Amaphuzu avelele
Ukudla kwe-soy kuyimithombo ebalulekile yokudla ye-isoflavones njenge-genistein, i-daidzein ne-glycitein, esebenza njenge-phytoestrogens (amakhemikhali asekelwe esitshalweni anesakhiwo esifana ne-estrogen). Abaningi umdlavuza webele kukhona i-estrogen receptor (i-hormone receptor) enhle futhi yingakho umuntu angase esabe ukuthi ukudla kwesoya kuhlotshaniswa yini nengozi eyengeziwe yomdlavuza webele. Le bhulogi ifingqa izifundo ezehlukene ezihlola ukuhlangana phakathi kokudla kwesoya nomdlavuza webele. Okutholwe kwalolu cwaningo kubonisa ukuthi ukudla ukudla kwe-soy ngenani elilinganiselwe akukhulisi ingozi yomdlavuza webele, kodwa ukuthatha izithako zesoya kungase kungabi inketho ephephile.
Ukudla kwe-Soy bekuyingxenye yokudla kwendabuko kwase-Asia kusukela eminyakeni eminingi futhi imikhiqizo yesoya isanda kuthola ukuthandwa emhlabeni wonke. Ngenxa yokuqukethwe kwayo kwamaprotheni aphezulu, imikhiqizo yesoya nayo isetshenziswa njenge-analogue enempilo yenyama futhi njengezixazululo ezivamile zokudla kwabadla inyama. Izinhlobo ezahlukahlukene zokudla kwesoya zifaka phakathi ukudla okungavutshiwe kesoya okufana nobhontshisi ophelele, i-tofu, i-edamame nobisi lwe-soy kanye nemikhiqizo yesoya ebilile efana ne-soy sauce, ubhontshisi obilisiwe, i-miso, i-nattō ne-tempeh.
Ukwengeza, ukudla kwe-soy nakho kuyimithombo ebalulekile yokudla ye-isoflavones njenge-genistein, i-daidzein ne-glycitein. Ama-Isoflavone ayizinhlanganisela zezitshalo zemvelo eziwela ngaphansi kwesigaba sama-flavonoid abonisa izakhiwo ze-antioxidant, anticancer, antimicrobial, and anti-inflammatory. Ama-Isoflavone asebenza njengama-phytoestrogens, angelutho ngaphandle kwamakhemikhali asekelwe ezitshalweni anesakhiwo esifana ne-estrogen. Ukuhlotshaniswa kokudla kwe-soy nomdlavuza webele kuye kwafundwa kanzima iminyaka eminingi. Le bhulogi igxile ezifundweni ezehlukene ezihlole ukuhlotshaniswa kokudla kwesoya nebele umdlavuza.
Inhlangano phakathi kweSoy Foods ne-Cancer Breast
Umdlavuza wesibeletho iyimbangela yesibili ehamba phambili yokushona komdlavuza kwabesifazane ngonyaka wezi-2020. Izinga lomdlavuza webele lenyuke kancane ngo-0.3% ngonyaka eminyakeni yamuva (I-American Cancer Society). Kuvame kakhulu kwabesifazane abaneminyaka ephakathi kuka-20-59. Ngaphezu kwalokho, umdlavuza wamabele wenza i-30% yawo wonke umdlavuza wabesifazane (Izibalo Zomdlavuza, 2020). Imidlavuza eminingi yamabele ingumdlavuza webele omuhle we-estrogen receptor (i-hormone receptor) futhi njengoba kushiwo ngaphambili, ukudla kwesoya kunama-isoflavones asebenza njengama-phytoestrogens. Ngakho-ke, umuntu angesaba ukuthi ukudla kwesoya kuhlotshaniswa nengozi eyengeziwe yomdlavuza webele (kufaka phakathi umdlavuza webele we-estrogen receptor). Ake sithole ukuthi izifundo zithini!
Okutholakele ku-Studies on Soy Foods ne-Cancer Breast
1. Ingozi Yomdlavuza We-Soy ne-Breast Cancer kubantu besifazane base-China
Ucwaningo lwakamuva olushicilelwe kwi-European Journal of Epidemiology luhlolisise ubudlelwano phakathi kokudla kwesoya kanye nengozi yesifo somdlavuza webele. Abaphenyi basebenzise idatha evela ocwaningweni olukhulu lweqembu elizobizwa ngeChina Kadoorie Biobank (CKB) cohort cwaningo lokuhlaziya. Lolu cwaningo lubandakanye abesifazane abangaphezu kuka-300,000 abaneminyaka ephakathi kuka-30-79 abavela ezifundeni eziyi-10 ngokwendawo nangokomnotho eChina. Laba besifazane babhaliswa phakathi kuka-2004 no-2008, futhi balandelelwa ngezigameko zomdlavuza webele cishe iminyaka eyishumi. Ngokwengeziwe, abacwaningi bathole imininingwane yokusetshenziswa kwesoya emibuthanweni yemibuzo yokudla okuyisisekelo, ukuvuka okumbili kanye nezikhumbuzo eziyishumi nambili zokudla okungama-10-h. (U-Wei Y et al, u-Eur J Epidemiol. 2019)
Ngokwedatha eqoqiwe, kusho ukuthi ukutholwa kwesoya kwalaba besifazane kwakungu-9.4 mg / ngosuku. Abesifazane abangama-2289 baba nomdlavuza webele ngesikhathi sokulandela seminyaka eyishumi. Ukuhlaziywa okuningiliziwe kwedatha akutholanga ukuhlangana okuphawulekayo phakathi kokudla kwesoya kanye nesifo somdlavuza webele.
Khonamanjalo, abacwaningi baphinde bacwaninga bathola izifundo ze-8 zangaphambili zeqembu ezivela emphakathini futhi benza ukuhlaziywa kwe-meta-response meta-analysis. Ukuhlaziywa kubonise ukuthi kukho konke ukwanda kwe-10 mg / ngosuku ekudleni kwesoya, kube nokuncipha okungu-3% engcupheni yomdlavuza webele. (U-Wei Y et al, u-Eur J Epidemiol. 2019)
Izindlela Zokuthatha Ukhiye:
Abaphenyi baphetha ngokuthi ukungeniswa kwesoya ngokulingene akuhlotshaniswa nakho ingozi yomdlavuza webele kwabesifazane baseChina. Baphinde basikisela ukuthi inani eliphakeme lokusetshenziswa kokudla kwesoya lingahlinzeka ngezinzuzo ezifanele zokunciphisa ingozi yomdlavuza webele.
2. I-Soy isoflavone Intake kanye ne-Menopausal Symptoms (MPS) phakathi kwabesifazane base-China abanomdlavuza webele wokuqala
Ocwaningweni lwakamuva, abacwaningi baphenye usoseshini ophakathi isoy isoflavone izimpawu zokudla kanye ne-menopausal (MPS) phakathi kwabesifazane baseChina abatholakala benomdlavuza webele wesigaba sokuqala. Ucwaningo lushicilelwe kwiBreast Cancer Research and Treatment Journal ngo-Ephreli 2020. Lusebenzise imininingwane esuselwa kuhlu lwemibuzo kusuka ezigulini zomdlavuza webele zaseChina ezingama-1462. Kwakunamaphoyinti wesikhathi sokulandelela amathathu phakathi neminyaka yokuqala emihlanu yokuxilongwa ngemuva kokuxilongwa. (U-Lei YY et al, Ukwelashwa Kwe-Cancer Res Treatment. 2020)
Izindlela Zokuthatha Ukhiye:
Okutholakele akubonisanga ukuhlangana phakathi kokudla kwe-soy isoflavone kanye nezimpawu zokuya esikhathini phakathi kweziguli zomdlavuza wamabele waseChina.
3. Ama-Soy isoflavones noMdlavuza Webele ku-Pre- and Post-Menopausal Women abavela emazweni ase-Asia naseNtshonalanga
Ukuhlaziywa kwe-meta okushicilelwe ephephabhukwini le-PLoS One ngo-2014 kufaka phakathi izifundo ezingama-30 zokubheka ezibandakanya abesifazane abangaphambi kokuya esikhathini kanye nezifundo ezingama-31 ezibandakanya abesifazane abangemva kokuya esikhathini ukuze bahlole ukuhlangana kokudla kwe-soy isoflavone nomdlavuza webele. Ezifundweni ezibandakanya abesifazane abangaphambi kokuya esikhathini, kwenziwa izifundo eziyi-17 emazweni ase-Asia kwathi eziyi-14 zenziwa emazweni aseNtshonalanga. Ezifundweni ezibandakanya abesifazane abasuke beye esikhathini sokuya esikhathini, kwenziwa izifundo eziyi-18 emazweni ase-Asia kwathi eziyi-14 zenziwa emazweni aseNtshonalanga. (UChen M et al, PLoS One. 2014)
Izindlela Zokuthatha Ukhiye:
Abaphenyi bathola ukuthi ukudla kwe-soy isoflavone kunganciphisa ubungozi besifo somdlavuza webele kubo bobabili abantu besifazane abangaphambi kokuya esikhathini nokuya esikhathini kwabesilisa emazweni ase-Asia. Kodwa-ke, ababutholanga ubufakazi obukhombisa ukuhlangana phakathi kokudla kwe-soy isoflavone kanye nomdlavuza webele wabesifazane be-premenopausal noma be-post-menopausal emazweni aseNtshonalanga.
4. Ukudla Kwe-Soy Ukudla kanye Nesifo sokuqhekeka kwamathambo kwabasinde umdlavuza webele
Ocwaningweni olukhulu olulindelwe olubizwa ngokuthi “I-Shanghai Breast Cancer Survival Study”, abacwaningi baphenye isigameko sokuphuka kwamathambo kanye nokuhlotshaniswa kwakho nokudla kwesoya kwabasinde emdlavuza webele. Ucwaningo lufake idatha evela ku-4139 isigaba 0-III ebeleni umdlavuza iziguli, iziguli ezingu-1987 ezandulela ukuya esikhathini kanye neziguli zangemuva kokuya esikhathini ezingama-2152. Ukudla kwesoya kwahlolwa ezinyangeni eziyisi-6 neziyi-18 ngemuva kokuxilongwa. Futhi, ukuphuka kwahlolwa ezinyangeni ze-18 naku-3, 5, kanye neminyaka engu-10 ngemuva kokuxilongwa.UZheng N et al, Umbukeli Womdlavuza we-JNCI. 2019)
Izindlela zokuthatha ukhiye:
Okutholakele ocwaningweni kukhombisa ukuthi ukusetshenziswa okwandisiwe kwe-soy isoflavone kunganciphisa ubungozi bokuphuka kwamathambo ezigulini zangaphambi kokuya esikhathini kodwa hhayi ezigulini zangemva kokuya esikhathini.
5. I-Soy isoflavones Ukuphindaphinda Komdlavuza Webele
Ocwaningweni olwenziwe ngu-Kang X et al., bahlaziye izinhlangano phakathi kokudla kwe-soy isoflavones kanye nokuphindaphinda komdlavuza webele nokufa. Ucwaningo lusebenzise idatha esekelwe kuhlu lwemibuzo evela ku-524 breast umdlavuza iziguli ukuze zihlaziywe. Ucwaningo lwenziwa ezigulini ezahlinzwa ngenxa yomdlavuza webele phakathi kuka-Agasti 2002 noJulayi 2003. Iziguli ziphinde zathola ukwelashwa kwe-adjuvant endocrine eSibhedlela Somdlavuza saseHarbin Medical University eChina. Isikhathi esimaphakathi sokulandelela sasiyiminyaka engu-5.1. Ucwaningo luphinde lwahlolwa isimo se-hormonal receptor kanye nokwelashwa kwe-endocrine. (UKang X et al, CMAJ. 2010).
Izindlela Zokuthatha Ukhiye:
Okutholakele ocwaningweni kukhombisile ukuthi ukudla okuphezulu kwama-soy isoflavones njengengxenye yokudla kunganciphisa ubungozi bokuphindeka ezigulini zomdlavuza webele zangemva kokuya esikhathini zokuya esikhathini ezathola i-estrogen receptor ne-progesterone receptor, nalabo ababethola ukwelashwa kwe-endocrine.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
6. Izakhamzimba ze-Dietary Soy Supplements kanye ne-Breast Cancer Risk kwabesifazane baseFrance
Ucwaningo olushicilelwe muva nje kwi-The American Journal of Clinical Nutrition ngo-2019, luphenye ubudlelwane obuphakathi kokudla okwengezwayo kokudla kukashukela kanye nengozi yomdlavuza webele. Ucwaningo lubandakanya imininingwane yabesifazane abangama-76,442 baseFrance abavela ku-INSERM (French National Institutes for Health and Medical Research) i-Etude Epidemiologique aupres de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) cohort. Abesifazane abafakiwe ocwaningweni babeneminyaka engaphezu kwengu-50 ubudala futhi bazalwa phakathi kuka-1925 no-1950. Balandelwa kusukela ngonyaka ka-2000 kuya kowezi-2011 ngesikhathi esilandelwayo seminyaka eyi-11.2. Ngaphezu kwalokho, ukusetshenziswa kwe-soy supplement kwahlolwa njalo eminyakeni engu-2-3. (UTouillaud M et al, Am J Umtholampilo Wezempilo. 2019)
Abaphenyi bathola ukuthi kwakungekho ukuhlangana okuphelele phakathi kokusetshenziswa kwamanje noma okwedlule kwezithako zokudla zesoya (eziqukethe ama-isoflavones) kanye nengozi yomdlavuza webele. Kodwa-ke, lapho behlaziya idatha ngesimo se-estrogen receptor (ER), kutholakale ukuthi kunengozi encane yomdlavuza webele we-estrogen receptor (ER +) kanye nengozi ephezulu yomdlavuza webele we-estrogen receptor (ER-) okwamanje abasebenzisi bokudla bengezela ukudla. Idatha iphinde yabonisa ukuthi abesifazane abanomlando womndeni womdlavuza webele babesengozini enkulu yomdlavuza webele we-ER. I-Premenopausal, abesifazane nabesifazane abasanda kungena esikhathini abangenawo umlando womdlavuza webele babe nengozi encane yomdlavuza webele we-ER +.
Izindlela Zokuthatha Ukhiye:
Okutholakele kulolu cwaningo kubonisa ukuthi kunezinhlangano eziphikisanayo zezithako zokudla zesoya ezine-estrogen receptor ne-ER-negative yomdlavuza webele. Ngaphezu kwalokho, abesifazane abanomlando womndeni wesifo somdlavuza webele kufanele baqaphele kakhulu ngenkathi bethatha izithako zokudla zesoya.
7. Umphumela Wokwengezwa KweSoy Kumakaki Wengozi Yomdlavuza Webele njengeMammographic / Breast Density
Ucwaningo olushicilelwe ngo-2015 luhlolisise umthelela wokwengezwa kwesoya ku-mammographic / ukuminyana kwamabele ezigulini zomdlavuza webele ezingama-66 ezake zaphathwa phambilini kanye nabesifazane abangama-29 abasengozini enkulu. Ubuningi beMammographic, obaziwa nangokuthi ukuminyana kwesifuba, yiphesenti lezicubu eziminyene zesifuba sonke. Ngenye yezinto eziyingozi kakhulu zomdlavuza webele. Ucwaningo lomtholampilo lwalubandakanya abesifazane abaneminyaka engama-30 kuya kwengama-75 ababengo:
- batholakala benomdlavuza webele futhi babelashwa noma bengalashwa ngezinga lokwelashwa kwama-hormone noma i-aromatase inhibitor (AI) okungenani ezinyangeni eziyisithupha ngaphambili, bungekho ubufakazi bokuphindeka; noma
- abesifazane abasengozini enkulu abaziwa I-BRCA1 / BRCA2 ukuguquka kwesimo, noma umlando womndeni ohambisana nomdlavuza webele owofuzo.
Abahlanganyeli bahlukaniswe ngamaqembu ama-2. Iqembu lokuqala lithole amaphilisi wesoya aqukethe ama-isoflavones angama-50 mg kanti iqembu elilawulayo lithole amaphilisi e-placebo aqukethe i-microcrystalin cellulose. Ama-mammograms edijithali namaskena we-MRI wesifuba atholwe ekuqaleni (ngaphambi kokungezelelwa) nezinyanga eziyi-12 ngemuva kwansuku zonke ithebhulethi ye-50 mg soy isoflavones noma i-placebo tablet supplementation. (UWu AH et al, iCancer Prev Res (Phila), 2015).
Izindlela Zokuthatha Ukhiye:
Ukuhlaziywa kutholakale ukwehla okuncane kwamaphesenti we-mammographic density (kulinganiswa ngokulinganisa kwenyanga 12 kuya kumazinga ayisisekelo) eqenjini elithole ukwesekwa kwesoya kanye neqembu lokulawula. Kodwa-ke, lezi zinguquko bezingahlukile phakathi kwezindlela zokwelashwa. Ngokufanayo, imiphumela yeziguli ezinomdlavuza webele kanye nabesifazane abasengozini enkulu nayo iye yaqhathaniswa. Ekuphetheni, abacwaningi bathi i-soy isoflavone supplementation ayithinti ubukhulu be-mammographic.
8. Ingozi Yokungena Kokudla Kwabasha Nabantu Abadala Nengozi Yomdlavuza Webele
Ocwaningweni olwashicilelwa ngo-2009, abacwaningi bahlaziya imininingwane evela eShanghai Women's Health Study ukuze bahlole ukuhlangana kokudla kwentsha kanye nokudla kwabantu abadala okunobungozi bomdlavuza webele. Ucwaningo lubandakanya abesifazane baseChina abangama-73,223 abaneminyaka ephakathi kuka-40-70 abaneminyaka engama-1996 kuya kwengama-2000 abaqashwa phakathi kuka-592 no-7. Imininingwane esuselwa kuhlu lwemibuzo isetshenziselwe ukuhlola ukudla okudliwayo ngesikhathi somuntu osemdala nasebusheni. Kubikwe izigameko ezingama-XNUMX zesifo somdlavuza webele ngemuva kokulandelwa cishe kweminyaka engu-XNUMX. (U-Lee SA et al, Am J Umtholampilo Womtholampilo. 2009)
Izindlela zokuthatha ukhiye:
Okutholakele ocwaningweni kukhombisile ukuthi ukudla ukudla okunoshukela okuphezulu kunganciphisa ingozi yomdlavuza webele phakathi kwabesifazane be-premenopausal. Abesifazane abasebenzisa inani eliphakeme lokudla kwesoya ngokungaguquguquki ngesikhathi sobusha babo nokuba badala babe nengozi enciphisiwe yomdlavuza webele. Kodwa-ke, abakutholanga ukuhlangana nokusetshenziswa kokudla kwesoya komdlavuza webele we-postmenopausal.
Yini okufanele siyenze kusuka kulezi Zifundo?
Lezi zifundo zikhomba ukuthi ukudla ukudla kwe-soy ngenani elilinganiselwe akukhulisi ingozi yebele umdlavuza. Ngaphezu kwalokho, izifundo ezimbalwa ziphakamisa ukuthi ukudla kwe-soy kungase kunciphise ingozi yomdlavuza webele, ikakhulukazi kwabesifazane baseShayina / base-Asia. Olunye ucwaningo luphinde lubonise ukuthi lezi zinzuzo zivame kakhulu kubantu besifazane abadla ukudla kwe-soy ngokungaguquki ngesikhathi sokukhula kwabo kanye nokukhula kwabo. Ukudla kwe-soy nakho kunganciphisa amazinga e-cholesterol futhi kunciphise ingozi yezifo zenhliziyo. Nokho, kungase kungabi njalo kuphephile ukuthatha izithako zokudla zesoya, ikakhulukazi ngabesifazane abanomlando womndeni womdlavuza webele. Ngokufingqa, kuphephile futhi kunempilo ukuthatha inani elilinganisiwe lokudla kwesoya njengengxenye yokudla / umsoco wethu esikhundleni sokuthatha Izithako. Gwema ukungeniswa kwesoyile ngaphandle kwalapho kunconywa abahlinzeki bakho bokunakekela impilo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy ezithinta ikhwalithi yempilo yazo futhi zibheke ezinye izindlela zokwelapha umdlavuza ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.