekanga kwee-multivitamins kunokunxulunyaniswa nokunyuka umhlaza ingozi kwaye inokubangela ingozi enokwenzeka. Kungoko ezi zongezo ze-multivitamin kufuneka zisetyenziswe kuphela kukhathalelo lomhlaza okanye uthintelo ekunconyweni kweengcali zonyango - kwimeko efanelekileyo kunye nemeko.
Iivithamini zizondlo eziyimfuneko ekutyeni nakweminye imithombo yendalo efunwa ngumzimba wethu. Ukunqongophala kweevithamini ezithile kunokubangela ukusilela okukhulu okubonakalisa ukuphazamiseka okungafaniyo. Ukutya okusempilweni okunesondlo kunye nokutya okwaneleyo kunye neevithamini kunxulunyaniswa nokwehliswa komngcipheko wokufa kwizifo zentliziyo kunye nomhlaza. Umthombo wezakhamzimba kufanelekile ukuba ube kukutya esikutyayo, kodwa kumaxesha akhawulezileyo esihlala kuwo, idosi yemihla ngemihla ye-multivitamin ithatha indawo yokutya okunesondlo.
Isongezelelo se-multivitamin ngemini siye saba yinto eqhelekileyo kubantu abaninzi kwihlabathi jikelele njengeyona ndlela yendalo yokunyusa impilo kunye nokuba sempilweni kunye nokuthintela izifo ezifana nomhlaza. Ukusetyenziswa kweeMultivitamini kuyanda ekukhuleni komntwana osele ekhulile ngokufumana izibonelelo zempilo kunye nokuxhasa impilo ngokubanzi. Uninzi lwabantu lukholelwa ekubeni idosi ephezulu yokutya ivithamini yinto yokulwa ukwaluphala, ukonyusa amajoni omzimba kunye nokuthintela isifo, nokuba ayisebenzi, ayinakwenza bubi. Kukho inkolelo yokuba ekubeni iivithamini zivela kwimithombo yendalo kwaye zikhuthaza impilo elungileyo, izixa ezingaphezulu zezi zithathwa njengezongezelelo kufuneka zisincede ngakumbi. Ngokusasazeka nokusetyenziswa gwenxa kweevithamini kunye neevithamini ezininzi kwilizwe liphela, kuye kwakho izifundo ezininzi zeklinikhi eziqwalaselweyo ezijonge imibutho yeevithamini ezahlukeneyo nendima yazo yokuthintela umhlaza.
Imithombo yokutya vs.Izixhobo zokutya
Uphononongo lwakutsha nje olwenziwe yiFriedman School kunye neTufts University School of Medicine luvavanye izibonelelo ezinokubakho kunye nokwenzakala kosetyenziso lweevithamini. Abaphandi bavavanya idatha kubantu abadala abangama-27,000 abasempilweni abaneminyaka engama-20 okanye ngaphezulu. Uphononongo luvavanye ukutya okunesondlo sevithamini njengokutya kwendalo okanye izongezo kunye nokunxulumana nabo bonke oonobangela bokufa, ukufa sisifo sentliziyo okanye umhlaza. (U-Chen F okqhubekayo, iiAnnals zeInt. Med, 2019)
Uphononongo lufumene izibonelelo ezinkulu zokufumana ukutya okunesondlo kwiivithamini ezivela kwimithombo yokutya yendalo endaweni yokufumana. Ukutya okwaneleyo kweVitamin K kunye neMagnesium ekudleni kunxulunyaniswa nomngcipheko omncinci wokufa. Ukutya okugqithisileyo kweCalcium kwizincedisi, ezingaphezulu kwe-1000 mg / ngosuku, kwakudityaniswa nomngcipheko ophezulu wokufa ngenxa yomhlaza. Ukusetyenziswa kwezongezelelo zeVitamin D kubantu ababengenazo iimpawu zokunqongophala kukaVitamin D kunxulunyaniswa nokwanda komngcipheko wokubulawa ngumhlaza.
Zininzi ezinye izifundo zeklinikhi ezivavanye umanyano lokusetyenziswa kweevithamini ezithile okanye izongezo zemultivitamin kunye umngcipheko womhlaza. Siza kulushwankathela olu lwazi malunga neevithamini ezithile okanye ii-multivitamini kubandakanya imithombo yazo yokutya yendalo, kunye nobungqina besayensi kunye nonyango malunga nezibonelelo kunye neengozi zomhlaza.
I-Vitamin A-Imithombo, izibonelelo kunye nobungozi kumhlaza
Imithombo: I-Vitamin A, ivithamin enyibilikayo enamafutha, sisakha-mzimba esibalulekileyo esixhasa umbono oqhelekileyo, ulusu olusempilweni, ukukhula kunye nokukhula kweeseli, ukuphucula ukusebenza komzimba, ukuzala kunye nokukhula komntwana. Ukuba sisondlo esibalulekileyo, iVitamin A ayivelwanga ngumzimba womntu kwaye ifunyenwe kukutya okusempilweni. Ifumaneka kwimithombo yezilwanyana njengobisi, amaqanda, isibindi kunye neoyile yesibindi sentlanzi ngohlobo lwe-retinol, uhlobo olusebenzayo lweVitamin A. Iyafumaneka nakwimithombo yezityalo efana iminqatha, ibhatata, ispinatshi, ipapaya, imango kunye ne thanga ngohlobo lwe carotenoids, ezi proaminamin A eziguqulwe zenziwa i-retinol ngumzimba womntu ngexesha lokwetyisa. Nangona iVitamin A idla isibonelelo sempilo yethu ngeendlela ezininzi, izifundo ezininzi zeklinikhi ziye zavavanya ubudlelwane phakathi kwevithamini A kunye neendidi ezahlukeneyo zomhlaza.
Umbutho weVitamin A ngoKwanda komngcipheko woMhlaza
Olunye uphononongo lwakutshanje oluqwalaselweyo lonyango lubonakalisile ukuba izongezo ezinjenge-beta-carotene zinokunyusa umngcipheko womhlaza wemiphunga ngakumbi kubantu abatshayayo ngoku kunye nabantu abanembali ebalulekileyo yokutshaya.
Kwisifundo esinye, abaphandi abavela kwinkqubo ye-Thoracic Oncology e-Moffitt Cancer Centre eFlorida, bafunda unxibelelwano ngokuvavanya idatha kwizifundo eziyi-109,394 kwaye bagqiba kwelokuba 'phakathi kwabantu abatshayayo ngoku, ukuxhaswa kwe-beta-carotene kwafunyanwa kunxulunyaniswa kakhulu nomngcipheko owandileyo wemiphunga umhlaza '(UTanvetyanon T okqhubekayo, Umhlaza, 2008).
Ngaphandle kolu phononongo, izifundo zangaphambili zenziwa nakwabatshayayo abangamadoda, njengeCARET (ICarotene kunye neRetinol Efficacy Trial) (Omenn GS et al, New Engl J Med, 1996), kunye ne-ATBC (Alpha-Tocopherol Beta-Carotene) (Iqela le-ATBC lokuThintela uMhlaza, i-Engl J Med eNtsha, 1994), ikwabonakalise ukuba ukuthatha iidosi eziphezulu zeVitamin A akuthintelanga umhlaza wemiphunga, kodwa kwabonisa ukonyuka okubonakalayo kumngcipheko womhlaza wemiphunga phakathi kwabathathi-nxaxheba.
Kolunye uhlalutyo oluhlanganisiweyo lwezifundo ezahlukeneyo zeklinikhi ezili-15 ezipapashwe kwijenali yaseMelika yoNyango lweKlinikhi ngo-2015, iimeko ezingaphezulu kwe-11,000 zahlalutywa, ukumisela umanyano lwamanqanaba eVithamini kunye nomngcipheko womhlaza. Kule isayizi enkulu kakhulu yesampulu, amanqanaba e-retinol ayanyaniswa ngokuqinisekileyo nomngcipheko wesifo somhlaza. (I-TJ ephambili okqhubekayo, Am J Clin. Isondlo, 2015)
Uhlalutyo lokujonga ngaphezulu kweesampulu ezingama-29,000 zabathathi-nxaxheba eziqokelelwe phakathi kowe-1985-1993 kwisifundo sokuthintela umhlaza se-ATBC, saxela ukuba kunyaka olandelayo wokulandelwa, amadoda ane-serum retinol yoxinaniso oluphezulu ayenomngcipheko ophakamileyo womhlaza webele (uMondul AM okqhubekayo, Am J Epidemiol, 3). Uhlalutyo lwamva nje lwe-NCI eqhutywa kufundwa kuthintelo lomhlaza lwe-ATBC ngokulandelelana ukuya kwi-2011, iqinisekisile iziphumo zangaphambili zombutho we-serum retinol yoxinzelelo oluphezulu kunye nomngcipheko okhulayo womhlaza wesibeletho (UHada M okqhubekayo, Am J Epidemiol, 2019).
Yiyo loo nto, ngaphandle kwento yokuba i-beta-carotene yendalo ibalulekile ekutyeni okunezakha-mzimba, ukungenisa kakhulu oku ngokusebenzisa izongezo ze-multivitamin kunokuba yingozi kwaye akunakuhlala kunceda kuthintelo lomhlaza. Njengoko uphononongo lubonisa, ukutya kakhulu i-retinol kunye ne-carotenoid supplements zinokwandisa umngcipheko wee-cancer ezifana nomhlaza wemiphunga kubantu abatshayayo kunye nomhlaza webala lobudoda emadodeni.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Umbutho weVitamin A ngokuNciphisa umngcipheko woMhlaza wolusu
Uphononongo lweklinikhi luvavanye idatha enxulumene nokutya kweVitamin A kunye nomngcipheko we-squamous cell carcinoma (SCC), uhlobo lomhlaza wolusu, oluvela kubathathi-nxaxheba kwizifundo ezibini ezikhulu, zokujonga ixesha elide. Ezi zifundo yayiziZifundo zezeMpilo zabaNesi (i-NHS) kunye nabaFundi abaLandelayo abaFundayo (HPFS). I-cutaneous squamous cell carcinoma (SCC) lolona hlobo lwesibini luqhelekileyo lomhlaza wolusu kunye nenqanaba leziganeko eziqikelelweyo ze-7% ukuya kwi-11% e-United States. Olu phononongo lubandakanya idatha evela kubafazi abangama-75,170 baseMelika abathathe inxaxheba kuphando lwe-NHS, beneminyaka yobudala engama-50.4, kunye namadoda angama-48,400 ase-US athe athatha inxaxheba kuphando lwe-HPFS, aneminyaka yobudala engama-54.3.UKim J okqhubekayo, JAMA Dermatol., 2019).
Iziphumo eziphambili zophononongo yayikukuba i-Vitamin A yokutya yayihambelana nomngcipheko omncinci womhlaza wolusu (i-SCC). Iqela elalinomyinge ophambili we-Vitamin A osetyenzisiweyo mihla le lalinomyinge we-17% wokunciphisa umngcipheko we-SCC enqamlezileyo xa kuthelekiswa neqela elalisebenzisa iVitamin A. Eyona nto yayifunyanwa ikakhulu kwimithombo yokutya hayi kwizongezo zokutya. Ukutya okuphezulu kwe-vitamin A iyonke, i-retinol, kunye ne-carotenoids, ezifumaneka ngokubanzi kwiziqhamo kunye nemifuno, zazinxulunyaniswa nomngcipheko omncinci we-SCC.
Imithombo, izibonelelo kunye nomngcipheko weVitamin B6 kunye neB12 kwiCancer
imithombo : I-Vitamin B6 kunye ne-B12 ziivithamini ezinyibilikayo ngamanzi ezifumaneka ngokutya okuninzi. I-Vitamin B6 yi-pyridoxine, pyridoxal kunye ne-pyridoxamine. Sisondlo esibalulekileyo kwaye yicoenzyme yokuphendula okuninzi emzimbeni, idlala indima kuphuhliso lwengqondo, ukwakheka kwehemoglobin kunye nokusebenza komzimba. Ukutya okune-Vitamin B6 kubandakanya iintlanzi, inkukhu, itofu, inyama yenkomo, ibhatata, iibhanana, iitapile, iiavokhado kunye neepistachios.
I-Vitamin B12, ekwabizwa ngokuba yi-cobalamin, iyanceda ekugcineni iiseli zemithambo-luvo kunye negazi kwaye kufanelekile ekwenzeni i-DNA. Ukunqongophala kwayo kwe-vitamin B12 kuyaziwa ukuba kunokubangela i-anemia, ubuthathaka kunye nokudinwa kwaye ke kubalulekile ukuba ukutya kwethu kwemihla ngemihla kubandakanya ukutya okune-Vitamin B12. Ngenye indlela, abantu basebenzisa iivithamini B ezongezelelweyo okanye i-B-complex okanye i-multivitamin supplements ezibandakanya ezi vithamini. Imithombo yevithamini B12 yintlanzi kunye neemveliso zezilwanyana ezinje ngobisi, inyama kunye namaqanda kunye nezityalo kunye neemveliso zezityalo ezinje ngetofu kunye neemveliso zesoya ezivundisiweyo kunye nolwandle.
Umbutho weVitamin B6 noMngcipheko woMhlaza
Inani elincinci lovavanyo lwezonyango olugqityiweyo ukuza kuthi ga ngoku alibonisanga ukuba ukongezwa kweevithamini B6 kunokunciphisa ukusweleka okanye kuncede ukuthintela umhlaza. Uhlalutyo lwedatha kwizifundo ezibini ezikhulu zekliniki eNorway alufumananga ntlangano phakathi kokongezwa kweevithamini B6 kunye neziganeko zomhlaza kunye nokufa. (Ebbing M, et al, JAMA, 2009) Ke ngoko, ubungqina bokusetyenziswa kwe vithamin B6 ukuthintela okanye ukunyanga umhlaza okanye ukunciphisa Ityhefu ehambelana nekhemotherapy ayicacanga okanye ayigqibi. Nangona, i-400 mg ye-vitamin B6 inokusebenza ngempumelelo ekunciphiseni imeko yesifo seenyawo, i-chemotherapy side-effect. (Chen M, et al, PLoS One, 2013) Ukongezwa kwe vithamini B6, nangona kunjalo, khange kubonise ukonyusa umngcipheko womhlaza.
Umbutho weVitamin B12 noMngcipheko woMhlaza
TNazi izinto ezixhalabisayo ekusebenziseni ixesha elide kwidosi ephezulu yeVitamin B12 kunye nokudibana kwayo nomngcipheko womhlaza. Izifundo ezahlukeneyo kunye nohlalutyo lwenziwa ukuphanda ifuthe leVitamin B12 yokutya kumngcipheko womhlaza.
Uvavanyo lolingo lwezonyango, olubizwa ngokuba yi-B-PROOF (iivithamini ze-B zoThintelo lwee-Osteoporotic Fractures) zolingo, lwenziwa eNetherlands ukuvavanya isiphumo sokongezwa kwemihla ngemihla ngevithamini B12 (500 μg) kunye ne-folic acid (400 μg), ye-2 ukuya kwiminyaka emi-3, kwizehlo zokwaphuka Idatha kolu phando isetyenziswe ngabaphandi ukuqhubela phambili ukuphanda ifuthe lokunyusa ixesha elide iVitamin B12 kumngcipheko womhlaza. Uhlalutyo lubandakanya idatha evela kubathathi-nxaxheba abangama-2524 besilingo se-B-PROOF kwaye kwafunyanwa ukuba ixesha elide le-folic acid kunye ne-vitamin B12 yokuncedisa yayinxulumene nomngcipheko ophezulu womhlaza jikelele kunye nomngcipheko ophezulu kakhulu womhlaza wesifo somhlaza. Nangona kunjalo, abaphandi bacebisa ukuqinisekisa oku kufunyanwa kwizifundo ezikhulu, ukuze kuthathwe isigqibo sokuba ngaba uVithamin B12 ukongezwa kufuneka kuthintelwe kuphela kwabo banesiphene se-B12 (Oliai Araghi S et al, Cancer Epidemiol Biomarkers Prev., 2019).
Kwesinye isifundo samazwe apapashwe kutshanje, abaphandi bahlalutye iziphumo ezivela kwizifundo ezingama-20 ezisekelwe kubantu kunye nedatha evela kuma-5,183 amatyala omhlaza wamaphaphu kunye nokulawulwa kwabo okungama-5,183, ukuvavanya ifuthe le-vitamin B12 yoxinzelelo kumngcipheko womhlaza ngokusebenzisa imilinganiselo ethe ngqo yokujikeleza ivithamini B12 iisampulu zegazi kwangaphambili. Ngokusekwe kuhlalutyo lwabo, bagqiba kwelokuba i-vitamin B12 ephezulu inxulunyaniswa nomngcipheko womhlaza wemiphunga kunye nawo onke amanqanaba aphindwe kabini eVitamin B12, umngcipheko unyuke nge ~ 15% (UFanidi A et al, Int J Cancer., 2019).
Iziphumo eziphambili kuzo zonke ezi zifundo zibonisa ukuba ukusetyenziswa kwexesha elide kwithamo eliphezulu iVitamin B12 inxulunyaniswa nomngcipheko owandayo womhlaza njengomhlaza obomvu kunye nomhlaza wemiphunga. Ngelixa oku akuthethi ukuba sisuse ngokupheleleyo iVitamin B12 kwizidlo zethu, kuba sifuna isixa esaneleyo seVitamin B12 njengenxalenye yokutya okuqhelekileyo okanye ukuba sinesiphene seB12. Into ekufuneka siyiphephe kukuxhasa kakhulu ivithamini B12 (ngaphaya kwenqanaba elaneleyo).
Imithombo, izibonelelo kunye nomngcipheko weVitamin C kuMhlaza
imithombo : Vitamin C, ekwabizwa ngokuba yi-ascorbic acid, yinto enyibilikayo emanzini, izondlo eziyimfuneko ezifumaneka kwimithombo emininzi yokutya. Ineempawu zokulwa ne-antioxidant ezinceda ukukhusela iiseli zethu kumonakalo obangelwe ziiradicals simahla. Ii-radicals zasimahla zizinto ezisebenzayo eziveliswayo xa umzimba wethu uhlanganisa ukutya kwaye uveliswa ngenxa yokuvezwa kwendalo njengokutshaya icuba, ungcoliseko lomoya okanye imitha yelanga yelanga. I-Vitamin C iyafuneka emzimbeni ukwenza i-collagen enceda ekunyangeni amanxeba; kwaye iyanceda ekugcineni iifayile ze- amajoni omzimba omelele kwaye omelele. Imithombo yokutya etyebile kuVitamin C ibandakanya iziqhamo zesitrasi ezinje ngeorenji, iidiliya kunye nelamuni, ipepile ebomvu naluhlaza, iziqhamo ze-kiwi, i-cantaloupe, amaqunube, imifuno enqatyisiweyo, imango, ipapaya, ipayinapile kunye nezinye iziqhamo nemifuno.
Umbutho oNcedo weVitamin C enomngcipheko womhlaza
Zininzi izifundo zeklinikhi eziphanda izibonelelo zokusebenzisa idosi ephezulu yeVitamin C kwii-cancer ezahlukeneyo. Uvavanyo lweklinikhi olwenziwe kakuhle lokusetyenziswa kukaVitamin C ngohlobo lokongezwa komlomo akufumananga zibonelelo kubantu abanomhlaza. Nangona kunjalo, kutsha nje, iVitamin C enikezwe ngaphakathi ifunyenwe ibonakalisa ifuthe elingafaniyo nedosi kwifom yomlomo. Ukufakwa kwabo ngaphakathi kufunyenwe kukhuselekile kwaye kuphucula ukusebenza kunye nokunciphisa ityhefu xa kusetyenziswa kunye nonyango lwe radiation kunye ne chemotherapy.
Uphononongo lweklinikhi lwenziwe kwizigulana ezinomhlaza ze-glioblastoma (GBM), ukuvavanya ukhuseleko kunye nefuthe le-ascorbate (Vitamin C) ukumiliselwa, okunikezelwa kunye nomgangatho wokunyangwa kwemitha kunye ne-temozolomide (RT / TMZ) ye-GBM. (UAllen BG okqhubekayo, uMhlaza kwiCancer Res., 2019Iziphumo zolu phononongo zibonisa ukuba ukufaka idosi ephezulu yeVitamin C okanye ukunyuka kwizigulana ezinomhlaza we-GBM kuphindwe kabini ukusinda kwabo ukusuka kwiinyanga ezili-12 ukuya kwiinyanga ezingama-23, ngakumbi kwizifundo ezazinophawu olubi lokuxela kwangaphambili. I-3 yezifundo ze-11 bezisaphila ngexesha lokubhalwa kolu phando kwi-2019. Iziphumo ezibi kuphela ezifunyenwe zezi zifundo yayingumlomo owomileyo kunye nokugodola okunxulunyaniswa nokunyuswa kwe-ascorbate, ngelixa ezinye iziphumo ebezingalindelekanga ezinamandla zokudinwa, isicaphucaphu kunye kwaneziganeko ezimbi zehematological ezinxulunyaniswa ne-TMZ kunye ne-RT zancitshiswa.
Ukongezwa kweVitamin C kukwabonakalise ukusebenza okuhambelanayo ne-arhente ye-hypomethylating agent (HMA) ye-Decitabine, ye-acute myeloid leukemia. Izinga lokuphendula kumachiza e-HMA liphantsi ngokubanzi, malunga ne-35-45% kuphela (I-Welch JS et al, i-Engl eNtsha. J Med., 2016). Uphononongo lwamva nje olwenziwe e-China kuvavanye ifuthe lokudibanisa iVitamin C kunye neDecitabine kwizigulana ezinomhlaza kubantu abadala abane-AML. Iziphumo zabo zibonise ukuba abaguli abanomhlaza abathathe i-Decitabine ngokudibene ne-Vitamin C babenenqanaba elipheleleyo lokuxolelwa okupheleleyo ngama-79.92% xa kuthelekiswa ne-44.11% kwabo bathathe i-Decitabine kuphela (UZhao H et al, Leuk Res., 2018Isizathu sesayensi esingemva kokuba uVitamin C ayiphucule njani impendulo yeDecitabine kwizigulana ezinomhlaza kwaye yagqitywa kwaye yayingengomphumela nje wamathuba.
Olu phononongo lubonisa ukuba idosi ephezulu ye-Vitamin C infusions ayinakuphucula kuphela ukunyamezelana nokunyanga kwamayeza e-chemotherapy, kodwa inokubangela ukonyusa umgangatho wobomi wezigulana kunye nokuhla utyhefu yemitha kunye nonyango lwerejimeni yonyango. Idosi ephezulu yevithamini C enikezwe ngomlomo ayifunxwanga ngokufanelekileyo ukufezekisa ukugxila okuphezulu kunye nokufakwa ngaphakathi kwe-vitamin C, kungoko kungakhange kubonise zibonelelo. Idosi ephezulu yovithamini C (ascorbate) ukumiliselwa ikwabonakalise isithembiso sokunciphisa ityhefu yee-chemotherapies ezinje nge-gemcitabine, i-carboplatin kunye ne-paclitaxel kwi-pancreatic kunye nee-ovarian cancer. (Welsh JL okqhubekayo, Cancer Chemother Pharmacol., 2013; Ma Y okqhubekayo, Sci. Guqula. IMed., 2014)
Imithombo, izibonelelo kunye nomngcipheko weVitamin D kuMhlaza
imithombo : I-Vitamin D sisondlo esidingekayo kwimizimba yethu ukugcina amathambo omelele ngokunceda ekufunxeni i-calcium ekutyeni nakwizongezo. Iyafuneka nakweminye imisebenzi emininzi yomzimba kubandakanya ukushukuma kwemisipha, ukubonakalisa imithambo-luvo nokusebenza kwamasosha ethu omzimba ukulwa usulelo. Imithombo yokutya etyebile kwiVitamin D ziintlanzi ezinamafutha ezifana nesalmon, ityhuna, imackerel, inyama, amaqanda, iimveliso zobisi, amakhowa. Imizimba yethu yenza iVitamin D xa ulusu luvezwe ngqo lilanga.
Umbutho weVitamin D noMngcipheko woMhlaza
Isifundo esiza kwenziwa seklinikhi senziwe ukujongana nombuzo wokuba ngaba ukuxhaswa kweVitamin D kuyanceda na kuthintelo lomhlaza. Uvavanyo lweklinikhi VITAL (VITamin D kunye novavanyo lwe-omegA-3) (NCT01169259) yayililizwe liphela, elalilindelwe, kunye noluhlu olungenamkhethe, ngeziphumo ezisandula ukupapashwa kwiNew England Journal of Medicine (UManson JE okqhubekayo, eNtsha Engl J Med., 2019).
Kwakukho abathathi-nxaxheba abangama-25,871 kolu phononongo ababandakanya amadoda aneminyaka engama-50 nangaphezulu kunye nabasetyhini abaneminyaka engama-55 nangaphezulu. Abathathi-nxaxheba bahlulwe ngokungacwangciswanga kwiqela elithatha iVitamin D3 (cholecalciferol) eyongezelelweyo ye-2000 IU ngemini, oko kukuthi amaxesha ama-2-3 isibonelelo sokutya esinconyelwayo. Iqela lolawulo lwe-placebo alikhange lithathe nasiphi na isongezelelo se-Vitamin D. Akukho namnye kubathathi-nxaxheba ababhalisileyo owayenembali yomhlaza ngaphambili.
Iziphumo zophononongo lwe-VITAL azibonisanga mahluko ngokokubaluleka kwesifo somhlaza phakathi kweVitamin D kunye namaqela e-placebo. Yiyo loo nto idosi ephezulu yokuxhasa iVitamin D yayingadibani nomngcipheko omncinci womhlaza okanye izehlo ezisezantsi zomhlaza. Ke, olu phando lukhulu, uvavanyo olungenamkhethe lubonisa ngokucacileyo ukuba idosi ephezulu yokuncedisa iVitamin D inokunceda kwiimeko ezinxulumene nethambo kodwa ukongezwa okuthe kratya akongezeli ixabiso kumbono wothintelo lomhlaza.
Imithombo, izibonelelo kunye nomngcipheko weVitamin E kuMhlaza
imithombo : Vitamin E liqela lezinto ezinokunyibilikisa ezinamafutha ezifumaneka kukutya okuninzi. Yenziwe ngamaqela amabini eekhemikhali: i-tocopherols kunye ne-tocotrienols, eyaba ngowona mthombo uphambili we-vitamin E kwizidlo zethu. Iipropathi zokulwa ne-vitamin E zinceda ekukhuseleni iiseli zethu kumonakalo obangelwe kukungasebenzi kakuhle kwee-radicals kunye noxinzelelo lwe-oxidative. Iyadingeka kwizibonelelo ezininzi zempilo ukusukela kukhathalelo lolusu ukuya ekuphuculeni impilo yengqondo kunye nengqondo. Ukutya okutyebileyo kwiVitamin E kubandakanya ioyile yombona, ioyile yemifuno, ioyile yesundu, iiamangile, iihazelnuts, iipinenuts, imbewu kajongilanga ngaphandle kwezinye iziqhamo kunye nemifuno. Ukutya okuphezulu kwii-tocotrienols zezi irayisi bran, i-oats, irye, irhasi kunye neoyile yesundu.
Umbutho weVitamin E enomngcipheko womhlaza
Izifundo ezininzi zeklinikhi zibonise ukwanda komngcipheko womhlaza kunye needosi eziphezulu zeVitamin E.
Isifundo esisekwe kwi-neuro oncology eyahlukeneyo kunye namasebe e-neurosurgery kwizibhedlele zase-US ahlalutya idatha yodliwanondlebe evela kwizigulana ezingama-470 ezenziwa emva kokuchongwa komhlaza wobuchopho i-glioblastoma multiforme (GBM). Iziphumo zibonise ukuba abasebenzisi beVitamin E bane ukufa okuphezulu xa kuthelekiswa nezigulana ezinomhlaza ezingakhange zisebenzise uVitamin E.UMulphur BH okqhubekayo, uNeurooncol Pract., 2015)
Kwesinye isifundo esivela eSweden naseCancer Registry yaseNorway, abaphandi bathathe indlela eyahlukileyo yokufumanisa umngcipheko womhlaza wobuchopho, i-glioblastoma. Bathathe iisampulu ze-serum ukuya kuthi ga kwiminyaka eyi-22 ngaphambi kokuchongwa kwe-glioblastoma kwaye bathelekisa ukugxilwa kweemetabolite zeesampulu zalabo bakhulisa umhlaza kwabo bangakhange benze njalo. Bafumene uxinzelelo oluphezulu kakhulu lwe-serum yeVitamin E isoform alpha-tocopherol kunye ne-gamma-tocopherol kwiimeko eziphuhlise i-glioblastoma. (UBjorkblom B okqhubekayo, Oncotarget, 2016)
I-Selenium enkulu kakhulu kunye novavanyo lwe-Vitamin E Cancer Prevention Trial (SELECT) yenziwa ngaphezulu kwamadoda angama-35,000 ukuvavanya umngcipheko wokuxhamla kuVitamin E. Olu vavanyo lwenziwa kumadoda awayeneminyaka engama-50 okanye ngaphezulu kwaye enamaqondo aphantsi e-antigen (PSA) amanqanaba e-4.0 ng / ml okanye ngaphantsi. Xa kuthelekiswa nabo bangakhange bathathe izongezo zeVitamin E (i-Placebo okanye iqela lesalathiso), uphononongo lufumene ukonyuka okupheleleyo komngcipheko womhlaza wedlala lobubovu kwabo bathatha izongezo ze-vitamin E Ke, ukongezwa kokutya kunye neVitamin E kunxulunyaniswa nomngcipheko okhulayo womhlaza wedlala lobudoda phakathi kwamadoda aphilileyo. (UKlein EA okqhubekayo, JAMA, 2011)
Kwi-alpha-tocopherol, isifundo se-beta-carotene se-ATBC sokuthintela umhlaza esenziwe kubantu abatshayayo abangaphezu kweminyaka engama-50 ubudala, abafumananga kuncitshiswa kweziganeko zomhlaza wemiphunga emva kweminyaka emihlanu ukuya kwesibhozo yokutya okune-alpha-tocopherol. (ENew J J Med, 1994)
Izibonelelo zeVitamin E kumhlaza we-Ovarian
Kwimeko ye-ovarian umhlaza, I-Vitamin E i-compound tocotrienol ibonise inzuzo xa isetyenziswe ngokudibanisa nomgangatho wokunyamekela ichiza i-bevacizumab (i-Avastin) kwizigulane ezichasene nonyango lwe-chemotherapy. Abaphandi baseDenmark, bafunde isiphumo seqela le-tocotrienol leVithamin E lidityaniswe ne-bevacizumab kwizigulana ezinomhlaza we-ovari ezingazange ziphendule kunyango lwe-chemotherapy. Uphononongo lubandakanya izigulane ze-23. Ukudityaniswa kweVithamin E/tocotrienol kunye ne-bevacizumab kubonise ubutyhefu obuphantsi kakhulu kwizigulana ezinomhlaza kwaye zinezinga le-70% lokuzinzisa isifo. (I-Thomsen CB okqhubekayo, i-Pharmacol Res., 2019)
Imithombo, izibonelelo kunye nomngcipheko weVitamin K kuMhlaza
imithombo : I-Vitamin K sisondlo esiphambili esifunekayo ekunqandeni igazi kunye namathambo asempilweni, ngaphandle kweminye imisebenzi emininzi emzimbeni. Ukusilela kwayo kunokubangela ukutyumka kunye nokuphuma kwegazi. Ifunyanwa ngokwendalo kukutya okuninzi kubandakanya imifuno enamagqabi aluhlaza njengesipinatshi, i-kale, i-broccoli, iletisi; kwioyile yemifuno, iziqhamo ezinjengeeblueberries namakhiwane nakwinyama, itshizi, amaqanda kunye neembotyi zesoya. Okwangoku abukho ubungqina beklinikhi bokunxulumana neVitamin K ngomngcipheko owandisiweyo okanye owehlileyo woMhlaza.
isiphelo
Zonke izifundo ezahlukeneyo zeklinikhi zibonisa ukuba iivithamini kunye nokutya okunesondlo ngohlobo lokutya kwendalo, iziqhamo, imifuno, inyama, amaqanda, iimveliso zobisi, iinkozo, ioyile njengenxalenye yokutya okusempilweni, okunesondlo yeyona nto iluncedo kuthi. Ukusetyenziswa gwenxa kweevithamini okanye izongezo zeevithamini ezingakhange kubonise ukongeza ixabiso ekuthinteleni umngcipheko womhlaza, kwaye kunokuba nakho ukubangela ingozi. Kwiimeko ezininzi, izifundo zifumene umbutho weedosi eziphezulu zeevithamini okanye iivithamini ezininzi ezinobungozi obonyukayo bomhlaza. Kwimeko ezithile ezithile kwimeko ye-Vitamin C ukumiliselwa kwizigulana ezinomhlaza ezine-GBM okanye iLeukemia okanye ukusetyenziswa kwe-tocotrienol / vitamin E kwizigulana ezinomhlaza we-ovari kubonise ifuthe eliluncedo ekuphuculeni iziphumo nasekunciphiseni iziphumo ebezingalindelekanga.
Ke ngoko, ubungqina benzululwazi bubonisa ukuba ukusetyenziswa kwesiqhelo kunye nokusetyenziswa ngokungafunekiyo kweevithamini kunye nezongezelelo ze-multivitamin akuncedi ekunciphiseni umngcipheko womhlaza. Ezi zincedisi ze-multivitamin kufuneka zisetyenziselwe umhlaza kwizindululo ezivela kwiingcali zonyango kwimeko efanelekileyo kunye nemeko. Kungoko imibutho kubandakanya iAkhademi yeZondlo kunye neDietetics, iAmerican Cancer Society, iAmerican Institute of Cancer Research kunye neAmerican Heart Association ayikukhuthazi ukusetyenziswa kokutya nezongezo okanye iivithamini ezininzi ukuthintela umhlaza okanye isifo sentliziyo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.