Amaphuzu avelele
Ucwaningo lomtholampilo ebeleni umdlavuza iziguli zahlola ukuhlangana kokusetshenziswa kwesengezo sokudla/ sokudla okunomsoco ngaphambi nangesikhathi sokwelashwa ngamakhemikhali, kanye nemiphumela yokwelashwa. Ngokumangalisayo, ukusetshenziswa kwe-antioxidant supplement (Amavithamini A, C no-E, i-carotenoids, i-coenzyme Q10) noma izithako ezingenayo i-oxidant (i-Vitamin B12, insimbi) ngaphambi nangesikhathi sokwelashwa kwakuhlotshaniswa nomthelela omubi ekwelapheni, ukuphindaphinda nokunciphisa ukusinda okuphelele.
Ukusetshenziswa Kwe-Dietary Supplement Ngeziguli Ezinomdlavuza
Ukuxilongwa komdlavuza kuyisenzakalo esishintsha ukuphila esihambisana nokukhathazeka kohambo lokwelashwa oluseduze nokwesaba ukungaqiniseki komphumela. Ngemva kokutholakala ne umdlavuza, iziguli zishukumiseleka ukuba zenze izinguquko endleleni yokuphila ezikholelwa ukuthi zizothuthukisa impilo nempilo yazo, zinciphise ingozi yokuphinda ziphinde, futhi zinciphise imiphumela emibi yokwelashwa kwazo ngamakhemikhali. Imvamisa, baqala ukusebenzisa izithasiselo zokudla/umsoco kanye nokwelashwa kwabo ngamakhemikhali. Kunemibiko yama-67-87% eziguli ezinomdlavuza ezisebenzisa izithasiselo zokudla ngemuva kokuxilongwa. (UVelicer CM et al, J Clin. I-Oncol., 2008Njengoba kunikezwe ukusabalala okuphezulu nokusetshenziswa okubanzi kokudla / izithako zokudla okunempilo yiziguli ezinomdlavuza ngesikhathi sokwelashwa kwazo, nokukhathazeka ukuthi ezinye izithasiselo, ikakhulukazi ama-antioxidants, zinganciphisa i-cytotoxicity ye-chemotherapy, kubalulekile ukuqonda ukuhlangana kokusetshenziswa kokudla / kokudla okunomsoco ukusetshenziswa ngesikhathi ukwelashwa ngamakhemikhali emiphumeleni, kufaka phakathi umthelela emiphumeleni emibi eyenziwe ngamakhemikhali njenge-peripheral neuropathy.
Isifundo se-DELCap
Njengengxenye yocwaningo lwezokwelapha lweqembu elikhulu lokubambisana ukuhlola izinhlobo zomthamo ze-DOX, cytophosphane (CP) kanye ne-PTX, ukuze zelashwe ingozi enkulu. umdlavuza webele, uhlolo olwaluzoba usizo lwenziwa ukuze kuhlolwe izinhlangano phakathi kokusetshenziswa kwe-supplement kanye nemiphumela yomdlavuza webele. Ucwaningo Lokudla, Ukuzivocavoca kanye Nendlela Yokuphila (DELCap) olusekelwe kuhlu lwemibuzo lwaklanyelwe ukuhlola izici zendlela yokuphila ikakhulukazi ukusetshenziswa kwezithako zamavithamini ngaphambi kokuxilongwa kanye nangesikhathi sokwelashwa ngamakhemikhali maqondana nemiphumela yokwelashwa, njengengxenye yalolu cwaningo lokwelapha (SWOG 0221, NCT 00070564). (UZirpoli GR et al, J Natl. I-Cancer Inst., 2017; I-Ambrosone CB et al, J Clin. I-Oncol, 2019Kwakuneziguli ezinomdlavuza webele eziyi-1,134 eziphendule imibuzo yemibuzo ngokusetshenziswa kwazo kwezithasiselo ngaphambi kokuqala kokwelashwa nangesikhathi sokwelashwa, zalandelwa ezinyangeni eziyisithupha ngemuva kokubhaliswa.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Isifinyezo semiphumela ebalulekile yocwaningo oluhlobene nokuhlangana kokusetshenziswa kokungezelelwa kokudla kanye nemiphumela yokwelashwa yile:
- “Ukusetshenziswa kwanoma isiphi isengezo se-antioxidant (Vitamin A, C no-E; carotenoids; coenzyme Q10) ngaphambi nangesikhathi sokwelashwa kwakuhlotshaniswa nengozi eyengeziwe yokuphindeka (isilinganiso sengozi esishintshiwe [adjHR [, 1.41; 95% CI, 0.98 kuya ku-2.04; P = 0.06) "(I-Ambrosone CB et al, J Clin Oncol., 2019)
- Ukusetshenziswa kwama-non-antioxidants afana ne-vitamin B12 ngaphambi nangesikhathi se-chemotherapy kwakuhlotshaniswa kakhulu nokusinda okungenazifo nokuphila okuphelele (P <0.01).
- Ukusetshenziswa kwesengezo sensimbi obejwayele ukusetshenziselwa ukuthuthukisa umthelela wecala le-anemia bekuhlotshaniswa kakhulu nokuphindeka, kusetshenziswe ngaphambi nangesikhathi sokwelashwa. (P <0.01)
- Ukusetshenziswa kweMultivitamin kwakungahlotshaniswa nemiphumela yokusinda.
- Ukuhlaziywa kwangaphambilini okushicilelwe kocwaningo lwe-DELCap kubonise ukuthi ukusetshenziswa kwe-multivitamin ngaphambi kokuxilongwa kuhlotshaniswa nezimpawu ezincishisiwe ze-chemotherapy ezibangelwa i-peripheral neuropathy, kepha ukusetshenziswa ngesikhathi sokwelashwa akutholakalanga kunenzuzo. (UZirpoli GR et al, J Natl Cancer Inst., 2017)
Isiphetho
Idatha engenhla ibonisa ukuthi izithasiselo zokudla/umsoco, amavithamini nama-antioxidants, asetshenziswa yi umdlavuza iziguli zithumela ukuxilongwa kwazo, futhi ngaphambi nangesikhathi sokwelashwa kwazo ngamakhemikhali, kufanele kwenziwe ngokucabangisisa nangokuqapha. Ngisho nento evamile futhi esetshenziswa njalo njengama-antioxidants nama-multivitamini ingaba namandla okuba nomthelela omubi emiphumeleni yokwelashwa uma isetshenziswa ngesikhathi sokwelashwa ngamakhemikhali.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.