Ingabe Ukudla Okudliwayo Kwemifino Kunganciphisa Ubungozi Bomdlavuza?

Amaphuzu avelele

Imifino enothe ngamaprotheni nefiber okuhlanganisa uphizi, ubhontshisi nodali kwaziwa ukuthi kunezinzuzo eziningi zezempilo ezihlanganisa ukuncipha kwengozi yezifo zenhliziyo, isifo sikashukela, i-cholesterol nokuqunjelwa kanye nomfutho wegazi othuthukisiwe. Ucwaningo oluhlukene olusekelwe kubantu (iqembu) luphinde lwabonisa ukuthi ukudla/ukudla okunothe ngemifino efana nophizi, ubhontshisi namalentili kungase kuhlotshaniswe nengozi encishisiwe yezinto ezithile. umdlavuza izinhlobo ezifana nomdlavuza webele, we-colorectal kanye nowe-prostate. Kodwa-ke, ukudla okusanhlamvu okuphakeme kungase kunganciphisi ingozi yomdlavuza we-endometrial.

Yini ama-legumes?

Izitshalo ze-leguminous zingezomndeni wepea noma owomndeni wezitshalo iFabaceae. Amaqhuqhuva ezimpande alezi zitshalo abamba amagciwane e-rhizobium futhi lawa mabhaktheriya wona alungisa i-nitrogen evela emkhathini iye enhlabathini, esetshenziswa yizimila ukuze zikhule, ngaleyo ndlela yakha ubudlelwane obusondelene. Ngakho-ke, izitshalo ezinemilenze zithandwa ngezinzuzo zazo zokudla okunomsoco kanye nezemvelo.

Izitshalo ze-leguminous zinama-pods anezinhlamvu ngaphakathi, ezaziwa nangokuthi imidumba. Uma isetshenziswa njengezinhlamvu ezomile, lezi zinhlamvu zibizwa ngokuthi ama-pulses.

Eminye imidumba edliwayo ihlanganisa uphizi; ubhontshisi ojwayelekile; udali; amantshontsho ubhontshisi; amakinati; izinhlobo ezahlukahlukene zobhontshisi owomile kubandakanya izinso, i-pinto, i-navy, i-azuki, i-mung, i-gram emnyama, umgijimi obomvu, i-ricebean, inundu nobhontshisi we-tepary; izinhlobo ezahlukahlukene zobhontshisi obanzi obomile kufaka phakathi ubhontshisi wehhashi nensimu, uphizi owomile, uphizi onamehlo amnyama, uphizi wejuba, ibambela groundnut, i-vetch, i-lupins; namanye afana namaphiko, i-velvet nobhontshisi we-yam. Ikhwalithi yokudla okunempilo, ukubukeka nokunambitheka kungahluka ezinhlotsheni ezahlukahlukene zamapulse.

Izinzuzo Zezempilo Zemidumba

Ama-pulses anomsoco ngokweqile. Imidumba efana nophizi, ubhontshisi kanye nodali kungumthombo omuhle kakhulu wamaprotheni nemicu yokudla futhi kwaziwa ukuthi kunezinzuzo ezihlukile zezempilo. Amaprotheni e-pea athathwa njengokudla noma izithasiselo futhi akhishwa ngefomu le-powder kophizi ohlukaniswe ophuzi noluhlaza.

Ngaphandle kwamaprotheni nemicu yokudla, imidumba nayo igcwele ezinye izakhamzimba ezibandakanya:

• Antioxidants
• Amaminerali afana ne-iron, i-magnesium, i-zinc, i-calcium, i-potassium
• Amavithamini B afana ne-folate, i-vitamin B6, i-thiamine
• Amakhabhohayidrethi afaka isitashi esingazweli  
• Ama-sterol ezitshalo zokudla ezifana ne-β-sitosterol 
• I-Phytoestrogens (isitshalo sihlanganiswa ne-estrogen njengempahla) njengeCoumestrol

Ngokungafani nokudla okufana nenyama ebomvu, ama-pulses awekho emafutheni agcwele. Ngenxa yalezi zinzuzo, imidumba enamaprotheni ehlanganisa uphizi, ubhontshisi kanye nodali kuthathwa njengokudla okunye okunempilo okuhle enyameni ebomvu futhi kusetshenziswa njengokudla okuyisisekelo emazweni amaningi emhlabeni jikelele. Ngokwengeziwe, lokhu futhi akubizi futhi kuyasimama.

Ukudla okudliwayo kufaka phakathi uphizi njengengxenye yokudla okunempilo nendlela yokuphila kungahlotshaniswa nezinzuzo ezahlukahlukene zezempilo ezibandakanya:

• Ukuvimbela ukuqunjelwa
• Ukunciphisa ubungozi besifo senhliziyo
• Ukunciphisa amazinga e-cholesterol
• Ukwenza ngcono umfutho wegazi
• Ukuvimbela isifo sikashukela sohlobo 2
• Ukukhuthaza ukulahleka kwesisindo

Kodwa-ke, kanye nalezi zinzuzo zezempilo, kukhona ezinye iziphazamiso ezaziwayo zala mafutha aphansi, uphizi wamaprotheni aphezulu, ubhontshisi kanye nodali njengoba kuqukethe izinto ezithile ezibizwa ngama-anti-nutrient. Lokhu kunganciphisa amandla omzimba wethu okuthola izakhamzimba ezithile. 

Izibonelo zalezi zinhlayiya ezinganciphisa ukumuncwa kwesakhi esisodwa noma eziningi kubandakanya i-iron, i-zinc, i-calcium ne-magnesium yi-phytic acid, ama-lectin, ama-tannins nama-saponins. Imidumba engaphekiwe iqukethe ama-lectin angadala ukuqunjelwa, kepha-ke, uma kuphekiwe, lactin akhona ebusweni bemidumba angasuswa.

Ukufakwa Kwemifino kanye Nengozi Yomdlavuza

Njengokudla okunomsoco okunezinzuzo ezehlukene zezempilo, abacwaningi emhlabeni wonke bebenentshisekelo yokuqonda ukuhlobana phakathi kokudla kwalezi zinhlobo zama-protein kanye ne-fiber yokudla okune-legumes ehlanganisa uphizi, ubhontshisi kanye nodali kanye nobungozi bokudla. umdlavuza. Izifundo ezehlukene ezisekelwe kubantu kanye nokuhlaziywa kwe-meta kwenziwe ukuze kuhlolwe le nhlangano. Kuye kwenziwa nocwaningo oluhlukahlukene ukuze kuphenywe ukuhlotshaniswa kwemisoco ethile etholakala ngamanani aphezulu ekudleni okunemidumba okufana nophizi, ubhontshisi nodali osengozini yezinhlobo zomdlavuza ezihlukene. 

Ezinye zalezi zifundo kanye nokuhlaziywa kwe-meta kuhlanganiswe kubhulogi.

Ubungozi Bomdlavuza We-Legume ne-Breast Cancer

Funda ngabesifazane base-Iranian

Ocwaningweni olusanda kwenziwa olushicilelwe ngoJuni 2020, abacwaningi bahlole ubudlelwane phakathi kokudla imidumba namantongomane kanye nengozi yomdlavuza webele kwabesifazane base-Iranian. Ukuhlaziya, idatha esuselwe kuhlu lwemibuzo yokudla okulinganiselwa kokudla okwenziwe nge-168-nto yatholwa ocwaningweni lokulawulwa kwamacala okubandakanya inani labantu elibandakanya iziguli ezingama-350 zomdlavuza webele kanye nezilawuli ezingama-700 ezineminyaka yobudala nezinga lezenhlalo zihambisana naleyo yomdlavuza webele iziguli. Imidumba ebhekwe kulolu cwaningo ibandakanya udali ocebile onamaprotheni, uphizi, amantshontsho nezinhlobo ezahlukene zobhontshisi, kufaka phakathi ubhontshisi obomvu nobhontshisi we-pinto. (UYaser Sharif et al, Umdlavuza weNutriti., 2020)

Ukuhlaziywa kutholakele ukuthi phakathi kwabesifazane abalandela ukuya esikhathini nababambe iqhaza esisindweni esijwayelekile, amaqembu athola imidumba ephezulu abe nengozi ephansi engama-46% yomdlavuza webele uma kuqhathaniswa nalawo adla imidumba ephansi.

Ucwaningo luphethe ngokuthi ukusetshenziswa okuthe xaxa kwamaprotheni kanye ne-fiber yokudla okune-legumes efana nophizi, ama-chickpeas nezinhlobo ezahlukene zikabhontshisi kungase kusizuzise ekwehliseni ubungozi bebele. umdlavuza. 

Isifundo Somdlavuza Webele weSan Francisco Bay Area

Ucwaningo olushicilelwe ngo-2018 luhlolisise ubudlelwane obuphakathi kokudla ama-legume / bean kanye nama-subtypes womdlavuza webele ngokuya ngesimo se-estrogen receptor (ER) ne-progesterone receptor (PR). Idatha yemvamisa yokudla yokuhlaziywa itholwe ocwaningweni lokulawulwa kwamacala abantu, olubizwa ngeSan Francisco Bay Area Cancer Study, ebandakanya amacala omdlavuza wamabele angama-2135 aqukethe ama-1070 Hispanics, ama-493 aseMelika aseMelika kanye nama-Whites angama-572 angewona amaSpanishi ; kanye nezilawuli ezingama-2571 ezinama-1391 Hispanics, ama-557 aseMelika aseMelika, kanye nabamhlophe abangama-623 abangewona amaSpanishi. (Meera Sangaramoorthy et al, Cancer Med., 2018)

Ukuhlaziywa kwalolu cwaningo kwathola ukuthi ukudla okuphezulu kwefayibha kabhontshisi, ubhontshisi obuphelele (kubandakanya ubhontshisi we-garbanzo ocebile ngamaprotheni kanye ne-fiber; omunye ubhontshisi onjenge-pinto kidney, omnyama, obomvu, i-lima, othosiwe, uphizi; nophizi onamehlo amnyama), kanye nezinhlamvu eziphelele. yehlisa ingozi yomdlavuza webele ngama-20%. Ucwaningo luphinde lwathola ukuthi lokhu kuncipha kwakubaluleke kakhulu ku-estrogen receptor kanye ne-progesterone receptor negative (ER-PR-) zomdlavuza, ngokunciphisa ubungozi kusuka ku-28 kuya ku-36%. 

Ubungozi Bomdlavuza We-Coumestrol kanye Nebele - Isifundo SeSweden

I-Coumestrol iyi-phytoestrogen (inhlanganisela yezitshalo enezici ze-estrogenic) ezivame ukutholakala kuma-chickpeas, uphizi ohlukanisiwe, ubhontshisi we-lima, ubhontshisi we-pinto kanye namahlumela wesoya. Ocwaningweni olushicilelwe ngonyaka ka-2008, abacwaningi bahlole ukuhlangana phakathi kokudla ama-phytoestrogens adlayo afaka i-isoflavonoids, i-lignans ne-coumestrol kanye nengozi yomdlavuza webele we-subtypes ngokuya ngesimo se-estrogen receptor (ER) ne-progesterone receptor (PR) kwabesifazane baseSweden. Lokhu kuhlola kwenziwa ngokususelwa kwimininingwane yemibuzo yokudla etholwe ocwaningweni lwamaqembu abantu olususelwa ku-1991/1992, olubizwa ngeScandinavia Women's Lifestyle and Health Cohort Study, phakathi kwabesifazane abangama-45,448 baseSweden abangaphambi nangemva kokuya esikhathini. Ngesikhathi sokulandelwa kuze kube nguDisemba 2004, kwabikwa ukuthi kunomdlavuza webele we-1014 ongahlaseli. (UMaria Hedelin et al, J Nutr., 2008)

Ucwaningo luthole ukuthi uma kuqhathaniswa nalabo abangazange badle i-coumestrol, abesifazane abathola ukudla okuphakathi kwe-coumestrol ngokuthatha uphizi ocebile wamaprotheni, ubhontshisi, udali njll kungahle kuhlotshaniswe nengozi encishisiwe engu-50% ye-estrogen receptor ne-progesterone receptor negative (ER -PR-) umdlavuza webele. Kodwa-ke, lolu cwaningo alutholanga kuncishiswa engcupheni yokuthola umdlavuza webele we-estrogen receptor ne-progesterone receptor. 

Ubungozi Bomdlavuza We-Legume and Colorectal

Ukuhlaziywa Kwemeta Kwabacwaningi abavela eWuhan, China

Ocwaningweni olwashicilelwa ngo-2015, abacwaningi baseWuhan, eChina benza ukuhlaziywa kwe-meta ukuhlola ubudlelwane phakathi kokusetshenziswa kwemidumba kanye nengozi yomdlavuza obala. Imininingwane yokuhlaziywa yathathwa ezifundweni ezisuselwa kubantu abangu-14 ezitholwe ngokususelwa ekucwaningweni kwezincwadi eMedline and Embase database kuze kube nguDisemba 2014. Bangu-1,903,459 ababambiqhaza namacala ayi-12,261 11,628,960 anikele ngeminyaka yomuntu engu-2015 efakiwe kulezi zifundo. (Beibei Zhu et al, Sci Rep. XNUMX)

Ukuhlaziywa kwe-meta kutholakale ukuthi ukusetshenziswa okuphezulu kwemidumba njengophizi, ubhontshisi kanye nobhontshisi kungahle kuhlotshaniswe nengozi encishisiwe yeColorectal Cancer, ikakhulukazi kuma-Asiya.

Ukuhlaziywa Kwemeta Kwabaphenyi abavela eShanghai, eRiphabhlikhi Yabantu baseChina

Ocwaningweni olwashicilelwa ngo-2013, abacwaningi baseShanghai, eChina benza ukuhlaziywa kwe-meta ukuhlola ubudlelwane phakathi kokudla imidumba njengophizi, ubhontshisi kanye nobhontshisi kanye nengozi yomdlavuza obomvu. Idatha itholakale ezifundweni ezi-3 ezisekelwe kubantu / iqoqo kanye nezifundo ze-11 zokulawulwa kwamacala ngamacala we-8,380 kanye nenani labahlanganyeli be-101,856, ngokusesha okuhlelekile kwemininingwane yeThe Cochrane Library, MEDLINE kanye ne-Embase bibliographic database phakathi kukaJanuwari 1, 1966 no-Ephreli 1, 2013. (UYunqian Wang et al, PLoS One., 2013)

Ukuhlaziywa kwe-meta kukhombisile ukuthi ukutholakala okuphezulu kwemidumba kungahle kuhlotshaniswe nokwehliswa okukhulu engcupheni ye-colorectal adenoma. Kodwa-ke, abacwaningi baphakamise ezinye izifundo ukuqinisekisa le nhlangano.

Isifundo Sezempilo Se-Adventist

Ocwaningweni olushicilelwe ngo-2011, abacwaningi bahlole ukuhlangana phakathi kokudla kokudla okufana nemifino eluhlaza ephekiwe, izithelo ezomisiwe, imidumba kanye nelayisi elinsundu kanye nengozi yama-polyp colorectal. Ngalokhu, imininingwane yatholakala emibuzweni yokudla neyendlela yokuphila evela ezifundweni ezi-2 zamaqoqo ezibizwa nge-Adventist Health Study-1 (AHS-1) kusuka ngo-1976-1977 kanye ne-Adventist Health Study-2 (AHS-2) kusukela ngo-2002-2004. Ngesikhathi sokulandelwa kwe-26-yr selokhu kwabhaliswa ku-AHS-1, kwabikwa inani lamacala amasha angama-441 ama-rectal / colon polyps. (Yessenia M Tantamango et al, Umdlavuza weNutriti., 2011)

Ukuhlaziywa kutholakale ukuthi ukusetshenziswa kwamaprotheni kanye nemicu equkethe imidumba ecebile okungenani ama-3 ngeviki kunganciphisa ubungozi bama-polyp colorectal ngama-33%.

Ngamafuphi, lezi zifundo zikhomba ukuthi imidumba (njengophizi, ubhontshisi, udali njll) ukudla kungahle kuhlotshaniswe nengozi encishisiwe yomdlavuza wobala.

Ubungozi Bomdlavuza We-Legume ne-Prostate

Ukufundwa yiWenzhou Medical University kanye neZhejiang University

Ocwaningweni olwashicilelwa ngo-2017, abacwaningi baseWenzhou Medical University naseZhejiang University, eChina benza ukuhlaziywa kwe-meta ukuhlola ubudlelwane phakathi kokudla imidumba kanye nengozi yomdlavuza wesinye. Imininingwane yalokhu kuhlaziywa ithathwe kuma-athikili we-10 afaka phakathi izifundo ze-8 ezenzelwe abantu / amaqoqo nabantu abangama-281,034 kanye namacala ezehlakalo ze-10,234. Lezi zifundo zitholwe ngokususelwa ekusesheni okuhleliwe kwezincwadi kumininingwane yolwazi ye-PubMed neWeb yeSayensi kuze kube nguJuni 2016. (UJie Li et al, Oncotarget., 2017)

Ukuhlaziywa kwe-meta kutholile ukuthi ngakunye kwama-gramu angama-20 ngosuku ukukhushulwa kokudla kwe-legume, ingozi yomdlavuza we-prostate yehliswe ngo-3.7%. Ucwaningo luphethe ngokuthi ukudla kakhulu imidumba kungahle kuhlotshaniswe nengozi encishisiwe yomdlavuza wesinye.

Isifundo seMultiethnic Cohort eHawaii naseLos Angeles

Ocwaningweni olushicilelwe ngonyaka we-2008, abacwaningi bahlole ubudlelwano phakathi kokudla okwenziwe ngemidumba, isoya kanye nokudla kwe-isoflavone kanye nengozi yomdlavuza wesinye. Ukuhlaziywa, idatha itholwe kusetshenziswa imibuzo yemvamisa yokudla esifundweni seMultiethnic Cohort Study eHawaii naseLos Angeles kusuka ngo-1993-1996, ebifaka amadoda angama-82,483. Ngesikhathi sokulandelwa okujwayelekile kweminyaka eyi-8, kwabikwa amacala omdlavuza we-prostate angama-4404 kufaka phakathi amacala we-1,278 angahlukaniswanga noma amabanga aphezulu abikiwe. (Ingoma-Yi Park et al, I-Int J Cancer., 2008)

Ucwaningo luthole ukuthi uma kuqhathaniswa nabesilisa abanemidumba ephansi kakhulu, kwehliswe ngo-11% inani lomdlavuza wendlala yesinye kanye nokunciphisa okungu-26% komdlavuza ongafinyeleleki ndawo noma osezingeni eliphakeme kulabo abanokudla okuphekwe kakhulu. Abaphenyi baphetha ngokuthi ukudla ngemidumba kungahle kuhlotshaniswe nokwehliswa okulinganiselwe kwengozi yomdlavuza wesinye.

Ucwaningo lwangaphambilini olwenziwe ngabaphenyi abafanayo lwaluphakamise nokuthi ukusetshenziswa kwezinhlamvu ezifana namaphizi, ubhontshisi, udali, ubhontshisi wesoyb njll kungahle kuhlotshaniswe nengozi encishisiwe yomdlavuza wendlala yabesilisa. (LN Kolonel et al, Cancer Epidemiol Biomarkers Prev., 2000)

Ingozi Yomdlavuza We-Legume ne-Endometrial

Ocwaningweni olushicilelwe ngo-2012, abacwaningi abavela e-University of Hawaii Cancer Center, eLos Angeles, bahlole ubudlelwane obuphakathi kwe-legume, i-soy, i-tofu ne-isoflavone kanye nobungozi bomdlavuza we-endometrial kwabesifazane abangemva kokuya esikhathini. Idatha yokudla itholakale kwabesifazane abangama-46027 be-post-menopausal abaqashwe esifundweni seMultiethnic Cohort (MEC) phakathi kuka-Agasti 1993 no-Agasti 1996. Ngesikhathi esilandelwayo seminyaka engu-13.6, kwatholakala ingqikithi yamacala omdlavuza we-endometrial angama-489. (UNicholas J Ollberding et al, J Natl Cancer Inst., 2012)

Ucwaningo luthole ukuthi ukudla okuphelele kwe-isoflavone, daidzein kanye nokudla kwe-genistein kungahle kuhlotshaniswe nengozi encishisiwe yomdlavuza we-endometrium. Kodwa-ke, ucwaningo alutholanga ukuhlangana okuphawulekayo phakathi kokudla okwandayo kwemidumba kanye nengozi yomdlavuza we-endometrium.

Isiphetho 

Ucwaningo oluhlukene olusekelwe kubantu lukhombisa ukuthi ukusetshenziswa kokudla okunothe ngamaprotheni kanye ne-fiber okufana nemifino noma ama-pulses okuhlanganisa uphizi, ubhontshisi nodali kungase kuhlotshaniswe nengozi encishisiwe yomdlavuza othize njengomdlavuza webele, we-colorectal kanye ne-prostate. Kodwa-ke, ucwaningo olusekelwe kubantu lwathola ukuthi ukudla okuphezulu kokudla okunemifino efana nophizi, ubhontshisi nodali kungase kunganciphisi ingozi ye-endometrial. umdlavuza.

I-American Institute of Cancer Research / World Cancer Research Fund Cancer nayo incoma ukufaka ukudla okudla ngemidumba (uphizi, ubhontshisi nodali) kanye nezinhlamvu ezigcwele, imifino nezithelo njengengxenye enkulu yokudla kwethu kwansuku zonke kokuvikela umdlavuza. Izinzuzo zezempilo zikaphizi ocebile onamaprotheni nofibre, ubhontshisi kanye nodali zifaka nokuncipha kwezifo zenhliziyo, isifo sikashukela, i-cholesterol nokuqunjelwa, ukukhuthaza ukwehla kwesisindo, ukwenza ngcono umfutho wegazi, njalo njalo. Ngamafuphi, kufaka phakathi inani elifanele lamafutha aphansi, imidumba enamaprotheni amaningi njengengxenye yokudla okunempilo kungasiza.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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