Iimbalasane
Idosi ephezulu kakhulu ye-Ascorbic Acid (Vitamin C) enikezwe ngaphakathi kunye nokudityaniswa kwe-chemotherapy efana ne-FOLFOX kunye ne-FOLFIRI, kwizigulana ezinomhlaza okanye esiswini somhlaza, zinokulawulwa ngokukhuselekileyo ngaphandle kwetyhefu eyongeziweyo. Ukuthatha idosi ephezulu Vitamin C okanye kubandakanya uVitamin C ukutya okunotyebileyo njengenxalenye ye Ukutya kwabaguli abanomhlaza kunye nechemotherapy inokuphucula impendulo epheleleyo kwaye inciphise ichemotherapy ehambelana neziphumo ebezingalindelekanga kumhlaza wesisu okanye esiswini. umhlaza.
Uvithamini C / Ascorbic Acid
I-Ascorbic Acid (i-Vitamin C) yinto eqhelekileyo kwaye isetyenziswa ngokubanzi i-antioxidant kunye ne-immunity immunity booster. Nangona kunjalo, indima yayo kwi umhlaza uthintelo kunye nonyango iye yaphikisana. Nangona ubungqina obuthile be-anecdotal bubonisa ukuba ukutya ukutya okucebileyo kwe-Vitamin C kunciphisa umngcipheko womhlaza, ubungqina obuvela kungenelelo, izilingo zeklinikhi ezingabonakaliyo kunye ne-ascorbate yomlomo azizange zibonise nayiphi na inzuzo. Kodwa kuphononongo lwakutsha nje olunedosi ephezulu ye-ascorbic acid ekuvezweni ngokufakwa kwi-intravenous ngokukhetha ukubulala iiseli zomhlaza, kwaye ibonise iziphumo ze-synergistic kunye namachiza e-cytotoxic. Idosi ephezulu kakhulu ye-ascorbic acid inokufezekiswa kuphela nge-intravenous infusion kwaye kule dose, i-ascorbic acid ingaba nemiphumo ye-pro-oxidant, ibangele ukwanda komonakalo we-DNA, oko kunokubangela ukufa kweseli yomhlaza. Ukongezelela, kukho ubungqina bokuqala bekliniki obubonisa ukuba idosi ephezulu ye-ascorbic acid inokunikezelwa ngokukhuselekileyo ecaleni kweziyobisi ze-cytotoxic ezifana ne-gemcitabine, i-paclitaxel kunye ne-carboplatin.Ma Y okqhubekayo, Sci. Guqula. IMed., 2014; Welsh JL okqhubekayo, Umhlaza Chemother Pharmacol, 2013)
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Sebenzisa iVitamin C / Ascorbic Acid kunye neChemotherapy kwiMetastatic Colorectal kunye neGastric Cancer
Ukuvavanya ukhuseleko kunye nedosi ephezulu yokunyamezela (MTD) ye-ascorbic acid / i-Vitamin C enokuthi inikwe kunye nokudibanisa i-cytotoxic chemotherapy regimens ezifana ne-FOLFOX kunye ne-FOLFIRI, abaphandi abavela kwi-Collaborative Innovation Centre ye-Cancer Medicine, iYunivesithi yaseSun Yat-sen e-China. wenze uvavanyo lweklinikhi olulindelekileyo lweSigaba soku-1 (NCT02969681) kwi-metastatic colorectal (mCRC) okanye esiswini umhlaza (MGC) izigulane. I-FOLFOX yindibaniselwano ye-chemotherapy equka izidakamizwa ze-3: i-leucovorin (i-Folinic acid), i-Fluorouracil kunye ne-oxaliplatin. Kwi-regimen ye-FOLFIRI, i-4 iziyobisi ze-cytotoxic - i-Folinic acid, i-Fluorouracil, i-Irinotecan kunye ne-Cetuximab isetyenziswa. (UWang F okqhubekayo, Umhlaza weBMC, 2019)
Izigulana ezingama-36 zamaTshayina zavavanywa ngedosi yokunyuka kwe-acid ye-ascorbic acid esuka kwi-0.2-1.5 g / kg yokunyanzeliswa kweyure ezi-3, kanye yonke imihla, kangangeentsuku 1-3, kunye IINKCUKACHA okanye i-FOLFIRI kumjikelo weentsuku ezili-14, de kwafezekiswa i-MTD. Kwabaguli abangama-36 ababhalisile, i-24 (23 ene-mCRC kunye ne-1 ene-mGC) yavavanywa ekuphenduleni isifo. Eyona mpendulo ibalaseleyo ibandakanya ukuphendula ngokungaginyiswanga kwizigulana ezilishumi elinesine (58.35%), isifo esizinzileyo kwithoba (37.5%), ngenqanaba lokulawula isifo le-95.8%. Abaphandi baxela ukuba akukho MTD ifikelelweyo kwaye abayifumananga nayiphi na ityhefu yokuthintela umda efunyenwe kunyuka kwethamo. Iziphumo ebezingalindelekanga zixhaphakileyo ezibangelwe yidosi ephezulu ye-ascorbic acid ibandakanya iintloko, ukukhanya-ukukhanya, umlomo owomileyo kunye nokunye okunetyhefu yamathumbu ngenxa yokufakwa ngaphakathi. Olu phononongo lukwabonakalise ukwehla komongo wethambo ongalunganga kunye neetyhefu zesisu ezinxulunyaniswa neerejimeni zekhemotherapy xa kunikwa idosi ephezulu ye-ascorbic acid kunye nekhemotherapy.
Iziphumo zolu phononongo zicebise "ukuba i-ascorbic acid / Vitamin C kwi-1.5 g / kg kube kanye yonke imihla kwiintsuku ezintathu zilandelelana zingalawulwa ngokukhuselekileyo kunye ne-FOLFOX okanye i-FOLFIRI chemotherapy kumjikelo weentsuku ezili-14." (UWang F okqhubekayo, Umhlaza weBMC, 2019)
isiphelo
Idosi ephezulu yeVithamin C kunye / okanye ukutya / isondlo esityebileyo kwiVithamin C enikwa kunye nechemotherapy inokuphucula impendulo epheleleyo kwaye yehlise ichemotherapy ehambelana neziphumo ebezingalindelekanga kumhlaza webala okanye esiswini. umhlaza.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukuphepha ukuqagela kunye nokukhetha okungakhethiyo) lolona nyango lulungileyo lwendalo umhlaza kunye neziphumo ebezingalindelekanga ezinxulumene nonyango.