Ukudla kwe-Flavonoid nezinzuzo zayo kuCancer

Amaphuzu avelele

Ucwaningo oluhlukile lukhombisa ukuthi i-flavonoids inezinzuzo ezahlukahlukene zezempilo kufaka phakathi izakhiwo zokulwa nomdlavuza, ukulwa nokuvuvukala kanye nomdlavuza futhi kutholakala kokudla okuhlukahlukene okubandakanya izithelo (njengama-cranberries, ama-blueberries, ama-blackberries, ama-bilberry, ama-apula acebile njll), imifino kanye iziphuzo. Ngakho-ke, ukufaka ukudla okucebile kwe-flavonoid njengengxenye yokudla kwethu kwansuku zonke kuzoba lusizo. Kodwa-ke, ngaphambi kokuthatha noma iziphi izithasiselo ze-flavonoid, iziguli ezinomdlavuza kufanele zixoxe njalo nabasebenza ngezempilo.

Yini ama-flavonoids?

I-Flavonoids iyiqembu lama-phenolic compounds kanye ne-subset yama-phytonutrients atholakala kakhulu ekudleni kwezitshalo okuhlukile. Ama-Flavonoid akhona ezinhlotsheni ezahlukahlukene zezithelo, imifino, amantongomane, imbewu, izinongo, okusanhlamvu, amagxolo, izimpande, iziqu, izimbali nokunye ukudla kwezitshalo kanye neziphuzo ezifana netiyi newayini. Ngokusetshenziswa okwandayo kwama-flavonoid ngokuthatha izithelo nokudla okunothe imifino, kwenziwa izifundo ezahlukahlukene emhlabeni wonke ukuhlola izinzuzo zazo zezempilo kanye nezindawo zokulwa nomdlavuza.

Amakilasi Ahlukene E-Flavonoids kanye Nemithombo Yokudla

Ngokuya ngesakhiwo samakhemikhali se-flavonoids, zihlukaniswa ngezihlokwana ezilandelayo.

1. Ama-Anthocyanins
2. AmaCalcones
3. I-Flavanones
4. Ama-Flavones
5. Ama-Flavonols
6. I-Flavan-3-ols
7. Ama-Isoflavone

Ama-Anthocyanins - Isizinda seFlavonoid nemithombo yokudla

Ama-Anthocyanins yizona zingulube ezibhekele ukuhlinzeka imibala ezimbalini nasezithelweni zezitshalo. Ziyaziwa njengezici ezinamandla zokulwa ne-antioxidant. Ama-Anthocyanins e-flavonoid asetshenziswa kakhulu embonini yokudla ngenxa yezinzuzo zayo zezempilo nokuzinza. 

Ezinye zezibonelo zama-anthocyanini yizi:

• UDelphinidin
• I-Cyanidin 
• I-Pelargonidin
• Malvidin 
• Peonidin futhi
• UPetunidin

Imithombo Yokudla ye-Anthocyanin flavonoids: Ama-Anthocyanins atholakala kakhulu esikhunjeni sangaphandle sezithelo / amajikijolo nemikhiqizo yamajikijolo afaka:

• amagilebhusi abomvu
• Amagilebhisi e-Merlot
• Iwayini elibomvu
• I-Cranberries
• Ama-currants amnyama
• Ama-raspberries
• Ama-Strawberries
• aluhlaza okwesibhakabhaka
• Ama-Bilberries futhi 
• Amajikijolo

I-Chalcones - Isisekelo seFlavonoid nemithombo yokudla

Ama-Chalcones angesinye isigaba se-flavonoids. Zaziwa nangokuthi yi-open-chain flavonoids. Ama-Chalcones kanye nemikhiqizo yawo kunezinzuzo eziningi zokudla okunempilo neziphilayo. Ama-chalcones okudla abonakala enomsebenzi wokulwa namaseli womdlavuza, aphakamisa ukuthi angaba nezindawo zokulwa nomdlavuza. Ama-Chalcones aziwa ukuthi ane-antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, kanye ne-immunosuppressive. 

Ezinye zezibonelo zama-chalcones yilezi:

• I-Arbutin 
• I-Phloridzin 
• Phloretin futhi 
• I-Chalconaringenin

Ama-flavonoids, ama-Chalcones, atholakala ngokudla okwehlukahlukene okufana nalokhu:

• Utamatisi wasengadini
• Ama-Shallots
• Ubhontshisi uyahluma
• Amapheya
• Ama-Strawberries
• Amajikijolo
• Licorice futhi
• imikhiqizo ethile kakolweni

I-Flavanones - I-Flavonoid Subclass & Imithombo Yokudla

I-Flavanones, eyaziwa nangokuthi i-dihydroflavones, ingezinye iziqeshana ezibalulekile zama-flavonoid anezakhi ezinamandla zokulwa ne-antioxidant nezamahhala ezinamandla. I-Flavanones inika ukunambitheka okumunyu ku-peel nejusi yezithelo ezisawolintshi. Lawa ma-citrus flavonoids akhombisa nezindawo ezilwa nokuvuvukala futhi asebenza njengamagciwane okwehlisa i-lipid ne-cholesterol.

Ezinye zezibonelo zama-flavanones yilezi:

• I-Eriodictyol
• IHesperetin futhi
• I-Naringenin

Ama-flavonoids, ama-Flavanones, atholakala kakhulu ekudleni okufana nazo zonke izithelo ezisawolintshi kufaka phakathi:

• Ama-oranges
• Limes
• Ulamula kanye
• Amagilebhisi

I-Flavones- I-Flavonoid Subclass & Imithombo Yokudla

Ama-Flavones ayisiqeshana se-flavonoids esikhona kabanzi emaqabungeni, ezimbalini nasezithelweni njengama-glucosides. Yizimbala ezitshalweni zezimbali eziluhlaza okwesibhakabhaka nokumhlophe. Ama-Flavones abuye asebenze njengezibulala-zinambuzane zemvelo ezitshalweni, enikeza ukuvikelwa ezinambuzaneni nasezifweni zefungal. Ama-Flavones ayaziwa ukuthi anezakhi ezinamandla zokulwa nokuvuvukala. 

Ezinye zezibonelo zama-flavone yilezi:

• Apigenin
• ILuteolin
• I-Baicalein
• I-Chrysin
• I-Tangeritin
• UNobiletin
• I-Sinensetin

Ama-flavonoids, ama-Flavones, atholakala kakhulu ekudleni okufana nalokhu:

• isilimo esinamagatsha anamanzi
• i-parsley
• upelepele obomvu
• chamomile
• I-Peppermint
• ginkgo biloba

I-Flavonols - I-Flavonoid Subclass & Imithombo Yokudla

I-Flavonols, esinye isiqeshana se-flavonoids namabhulokhi wokwakha ama-proanthocyanins, atholakala ezinhlobonhlobo zezithelo nemifino. Ama-Flavonols aziwa njengezinzuzo eziningi zezempilo kufaka phakathi amandla we-antioxidant kanye nengozi encishisiwe yesifo semithambo. 

Ezinye zezibonelo zama-flavonols zifaka:

• I-Fisetin 
• Quercetin
• I-Myricetin 
• Rutin
• Kaempferol
• I-Isorhamnetin

Ama-flavonoids, ama-Flavonols, akhona kakhulu ekudleni okufana nalokhu:

• Anyanisi
• Kale
• utamatisi
• Apples
• Amagilebhisi
• amajikijolo
• Itiye
• Iwayini elibomvu

I-Flavan-3-ols - I-Flavonoid Subclass & Imithombo Yokudla

I-Flavan-3-ols yi-flavonoids enkulu yetiye enezinzuzo ezahlukahlukene zezempilo. I-Flavan-3-ols yaziwa ngokuthi inezakhi ze-antioxidant, anti-inflammatory kanye ne-anti-cancer. 

Ezinye zezibonelo ze-flavan-3-ols zifaka:

• AmaCatechin kanye nama-gallate derivatives awo: (+) - Catechin, (-) - Epicatechin, (-) - Epigallocatechin, (+) - Gallocatechin
• Abama-Thelavlav, Thearubigins
• Ama-proanthocyanidins

Ama-flavonoids, i-Flavan-3-ols, akhona kakhulu ekudleni okufana nalokhu:

• itiye elimnyama
• green tea
• Itiye elimhlophe
• tea oolong
• Apples
• imikhiqizo esekwe ukhokho
• amagilebhisi ansomi
• amagilebhusi abomvu
• Iwayini elibomvu
• aluhlaza okwesibhakabhaka
• ama-strawberries

Ama-Isoflavones - I-Flavonoid Subclass & Imithombo Yokudla

Ama-Isoflavonoids elinye iqembu elincane lama-flavonoids kanti okunye kwawo okuphuma kwesinye isikhathi kubizwa ngokuthi ama-phytoestrogens ngenxa yomsebenzi wawo we-estrogenic. Ama-Isoflavones ahlotshaniswa nezindawo zokwelapha kufaka phakathi i-anticancer, antioxidant, kanye ne-cardioprotective izakhiwo ngenxa yokusebenza kwe-estrogen receptor.

Ezinye zezibonelo zama-isoflavones yilezi:

• IGenistein
• UDaidzein
• I-Glycitein
• I-Biochanin A
• IFormononetin

Phakathi kwalokhu, ama-isoflavones afana ne-genistein ne-daidzein yi-phytoestrogens ethandwa kakhulu.

Ama-flavonoids, ama-isoflavones, atholakala kakhulu ekudleni okufana nalokhu:

• AmaSoybe
• Ukudla kweSoy nemikhiqizo
• Izitshalo ze-leguminous

Amanye ama-isoflavonoids nawo angaba khona kuma-microbes. 

Izakhiwo Zokulwa Nomdlavuza we-Flavonoids ezikhona Ezithelweni, Imifino & Iziphuzo

Ama-Flavonoids aziwa njengezinzuzo eziningi zezempilo ngenxa yezakhi zawo zokulwa nokuvuvukala. Ezinye izinzuzo zezempilo zokudla okunothile kwe-flavonoid zibhalwe ngezansi.

• Ukufaka ama-flavonoid ekudleni kwethu kungasiza ukuphatha umfutho wegazi ophezulu.
• I-Flavonoids ingasiza ekwehliseni izehlakalo zokuhlaselwa yisifo senhliziyo noma isifo sohlangothi.
• I-Flavonoids ingasiza futhi ekunciphiseni ubungozi besifo sikashukela.
• Ezinye izifundo zibike ukuthi ama-flavonoids angathuthukisa ukwakheka kwamathambo futhi avimbele ukubuyiselwa kwamathambo.
• Ama-Flavonoids angathuthukisa ukuqonda kubantu abadala asebekhulile.

Kanye nazo zonke izinzuzo zezempilo ezibalwe ngenhla, ama-flavonoid atholakala kakhulu ekudleni okufana nezithelo, imifino neziphuzo nawo ayaziwa ukuthi anezindawo zokulwa nomdlavuza. Ama-Flavonoids angadla ama-radicals amahhala angalimaza ama-macromolecule anjenge-DNA. Lokhu kungasiza futhi ekulungisweni kwe-DNA futhi kuvimbele nokuhlasela kwe-angiogenesis nokuhlasela kwesimila.

Manje sizosondeza kwezinye zezifundo ezenziwayo zokuhlola izindawo ezilwa nomdlavuza zokudla okumbalwa kwe-flavonoids / flavonoid okubandakanya izithelo, imifino neziphuzo. Ake sibone ukuthi lezi zifundo zithini!

Ukusetshenziswa kweSoy Isoflavone Genistein kanye neChemotherapy kuMetastatic Colorectal Cancer

I-Metastatic Colorectal Cancer ine-prognosis engemihle ngokusinda kweminyaka emi-2 ngaphansi kuka-40% kanye nokuphila kweminyaka emi-5 ngaphansi kuka-10%, yize kunenqubo yokwelashwa okunenhlanganisela enamandla kakhulu (AJCC Cancer Staging Handbook, 8th Edn). Izifundo ezahlukahlukene zikhombisile ukuthi abantu basempumalanga ye-Asia abadla ukudla okunothile okuhambisana ne-Soy bahlotshaniswa nengozi ephansi yomdlavuza obomvu. Ucwaningo oluningi lwezilingo lwangaphambi kokuhlolwa lubonise nezimpawu zokulwa nomdlavuza we-soy isoflavone Genistein, kanye nekhono layo lokunciphisa ukumelana namakhemikhali kumaseli womdlavuza.  

Abaphenyi e-Icahn School of Medicine eNtabeni iSinayi, eNew York, bahlole ukuphepha nokusebenza kokudla i-isoflavone Genistein kanye nezinga elijwayelekile lokuhlanganiswa kokunakekelwa kwamakhemikhali esifundweni somtholampilo esizoba sezigulini zeColorectal Cancer (NCT01985763) (Pintova S et al , I-Cancer Chemotherapy & Pharmacol., 2019). Ucwaningo lubandakanya iziguli eziyi-13 ezinomdlavuza we-metastatic colorectal ngaphandle kokwelashwa kwangaphambilini, kanti iziguli eziyi-10 ziphathwe ngenhlanganisela ye-FOLFOX chemotherapy kanye neGenistein neziguli ezi-3 ziphathwe nge-FOLFOX + Bevacizumab kanye noGenistein. Ukuhlanganisa uGenistein nalawa chemotherapies kutholakale kuphephile futhi kubekezeleleka.

Kube nokuthuthuka ekuphenduleni okungcono kakhulu jikelele (BOR) kulezi ziguli ezinomdlavuza we-metastatic colorectal ezithatha i-chemotherapy kanye noGenistein, uma kuqhathaniswa nalabo ababikwe ukwelashwa ngamakhemikhali bodwa ezifundweni zangaphambili. I-BOR yayingu-61.5% kulolu cwaningo uma kuqhathaniswa ne-38-49% ezifundweni ezedlule ezinemithi efanayo yokwelashwa ngamakhemikhali. (USaltz LB et al, J Clin Oncol, 2008) Ngisho nokuqhubekela phambili kwamahhala okusinda, okukhombisa isikhathi lapho isimila singakaqhubeki nokwelashwa, bekungumlingani wezinyanga eziyi-11.5 ngokuhlanganiswa kweGenistein kulolu cwaningo kuqhathaniswa no-8 izinyanga zokwelashwa ngamakhemikhali kuphela kususelwa ocwaningweni lwangaphambili. (USaltz LB et al, J Clin Oncol., 2008)

Ucwaningo lukhombisa ukuthi kungaphepha ukusebenzisa i-soy isoflavone Genistein supplement kanye ne-chemotherapy ehlanganisiwe i-FOLFOX yokwelapha umdlavuza we-metastatic colorectal. Ukuhlanganisa uGenistein ne-chemotherapy kunamandla okuthuthukisa imiphumela yokwelashwa. Kodwa-ke, lokhu okutholakele, yize kuthembisa, kuzodingeka kuhlolwe ezifundweni ezinkulu zemitholampilo.

Ukusetshenziswa kwe-flavonol Fisetin kuColorectal Cancer

I-flavonol - I-Fisetin ingumenzeli wombala otholakala ngokwemvelo ezitshalweni nasemifino eminingi kubandakanya ama-strawberry, ama-apula acebile nefayibha. Kuyaziwa ukuthi kunezinzuzo ezahlukahlukene zezempilo ezinjenge-neuroprotective, anti-inflammatory, kanye ne-anti-carcinogenic. Kwenziwe izifundo ezahlukahlukene zokuhlola umphumela we-Fisetin emiphumeleni ye-chemotherapy ezigulini zomdlavuza ezibalabala.

Ucwaningo lomtholampilo lwenziwa ngonyaka we-2018 ngabaphenyi abavela e-Iran ukutadisha imiphumela yokwengezwa kwe-fisetin ezintweni ezihlobene nokuvuvukala nokwanda komdlavuza (i-metastasis), ezigulini zeColorectal Cancer ezithola i-adjuvant chemotherapy (Farsad-Naeimi A et al, Food Funct. 2018). Ucwaningo lubandakanya iziguli ezingama-37 ezineminyaka engama-55 ± 15 ubudala, ezamukelwe eMnyangweni we-Oncology waseTabriz University of Medical Sciences, e-Iran, ezinomdlavuza wesigaba II noma III, ezineminyaka yobudala engaphezulu kwezinyanga ezintathu. I-Oxaliplatin ne-capecitabine kwakuyindlela yokwelashwa ngamakhemikhali. Ezigulini ezingama-3, iziguli eziyi-37 ziphinde zathola i-18 mg ye-fisetin amasonto ayi-100 elandelanayo. 

Ucwaningo luthole ukuthi iqembu elisebenzisa isengezo se-fisetin linokuncipha okukhulu kwesifo sokuvuvukala komdlavuza we-pro-cancer IL-8 uma kuqhathaniswa neqembu elilawulayo. Ucwaningo luphinde lwabonisa ukuthi ukwengezwa kweFisetin futhi kwehlise amazinga ezinye zezinto zokuvuvukala nezimetastasis ezifana ne-hs-CRP ne-MMP-7.

Lokhu kuhlolwa okuncane komtholampilo kukhombisa inzuzo engaba khona ye-fisetin ekwehliseni izimpawu zokuvuvukala komdlavuza ezigulini ezinomdlavuza onobala lapho zinikezwa kanye ne-chemotherapy yazo ye-adjuvant.

Ukusetshenziswa kweFlavan-3-ol Epigallocatechin-3-gallate (EGCG) ezigulini ezinomdlavuza we-Esophageal eziphathwa nge-Radiation Therapy

I-Epigallocatechin-3-gallate (EGCG) iyi-flavonoid / flavan-3-ol enezakhi ezinamandla zokulwa nokuvuvukala. Ibuye isetshenziselwe ukunciphisa ubungozi bemidlavuza ethile nokunciphisa imiphumela ethile emibi yamakhemikhali. Ingesinye sezithako esiningi kakhulu esitholakala kutiye oluhlaza futhi sitholakala netiye ezimhlophe, oolong, nezimnyama.

Esifundweni sesigaba sesibili somtholampilo esenziwa yiShandong Cancer Hospital and Institute eChina, imininingwane evela ezigulini ezingama-51 ifakiwe, lapho iziguli ezingama-22 zathola ukwelashwa okufanayo ngamakhemikhali (iziguli eziyi-14 zaphathwa nge-docetaxel + cisplatin kwalandelwa i-radiotherapy kanye ne-8 nge-fluorouracil + cisplatin elandelwa yi-radiotherapy) kanti iziguli ezingama-29 zathola ukwelashwa ngemisebe. Iziguli ziqashwe masonto onke ngemisebe ebangelwa imisebe ebangelwa i-esophagitis (ARIE). (UXiaoling Li et al, Ijenali Yezokudla Kwezokwelapha, i-2019).

Ucwaningo luthole ukuthi ukwesekwa kwe-EGCG kunciphise ubunzima be-esophagitis / kokugwinya ezigulini zomdlavuza we-esophageal eziphathwe ngemithi yokwelashwa kwemisebe ngaphandle kokuthinta kabi ukusebenza kwelashwa ngemisebe. 

Izici Zokulwa Nomdlavuza we-Apigenin

I-Apigenin itholakala ngokwemvelo ezinhlobonhlobo zamakhambi, imifino nezithelo kufaka phakathi isilimo esidliwayo esinamagatsha anamanzi, u-anyanisi, izithelo zomvini, amagilebhisi, ama-apula, i-chamomile, i-spearmint, i-basil, i-oregano. I-Apigenin inezindawo zokulwa ne-antioxidant kanye nezakhiwo ezilwa nokuvuvukala nezokulwa namagciwane. Izifundo ezahlukahlukene zangaphambi komtholampilo ezenziwe ezinhlobonhlobo zemigqa yamangqamuzana omdlavuza kanye nezinhlobo zezilwane ezisebenzisa i-Apigenin nazo zikhombisile imiphumela yokulwa nomdlavuza. Ama-Flavonoids afana ne-Apigenin asiza ezenzweni zokuvimbela umdlavuza ukunciphisa ubungozi obungaba khona esikhathini esizayo bokuba nesimila kepha futhi iyakwazi ukusebenza ngokubambisana namanye ama-chemotherapies ukukhulisa ukusebenza komuthi (Yan et al, Cell Biosci., 2017).

Ezifundweni ezihlukene zisebenzisa isiko lamaseli namamodeli ezilwane, i-Apigenin ithuthukise ukusebenza kahle kwe-gemcitabine chemotherapy ngenye indlela okunzima ukwelapha umdlavuza we-pancreatic (Lee SH et al, Cancer Lett., 2008; Strouch MJ et al, Pancreas, 2009). Kolunye ucwaningo nge-prostate umdlavuza amaseli, i-Apigenin lapho ihlanganiswa nesidakamizwa se-chemotherapy i-Cisplatin yawuthuthukisa kakhulu umphumela wayo we-cytotoxic. (U-Erdogan S et al, Biomed Pharmacother., 2017). Lezi zifundo ziphakamisa ukuthi i-Apigenin etholakala ezithelweni ezahlukene, imifino kanye namakhambi inamandla okulwa nomdlavuza.

Izindawo Zokulwa Nomdlavuza Zama-apula acebile weFlavonoid neFiber 

Ama-apula acebile ngama-antioxidants ahlukahlukene, kufaka phakathi ama-flavonoid afana ne-quercetin ne-catechin. Ama-apula acebile nefayibha, amavithamini, namaminerali, konke okuzuzisa impilo. Izici ze-antioxidant zalawa ma-phytochemicals kanye ne-fiber ema-apula zingavikela i-DNA emonakalweni we-oxidative. Izifundo ezahlukahlukene zenziwa ukuze kuhlolwe umthelela walokhu kusetshenziswa kwama-aphula acebile we-flavonoid / vitamin / fiber engcupheni yomdlavuza. 

Ukuhlaziywa kwe-meta yezifundo ezihlukene zokuqaphela ezikhonjwe usesho lwezincwadi ku-PubMed, Web of Science kanye nesizindalwazi se-Embase kutholwe ukuthi ukusetshenziswa okuphezulu kwe-apula elicebile le-flavonoid/vitamin/fiber kwakuhlotshaniswa nengozi encishisiwe yamaphaphu. umdlavuza.(Roberto Fabiani et al, Public Health Nutr., 2016) Ezimbalwa zezifundo zokulawulwa kwecala nazo zathola ingozi encishisiwe ye-colorectal, isifuba kanye nomdlavuza we-digestive tract ngokusetshenziswa okwenyuka kwama-apula. Izakhiwo zokulwa nomdlavuza zama-apula, nokho, azikwazi ukuthi zibangelwa ama-flavonoid kuphela, njengoba kungenzeka futhi ngenxa yezakhi ezifana namavithamini, amaminerali kanye nemicu. Amafayibha okudla (okuphinde atholakale kuma-apula) ayaziwa ukunciphisa ingozi yomdlavuza wamakholoni.(Yu Ma et al, Medicine (Baltimore), 2018)

Izinzuzo zezempilo zama-Cranberries acebile we-Flavonoid

Ama-Cranberries awumthombo omuhle wezakhi ze-bioactive kufaka phakathi ama-flavonoid anjenge-anthocyanins, amavithamini nama-antioxidants futhi anezinzuzo ezahlukahlukene zezempilo. Enye yezinzuzo ezinkulu zezempilo ze-Cranberry akhiphe izimpushana ukuthi yehlisa ukutheleleka kwe-urinary tract (UTIs). Izinzuzo zezempilo zeProanthocyanidin ezitholakala kuma-cranberries zifaka phakathi ukuvimbela ukukhula kwamagciwane abangela ukwakheka koqwembe, izimbotshana kanye nezigaba zokuqala zesifo sezinsini. Izifundo eziningi zangaphambi kokuhlinzwa kanye nezifundo ezimbalwa zabantu nazo zenziwa ukuhlola ukuthi isithelo se-cranberry naso sinenzuzo eyengeziwe yezempilo izindawo zokulwa nomdlavuza.

Esifundweni esilawulwa nge-placebo esiyimpumputhe esiphindwe kabili, abacwaningi baphenye izinzuzo zezempilo zama-cranberries ngokuhlola imiphumela yokusetshenziswa kwe-cranberry kumanani we-prostate ethize antigen (PSA) namanye amakaki emadodeni anomdlavuza wendlala yesinye ngaphambi kwe-radical prostatectomy. (UVladimir Student et al, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub., 2016) Ucwaningo luthole ukuthi ukusetshenziswa kwansuku zonke kwesithelo se-cranberry esimpuphu kunciphise i-serum PSA ezigulini ezinomdlavuza we-prostate ngama-22.5%. Abaphenyi baphetha ngokuthi le nzuzo yezempilo kungenzeka ukuthi ingenxa yezakhi zezithako ze-cranberries ezilawula ukubonakaliswa kofuzo oluphendula nge-androgen, oludlala indima ebaluleke kakhulu ekukhuleni nasekuqhubekeni komdlavuza wesinye.

Isiphetho

Ucwaningo oluhlukene lukhombisa ukuthi ama-flavonoid anezinhlobonhlobo zezinzuzo zezempilo okuhlanganisa izakhiwo zokulwa nomdlavuza futhi atholakala ekudleni okuhlukahlukene okuhlanganisa izithelo (njenge-fiber ecebile. ama-apula, amagilebhisi, ama-cranberries, ama-blueberries), imifino (efana notamatisi, izitshalo ze-leguminous) neziphuzo (njengetiye newayini elibomvu). Ukuthatha ukudla okucebile kwe-flavonoid njengengxenye yokudla kwethu kwansuku zonke kuyoba yinzuzo. Kodwa-ke, ngaphambi kokufaka noma yiziphi izithasiselo ze-flavonoid noma igxile njengengxenye ye Ukudla kwesiguli somdlavuza, umuntu kufanele axoxe ngayo nabasebenzi bezempilo. 

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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