Iimbalasane
Ukuxelwa kweziphumo zeklinikhi zokuvavanywa kwamachiza e-cytotoxic chemotherapy kuthoba ingozi kunye neetyhefu zamachiza ngokuchaza okunamandla kwaye kuhlala kulahlekisa. Izifundo ekuthiwa iyeza linyamezeleke kwaye zixele ngaphezulu kwesithathu sezigulana eziyeka iyeza ngenxa yeziganeko ezimbi. Ukunxibelelana gwenxa kwetyhefu yeziyobisi kufuneka kuthintelwe kwaye iziphumo ebezingalindelekanga ezinokubakho zichazwe ngokuchanekileyo.
Ngaba ukhe wayibona intengiso yeziyobisi ezitsha ezize kwintengiso ezigcwele ngabantu abonwabileyo ngexesha lokuthengisa kwaye ekugqibeleni, kuba iinkampani zamachiza zibophelelekile ngokwasemthethweni ukuba zenze njalo, ilizwi elikhawulezayo neliphantsi ngokwenene lifundwa uluhlu oloyikisayo lweziphumo ebezingalindelekanga eziphantse zife ngokufa okunokubakho? Ngokucacileyo, iinkampani zamachiza zizakuzama ukunciphisa naziphi na iziphumo ebezingalindelekanga ezinokubangelwa ngamachiza azo nokuba, kwaye kwiimeko ezininzi oku kuyinyani, iziphumo ebezingalindelekanga zinokuba mbi kunengxaki yoqobo amayeza azama ukuyilungisa. Kwangokunjalo, uninzi lwezilingo zeklinikhi zisebenzisa ulwimi olungachazi ngokupheleleyo ubungozi obunokubakho (obukhokelela kunxibelelwano olungalunganga) kunye neziphumo ebezingalindelekanga zamachiza amiselweyo ekhemotherapy.
Isizathu sokuba ubungozi beziyobisi zityhefuwe phantsi kwisigulana esinokubakho kungenxa yolwimi olulahlekisayo nolugqithisileyo olusetyenziswa ziinkampani zeeparma. Kwaye ukukhalisa i-alamu kwabanye oogqirha kunye nabaphandi bezonyango malunga nengxaki, abaphandi bezonyango baseMassachusetts General Hospital eBoston bapapasha inqaku kwiNew England Journal of Medicine. Kweli nqaku, bafumanise ukuba iimvavanyo zeklinikhi zihlala zichaza iziphumo ebezingalindelekanga zamachiza e-chemo 'njengokulawuleka,' 'ngokukhuselekileyo nangokusebenzayo' okanye 'ngokunyamezelwa ngokubanzi' xa kungekho nanye kwezi ekufutshane nokuba ichaze ngokupheleleyo ubungakanani bengxaki. Umzekelo, kwi umhlaza ongathandabuzekiyo uphononongo phakathi kwamaqela amabini athatyathwa 'njengokunyamezelwa kakuhle,' ”izehlo ezimbi zikhokelele ekuyekisweni kwe-chemotherapy kwi-39% yezigulana kwiqela elinye lonyango kunye ne-27% kwelinye. Bebonke, ngabantu abali-13 ababhubhe ngenxa yesiganeko esibi ”(Chana A. Sacks okqhubekayo, N ENGL J MED., 2019). Ukubeka ilebheli emnene kwichiza elinetyhefu yokoqobo ebangele ukuba abanye abantu bafe akulunganga. Iziphumo kumgangatho wobomi zisaphononongwa zizifundo ezingenakubalwa kodwa eyona nto iphambili kukuba izifundo zeklinikhi zifuna indlela entsha yokuba bazokwazisa njani abasebenzisi abanokubakho kunye noogqirha malunga neziphumo ebezingalindelekanga zamachiza abo.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-Regorafenib njengomzekelo weziyobisi ezinobungozi obubalulekileyo
I-Regorafenib ijoliswe kuyo umhlaza iyeza elivunyiweyo yi-FDA ukunyanga umhlaza we-metastatic colorectal kuphela ukuba izigulane ziye zasilela ezinye iintlobo zechemotherapy ezifana ne-OXA, i-fluoropyridine, i-IRN esekelwe kwi-chemotherapies kunye nonyango lwe-anti-VEGF. Ichiza elifana ne-Regorafenib laye lanxulunyaniswa netyhefu ebalulekileyo kwiidosi ezivunyiweyo, ezigunyazise ukuphononongwa kwakhona kweshedyuli yedosi kunye neprofayili yetyhefu emva kokuvunywa. Ke nangona eli chiza lingqiniwe ukuba liyasebenza ngokwamandla alo okuphelisa amathumba, oogqirha kufuneka balumke kakhulu kuzo zombini iidosi zokuzisa kunye nokwazisa izigulana ngetyhefu enokuthi iza nokuthatha ichiza elinjalo. Kuphononongo olwenziwa ngabaphandi bezonyango abavela kwiYunivesithi yaseColumbia eNew York malunga nokusebenza kunye neziphumo ezinokuthi zibe kho zeRegorafenib, ulingo lwe-GRID lwenziwa kubhaliswa abantu abali-199 abathatha i-160mg ye-Regorafenib ngomlomo kwiiveki ezi-3 kwezi-4 kumjikelo ngamnye kunye neziphumo ezibi zixeliwe I-98% yezigulane kunye "nezona mpendulo zixhaphakileyo ezimbi zichazwe zizenzo zesikhumba sesandla (56%), uxinzelelo lwegazi (48.5%), isifo sohudo (40%) kunye nokukhathala (38.6%)" (UDemetri GD okqhubekayo, Lancet, 2013; IKrishnamoorthy SK okqhubekayo, Therap Adv Gastroenterol., 2015). Ngaphezulu koku, bekukho umonakalo omkhulu kulusu ezandleni zomntu oxelwe zizigulana.
Eyona nto iphambili kukuba abaguli kufuneka bazi ukuba bangena entwenini kwaye oku akunakwenzeka ukuba balahlekisiwe ngamagama abanzi ngenjongo okanye ngokungacwangciswanga (uthungelwano olugwenxa) olungaphumeleliyo ukuchaza ngokuchanekileyo iingxaki ezinokubakho ezinje ngetyhefu, ezinokuthi zikhokelele .
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukuphepha ukuqagela kunye nokukhetha okungakhethiyo) lolona nyango lulungileyo lwendalo umhlaza kunye neziphumo ebezingalindelekanga ezinxulumene nonyango.