Ngowuphi umhlaza onokuzuza ngokubandakanya iCalcium D-glucarate ekutyeni kwabo?

Iimbalasane

I-Calcium D-glucarate yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweCalcium D-glucarate kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, iCalcium D-glucarate inokuzuza abo banePrimary Cervical Neuroendocrine Tumor ehamba neDocetaxel. Ngaphaya koko, ngelixa iCalcium D-glucarate inokunceda abantu abanomngcipheko wemfuzo "CDKN2A", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweCalcium D-glucarate kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iCalcium D-glucarate lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neCalcium D-glucarate endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iCalcium D-glucarate kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iCalcium D-glucarate ukuba unemfuzo enokuthanani nomhlaza onxulumene ne-CDKN2A gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya iCalcium D-glucarate kwisidlo sakho ukuba ufunyaniswe une-Primary Cervical Neuroendocrine Tumor? Ngaphezu koko, kufuneka ulungelelaniswe njani ukusetyenziswa kwakho kweCalcium D-glucarate ukuba ufumana unyango lweDocetaxel okanye ukuba isicwangciso sakho sonyango siyatshintsha kwiDocetaxel? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neCalcium D-glucarate yendalo, ngoko isoloko iluncedo' okanye 'iCalcium D-glucarate yonyusa ukhuselo lomzimba' ayonelanga ekutyeni okunolwazi/kukhetho lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iCalcium D-glucarate kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeCalcium D-glucarate kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo. , imizila yemfuza kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, olufana nePrimary Cervical Neuroendocrine Tumor, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neCalcium D-glucarate. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDKN2A uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwijeni? Ukusuka kumbono wesondlo, ngaba umngcipheko ohambelana ne-Primary Cervical Neuroendocrine Tumor ulingana nomnye umhlaza? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bafumana olunye unyango njengabo bafumana iDocetaxel? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Calcium D-glucarate – Isongezo seSondlo

I-Calcium D-glucarate eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Glucaric Acid, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngakumbi uMjikelo weSeli, olawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, njengokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeCalcium D-glucarate, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iCalcium D-glucarate kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweCalcium D-glucarate ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeCalcium D-glucarate

Ukuphendula umbuzo othi 'Ndingayiphepha nini iCalcium D-glucarate kumxholo woMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeCalcium D-glucarate ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba iCalcium D-glucarate ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka Ingqwalaselo yomntu ngamnye kwizigqibo ezinjalo.

1. Ngaba i-Calcium D-glucarate Supplements iya kunceda i-Cervical Cervical Neuroendocrine Tumor Patients eziphantsi koNyango lwe-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABHD6, STOX1 kunye ne-PDZD4, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-Cell Cycle. Ukusebenza konyango lomhlaza, njenge-Docetaxel, kugqitywe ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seCalcium D-glucarate lukhetho olunengqiqo kwabo banePrimary Cervical Neuroendocrine Tumor ehamba neDocetaxel. Oku kungenxa yokuba i-Calcium D-glucarate ichaphazela iindlela ezifana ne-Cell Cycle, enokuthi inqanda izinto eziqhuba i-Primary Cervical Neuroendocrine Tumor okanye izuze ukusebenza kwe-Docetaxel.

2. Ngaba iCalcium D-glucarate Supplements ikhuselekile kuBantu abasempilweni abaneCDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDKN2A kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints kunye ne-Cell Cycle, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDKN2A ehambelana noMhlaza woLusu, cinga ngokufaka izongezo zeCalcium D-glucarate kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngendlela eyiyo iindlela ezifana neCell Cycle, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDKN2A kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neCalcium D-glucarate, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• I-genomics yeklinikhi edibeneyo yomhlaza we-metastatic.
• I-Paclitaxel inqanda ukuqhubela phambili kweeseli ze-mitotic ukuya kwisigaba se-G1 ngokuphazamiseka kokubunjwa kwe-spindle ngaphandle kokuchaphazela eminye imisebenzi ye-microtubule ngexesha le-anaphase kunye ne-telephase.