Iimbalasane
Izehlo zomhlaza wekoloni zonyuka nge-2% ngonyaka kwiqela elincinci. Uhlalutyo lwedatha yokutya efunyenwe kwizigulane ze-1171 ezinomhlaza we-metastatic colorectal eziye zabhaliswa kwisifundo esikhulu seqela elibizwa ngokuba yiCancer kunye neLeukemia Group B (Alliance) / SWOG 80405 isifundo, safumanisa ukuba ukusetyenziswa kwansuku zonke kweekomityi ezimbalwa zekhofi (i-caffeine-rich or decaffeinated) inokunxulunyaniswa nokuphuculwa kokuphila, ukunciphisa ukufa kunye nokuqhubekela phambili komhlaza. Nangona kunjalo, olu nxulumano alulobudlelwane besizathu-kunye-nesiphumo kwaye alwanelanga ukucebisa kofu kwizigulane ezinomhlaza we-metastatic colorectal/colon.
Ikofu kunye neCaffeine
Kofu sesinye seziselo ezidumileyo kwihlabathi liphela. Kuyaziwa ukuba iqulethe izinto ezininzi ze-phytochemical, enye yazo i-caffeine. Izigidi zabantu kwihlabathi liphela zizonwabela iziselo ezinecaffeine kunye nokutya okunje ngekofu, iisoda, iziselo ezithambileyo, iti, iziselo zempilo kunye netshokholethi. I-caffeine iyaziwa ngokuba ne-antioxidant kunye ne-anti-inflammatory properties. I-caffeine inokunyusa uvakalelo lwe-insulin kwiithishu. I-Kahweol, enye icandelo kwikofu nayo ineempembelelo ezichasayo kunye ne-proapoptotic ezinokunciphisa ukuqhubela phambili kwee-cancer.
Kule minyaka ingamashumi idlulileyo, abaphandi bafumene umdla wokuqonda ifuthe lokusela ikofu nokuba ingaba kunjalo ukusela ikofu Ucebile kwi-caffeine unokufaka isandla kwimisebenzi yokulwa nomhlaza. Uninzi lwezifundo zokujonga ubukhulu becala zifumanise ukuba ayinabungozi.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Ikofu yeColorectal / Colon Cancer
ICrorectal Cancer
Umhlaza ongumbala ngowesithathu uxhaphakileyo kumhlaza wamadoda nakowesibini uxhaphakileyo kubantu besetyhini (kwiNgxowa-mali yoPhando loMhlaza kwiHlabathi liphela). I-1 kumadoda angama-23 kunye ne-1 kwabasetyhini abangama-25 babonwa njengabasemngciphekweni wokuhlaselwa ngumhlaza ongqalileyo (American Cancer Society). Ngokwamanqanaba eziganeko zeNational Cancer Institute, kuya kubakho i-1,47,950 yamatyala esifo somhlaza esandula ukufunyanwa e-United States ngo-2020, kubandakanya umhlaza wamathumbu angama-104,610 kunye nama-43,340 amatyala omhlaza. (URebecca L Siegel okqhubekayo, CA Umhlaza J Clin., 2020) Ukongeza, imeko yomhlaza wekolon inyuke nge-2% minyaka le kwiqela elincinci elineminyaka engaphantsi kwe-55 enokuthi ibangelwe kukujonga okuncinci kweli qela linetyala kukusilela kweempawu, indlela yokuphila engenampilo kunye nokutya okunamafutha aphezulu, ukutya okunefayibha ephantsi. Izifundo ezininzi zovavanyo kunye nokujonga zikwacebisa unxibelelwano phakathi kokutya kunye nendlela yokuphila kunye neziganeko kunye nokufa kwabantu abanomdlavuza wekolon.
Ukusela ikofu kuphucula ukusinda kwizigulana ezinomhlaza omnyama
Ikofu inezinto ezininzi eziphambili ezifana ne-caffeine ene-antioxidant kunye nemisebenzi echaseneyo nokudumba kwaye ihlala ifundwa ukuvavanya iipropathi ezichasene nomhlaza. Ukuxhathisa kwe-insulin kuthathwa njengokuchaphazela kakubi iziphumo zomhlaza weColon. I-Caffeine inokuphinda ikhuthaze izicwili kwiziphumo ze-insulin kunye nokunciphisa amanqanaba e-insulin egazini, indlela enokwenzeka yokunciphisa umngcipheko womhlaza.
Izifundo ezahlukeneyo zokujonga izinto ngaphambili beziphakamise unxibelelwano phakathi kokusela ikofu (ityebile ye-caffeine kunye nekofu ene-caffeine) kunye nomngcipheko womhlaza womhlaza kunye neziphumo zomhlaza. Nangona kunjalo, iziphumo ezivela kwezi zifundo zixutywe. Kuphononongo lwakutsha nje olupapashwe kwijenali ye-JAMA Oncology, abaphandi beDana-Farber Cancer Institute kunye neHarvard Medical School eBoston nakwamanye amaziko eMelika bavavanya umbutho wokusetyenziswa kwekofu kunye nokuqhubela phambili kwesifo kunye nokufa abaguli abanomhlaza ophakamileyo okanye we-metastatic colorectal cancer. (UChristopher Mackintosh okqhubekayo, JAMA Oncol., 2020)
Uvavanyo lwenziwe ngokusekelwe kwidatha evela kwizigulane zamadoda ze-1171, kunye nobudala obuphakathi kweminyaka engama-59, abaye babhaliswa kuphononongo lweqela elikhulu lokuqwalasela elibizwa ngokuba yiCancer kunye neLeukemia Group B (Alliance) / SWOG 80405 isifundo, isigaba se-3 solingo lwekliniki oluye lwafunyanwa. kuthelekisa ukongezwa kwamachiza i-cetuximab kunye/okanye i-bevacizumab kwi-chemotherapy eqhelekileyo kwizigulana ezinomhlaza onganyangwanga ngaphambili, wasekuhlaleni okanye umhlaza we-colorectal. Idatha yokutya iqokelelwe ukususela ngo-Oktobha 27, i-2005, ukuya kuJanuwari 18, i-2018 efunyenwe kwi-questionnaire yokutya rhoqo ezaliswe zizigulane ngexesha lokubhalisa kwabo. Abaphandi bahlalutya kwaye badibanisa le datha yokutya (ekwabandakanya ulwazi malunga ne-caffeine ecebileyo kofu okanye ukusetyenziswa kwekhofi ye-decaffeinated) kunye neziphumo ngexesha lonyango lomhlaza, ukususela ngoMeyi 1 ukuya ku-Agasti 31, 2018.
Uphononongo lufumanise ukuba ukunyuka kwekomityi enye ngemini kunokunxulunyaniswa nomngcipheko omncinci wokuqhubela phambili komhlaza kunye nokufa. Uphononongo lufumanise ukuba abathathi-nxaxheba abasela i-1 ukuya kwi-2 yeekomityi zekofu ngemini babenomngcipheko wokuncipha wokufa xa kuthelekiswa nalabo abangazange basele ikofu. Ukongeza, abaphandi bafumanise ukuba abo basele ngaphezulu kweekomityi ezine ngemini babene-3% yokunyuka kokuphila okuphucukileyo kunye neepesenti ezingama-36 zonyusa amathuba okuqhubeka kokuphila ngokukhululekileyo, xa kuthelekiswa nabo bangazange basele ikofu. Ezi zibonelelo zomhlaza wekolon ziye zajongwa kuzo zombini ikofu ene-caffeine kunye nekhofi ene-decaffeine.
isiphelo
Njengoko iziganeko zomhlaza wekoloni ziye zanda nge-2% ngonyaka kwiqela elincinane, abaphandi baye bajonga amayeza endalo ukunceda ukuphucula iziphumo zonyango kunye nokuphila kwezi zigulana. Iziphumo zolu phononongo lokuqwalasela ngokucacileyo ziseke ubudlelwane obuhle phakathi kokusetyenziswa kwekofu kunye nokuphila kunye nokunciphisa umngcipheko wokuqhubela phambili kwesifo kunye nokufa kwizigulane ezinomdlavuza ophezulu okanye we-metastatic colorectal / colon. Nangona kunjalo, lo mbutho akufanele uthathwe njengobudlelwane besizathu kunye nesiphumo kwaye akwanelanga ukucebisa ikofu kwizigulane ezinomhlaza we-metastatic colorectal / colon. Abaphandi baye bacebisa uphando olongezelelweyo ukuchonga iindlela ezisisiseko zebhayoloji. Kwakhona bagxininise imida yophando njengokungaqwalaselwanga ezinye izinto ezibalulekileyo ezingabanjwanga kulingo kubandakanywa nemikhwa yokulala, umsebenzi, umsebenzi womzimba ongahambelani nokuzivocavoca okuzinikeleyo, okanye utshintsho ekusebenziseni ikofu emva kokuxilongwa komhlaza wekoloni. Ukongeza, kuba uninzi lwabaguli abasela ikofu ngexesha lonyango lomhlaza kusenokwenzeka ukuba bayisele ngaphambi kokuba baxilongwe, bekungacacanga ukuba kofu abaselayo baye baphuhlisa imihlaza enobundlobongela, okanye ikofu ichaphazele amathumba asebenzayo ngokuthe ngqo. Kuyo nayiphi na imeko, ukusela ikomityi yekofu akubonakali kuyingozi kwaye kusenokungabangeli le mihlaza iphambili njengomhlaza wekoloni!
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.