Ukusetyenziswa kweAloe Vera Extract / Ijusi kwizigulana ezinomhlaza

Iimbalasane

Uphononongo lubonisa ukuba ukusetyenziswa kwe-aloe vera mouthwash kunokunceda izigulane ze-leukemia kunye ne-lymphoma ekunciphiseni i-chemotherapy-induced stomatitis, kunye ne-radiation-induced mucositis kwizigulane zomhlaza wentloko kunye nentamo. Nangona kunjalo, ubungqina besayensi obucebisa izibonelelo zokungeniswa ngomlomo kwejusi ye-aloe vera ngabaguli abanomhlaza abafumana ichemotherapy okanye unyango lweradiation luncinci. Uphononongo luka-2009 lucebise ngeenzuzo ezinokubakho zekhala lomlomo ekunciphiseni ubungakanani bethumba, ukulawula izifo kunye nokuphucula ukusinda kweminyaka emi-3. Nangona kunjalo, izifundo ezinkulu ziyafuneka ukuze kuqinisekiswe ezi zibonelelo umhlaza izigulana (kungakhathaliseki ukuba zenza ichemotherapy/radiation therapy okanye hayi) kwakunye nokuvavanya ubutyhefu, ukhuseleko kunye neziphumo ebezingalindelekanga zokungeniswa ngomlomo kweAloe vera juice phambi kokucebisa ukuba isetyenziswe.

Yintoni iAloe Vera?

I-Aloe Vera sisityalo esinamayeza esinencasa esikhula kwindawo ezomileyo nezitshisayo eAfrika, eAsia, eYurophu nakwezinye iindawo zaseMelika. Igama lithathwe kwigama lesi-Arabhu elithi "Alloeh" elithetha "ukukhanya okuqaqambileyo," kunye negama lesi-Latin elithi "vera" elithetha "okwenyani". 

Ijusi kunye nejeli ekhutshwe kwizityalo zeAloe vera ziyaziwa ngeempawu zazo zokuphilisa. I-Aloe vera isetyenzisiwe njengesityalo sokunyanga kangangeenkulungwane ukunyanga impilo kunye nolusu. Ezinye zezinto eziphambili ezisebenzayo zibandakanya:

• I-Anthraquinones ezinje ngeBarbaloin (Aloin A), Chrysophanol, Aloe-emodin, Aloenin, Aloesaponol
• IiNaphthalenones
• Iipolysaccharides ezinje ngeAcemannan
• I-Sterols ezinje ngeLupeol
• Iiproteni kunye nee-Enzymes
• Izinto eziphilayo 

Izibonelelo zokuSetyenziswa kweMixholo yeAloe Vera Gel

ialoe vera ibonisa uluhlu lweempawu zonyango ezibandakanya ukulwa nokudumba, i-anti-microbial, i-anti-viral, kunye ne-antioxidant properties. Ijeli yeAloe vera isetyenziselwa ukunyanga nokupholisa amanxeba/ukurhawuka kolusu, ukutsha okungephi, ukutshiswa lilanga, ukwenzakala okubangelwa yimitha yolusu, iimeko zolusu ezinxulumene ne psoriasis, amaqhakuva, inkwethu kunye nolusu olumanzi. Ijeli inceda ekuthomalaliseni ulusu oludumbileyo. Ine-sterols ezinokukhuthaza ukuveliswa kwe-collagen kunye ne-hyaluronic acid enokunceda ukuvuselela ulusu kunye nokuphucula ukuthungwa kwesikhumba, ngaloo ndlela inciphisa ukubonakala kwemibimbi.

Izibonelelo zokusela iAloe Vera Juice

Iinzuzo ezinokubakho zokusela iAloe vera juice ngo umhlaza Izigulana eziphantsi konyango olufana nechemotherapy okanye unyango lweradiation kunye nezo zinganyangwanga, akaziwa.

Nangona kunjalo, ezi zilandelayo zezinye zezibonelelo zempilo ezinokubakho (ngokubanzi).

• Sebenzisa incindi yeAloe vera njengokuhlamba umlomo kunciphisa iplagi yokwakha kunye nokudumba kweentsini
• Igcina ulusu lunamanzi, luphucula impilo yolusu, ukunciphisa amabala akhokelela kulusu olucacileyo
• Inceda ekunciphiseni ukuqhina 
• Uncedo ekulawuleni amanqanaba eswekile yegazi
• Inceda ekukhutsheni umzimba emzimbeni
• Inceda ekunciphiseni ukutsha kwentliziyo / i-asidi Reflux 

Iziphumo ebezingalindelekanga zeAloe Vera Juice Ukungenisa

Ngaphandle kwezibonelelo ezinokubakho ezichazwe ngaphambili, ukungenisa ngomlomo incindi yeAloe vera kunxulunyaniswa neziphumo ebezingalindelekanga ezininzi ezibandakanya:

1. Ukuqunjelwa notyatyazo- ukuba isicatshulwa siqulathe izixa ezikhulu zekhalusi, ikhompawundi efumaneka phakathi kwegqabi elingaphandle lesityalo se-Aloe vera kunye nejeli ngaphakathi, neziphumo zokuthambisa.
2. Isihlunu kunye nokuhlanza
3. Amanqanaba e-potassium asezantsi xa ijusi yeAloe vera ithathwa kunye nekhemotherapy
4. I-Aloe vera inyanzelise ityhefu ekhokelela ekubanjweni kunye nokungalingani kwe-electrolyte.
5. Ukudibana neziyobisi eziyimigca yeCytochrome P450 3A4 kunye ne-2D6.

Njengokungeniswa kwejusi ye-aloe vera, inaliti ye-Aloe vera ayikhuthazwa kwizigulana ezinomhlaza. Emva phayaa ngo-1990, uninzi lwezigulana ezinomhlaza zafa emva kokufumana inaliti ye-Aloe vera (acemannan) njengenxalenye yonyango lomhlaza. Yiyo loo nto, umntu kufuneka athathele ingqalelo iziphumo ebezingalindelekanga ezinokubakho kwaye adibane nengcali yezempilo ngaphambi kokuba athathe incindi ye-aloe vera.

Izifundo ezinxulumene nokusetyenziswa kweAloe Vera kuMhlaza

Akukho bungqina bubonisa ukuba kunokwenzeka iziselo zokusela i-aloe vera juice ngabaguli abanomhlaza. Nangona kunjalo, ezinye zezibonelelo ze-aloe vera mouthwash kunye nokusetyenziswa kwezihloko kwizigulana ezinomhlaza zichazwe ngezantsi.

Impembelelo yeAloe Vera Umlomo wokuhlanjwa kwiChemotherapy-eyenze iStomatitis kwiLymphoma kunye neLeukemia Patients 

I-Chemotherapy yonyango lokuqala lomhlaza we-leukemia kunye ne-lymphoma. Enye yezona ziphumo zixhaphakileyo ze-chemotherapy yi-stomatitis. I-Stomatitis, ekwabizwa ngokuba yi-oral mucositis, kukudumba okubuhlungu okanye izilonda ezenzeka emlonyeni. I-Stomatitis okanye i-mucositis yomlomo ihlala ikhokelela kwiingxaki ezinje ngokusuleleka kunye nokuphuma kweg) okukhokelela kubunzima bokutya, ukuphazamiseka kwesondlo kunye nokungazinzi.

Kuvavanyo lweklinikhi olwenziwe ngabaphandi beYunivesithi yaseShiraz yezeNzululwazi yezoNyango, eIran ngo-2016, bavavanya ifuthe lesisombululo se-Aloe vera kwi-stomatitis kunye nokuqina kwentlungu okunxulumene nezigulana ezingama-64 ezine-Acute Myeloid Leukemia (AML) kunye ne-Acute Lymphocytic Leukemia (BONKE) unyango lwe-chemotherapy. Iqelana lezi zigulana zacelwa ukuba zisebenzise i-Aloe vera mouthwash kangangemizuzu emibini kathathu ngemini kangangeeveki ezi-2, ngelixa ezinye izigulana zisebenzisa ukuhlamba umlomo okucetyiswa ngamaziko anomhlaza. (Parisa Mansouri okqhubekayo, Int J Midwifery Nursing yasekuhlaleni., 2016)

Uphononongo lufumanise ukuba abaguli abasebenzisa isisombululo se-Aloe vera mouthwash banokuncitshiswa okubonakalayo kwi-stomatitis kunye nokuqaqanjelwa kweentlungu ezinxulumene noko xa kuthelekiswa nabo babesebenzisa ukuhlamba umlomo okuqhelekileyo. Abaphandi bagqiba kwelokuba i-Aloe vera mouthwashes inokuba luncedo ekunciphiseni i-stomatitis okanye i-oral mucositis kunye neentlungu ezinxulumene noko kwi-leukemia nakwizigulana ze-lymphoma ezenza i-chemotherapy, kwaye zinokuphucula imeko yesigulana.

Impembelelo ye-Aloe vera mouthwash kwi-Radiation-indened Mucositis kwiNtloko nakwizigulana ezinomhlaza womqala.

I-Mucositis ibhekisa kukudumba okubuhlungu okanye ulceration wee-mucous membranes naphina ecaleni kwendlela yesisu, engathintelwanga emlonyeni. Kuvavanyo lweklinikhi olwenziwe lwaza lwapapashwa ngabaphengululi beYunivesithi yaseTehran yezeNzululwazi yezoNyango (TUMS), eIran ngo-2015, bavavanya ukusebenza kwe-Aloe vera mouthwash ekunciphiseni i-mucositis ebangelwa yimitha kwizigulana ezingama-26 zentloko kunye nentamo yomhlaza ezazicwangciselwe ukwamkelwa. unyango lwemitha oluqhelekileyo kwaye luyithelekise ne-benzydamine mouthwash. (UMahnaz Sahebjamee okqhubekayo, uMlomo weMpilo eyaNgaphambili.

Uphononongo lufumanise ukuba amaxesha phakathi konyango lwe-radiation kunye nokuqala kwe-mucositis kunye nobunzima obukhulu be-mucositis bezifana kwiqela lesigulana elisebenzisa i-Aloe vera (iintsuku eziyi-15.69 ± 7.77 kunye neentsuku ezingama-23.38 ± 10.75 ngokulandelelana) kunye neqela elisebenzisa i-benzydamine ( Iintsuku eziyi-15.85 ± 12.96 kunye neentsuku ezingama-23.54 ± 15.45 ngokulandelelana). 

Abaphandi bagqibe kwelokuba i-Aloe vera mouthwash inokusebenza njenge-benzydamine mouthwash kulibaziseko lwe-mucositis ebangelwa yimitha, ngaphandle kweziphumo ebezingalindelekanga.

Impembelelo yeAloe arborescens kwizigulana ezinomhlaza weMetastatic 

I-Aloe arborescens, sesinye isityalo esimnandi esisesinye uhlobo lwe-Aloe, ekwabelwana ngaso yi-Aloe vera. 

Kwisifundo seklinikhi esapapashwa ngabaphandi besibhedlele iSt.Gerardo e-Itali, abaphandi bavavanya izigulana ezingama-240 ezazinethumba eliqinileyo eliye lafumana ichemotherapy ngeAloe nangaphandle kwayo. Phakathi kwezigulana ezibandakanyiweyo kuphononongo, abaguli abanomhlaza wemiphunga bafumana i-cisplatin kunye ne-etoposide okanye i-vinorelbine, abaguli abanomhlaza abathandanayo bafumana i-oxaliplatin kunye ne-5-FU, abaguli abanomhlaza esiswini bafumana i-5-FU kunye nezigulana ezinomhlaza wepancreatic bafumana iGemcitabine. Iqelana lezi zigulana lifumene iAloe ngomlomo. (UPaolo Lissoni okqhubekayo, eVivo., Jan-Feb 2009)

Olu phononongo lufumanise ukuba abaguli abafumene zombini ichemotherapy kunye ne-Aloe babeneepesenti ephezulu yokunciphisa ubungakanani besisu, ulawulo lwezifo kunye nezigulana ezisinde iminyaka emi-3 ubuncinci.

Nangona kunjalo, izifundo ezikhulu ziyacetyiswa ukuvavanya ubuthi, ukhuseleko kunye neziphumo ebezingalindelekanga zokungenisa ngomlomo kweAloe arborescens / aloe vera.

Impembelelo yesicelo seMixholo kwi-Radiation-induction Dermatitis kwizigulana ezinomhlaza

I-Dermatitis ibhekisa kukudumba kolusu. Imitha ebangela i-dermatitis ixhaphake kwizigulana ezinomhlaza ezifumana i-radiotherapy.

1. Kuvavanyo lwangaphambili lwezonyango olwenziwe ngabaphandi beYunivesithi yaseTehran yezeNzululwazi e-Iran, bafunde ngefuthe le-Aloe vera lotion kwi-radiation-induced dermatitis kwizigulana ezingama-60 zomhlaza kubandakanya abo banomhlaza wamabele, umhlaza we-pelvic, umhlaza wentloko nentamo. kunye neminye imihlaza, eyayimiselwe ukufumana i-radiotherapy. Abangama-20 kwaba baguli bafumana ikhemotherapy ngaxeshanye. Ngokusekwe kwiziphumo ezivela kolu phando, abaphandi bagqibe kwelokuba ukusetyenziswa kwe-Aloe vera kunokunceda ekunciphiseni ubungakanani be-radiation ebangelwa yimitha. (P Haddad okqhubekayo, uCurr Oncol., 2013)

2. Kwisifundo esapapashwa kwi-2017, abaphandi beYunivesithi yaseShiraz yezeNzululwazi e-Iran benze isifundo esifanayo kwizigulana ezili-100 ezifunyenwe zinomhlaza webele ukuvavanya ifuthe le-Aloe vera gel kwi-radiation-induced dermatitis. Nangona kunjalo, iziphumo ezivela kolu phononongo zifumanise ukuba i-Aloe vera gel application ayinampembelelo intle kubukho okanye ubukrakra be-radiation-induced dermatitis kwizigulana ezinomhlaza wamabele. (UNiloofar Ahmadloo okqhubekayo, I-Asia Pac J Cancer Prev., 2017)

Ngenxa yeziphumo ezingqubanayo, asinakugqiba ukuba ngaba isicelo sealoe vera siluncedo ekunciphiseni i-dermatitis ebangelwa yimitha kwizigulana ezinomhlaza, ngakumbi abaguli abanomhlaza wamabele. 

Impembelelo yesicelo seMixholo kwiProctitis ebangelwa yimitha yezigulana kwizigulana ezinomhlaza wePelvic 

Iproctitis ibhekisa kukukrala komphetho wengaphakathi le-rectum yangaphakathi. 

Kwisifundo esapapashwa kwi-2017, abaphandi beYunivesithi yaseMazandaran yezeNzululwazi e-Iran bavavanye ifuthe lesicelo seoyile ye-Aloe vera kwi-proctitis ebangelwa yimitha kwizigulana ezinomhlaza we-pelvic. Aba baguli banomhlaza babonakalise enye okanye nangaphezulu kweempawu kubandakanya ukopha ngamanqwanqwa, iintlungu zesisu / zesisu, urhudo okanye ukungxamiseka kwelindle. Olu phononongo lufumene ukuphucuka okubalulekileyo kurhudo, ukungxamiseka komchamo kunye nendlela yokuphila. Nangona kunjalo, iziphumo azibonisanga kuphuculo lubalulekileyo kukopha kunye neentlungu zesisu / zethambo. (Adeleh Sahebnasagh okqhubekayo, J Enye indlela yokuGqibezela iMed., 20)

Abaphandi bagqibe kwelokuba ukusetyenziswa kweoyile ye-Aloe vera kunokuba luncedo ekunciphiseni iimpawu ezimbalwa ezinxulunyaniswa neproctitis ebangelwa yimitha efana nesifo sorhudo kunye nokungxamiseka kwelindle.

Izifundo ze-in vitro zokuvavanya iipropathi ezichasene nomhlaza zecandelo elisebenzayo (iAloe-emodin)

Isifundo se-in vitro sifumanise ukuba i-Aloe-emodin, iphytoestrogen ekhoyo e-Aloe vera eneempawu ze-estrogenic, inokunceda ekunciphiseni ukwanda kweseli somhlaza wamabele. (UPao-Hsuan Huang okqhubekayo, uQinisekiso oluSekwe kwiNkxaso ye-Alternat Med., 2013)

Olunye uphononongo lwe-vitro lukwafumanise ukuba i-Aloe-emodin inokubangela i-apoptosis exhomekeke kuxinzelelo (ukufa kweseli) kwiiseli ezinomhlaza. (UChunsheng Cheng okqhubekayo, iMed Sci Monit., 2018)

Nangona kunjalo, abukho ubungqina benzululwazi obuxhasa ukusetyenziswa kweAloe-emodin ebantwini kunyango lomhlaza.

isiphelo

Iziphumo eziphambili zophando zibonisa ukuba ukusetyenziswa kwe-aloe vera mouthwash kunokunceda ekunciphiseni i-chemotherapy-induced stomatitis kwizigulane ze-leukemia kunye ne-lymphoma, kunye ne-radiation-induced mucositis kwizigulane zomhlaza wentloko kunye nentamo. Ubungqina besayensi obucebisa ukuba uncedo lokungeniswa ngomlomo kwejusi yealoe vera kwizigulana ezinomhlaza luncinci. Uphononongo oluphonononge impembelelo yokufunxa ikhala elikhutshwe kwiAloe arborescens (esinye isityalo sohlobo olufanayo “Ikhala” ekwabelwana ngalo neAloe vera) kwizigulana ezinomhlaza wemetastatic ezinyangwa ngechemotherapy, lucebise ngenzuzo enokubakho yekhala lomlomo ekunciphiseni ithumba. ubukhulu, ukulawula izifo kunye nokuphucula inani lezigulane eziphila iminyaka emi-3. Nangona kunjalo, amaphononongo amakhulu ayafuneka ukuseka ezi ziphumo kunye nokuvavanya ubutyhefu, ukhuseleko kunye neziphumo ebezingalindelekanga zokungeniswa ngomlomo kwejusi yeAloe vera, ngakumbi umhlaza izigulana eziphantsi kwechemotherapy kunye nonyango lweradiation. Ngelixa ubungqina bezenzululwazi bucebisa ukuba ukusetyenziswa kweAloe vera kunokunceda ekunciphiseni ezinye zeempawu ze-radiation-induced proctitis kwizigulana ezinomhlaza we-pelvic, impembelelo yayo kwi-radiation-induced dermatitis ayiquki.

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.

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