Zeziphi iintlobo zomhlaza ekufuneka ndizithintele kwi-Retinol Supplement

Iimbalasane

Izongezo zesondlo ezifana ne-Retinol zinezibonelelo ezininzi zempilo kwaye zisetyenziswa kakhulu zizigulana ezinomhlaza kunye nabo basengozini yomhlaza. Kodwa, ngaba kukhuselekile ukuthatha izongezelelo zeRetinol kuzo zonke iintlobo zomhlaza kwaye ngaphandle kokuqwalasela naluphi na unyango oluqhubekayo kunye nezinye iimeko zokuphila? Inkolelo eqhelekileyo kodwa intsomi kuphela kukuba nantoni na yendalo inokuzuza kuphela kum okanye ingenzi nto. Njengomzekelo omnye, ukusetyenziswa kwegrapefruit kunye namayeza athile akukhuthazwa. Omnye umzekelo, ukusetyenziswa kwesipinashi kunye namayeza athile okunciphisa igazi kunokubangela ukusebenzisana kakubi kwaye kufuneka kugwenywe. Kuba umhlaza, isondlo esibandakanya ukutya kunye nezongezelelo zendalo zibonakaliswe ukuba zinefuthe kwiziphumo. Yiyo loo nto umbuzo osoloko ubuzwa ngabaguli abanomhlaza kwiingcali zokutya kunye noogqirha uthi "Ndimele nditye ntoni kwaye kufuneka ndiphephe ntoni?". 

Ukuthatha izongezo zeRetinol ezinesondlo kunokunceda izigulana ezingezo-Hodgkin Lymphoma kunyango lomhlaza weVorinostat. Kodwa kuthintele ukuxhaswa kweRetinol ukuba kunyango lwePaclitaxel lweAdenoid Cystic Carcinoma. Kwangokunjalo, ukuthatha isongezelelo sesondlo iRetinol kunokunceda abantu abasempilweni abasemngciphekweni wemfuza ngenxa yomhlaza ngenxa ye-CDKN1B yemfuza. Kodwa kuthintele ukuthatha isongezelelo sesondlo iRetinol xa usemngciphekweni wemfuzo ngenxa yokutshintsha kohlobo lwe-CHEK2.

Ukuthabatha - imeko yakho nganye iya kuba nefuthe kwisigqibo sakho ukuba isongezelelo sesondlo iRetinol ikhuselekile okanye akunjalo. Kwaye nokuba esi sigqibo kufuneka siphinde sihlaziywe njengoko iimeko zitshintsha. Iimeko ezinje ngohlobo lomhlaza, unyango oluqhubekayo kunye nezixhasi, ubudala, isini, ubunzima, ukuphakama, indlela yokuphila kunye naluphi na utshintsho kwimfuza oluchongiweyo. Ke umbuzo osemthethweni wokuba ubuze nakuphi na ukunconywa kokutya kunye nokongezwa kwendalo yindlela enxulumene ngayo nomxholo wakho. 

Uluhlu olufutshane

Izongezo zesondlo-iivithamini, imifuno, iiminerali, iiprobiotic, kunye nolunye udidi olukhethekileyo luyanda. Izongezo ziindawo eziphezulu zezinto ezisebenzayo ezifumaneka nakwizinto ezahlukeneyo zokutya. Umahluko kukutya okunesithako esisebenzayo esingaphezulu kwesinye kwisiseko esisezantsi sokusasazeka. Khumbula ukuba nganye yezi zithako inesayensi yayo kunye neendlela zebhayoloji kwinqanaba leemolekyuli-yiyo loo nto ukhethe indibaniselwano elungileyo yezongezo ezinje ngeRetinol ngokusekwe kwimeko kunye neemeko. 

Ke umbuzo ngowokuba ungathatha iRetinol yokuncedisa? Ngaba kufanelekile ukuba uyithathe xa usemngciphekweni wemfuza womhlaza kuguquko lofuzo CHEK2? Ngaba kufanelekile ukuba uyithathe xa usemngciphekweni wemfuza womhlaza ekutshintsheni kohlobo lweCDKN1B? Ngaba kuya kufuneka uyithathe xa ufunyaniswe une-Adenoid Cystic Carcinoma? Ngaba kufuneka uthathe i-Retinol supplement xa ufumanisa ukuba une-Hodgkin Lymphoma? Ngaba kufuneka uyithathe xa unyangwa iPaclitaxel? Ngaba kuya kufuneka uqhubeke uyithatha ukuba utshintsha unyango lwakho ukusuka ePaclitaxel ukuya kwiVorinostat? Ke inkcazo ngokubanzi enje-yeyendalo okanye inyusa ukhuseleko inokungamkeleki kwaye yanele ukukhetha iRetinol. 

Cancer

Umhlaza uhlala uyingxaki yengxaki engasonjululwanga. Ukufumaneka okuphuculweyo konyango lomntu kunye nokubeka esweni umhlaza ngegazi kunye namathe kuye kwaba zizinto ezibalulekileyo zokuphucula iziphumo. Ukungenelela kwangoko-ngcono impembelelo kwisiphumo. Ukuvavanywa kwemfuza kunakho ukuvavanya umngcipheko womhlaza kunye nokuchaphazeleka kwasekuqaleni. Kodwa ngaphandle kokubeka iliso rhoqo kwiimeko ezininzi akukho zindlela zongenelelo ngoncedo ezikhoyo. Emva kokuchongwa komhlaza onje nge-Adenoid Cystic Carcinoma okanye i-Non-Hodgkin Lymphoma, unyango luyazenzela kwi-tumor genomics kunye nezinto ezinje ngesifo, ubudala kunye nesini. Ngexesha lokuxolelwa komhlaza (emva kokuba umjikelo wonyango ugqityiwe) -ukubeka esweni kuvavanyo lwako nakuphi na ukubuyela umva kwaye ngokufanelekileyo uthathe isigqibo ngamanyathelo alandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bathatha izongezo zesondlo ezinje ngeRetinol.

Ke umbuzo ngulo wokuba ngaba bonke ubungozi bokutshintsha kwemfuza kunye neentlobo zomhlaza kufuneka zithathelwe ingqalelo xa kusenziwa isigqibo sokusebenzisa iRetinol? Ngaba iimpembelelo zebhayoloji yengozi yemfuza yomhlaza ngenxa yokutshintsha kohlobo lwe-CHEK2 ngokufanayo nangenxa yokutshintsha kwemfuza CDKN1B? Ngaba iimpembelelo ze-Adenoid Cystic Carcinoma efanayo ne-Non-Hodgkin Lymphoma? Ngaba iyafana ukuba unyango iPaclitaxel okanye iVorinostat? 

I-Retinol-Isongezelelo seZondlo

I-retinol okanye ivithamin A1 yivithamin enyibilikayo ngamafutha eyeye ivithamini A usapho. Ifumaneka ekutyeni okwahlukeneyo kwaye ikwasetyenziswa njengesongezelelo sokutya. Ukuthathwa kwe-retinol ixhasa ulusu, iliso, kunye nempilo yokuzala, ukukhula okuqhelekileyo kubantwana, kubonelela ukuchasana nosulelo olunjengomkhuhlane kunye nomkhuhlane, kwaye kubalulekile ekusebenzeni komzimba. Nangona kunjalo, idosi ephezulu ye-retinol inokukhokelela ekwandiseni isibindi, ulusu olomileyo, okanye i-hypervitaminosis A.

Njengoko bekutshiwo ngaphambili, iRetinol sisithako esisebenzayo esifumaneka kwizinto ezahlukeneyo zokutya. Ukutya okufana neBarley, iMbona kunye neQuinoa kuqulethe iRetinol kumanqanaba oxinzelelo ohlukeneyo kunye nezinye izinto ezisebenzayo. Iindlela zeemolekyuli ezilawulwa yiRetinol zibandakanya i-Focal Adhesion, Ukudumba, ukutyikitywa kwe-Estrogen, umjikelo weseli kunye nomqondiso weNFKB. Ezi ndlela zeselfowuni ngokuthe ngqo okanye ngokungathanga ngqo zilawula umhlaza othile wokuphela kwemolekyuli njengokukhula, ukusasazeka kunye nokufa. Ngenxa yalo mmiselo webhayoloji- wesondlo somhlaza, ukhetho oluchanekileyo lwezincedisi ezinje ngeRetinol ngokukodwa okanye ngokudibeneyo sisigqibo esibalulekileyo ekufuneka senziwe. Xa usenza izigqibo malunga nokusetyenziswa kwesongezelelo iRetinol yomhlaza- ziqwalasele zonke ezi zinto kunye neenkcazo. Kungenxa yokuba kunjalo kunyango lomhlaza- Ukusetyenziswa kweRetolol akunakuba sisigqibo esilinganayo-zonke izigqibo kuzo zonke iintlobo zomhlaza.

Ukukhetha i-Retinol Supplements yeCancer yakho

Isizathu sokuba kungabikho ndlela ilula yokuphendula umbuzo othi "Ndingayiphepha nini iRetinol yoMhlaza" kungenxa yokuba "ixhomekeke!". Njengonyango olufanayo alusebenzi kwisigulana ngasinye somhlaza, ngokusekwe kwimeko yakho iRetinol inokuba yingozi okanye ikhuseleke. Kunye nomhlaza kunye nemfuza ehambelana nayo-unyango oluqhubekayo, izongezo, iindlela zokuphila, i-BMI kunye ne-aleji zizinto zonke ezenza isigqibo sokuba iRetinol kufuneka ithintelwe okanye hayi kwaye ngoba.

1. Ngaba iRetinol Supplements iyakuxhamla iAdenoid Cystic Carcinoma / Izigulana ezinomhlaza ezinyangwa iPaclitaxel?

I-Adenoid Cystic Carcinoma ibonakaliswa kwaye iqhutywe ziinguqu ezithile zofuzo ezifana ne-NFIB kunye ne-MYB ekhokelela kwiinguqu ze-biochemical pathway kwi-Focal Adhesion, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Notch Signaling kunye ne-Cholesterol Metabolism. A umhlaza unyango olufana ne-Paclitaxel lusebenza ngendlela ethile yendlela yokusebenza. Injongo kukuba kubekho ukudibana okuhle phakathi konyango kunye neendlela zokuqhuba umhlaza kwindlela yobuqu esebenzayo. Kwimeko enjalo nakuphi na ukutya okanye isongezelelo sesondlo esinesiphumo esichaseneyo nonyango okanye esinciphisa ukudibana kufuneka kuphetshwe. Ngokomzekelo, i-Retinol kufuneka igwenywe kwi-Adenoid Cystic Carcinoma kunye nonyango lwe-Paclitaxel. I-Retinol inefuthe kwiindlela ze-Focal Adhesion enokuthi ikhuthaze abaqhubi besifo kunye/okanye itshitshise isiphumo sonyango. Ukongezelela, izongezelelo ze-Retinol zine-CYP3A4 (i-drug metabolizing enzyme) intsebenziswano kunye nonyango lwe-Paclitaxel, kwaye ke kufuneka igwenywe ngabaguli abanomhlaza abafumana olu nyango. (UKun Wang okqhubekayo, Biochem Pharmacol., 2008; UPius S Fasinu okqhubekayo, ngaphambili Oncol., 2019Eminye yemiba ekufuneka ithathelwe ingqalelo xa ukhetha isondlo luhlobo lomhlaza, unyango kunye nezongezo ezithathwa ngoku (ukuba zikhona), ubudala, isini, i-BMI, indlela yokuphila kunye naluphi na ulwazi lokutshintsha kwemfuza (ukuba lukhona).

2. Ngaba iRetinol Supplements izakuxhamla kwizigulana ezingekho kwiHodgkin Lymphoma ezifumana unyango lweCancer Vorinostat?

I-non-Hodgkin Lymphoma ibonakaliswa kwaye iqhutywa kukutshintsha okuthile kwemfuza njenge-KMT2D kunye ne-CREBBP ekhokelela kutshintsho lwendlela ye-biochemical kwi-Inflammation, i-NFKB Signaling, i-Endoplasmic Reticulum Stress, i-PI3K-AKT-MTOR Signaling kunye ne-P53 Signaling. Unyango lomhlaza njengeVorinostat lusebenza ngeendlela ezithile zendlela. Injongo kukuba kubekho ukungqubana okuhle phakathi konyango kunye neendlela zokuqhuba umhlaza wendlela eyenzelwe umntu. Kwimeko enjalo nakuphi na ukutya okanye isongezelelo sesondlo esinefuthe elifanelekileyo kunyango okanye ukunciphisa ukungqubana kufuneka kuthathelwe ingqalelo. Njengomzekelo, isongezelelo seRetinol kufuneka siqwalaselwe kwi-Non-Hodgkin Lymphoma kunye nonyango lweVorinostat. Ukuncedisa i-Retinol kuneempembelelo ezindleleni Ukuvuvukala kunye nokutyikitywa kweNFKB okuthintela abaqhubi besifo (i-Non-Hodgkin Lymphoma) kunye / okanye ukuphucula iziphumo zonyango. 

3. Ngaba iRetinol Supplements Safe for a Healthy Individual with CHEK2 Mutation Associated Risk?

Iinkampani ezahlukeneyo zibonelela ngeepaneli zemfuza ukuba zivavanywe kuvavanyo lomngcipheko wemfuza kwiicancer ezahlukeneyo. Ezi paneli zigubungela zofuzo ezinxulunyaniswa nomhlaza webele, isibeleko, isibeleko, iprostate, kunye nenkqubo yesisu kunye nabanye. Ukuvavanywa kwemfuza kwezi ntlobo zemfuza kunokuqinisekisa ukuxilongwa kunye nokunceda ekukhokeleni kunyango nakwizigqibo zolawulo. Ukuchongwa okwahlukileyo okubangela isifo kunokukhokelela kuvavanyo kunye nokuchongwa kwezihlobo ezisemngciphekweni. I-CHEK2 yenye yemfuza efumaneka ngokubanzi kwiiphaneli zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CHEK2 kubangela iindlela ze-biochemical Signaling, i-Estrogen Signaling, i-DNA Repair, i-Stem Cell Signaling, i-P53 Signaling kunye ne-Cell Cycle ukuze ibe nefuthe. Ezi ndlela zingabaqhubi abathe ngqo okanye abangathanga ngqo umhlaza isiphelo semolekyuli. I-Retinol kufuneka iphetshwe xa iphaneli yofuzo ichonga ukuguqulwa kwe-CHEK2 yoMhlaza wamabele. I-Retinol ichaphazela iindlela I-Estrogen Signaling kunye ne-DNA Repair kwaye idala iziphumo ezibi kunye ne-CHEK2 kunye neemeko ezinxulumene nazo.

4. Ngaba iRetinol Supplements ikhuselekile kubantu abasempilweni abane-CDKN1B yeDigital Associated Risk?

I-CDKN1B yenye yemfuza ekhoyo kwiiphaneli ze umhlaza uvavanyo lomngcipheko. Ukuguqulwa kwe-CDKN1B kubangela iindlela ze-biochemical Cycle Cycle, i-Stem Cell Signaling, i-FOXO Signaling, i-PI3K-AKT-MTOR yokuSayina kunye ne-Cell Cycle Checkpoints ukuze ibe nefuthe. Ezi ndlela ziqhuba ngokuthe ngqo okanye ngokungathanga ngqo zokuphela kweemolekyuli zomhlaza. I-Retinol xa iphaneli yofuzo ichonga ukuguqulwa kwe-CDKN1B ye-Neuroendocrine Cancer. I-Retinol ichaphazela iindlela I-Cycle Cycle kunye ne-Stem Cell Signaling kwaye idala umphumo wokongeza nge-CDKN1B kunye neemeko ezinxulumene nazo.

* Ezinye izinto zibandakanyiwe njenge-BMI, indlela yokuphila, unyango

Ukuququmbela

Ezona zinto zibini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azifani kuye wonke umntu. Isondlo esibandakanya ukutya kunye nezongezelelo zesondlo ezifana neRetinol, sisixhobo esisebenzayo esinokulawulwa nguwe, ngelixa ujongene nomhlaza.

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.

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