Iimbalasane
Kuphononongo lwakutsha nje lwedatha evela kumadoda nabasetyhini eUnited States, abathathe inxaxheba kwizifundo ezimbini ezinkulu, zophononongo lwexesha elide, abaphandi bavavanya unxibelelwano phakathi kwe-retinoid yendalo ye-Vitamin A (Retinol) kunye nomngcipheko we-cutaneous squamous cell carcinoma (SCC) , uhlobo lwesibini oluqhelekileyo lwesikhumba umhlaza phakathi kwabantu abanolusu olukhanyayo. Uhlalutyo luqaqambise umngcipheko oncitshisiweyo womhlaza wolusu ngokunyuka kweVithamin A (iRetinol) (uninzi efunyenwe kwimithombo yokutya kwaye hayi izongezo).
Vitamin A (Retinol) -I-Retinoid yendalo
I-Vitamin A, i-retinoid yendalo e-soluble-fat-soluble, iyisondlo esibalulekileyo esixhasa umbono oqhelekileyo, ulusu oluphilileyo, ukukhula kunye nokuphuhliswa kweeseli, ukuphuculwa kokusebenza komzimba, ukuveliswa kunye nokuphuhliswa komntwana. Ukuba sisondlo esibalulekileyo, IVithamini A ayiveliswa ngumzimba womntu kwaye ifunyanwa ekutyeni kwethu okunempilo. Ngokuqhelekileyo kufumaneka kwimithombo yezilwanyana ezifana nobisi, amaqanda, ushizi, ibhotela, isibindi kunye neoli yentlanzi-isibindi ngendlela ye-retinol, ifom esebenzayo ye-Vitamin A, kunye nemithombo yezityalo ezifana ne-karoti, i-broccoli, i-potato, ebomvu. i-bell pepper, isipinatshi, i-papaya, imango kunye nethanga ngendlela ye-carotenoids, eguqulwa ibe yi-retinol ngumzimba womntu ngexesha lokugaya. Le bhlog icacisa uphononongo oluhlalutye umanyano phakathi kokuthathwa kweVithamin A yendalo kunye nomngcipheko womhlaza wolusu.
Vitamin A kunye nomhlaza wolusu
Nangona iVitamin A idla isibonelelo sempilo yethu ngeendlela ezininzi, izifundo ezahlukileyo ngaphambili zabonisa ukuba ukutya kakhulu i-retinol kunye ne-carotenoids kunokunyusa umngcipheko wee-cancer ezifana nomhlaza wemiphunga kubantu abatshayayo kunye nomhlaza wesibeletho emadodeni. Nangona kunjalo, ngenxa yedatha encinci kunye nengahambelaniyo, umbutho weVitamin A yokutya kunye nomngcipheko womhlaza wolusu awuzange umiselwe ngokucacileyo.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Umanyano phakathi kweVitamin A (Retinol) kunye nomngcipheko weCutaneous squamous Cell Carcinoma- Uhlobo loMhlaza weSikhumba
Abaphandi abavela kwiWarren Alpert Medical School yeYunivesithi yaseBrown eProvidence, eRhode Island; iHarvard Medical School eBoston, Massachusetts; kunye neYunivesithi yaseInje eSeoul, eMzantsi Korea; ivavanye idatha enxulumene nokuthathwa kweVithamin A kunye nomngcipheko we-cutaneous squamous cell carcinoma (SCC), uhlobo lwesikhumba umhlaza, ukusuka kubathathi-nxaxheba kwizifundo ezibini ezinkulu, ezihlala ixesha elide ezibizwa ngokuba yi-Nurses' Health Study (NHS) kunye ne-Health Professionals Follow-Up Study (HPFS) (Kim J et al, JAMA Dermatol., 2019). I-Cutaneous squamous cell carcinoma (SCC) lolona hlobo lwesibini luxhaphakileyo lomhlaza wolusu ngomlinganiselo oqikelelwayo wezehlo ezixelwe njenge-7% ukuya kwi-11% e-US. Olu phononongo lubandakanya idatha evela kwi-75,170 yabasetyhini base-US abathathe inxaxheba kwisifundo se-NHS, kunye nobudala obuphakathi kweminyaka eyi-50.4, kunye namadoda angama-48,400 ase-US athathe inxaxheba kwisifundo se-HPFS, kunye nobudala obuphakathi kwe-54.3 iminyaka. Idatha ibonise inani labantu be-3978 abanomdlavuza wesikhumba se-squamous ngexesha le-26 iminyaka kunye ne-28 iminyaka yokulandelelana kwexesha kwi-NHS kunye nezifundo ze-HPFS ngokulandelanayo.UKim J okqhubekayo, JAMA Dermatol., 2019).
Iziphumo eziphambili zophando zidweliswe apha ngezantsi:
a. Kukho unxulumano oluphambeneyo phakathi kokuthathwa kwe-vitamin A ye-retinoid yendalo kunye nomngcipheko wokuba i-squamous cell carcinoma yesikhumba (uhlobo lomhlaza wolusu).
b. Abathathi-nxaxheba babeka iqela phantsi kwecandelo le-avareji ephezulu yokusetyenziswa kwe-vitamin A ine-17% yokunciphisa umngcipheko we-squamous cell carcinoma xa kuthelekiswa neqela elalisebenzisa i-vitamin A.
c. I-Vitamin A ubukhulu becala ifunyenwe kwimithombo yokutya hayi kwizongezo zokutya kwezi meko zinomngcipheko ocuthayo we-squamous cell carcinoma / cancer.
d. Ukutya okuphezulu kwevithamini A, i-retinol, kunye ne-carotenoids ezinjenge-beta cryptoxanthin, i-lycopene, i-lutein kunye ne-zeaxanthin, ezifumaneka ngokubanzi kwiziqhamo kunye nemifuno enjengepapaya, imango, iipesika, iiorenji, iitangerines, ipepile yentsimbi, umbona, ivatala, iitumato kunye nemifuno eluhlaza, yayayanyaniswa nomngcipheko omncinci we-squamous cell carcinoma / cancer.
e. Ezi ziphumo zazibalasele ngakumbi kubantu abane-moles kunye nabo babenempendulo yokutshiswa lilanga njengabantwana okanye abakwishumi elivisayo.
isiphelo
Ngamafutshane, olu phando lungentla lubonisa ukuba ukonyuka kokusetyenziswa kwe-retinoid yendalo Vitamin A / Retinol (efumaneka ikakhulu kwimithombo yokutya hayi kwizongezo) inokunciphisa umngcipheko wohlobo lomhlaza wolusu obizwa ngokuba yi-cutaneous squamous cell carcinoma. Kukho ezinye izifundo eziqaqambisa ukuba ukusetyenziswa kwee-synthetic retinoids kubonise umphumo ongathandekiyo kumngcipheko wesifo somhlaza. (URenu George okqhubekayo, Australas J Dermatol., 2002) Ngoko ke Ukuba nokutya okunokulinganisela, okunempilo kunye nomlinganiselo ofanelekileyo we-retinol okanye i-carotenoids kuthathwa njengenzuzo. Ngelixa ezi ziphumo zijongeka zithembisa i-SCC yesikhumba, uphononongo aluzange luvavanye isiphumo sokuthatha ivithamin A kwezinye iintlobo zolusu. i cancer, oko kukuthi, i-basal cell carcinoma kunye ne-melanoma. Uphononongo olongezelelweyo luyafuneka ukuze kuvavanywe ukuba ingaba i-vitamin (Retinol) A supplementation inendima kwi-chemoprevention ye-SCC.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.