Amaphuzu avelele
I-DIM noma i-diindolylmethane, isengezo esisetshenziswa kakhulu, yi-metabolite ye-I3C (indole-3-carbinol), etholakala kakhulu kwimifino enempilo efana ne-broccoli, iklabishi, ukholifulawa ne-kale. Iziguli ezinomdlavuza zivame ukuzama ukufaka izithasiselo zokudla okungahleliwe kanye nokwelashwa kwazo okuqhubekayo komdlavuza ukuthuthukisa ikhwalithi yempilo noma ukwelashwa kwazo, ngokucabanga ukuthi ukuthatha noma iziphi izithako zemvelo noma zezitshalo kanye nokwelashwa kwazo okuqhubekayo kuhlala kuphephile futhi kungalimazi. Lokhu akulona iqiniso ngaso sonke isikhathi. Ngokuya ngohlobo lomdlavuza nokwelashwa, umthelela walezi zithasiselo ungahluka futhi ungaphazamisa nokwelashwa okuthile komdlavuza. Kule bhulogi, sixoxa ngocwaningo olunjalo lomtholampilo olutholile ukuthi i-DIM (diindolylmethane) ingaphazamisa iTamoxifen, indlela ejwayelekile yokwelashwa komdlavuza webele, futhi yehlise amazinga e-metabolite esebenzayo yeTamoxifen. Ukusebenzisana kwe-DIM-tamoxifen kungahle kuthinte ukusebenza kokwelapha kweTamoxifen ngakho-ke kungcono ukungafaki izengezo ze-DIM njengengxenye yesifuba Ukudla kweziguli ezinomdlavuza ngesikhathi sokwelashwa nge-Tamoxifen. Lokhu kugqamisa isidingo sohlelo lokondleka komuntu siqu olunokudla okufanele kanye nezithako ezisekela lokho okuqondile umdlavuza ukwelashwa futhi uthole izinzuzo futhi uhlale uphephile.
Ukusetshenziswa kwe-DIM (diindolylmethane) kuMdlavuza Webele
Kunenani elikhulu labasinde kumdlavuza webele abazinika bona izithasiselo zokudla ezitholakala esitshalweni esisebenzayo ngenhloso yokuvimbela. umdlavuza ukuphinda futhi uthole izinzuzo zokusinda. Ukukhethwa kwezithasiselo abazithathayo akuhleliwe ngokusekelwe ekudluliseleni okuvela kubangani nomndeni, noma ngokusekelwe ekusesheni kwabo kuwebhu kanye nolwazi ku-inthanethi.
Isengezo esisetshenziswa kakhulu yi-DIM (diindolylmethane), i-metabolite ye-I3C (indole-3-carbinol), etholakala kwimifino ebethelwe njenge-broccoli, ukholifulawa, i-kale, iklabishi, namahlumela eBrussels. Lokhu kusetshenziswa kabanzi kwe-DIM phakathi kweziguli ezinomdlavuza webele kungasuselwa kokutholakele ezifundweni zomtholampilo ezibukwayo ezibandakanya ucwaningo lwabesifazane lwe-Women's Healthy Eating and Living (WHEL) lweziguli ezinomdlavuza webele ezingaphezu kuka-3000 ezithola ukuhlangana kokuncipha kwengozi yokuphindeka komdlavuza webele kwabesifazane Ukwelashwa kweTamoxifen, nayo eyayidla imifino ebethelwe njengengxenye yokudla kwayo. Le nhlangano njengabacwaningi ingaxhunyaniswa nomsebenzi wama-phytochemicals afana ne-DIM kule mifino ebethelelanayo enezinto ezilwa nomdlavuza nezokulwa nokuvuvukala (I-Thomson CA, i-Breast Cancer Res Treat., 2011). Okunye ukuhlaziywa kwe-meta kwakamuva kokulawulwa kwamacala we-13 kanye nezifundo ezizayo zeqembu kuphakamise nokuthi ukusetshenziswa okuphezulu kakhulu kwemifino ye-cruciferous (ecebile nge-indole-3-carbinol) efana ne-broccoli, i-kale, iklabishi, ukholifulawa nesipinashi ekudleni kwakuhlotshaniswa kakhulu ngengcuphe ephansi engu-15% yomdlavuza webele (Liu X et al, Breast, 2013).
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
I-DIM (diindolylmethane) kanye nokusebenzisana kweTamoxifen kuCancer yeBele
Iziguli ezinomdlavuza webele ezine-hormone positive (Estrogen Receptor ER +) umdlavuza webele welashwa ngomuthi osizayo we-Tamoxifen endocrine therapy isikhathi esengeziwe seminyaka engu-5-10 ngemuva kokuhlinzwa kwabo kanye nokwelashwa ngemisebe ye-chemo-radiation. I-Tamoxifen i-estrogen receptor modulator ekhethiwe (i-SERM) esebenza ngokuncintisana ne-hormone ye-estrogen yokubopha i-ER ezicutshini zamabele, ngaleyo ndlela ivimbele imiphumela ye-pro-cancer ye-estrogen. I-Tamoxifen, isidakamizwa somlomo, ihlanganiswa nama-enzyme e-cytochrome P450 esesibindi iye kuma-metabolites ayo asebenzayo angabalamuli abakhulu bokusebenza kwe-tamoxifen. Kunezithasiselo ezijwayelekile ezithathwe ezitshalweni ezingaphazamisa imetabolism yeTamoxifen futhi ngaleyo ndlela zinciphise ukugxila kwesidakamizwa esingaphansi komngcele waso wokwelashwa. Isilingo esisodwa somtholampilo esilawulwa ngokungahleliwe, esiyimpumputhe, esetshenziswa i-placebo sokusetshenziswa kwesengezo se-DIM, i-metabolite ye-indole-3-carbinol eyakhiwe evela emifino ebethelwe, kanye neTamoxifen, ezigulini zomdlavuza webele, ikhombisile lo mkhuba owesabekayo wokuncipha kwe-tamoxifen , ukuthi iziguli ezinomdlavuza webele ezikusengezo se-DIM kudingeka zazi.
Imininingwane Yesifundo
Imininingwane yokuhlolwa komtholampilo okungahleliwe, okulawulwa yi-placebo ukuze kuhlolwe ibele elihlongozwayo umdlavuza umsebenzi we-chemopreventive we-DIM ezigulini zomdlavuza webele ezithatha ukwelashwa kwe-Tamoxifen zifingqiwe ngezansi (NCT01391689) (Ref: Thomson CA, Breast Cancer Res. Treat., 2017).
- Kwakunabesifazane abangu-130 ababhalelwe i-Tamoxifen, ababehlukaniswe ngezikhathi ezithile baba ngamaqembu amabili: iqembu elathola izinyanga eziyi-12 noma i-DIM supplement ku-150 mg, kabili ngosuku, noma i-placebo. Abesifazane abangama-98 baqede isifundo (iqembu le-placebo elingu-51, iqembu lama-47 le-DIM).
- Isiphetho sokuqala socwaningo bekungukuhlola ushintsho kumazinga wokuchama we-metabolites ye-estrogen hormone 2/16-hydroxyestrone, leyo eyi-anti-tumorigenic metabolite. Amanye amaphuzu wokugcina wesibili nawo ahlolwe kufaka phakathi i-serum estrogens, ukuminyana kwesifuba kusetshenziswa i-mammography noma i-MRI, namazinga ama-tamoxifen metabolites.
- I-DIM inyuse izinga le-anti-tumorigenic estrogen metabolite ngokuqhathaniswa ne-placebo, okuwumphumela omuhle wokuvikela izifo.
- Alukho ushintsho olutholakele ekucineni kwesifuba phakathi kwala maqembu womabili.
- Ukutholwa okumangazayo ukuthi kube nokuncipha kwamazinga e-plasma wama-metabolites asebenza ngokwemithi we-tamoxifen (endoxifen, 4-hydroxy tamoxifen, ne-N-desmethyl tamoxifen). Eqenjini le-DIM, kube nokuncipha okuphawulekayo kwezibalo emazingeni e-plasma wama-metabolites asebenzayo we-tamoxifen, nemiphumela yalokhu kuncipha kubonakala emavikini angu-6 futhi yazinza ngokuhamba kwesikhathi. Amaleveli ama-tamoxifen metabolites asebenzayo kwabesifazane abaseqenjini le-DIM abonwa njengaphansi komkhawulo wokwelashwa wokusebenza kwe-tamoxifen.
Isiphetho
Nakuba ukuncipha kwamazinga e-tamoxifen kubonisa ukuphazamiseka noma ukusebenzisana phakathi kwe-DIM ne-Tamoxifen metabolism, abacwaningi balolu cwaningo basikisela ucwaningo olwengeziwe ukuze banqume ukuthi amazinga anciphile e-tamoxifen metabolites esebenzayo anganciphisa kakhulu izinzuzo zomtholampilo ze-tamoxifen. Kodwa-ke, njengoba idatha yomtholampilo ikhombisa ukuthambekela kokusebenzelana phakathi kwe-DIM (metabolite ye-indole-3-carbinol) ne-tamoxifen, kungaba ngcono kumabele. umdlavuza iziguli ekwelapheni nge-tamoxifen ukuze ziphambukele ohlangothini lokuqapha futhi zigweme ukuthatha i-DIM ngenkathi zelashwa nge-Tamoxifen. Ukudla okusekelwe ezitshalweni okuhlanganisa imifino ye-cruciferous equkethe i-indole-3-carbinol ingase inikeze inzuzo edingekayo ngokuthatha isithasiselo sokudla se-DIM ngenkathi ulashwa ngama-hormone omdlavuza webele.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.