Ukutya kweCutaneous Squamous Cell Carcinoma!

intshayelelo

Ukutya kweCutaneous Squamous Cell Carcinoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Cutaneous squamous cell carcinoma (cSCC) luhlobo oluxhaphakileyo lomhlaza wolusu ovela kwiiseli zesquamous eluswini. Ukuma okuchanekileyo kwe-cSCC kubalulekile ekumiseleni ubungakanani bomhlaza kunye nezigqibo ezikhokelayo zonyango. I-Metastasis, okanye ukusasazeka kwe-cSCC kwamanye amalungu omzimba, yinkxalabo kwizigaba eziphambili. Izehlo ze-cSCC zibalulekile, ngakumbi kubantu abanembali yokutshiswa lilanga okanye amajoni omzimba abuthathaka. Iingcali zedermatologists zisebenzisa i-pathology outlines ukuchonga iimpawu kunye neempawu ze-cSCC. Ukhetho lonyango lwe-cSCC lubandakanya utyando lokusikwa, unyango ngemitha, kunye namayeza endalo, ngokuxhomekeke kwinqanaba nendawo umhlaza. Uqikelelo lwe-cSCC luthandeka jikelele, kunye namazinga aphezulu okusinda xa efunyenwe kwaye enyangwe kwangoko. Ikhowudi efanelekileyo usebenzisa inkqubo ye-ICD-10 iqinisekisa amaxwebhu achanekileyo e-cSCC kwiirekhodi zonyango. Kwezinye iimeko, i-cSCC inokuba kwi-situ, oku kuthetha ukuba ivalelwe kumphezulu wolusu. Nangona kunjalo, amanqanaba aphambili anokufuna unyango olundlongondlongo kunye nokujongwa ngokusondeleyo. Kubalulekile ukwahlula i-cSCC kweminye imihlaza yolusu, efana nemelanoma, efuna iindlela ezahlukeneyo zolawulo. I-epidemiology ye-cSCC iqaqambisa ukubaluleka kokufunyanwa kwangoko kunye neenzame zokuthintela. Kutshanje, ukusetyenziswa kwe-immunotherapy nge-cemiplimab kubonise isithembiso njengokhetho lonyango lwe-cSCC ephezulu okanye ye-metastatic. Uphando oluqhubekayo kunye nezikhokelo zonyango zinegalelo kwiziphumo ezingcono kubantu abane-cSCC. Kubalulekile ukuba abantu abasemngciphekweni bakhusele ulusu lwabo kwimitha ye-UV enobungozi kwaye bajongwe rhoqo ulusu ukuze bafumanise kwaye banyange i-cSCC kwangethuba.

KwiCutaneous Squamous Cell Carcinoma ingaba ayinamsebenzi ukuba yeyiphi imifuno, iziqhamo, iindongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza ngowomhlaza ofana neCutaneous Squamous Cell Carcinoma ingaba inomsebenzi wokutya endikutyayo okanye endingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza ofana neCutaneous Squamous Cell Carcinoma?

Umzekelo ingaba inomsebenzi ukuba iCauliflower yemifuno ityiwa kakhulu xa ithelekiswa neMalabar Spinatshi? Ngaba kuyawenza umahluko xa kukhethwa isiqhamo iPummelo kuneNance? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neButternut phezu kweChestnut kunye neepulses ezifana neAdzuki Bean phezu kwePigeon Pea. Kwaye ukuba into endiyityayo ibalulekile - ke umntu uchonga njani ukutya okucetyiswayo kwiCutaneous Squamous Cell Carcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwiCutaneous Squamous Cell Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo iQuercetin, Formononetin, Lupeol, Naringin, Curcumin. Kwaye i-Nance iqulethe izithako ezisebenzayo i-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Cutaneous Squamous Cell Carcinoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo seCutaneous Squamous Cell Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiCutaneous Squamous Cell Carcinoma?

Isondlo somntu somhlaza esifana neCutaneous Squamous Cell Carcinoma siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Cutaneous Squamous Cell Carcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neCutaneous Squamous Cell Carcinoma

Zonke ii-cancer ezifana ne-Cutaneous Squamous Cell Carcinoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya. Iindlela ze-Biochemical ezifana ne-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation, i-Extracellular Matrix Remodelling, i-Molecule encinci yezoThutho ziyinxalenye yenkcazo yesignesha ye-Cutaneous Squamous Cell Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwiCutaneous Squamous Cell Carcinoma kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwiCutaneous Squamous Cell Carcinoma xa uthatha unyango lomhlaza iCemiplimab, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-RELN, i-APOB, i-FAT4, i-MUC16 kunye ne-COL11A1 zezona zixhobo ziphezulu ezixeliweyo ze-Cutaneous Squamous Cell Carcinoma. I-RELN ixelwe kwi-17.3% yezigulane ezimele kuzo zonke iimvavanyo zeklinikhi. Kwaye i-APOB ixelwe kwi-15.6%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-37 ukuya kuma-93. I-77.4 % yedatha yezigulane ichongwe njengamadoda. I-Cutaneous Squamous Cell Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela ze-biochemical kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeCutaneous Squamous Cell Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CAULIFLOWER okanye i-MALABAR SPINACH?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Brassinin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Suppressive Histone Methylation kunye ne-MYC Signaling kunye nabanye. ICauliflower iyacetyiswa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yiCemiplimab. Oku kungenxa yokuba i-Cauliflower iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukuze zikhuthaze isiphumo se-Cemiplimab.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno iMalabar Isipinatshi yiQuercetin, Formononetin, Lupeol, Curcumin, Cinnamaldehyde. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-G-protein-coupled Receptor Signaling kunye ne-Natural Killer Cell Activation kunye nabanye. I-Malabar Spinatshi ayikhuthazwa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Cemiplimab kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-MALABAR SPINACH FOR Cutaneous Squamous Cell Carcinoma KUNYE NONYANGO lweCemiplimab.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Angiogenesis, i-JAK-STAT Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Natural Killer Cell Activation kunye nabanye. UNance uyacetyiswa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yiCemiplimab. Oku kungenxa yokuba i-Nance ilungisa ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo se-Cemiplimab.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiQuercetin, Formononetin, Lupeol, Naringin, Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PPAR Signaling kunye ne-Interferon Signaling kunye nabanye. IPummelo ayikhuthazwa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Cemiplimab kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO YE-Cutaneous Squamous Cell Carcinoma KUNYE NONYANGO lwe-Cemiplimab.

Khetha Nut BUTTERNUT okanye CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Amino Acid Metabolism, i-JAK-STAT Signaling, i-PI3K-AKT-MTOR yokuSayina kunye ne-MYC Signaling kunye nabanye. IButternut iyacetyiswa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yiCemiplimab. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Cemiplimab.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-G-protein-coupled Receptor Signaling kunye ne-PPAR Signaling kunye nabanye. I-Chestnut ayikhuthazwa kwiCutaneous Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Cemiplimab kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-CHESTNUT YE-Cutaneous Squamous Cell Carcinoma KUNYE NONYANGO lwe-Cemiplimab.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Cutaneous Squamous Cell Carcinoma okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or RADISH?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, ii-Checkpoints ze-Cell Cycle, i-PI3K-AKT-MTOR yokuSayina kunye ne-P53 yokuSayina kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko weCutaneous Squamous Cell Carcinoma xa ingozi yemfuzo eyayanyaniswa nayo yi-APOB. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeRadish yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso, Ukuzalisekisa i-Cascade kunye ne-MYC Signaling kunye nabanye. IRadish ayikhuthazwa xa umngcipheko weCutaneous Squamous Cell Carcinoma xa umngcipheko wemfuzo unxulunyaniswa ne-APOB kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBUR YEMIZI YEZIGIDI IYACEBISWA NGAPHEZU KWERADISHI NGEMNGCIPHEKO YOMHLAZA YE-APOB.

Khetha iSiqhamo JAVA PLUM okanye i-NATAL PLUM?

Iziqhamo zeJava Plum ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-Cell Cycle Checkpoints, i-PI3K-AKT-MTOR Umqondiso kunye ne-Apoptosis kunye nabanye. IJava Plum iyacetyiswa kumngcipheko weCutaneous Squamous Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-APOB. Oku kungenxa yokuba iJava Plum yonyusa ezo ndlela zebhayokhemikhali ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zaseNatal Plum yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana noThutho lweMolekyuli encinci, i-Extracellular Matrix Remodeling kunye ne-Cell Cycle Checkpoints kunye nezinye. INatal Plum ayikhuthazwa xa umngcipheko weCutaneous Squamous Cell Carcinoma xa umngcipheko wezofuzo unxulunyaniswa ne-APOB kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO JAVA PLUM KUNCEBISWA NGAPHEZU KWE-NATAL PLUM YE-APOB genetic RISK YOMHLAZA.

Khetha i Nut COMMON HAZELNUT okanye iFLXSEED?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Focal Adhesion kunye ne-P53 Signaling kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kumngcipheko weCutaneous Squamous Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-APOB. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso, Ukuzalisekisa i-Cascade kunye ne-MYC Signaling kunye nabanye. I-Flaxseed ayikhuthazwa xa umngcipheko weCutaneous Squamous Cell Carcinoma xa umngcipheko wezofuzo unxulumene ne-APOB kuba yonyusa iindlela zokutyikitya kuyo.

IHAZELNUT EQHELEKILEYO INCEBISIWE NGAPHEZU KWEFLAXSEED KWI-APOB genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neCutaneous Squamous Cell Carcinoma. Izigulana zeCutaneous Squamous Cell Carcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana neCutaneous Squamous Cell Carcinoma, nganye ineemfuza ezahlukeneyo zethumba ezinokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neCauliflower kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Cutaneous Squamous Cell Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Uhlalutyo lwe-genomic lwe-metastatic cutaneous squamous cell carcinoma.
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• Iziphumo kunye nokubaluleka kwe-formononetin kumanqanaba okubonakaliswa kwe-HIF-1α kunye ne-VEGF kwizicubu zomhlaza womlomo wesibeleko.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.
• I-ROS-mediated activation kunye ne-mitochondrial translocation ye-CaMKII inegalelo kwi-Drp1 exhomekeke kwi-mitochondrial fission kunye ne-apoptosis kwiiseli zomhlaza webele ezine-triple-negative yi-isorhamnetin kunye ne-chloroquine.
• I-Betulinic acid iyonakalisa i-metastasis kwaye inciphisa iiseli ze-immunosuppressive kwiimodeli zomhlaza wamabele.
• I-Estrogen receptor modulators i-genistein, i-daidzein kunye ne-ERB-041 inqanda ukufuduka kweeseli, ukuhlasela, ukwanda kunye nokwakheka kwe-sphere ngokumodareyitha kwe-FAK kunye ne-PI3K / AKT yokubonisa umhlaza we-ovari.