Iimbalasane
Umhlaza webele we-Metastatic ngumhlaza ophucukileyo osasazeke kwamanye amalungu omzimba ngaphaya kwethishu yebele, kwaye unesifo esibi kakhulu. Unyango lwe-metastatic breast neoplasm enobungozi luhamba lubhekise kuluntu olusekwe kwiimpawu zomhlaza. Isondlo esifana nesakho (ukutya kunye nesongezelelo) iingcebiso ezisekwe kwiimpawu zomhlaza kunye nonyango ziyasilela kwaye ziyafuneka kakhulu ukuphucula iimeko zokuphumelela kunye nomgangatho wobomi besigulana somhlaza. Le bhlog ibalaselisa iimfuno, izikhewu kunye nemizekelo yesondlo somntu / ukutya (ukutya kunye nokongezwa) komhlaza webele we-metastatic.
Isiseko somhlaza webele
Umhlaza webele ngowona mhlaza ufunyanwa ngesiqhelo kwaye sesinye sezizathu eziphambili zokufa okunxulumene nomhlaza kwabasetyhini kwihlabathi liphela. Enye yezona zinto zixhaphakileyo zomhlaza wamabele kukuxhomekeka kwehomoni yesini, i-estrogen (ER) kunye neprogesterone (PR) yokwamkela kunye nokukhula komntu kwisifo 2 (ERBB2, ekwabizwa ngokuba yi-HER2) esibi - (ER + / PR + / HER2- uhlobo olungaphantsi). Ihommone subtype enesifo somhlaza wamabele ine-prognosis elungileyo enesilinganiso sokusinda seminyaka emi-5 kakhulu se-94-99% (I-Waks kunye ne Winer, JAMA, 2019). Ezinye iintlobo zamabele umhlaza Ngaba i-hormone receptor negative, i-HER2 i-subtype enhle kunye ne-triple negative breast cancer (TNBC) subtype eyi-ER, PR kunye ne-HER2 engalunganga. I-subtype ye-TNBC inelona xilongo libi kakhulu kunye namathuba aphezulu okuqhubekela phambili kwisifo senqanaba kade esiye sasasazeka kwaye sasasazeka kwamanye amalungu omzimba.
Umhlaza webele leMastastatic ngowona sele uphucukile kakhulu, kwinqanaba lesine lomhlaza osele unwenwele nakwamanye amalungu omzimba (amaxesha amaninzi ithambo, imiphunga, isibindi okanye ingqondo). Kukho kuphela iipesenti ezi-6 zabasetyhini abafunyaniswa benesifo se-metastatic neoplasm ekuqaleni kwesifo. Uninzi lwamanye amatyala wesifo esingafunekiyo okanye se-metastatic neoplasm kuxa umhlaza ubuyele kwisigulana emva kokugqiba unyango lwangaphambili kunye nokuxolelwa iminyaka emininzi. Umhlaza webele we-Metastatic, oxhaphake kakhulu kwabasetyhini kodwa ufumaneke nakwipesenti encinci yamadoda, unesifo esibi kakhulu sokusinda kweminyaka emi-5 esingaphantsi kwama-30% ngokwedatha evela kwi-American Cancer Society Publication (Cancer Facts and Figures, 2019 ). Ukusinda okupheleleyo kwe-metastatic TNBC kuphela unyaka omnye xa kuthelekiswa neminyaka emi-1 kwezinye ii-subtypes ezimbini. (I-Waks AG kunye ne-Winer EP, JAMA 2019)
Unyango kwiMetastatic Breast Cancer
Umhlaza webele weMetastatic uphathwa ngeendlela ezahlukeneyo zonyango kubandakanya iiklasi ezahlukeneyo zechemotherapy, i-immunotherapy, unyango ekujoliswe kulo, unyango lwehomoni kunye yonyango ngenketho yokulinga kunye neempazamo, kuba akukho lonyango luchaziweyo kulo mhlaza. Ukhetho lonyango luxhomekeke kwiimpawu zeemolekyuli zeseli zomhlaza wamabele zangaphambili, unyango lomhlaza wamabele odlulileyo, imeko yeklinikhi yesigulana kunye nalapho umhlaza usasazeke khona.
Ukuba umhlaza wamabele usasazekile waya emathanjeni, emva koko kunye nonyango lwe-endocrine, ichemotherapy okanye unyango ekujolise kulo, isigulana sinyangwa ngeearhente zokuguqula amathambo ezinje nge-bisphosphonates. Olu ncedo ngononophelo lonyango kodwa alubonisanga ekuphuculeni ukusinda ngokubanzi.
Ukuba umhlaza webele onomdla webele uqhubele phambili kwisifo se-IV semastatic, abaguli banyangwa ngonyango lwe-endocrine eyandisiweyo kunye neearhente eziguqula okanye zithintela ii-estrogen receptors, okanye zithintela ukuveliswa kwe-estrogen emzimbeni. Unyango lwe-endocrine, ukuba alusebenzi, lusetyenziswa ngokudibanisa namanye amayeza e-chemotherapy okanye amachiza ekujoliswe kuwo anjenge-cell cycle kinase inhibitors okanye iziyobisi ezijolise kwiindawo ezithile zokubonisa zangaphakathi, ngokusekwe kwiimpawu zemolekyuli kunye ne-genomic yomhlaza.
Ukungabinayo i-hormone, i-HER2 positive, umhlaza webele we-metastatic, ukhetho oluphambili kunyango lwe-HER2 ekujolise kuyo iziyobisi okanye i-molecule inhibitors ezincinci. Oku kudityaniswe namanye amayeza e-chemotherapy.
Nangona kunjalo, kwi-TNBC ye-metastatic cancer ezinesifo esibi kakhulu, akukho khetho lonyango luchaziweyo. Isekwe kubukho bolunye utshintsho oluphambili kolu hlobo lomhlaza. Kwimeko ye-BRCA yomhlaza, inyangwa nge-poly-ADP ribose (PARP) inhibitors. Ukuba le mihlaza inezibonakaliso zokuhlolwa kwe-immune, inokunyangwa ngamachiza e-immunotherapy njenge-immune checkpoint inhibitors. Ngenye indlela, ezi zigulana ziphathwa ngokunyanga ngamayeza anje ngeplatinam (Cisplatin, Carboplatin), adriamycin (Doxorubicin), iziyobisi zetax (Paclitaxel), topoisomerase inhibitors (Irinotecan, Etoposide) kunye neemvume ezahlukeneyo kunye nokudityaniswa kwezi, ukulawula. ukusasazeka kwesi sifo. Ukudibanisa i-chemotherapy esetyenziselwa unyango lomhlaza webele we-metastatic nangona kunjalo inetyhefu ephezulu kakhulu kunye nefuthe elibi elibi kubomi bezigulana.
Isidingo seZindululo zeZondlo zoBuntu zabaGuli abanomhlaza
Ukuxilongwa komhlaza kukodwa sisiganeko esiguqula ubomi esihambelana noxinzelelo lohambo lonyango oluzayo kunye noloyiko lokungaqiniseki kwesiphumo. Emva kokufunyaniswa ukuba unomhlaza, abaguli bakhuthazekile ukuba benze utshintsho kwindlela yokuphila abakholelwa ukuba iya kuyiphucula impilo kunye nokuba sempilweni, ukunciphisa imeko umngcipheko wokuphindaphinda, kunye nokunciphisa iziphumo ebezingalindelekanga zonyango lwabo lwe-chemotherapy. Rhoqo, baqala ukusebenzisa izongezo zokutya ngokungakhethiyo, kunye nonyango lwabo lwe-chemotherapy, ukunceda ukunciphisa iziphumo ebezingalindelekanga kunye nokuphucula impilo kunye nokuba sempilweni. Kukho iingxelo ze-67-87% yezigulana ezinomhlaza ezisebenzisa izongezo zokutya emva kokuxilongwa. (IVelicer CM okqhubekayo, J Clin. I-Oncol., 2008)
Nangona kunjalo, iingcebiso zesondlo kunye nezokutya kwizigulana ezinomhlaza namhlanje azenzelwanga mntu. Ngaphandle kwenkqubela phambili kwi-genomics, i-metabolomics, iiproteomics eziphucule ukuqonda kwethu kwiimpawu zomhlaza kunye nokwenza ukuba iindlela ezichanekileyo zonyango, isikhokelo sesondlo ukuba ngaba sikhona kakhulu. Isikhokelo sesondlo asixhomekekanga kuhlobo oluthile lomhlaza kunye neempawu zofuzo zomhlaza, okanye uhlobo lonyango olunikwa isigulana. Izikhokelo ngokubanzi zesondlo / ukutya njengoko kucetyiswa yiAmerican Cancer Society kubandakanya:
- Ukugcina ubunzima obusempilweni;
- Ukwamkela indlela yokuphila esebenzayo;
- Ukutya ukutya okusempilweni kugxininiswa kwimithombo yezityalo; kwaye
- Ukunciphisa ukusela utywala.
Unyango lweendlela zomhlaza ezahlukileyo lusekwe kubungqina kwaye luyacetyiswa zizikhokelo zomphakathi ezahlukeneyo ezinje ngeNational Comprehensive Cancer Network (NCCN) okanye iAmerican Cancer Society (ACS). Ubungqina obufunyenwe iziyobisi busekwe kwizilingo ezinkulu zeklinikhi (RCTs) ezinkulu. Unyango oluninzi lujolise kwiimpawu zomhlaza ezithile zomhlaza. Ngaphandle koko, uninzi lomhlaza oqhubele phambili njenge-metastatic TNBC, azikho izikhokelo ezisemgangathweni kunye neerejimeni zonyango ezaziwayo ukuba ziyasebenza. Unyango lwale subtype lusasekwe kwiindlela zokulinga kunye neempazamo.
Nangona kunjalo, abukho ubungqina obunje ngokusekwe kwisondlo esenzelwe umntu / iingcebiso zokutya. Kukho ukunqongophala kwee-RCTs ukuvelisa ubungqina bokuphuhlisa iingcebiso zesondlo kunye nezikhokelo zokutya ukuxhasa iintlobo ezahlukeneyo zomhlaza kunye nonyango. Esi sisithuba esikhulu esinaso ngoku kukhathalelo lwethu lomhlaza namhlanje. Ngaphandle kolwazi olwandayo lokunxibelelana kwemfuza yesondlo, ubunzima bezenzo zezondlo kunye nokunxibelelana kunzima ukujongana ngokufanelekileyo ngalo naluphi na uyilo olunye lophando lweRCT. (IBlumberg J okqhubekayo, Isondlo. Matshi, 2010)
Ngenxa yolu thintelo, inqanaba lobungqina benkxaso yesondlo kunye nokuzithemba ekuchazeni isondlo / iimfuno zokutya kwizigulane ezinomhlaza ziya kuhlala zihluke kwizinto ezifunekayo kuvavanyo lwamachiza. Ukongeza, isondlo / isikhokelo sokutya ngokungafaniyo nonyango lwamachiza lungokwemvelo, lukhuselekile kwaye lunxulumene neziphumo ebezingalindelekanga ezisezantsi ukuya kwezincinci kwiimeko ezininzi. Nangona kunjalo, iingcebiso zomntu ngamnye zesondlo kumxholo othile we umhlaza uhlobo kunye nonyango olusekelwe kwiindlela zenzululwazi ezigqithisayo kunye nengqiqo exhaswa yidatha yovavanyo, nangona ingafani nobungqina obusekelwe kwi-RCT, inokubonelela ngesikhokelo esingcono kwizigulane kunye nokuphucula ukunakekelwa komhlaza odibeneyo.
Njengokuba kukho i-heterogeneity nkqu nakwi-cancer kunye nonyango lwe-metastatic malignant neoplasms yohlobo olunye lwethishu, iingcebiso zesondlo njengenxalenye yokhathalelo lomhlaza oludibeneyo ziya kufuna ukwenziwa umntu. Isondlo esifanelekileyo esixhasayo kwaye okubaluleke ngakumbi kukutya okunokuphetshwa kwimeko ezithile kwaye ngexesha lonyango kunokuba negalelo ekuphuculeni iziphumo.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izibonelelo zokuXhasa ukuNcedisa abaNtu / ukutya (ukuTya kunye neziXhobo) zeMetastatic Breast Cancer
Njengoko iimpawu zesifo kunye nonyango lomhlaza webele we-metastatic ziyohluka kakhulu ngokusekwe kwisifo esisezantsi, iimfuno zesondlo / ukutya okuxhasayo (ukutya kunye nezongezo) ngekhe kubungakanani obulingana nabo bonke. Iya kuxhomekeka kwiimpawu zemfuza zomhlaza webele we-metastatic kunye nohlobo lonyango olufunyenweyo. Yiyo loo nto imeko yemfuza yesi sifo, ezinye izinto eziphambili zesigulana ngasinye ngokwesalathiso somzimba (BMI) ukuvavanya amanqanaba okutyeba, izinto zokuphila ezinje ngomsebenzi womzimba, ukusela utywala njlnjl. isondlo esinokuxhasa kwaye sisebenze ekuphazamiseni umhlaza kuwo onke amabakala esi sifo.
Ukubaluleka kokubonelela ngesondlo somntu / isikhokelo sokutya esilungiselelwe umhlaza othile kunye nonyango, kwizigulana ezinesifo se-metastatic breast neoplasms ezinobungozi zinokubonelela ngezi zibonelelo zilandelayo: (IWallace TC okqhubekayo, J. yeAmer. Ikhonkco. YeNutr., 2019)
- Ukuphucula amandla kunye nokukhuseleka kwesigulana ngaphandle kokuphazamisa ukusebenza konyango.
- Uncedo ekunciphiseni iziphumo ebezingalindelekanga kunyango.
- Uncedo ekuphuculeni ukusebenza ngokukuko konyango ngokukhetha ukutya kunye nezongezo ezinokuthi zisebenzisane nendlela yokusebenza kwonyango oluqhubekayo ngokumodareyitha iindlela ezifanelekileyo, okanye ukuthintela iindlela ezinokubakho zokumelana.
- Kulumkele ukutya kunye nezongezo ezinokuphazamisa unyango oluqhubekayo ngokunxibelelana kwezidakamizwa ezinesondlo ezinokuthi zinciphise ukusebenza okanye zonyuse ityhefu yonyango.
Imizekelo yeSondlo esenzelwe wena / Ukutya (Ukutya kunye neziXhobo) seMetastatic Breast Cancer
Ukutya / ukutya okunesondlo (ukutya kunye nezongezo) izindululo kwizigulana ezinomdlavuza we-metastatic eziqhubeka nokuba kunyango lwe-endocrine enje ngeTamoxifen iya kwahluka kakhulu kwezinye izigulana ezinomhlaza wamabele.
Imizekelo yokutya / iziXhobo zokuthintela ukuba kunyango kunye neeModyuli ze-Estrogen
Kwizigulana ezikwiimodulators ze-estrogen, eminye imizekelo yokutya kunye nezongezo kuya kufuneka baziphephe ezinokuphazamisa unyango lwabo lwe-endocrine kunye nengqiqo yesayensi ichazwe apha ngezantsi:
Curcumin
CurcuminIsithako esisebenzayo esivela kwi-curry spice turmeric, sisongezo sendalo esidumileyo phakathi kwabaguli abanomhlaza kunye nabasindileyo anti-umhlaza kunye neempawu ezichasayo. Ke ngoko, amathuba ezigulana ezinomhlaza wamabele ezithatha iCurcumin ngelixa unyango lweTamoxifen luphezulu.
Ichiza lomlomo iTamoxifen lixutywe emzimbeni kwii-metabolites zalo ezisebenzayo ze-cytochrome P450 enzymes esibindini. I-Endoxifen yimetabolite esebenzayo yeTamoxifen, leyo ngumlamli ophambili wokusebenza kwonyango lwe-tamoxifen (UDel Re M okqhubekayo, Pharmacol Res., 2016). Uphando olusandula kupapashwa oluzayo (EudraCT 2016-004008-71 / NTR6149) oluvela e-Erasmus MC Cancer Institute eNetherlands, lubonise unxibelelwano olubi phakathi kweCurcumin kunye neTamoxifen kwizigulana ezinomhlaza wamabele (I-Hussaarts KGAM okqhubekayo, umhlaza (iBasel), 2019). Iziphumo zibonise ukuba uxinzelelo lwe-metabolite esebenzayo ye-Endoxifen yehle ngendlela ebonakalayo xa iTamoxifen yathathwa kunye nokongezwa kweCurcumin.
Izifundo ezinjengalezi azinakungahoywa, nangona kwinani elincinci lebele umhlaza izigulane, kwaye unike isilumkiso kubasetyhini abathatha i-tamoxifen ukuba bakhethe izongezo zendalo abazithathayo ngononophelo, ezingaphazamisi ukusebenza kwechiza lomhlaza nangayiphi na indlela. Ngokusekelwe kobu bungqina, i-Curcumin ayibonakali iyongezelelo efanelekileyo ukuba ithathwe kunye neTamoxifen. Nangona kunjalo, oku akuthethi ukuba i-curcumin njenge-spice kunye ne-flavoring in curries kufuneka igwenywe ngokupheleleyo.
I-DIM (diindolylmethane) eyongezelelweyo
Olunye uncedo oluqhelekileyo nolusetyenziswa ngokubanzi phakathi kwabaguli abanomhlaza wamabele yi-DIM (diindolylmethane), imetabolite ye-I3C (Indole-3-carbinol), efumaneka imifuno eluhlaza Njenge-broccoli, icauliflower, i-kale, ikhaphetshu, ihlumelo lebrussel. Olu thando lwe-DIM lunokusekwa kwizifundo zeklinikhi ezibonise ukuba ukusetyenziswa okuphezulu kwemifuno ye-cruciferous ekutyeni / kwisondlo kunxulunyaniswa kakhulu nomngcipheko ophantsi we-15% womhlaza webele. (U-Liu X okqhubekayo, Isifuba, 2013Nangona kunjalo, isifundo esinganyangekiyo, esingaboniyo, esine-placebo esilawulwa sonyango esivavanye ukusetyenziswa kwe Isongezelelo se-DIM Kunye neTamoxifen kwizigulana ezinomhlaza wamabele, ibonakalisile imeko eyoyikisayo ye-tamoxifen esebenzayo yokunciphisa imetabolite, ngaloo ndlela amandla okunciphisa ukusebenza kwonyango lwe-endocrine. (NCT01391689) (I-Thomson CA, indawo yomhlaza webele. Nyanga., 2017).
Kuba idatha yeklinikhi ibonisa imeko yokunxibelelana phakathi kwe-DIM kunye ne-tamoxifen, izigulana ezinomhlaza wamabele ngelixa unyango lwe-tamoxifen kufuneka luye kwicala lokulumkisa kwaye kuthintele ukuthatha isongezelelo se-DIM. Ukutya okutya ukutya okusekwe kwizityalo ezityebileyo kwimifuno ebethelelweyo kunokubonelela ngesibonelelo esifunekayo ngokuthatha isongezelelo se-DIM kule meko.
Ukutya okuNcedo kunye nokuKhethiweyo kuMhlaza weMastast Breast
Kukho ukutya okuninzi kunye nezongezo ezinxulumene nokuphucula iziphumo zezigulana ezinomhlaza wamabele. Uhlalutyo lweemeta lwezifundo ezininzi ezinokubakho kunye nee-RCTs ezisandula ukupapashwa ngabaphandi abavela e-Institut Curie eFrance baxele ukuba ukutya okunamafutha asezantsi kunxulunyaniswa nokusinda okungcono. Kwakhona, ukutya okutyebileyo phytoestrogens kwiziqhamo kunye nemifuno, kunciphise umngcipheko wokuphindaphinda komhlaza. Kwaye, ukutya okusempilweni kunye nokutya okusekwe kwizityalo kunxulunyaniswa nokuphucuka kokusinda ngokubanzi kunye nomngcipheko wokufa. (Maumy L okqhubekayo, Umhlaza weBull, 2020)
Uphononongo olupapashwe kwangoko kulo nyaka kuvavanye ifuthe lokutya / ukutya okunesondlo kwi-ketogenic yezigulana ezinomhlaza wamabele. Bafumanise ukuba ukutya kwe-ketogenic kunye nonyango oluqhubekayo lwe-chemotherapy luphucule ubomi ngokubanzi ngaphandle kweziphumo ebezingalindelekanga kwizigulana. (IKhodabakhshi A, iNutr. Umhlaza, 2020Ukutya kwe-ketogenic kukutya okune-carbohydrate ephantsi kakhulu ejolise ekukhuthazeni imetabolism yamafutha kwimizimba ye-ketone (kunee-carbohydrate kwi-glucose) ukubonelela ngowona mthombo wamandla emzimbeni. Iiseli eziqhelekileyo emzimbeni wethu zinokutshintsha zisebenzise imizimba ye-ketone yamandla, kodwa iiseli zomhlaza azikwazi ukuyisebenzisa ngokufanelekileyo imizimba ye-ketone yamandla ngenxa ye-tumor metabolism engaqhelekanga. Oku kwenza ukuba iiseli zesisu zibe semngciphekweni kwaye ukongeza, imizimba ye-ketone inciphisa i-angiogenesis yethumba kunye nokudumba ngelixa kuphucula ukubola kweseli. (IWallace TC okqhubekayo, J. yeAmer. Ikhonkco. YeNutr., 2019)
Kuba iithagethi zonyango ezichaziweyo kufuneka zifikelelwe ngokusekwe kwiimpawu zomhlaza kunye nohlobo lonyango, ukuchaneka kunye nesondlo esenzelwe umntu kufuneka sisekwe kukutya okukodwa kunye nezongezo ezinendlela esekwe kakuhle yezenzo kwinqanaba leemolekyuli ngokwempembelelo yazo kwimfuza kunye iindlela. (UReglero C kunye noReglero G, izondlo, ngo-2019)
Umzekelo, enye indlela yokuthintela i-metastasis yomhlaza kukuthintela i-angiogenesis, ukuhluma kwemithambo yegazi entsha, eya kuthi ithintele ukumelana ne-chemotherapy. Kukho ukutya kunye nezongezo ezine-bioactive silibinin, ezinjenge artichoke kunye ubisi thistile, eziboniswe ngokwenzululwazi ukuthintela i-angiogenesis. Isincomo esenzelwe wena / iingcebiso zokutya koku kutya / izongezo kule meko yomhlaza webele we-metastatic owenza i-chemotherapy, unokunceda ekuphuculeni ukusebenza konyango kunye nokuthintela ukuphindaphinda. (UBinienda A, et al, iiarhente zeAnticancer Med Chem, 2019)
Kwangokunjalo, ezinye iimpawu eziphambili zomhlaza kunye nonyango zinokuhlalutywa ukuze kufunyanwe ukutya okufanelekileyo kwezesayensi kunye nezongezo kuyilo lokondla lomntu kwizigulana ezinomhlaza ukufanisa uhlobo lomhlaza onjengomhlaza webele we-metastatic kunye nonyango.
isiphelo
Njengoko iingcebiso zonyango zisiya kubuntu obusekwe kwi-genomics yomhlaza kunye neempawu zomhlaza wemolekyuli yesigulane ngasinye, ukhathalelo lomhlaza odibeneyo kufuneka luqhubele phambili kwisondlo esixhasayo somntu / ukutya okusekwe kwinqanaba kunye nohlobo umhlaza kunye nonyango. Lo ngummandla ongasetyenziswanga kakhulu onokunceda kakhulu ekuphuculeni iziphumo kunye nomgangatho wobomi kwizigulana ezinomhlaza webele we-metastatic. Xa usempilweni entle, ukutya kwendalo kunye nezongezelelo azinabungozi. Kodwa, xa umxholo umhlaza apho umzimba sele ujongene ne-dysregulation yangaphakathi kwi-metabolism kunye nokukhuseleka ngenxa yesifo kunye nonyango oluqhubekayo, kunye nokutya kwendalo, ukuba ayikhethwanga ngokuchanekileyo, Unokubangela ingozi. Ke ngoko, isondlo esenzelwe wena esisekwe kwisibonakaliso somhlaza (njengomhlaza wamabele) kunye nohlobo lonyango lunokuxhasa iziphumo eziphuculweyo kunye nokuba sisigulana.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) lolona nyango lwendalo olungcono lomhlaza kunye nokunxulumene nonyango i-side-effectts.