Iimbalasane
Uphononongo lweklinikhi lubonakalisile ukuba kukhuselekile ukusebenzisa isoyoflavone Genistein isongezo kunye nokudityaniswa kwekhemotherapy i-FOLFOX kunyango lwezigulana ezinomhlaza we-metastatic colorectal. Ukudibanisa ukongezwa kwe-Genistein kunye ne-chemotherapy kunakho ukuphucula iziphumo zonyango lwe-FOLFOX zonyango kwizigulana ezinomhlaza we-metastatic colorectal.
Umhlaza weMetastatic Colorectal Cancer
I-Metastatic Colorectal Cancer (mCRC) ine-prognosis embi kwaye iminyaka emi-2 yokusinda ingaphantsi kwama-40% kunye neminyaka emi-5 yokusinda ingaphantsi kwe-10%, nangona kukho indibaniselwano eyingozi kakhulu yonyango lonyango lwechemotherapy. (I-AJCC Cancer Staging Handbook, i-8th Edn).
I-Metastatic Colorectal Cancer Chemotherapy Regimens
Iirejimeni zomhlaza we-Metastatic Colorectal ziquka i-5-Fluorouracil kunye neyeza leplatinam i-Oxaliplatin, kunye okanye ngaphandle kwe-antiangiogenic (inqanda ukubunjwa kwemithambo yegazi kwi-tumor) arhente i-Bevacizumab (Avastin). Iirejimeni ezintsha ezibandakanya i-FOLFIRI (i-fluorouracil, i-leucovorin, i-irinotecan), i-FOLFOX (i-5-Fuorouracil, i-oxaliplatin), i-CAPOX (i-capecitabine, i-oxaliplatin) kunye ne-FOLFOXIRI (i-fluorouracil, i-oxaliplatin, i-leucovorin, i-irinotecan izigulane ze-irinotecan) nazo zibonise iziphumo ze-proCmisi.
Apha, siza kuxoxa ngeerejimeni eziphambili ze-mCRC ezikulingo lwezonyango kwaye zithathwa njengezisebenzayo ngokuchasene neMetastatic Colorectal Cancer (mCRC).
Ukusebenza kwe-FOLFOXIRI kwi-Metastatic Colorectal Cancer Patients
Izifundo ezininzi zijolise kwi-metastatic colorectal eyahlukeneyo umhlaza iirejimeni kunye nokusebenza kwazo kwizigulane ze-mCRC. I-FOLFOXIRI lunyango lodidi lokuqala lwendibaniselwano ye-mCRC equka i-fluorouracil, i-oxaliplatin, i-leucovorin kunye nendibaniselwano yamachiza e-irinotecan. Kulingo lwe-TRIBE, olupapashwe kutshanje ngo-2020, ukuqaliswa kwakhona kwe-FOLFOXIRI ene-bevacizumab kukhokelele kwiziphumo ezingcono kakhulu kune-FOLFIRI kunye ne-bevacizumab kodwa nethuba letyhefu ephezulu njengoko ixesha elininzi lechemotherapy lalifuneka kwaye uninzi lweziphumo ezibi kakhulu zabonwa kwizigulana ezinjalo. (UGlynne-Jones R, et al. I-Lancet Oncology, 2020). Esi sicwangciso sokudibanisa amachiza asebenzayo kodwa e-cytotoxic kunye namachiza e-antiangiogenic siye saphakamisa iinkxalabo kwii-oncologists ngokumalunga nokhuseleko kunye netyhefu.
Iinkcukacha zohlalutyo lwe-Meta: XELOX vs. FOLFOX kwi-Metastatic Colorectal Cancer
Uphononongo ngo-2016 nguGuo Y, et al. kuthelekisa ukusebenza kwe-capecitabine kunye ne-fluorouracil, nganye idibene ne-oxaliplatin, kwizigulane ze-mCRC ngokudibanisa ne-chemotherapy (UGuo, uYu et al. Uphando lomhlaza, 2016).
- Izilingo ezisibhozo ezilawulwa ngokungahleliwe (RCTs) zisetyenziselwe uhlalutyo olubandakanya izigulane ze-4,363 zizonke.
- Isiphelo esiphambili sophononongo yayikukuvavanya ukhuseleko kunye nokusebenza kakuhle kwe-chemotherapy regimens XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (i-fluorouracil kunye ne-oxaliplatin) kwizigulane zomhlaza we-metastatic colorectal.
- Izigulane ezingama-2,194 ziye zanyangwa ngerejimeni ye-XELOX ngelixa izigulane ezingama-2,169 ziye zanyangwa ngerejimeni ye-FOLFOX.
Iziphumo zohlalutyo lwe-Meta: XELOX vs. FOLFOX kwi-Metastatic Colorectal Cancer
- Iqela le-XELOX lineziganeko eziphezulu ze-hand-foot syndrome, isifo sohudo kunye ne-thrombocytopenia ngelixa iqela le-FOLFOX lineziganeko eziphezulu ze-neutropenia kuphela.
- Iiprofayili zetyhefu ezifunyenwe kuhlalutyo oludityanisiweyo lwamaqela omabini zahlukile kodwa uphando olongezelelweyo ngalo mba luyafuneka.
- Ukusebenza kwe-XELOX kwizigulane ze-mCRC kufana nokusebenza kwe-FOLFOX.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izibonelelo zeGenistein zomhlaza
I-Genistein yi-isoflavone ngokwemvelo efumaneka kukutya okufana neemveliso zesoya kunye neembotyi zesoya. I-genistein ikwafumaneka ngohlobo lwezongezo zokutya kwaye iyaziwa ngokuba neenzuzo ezininzi zempilo ngenxa ye-antioxidant, i-anti-inflammatory kunye ne-anti-cancer properties. Ezinye zezinye izibonelelo zempilo jikelele zezongezo ze-genistein (ukongeza kwiipropathi ezichasene nomhlaza) ziquka:
- Ngamana unokunceda ukunciphisa amanqanaba eswekile yegazi
- Ngamana unokunceda ukunciphisa iimpawu zokuyeka ukuya exesheni
- Ngamana unokunceda ukuphucula impilo yentliziyo
- Ngamana unokukhuthaza impilo yethambo kunye nengqondo
Kule bhlog siza kuxoxa malunga nokuba ukusetyenziswa kwe-Genistein yokuncedisa kunenzuzo kwi-metastatic colorectal umhlaza izigulane.
Ukusetyenziswa kwe-Genistein Supplement kwiColorectal Cancer
Izifundo ezininzi zibonise umanyano lomngcipheko omncinci wee-colorectal cancer ezinabantu baseMpuma Asia abatya ukutya okunotyebileyo kweSoy. Zininzi izifundo zaphambi kovavanyo eziye zabonisa iipropathi ezichasene nomhlaza zesoya isoflavone Genistein, kunye nokukwazi kwayo ukunciphisa ukumelana nekhemotherapy kwiiseli zomhlaza. Yiyo loo nto, abaphandi kwiSikolo i-Icahn seZonyango kwiNtaba yeSinayi, eNew York, kuvavanywe ukhuseleko kunye nokusebenza kokusebenzisa isoy isoflavone Genistein kunye nomgangatho wokunyamekela indibaniselwano ngekhemotherapy kwisifundo esinokubakho kwiklinikhi kwizigulana ezinomhlaza we-metastatic colorectal. (NCT01985763) (UPintova S et al, iCancer Chemotherapy kunye neFarmacol., 2019)
Iinkcukacha zoFundo lweKlinikhi kusetyenziso lweGenistein Supplement kwiColorectal Cancer
- Kwakukho izigulane ze-13 ezine-mCRC ezingenalo unyango lwangaphambili oluye lwaphathwa ngokudibanisa i-FOLFX kunye ne-Genistein (N = 10) kunye ne-FOLFOX + Bevacizumab + Genistein (N = 3).
- Isiphelo sokugqibela sesifundo yayikukuvavanya ukhuseleko kunye nokunyamezeleka kokusebenzisa uGenistein ngokudityaniswa kwekhemotherapy. Isiphelo sesibini yayikukuvavanya eyona mpendulo ibalaseleyo (BOR) emva kwemijikelo ye-6 ye-chemotherapy.
- UGenistein ngedosi ye-60 mg / ngosuku, wanikwa ngomlomo kangangeentsuku ezisi-7 rhoqo kwiiveki ezi-2, ukuqala ngeentsuku ezi-4 ngaphambi kwe-chemo kunye nokuqhubeka kwiintsuku ze-1-3 ze-chemo infusion. Oku kuvumele abaphandi ukuba bavavanye iziphumo ebezingalindelekanga kunye noGenistein yedwa kwaye phambi kwe-chemo.
Iziphumo zoPhando lweKlinikhi kusetyenziso lweGenistein Supplement kwiColorectal Cancer
- Indibaniselwano yeGenistein ne chemotherapy yafunyanwa ikhuselekile kwaye inyamezeleka.
- Iziganeko ezimbi ezichazwe ngoGenistein kuphela zazintle kakhulu, ezinjengentloko, isicaphucaphu kunye nokukhanya okushushu.
- Iziganeko ezimbi ezichaziweyo xa uGenistein wanikwa kunye ne-chemotherapy zazinxulumene neziphumo ebezingalunganga ze-chemotherapy, ezinje nge-neuropathy, ukudinwa, urhudo, nangona kunjalo, akukho namnye kwizigulana owafumana umnyhadala webanga lesi-4.
- Kwakukho ukuphuculwa kweyona mpendulo ibalaseleyo (BOR) kwezi zigulana ze-mCRC zithatha i-chemotherapy kunye noGenistein, xa kuthelekiswa nezo zixeliweyo kunyango lwe-chemotherapy kuphela kwizifundo zangaphambili. I-BOR yayiyi-61.5% kolu phando ngokuchasene ne-38-49% kwizifundo zangaphambili kunye nonyango olufanayo lwe-chemotherapy. (USaltz LB okqhubekayo, J Clin Oncol, 2008)
- Nditsho nenkqubela phambili yasimahla yokufumana inkululeko, ebonisa ixesha elixa ithumba lingaqhubekiyo nonyango, yayili-11.5 leenyanga ngokudityaniswa kweGenistein vs. (USaltz LB okqhubekayo, J Clin Oncol., 2008)
isiphelo
Olu phononongo, nangona kwinani elincinci kakhulu lezigulana, lubonisa ukuba kusetyenziswa isoy isoflavone uGenistein ukuxhaswa kunye nokudibanisa i-chemotherapy kwakukhuselekile kwaye akuzange kwandise ubuthi be-chemotherapy kwiColorectal Cancer. Ukongeza, ukusebenzisa uGenistein ngokudibeneyo ne-FOLFOX kunokuba nakho ukuphucula unyango kwaye kunganciphisa iziphumo ebezingalindelekanga zekhemotherapy. Ezi ziphumo, nangona zithembisa, ziya kufuna ukuvavanywa kwaye ziqinisekiswe kwizifundo ezikhulu zeklinikhi.
Kukuphi ukutya okutyayo, kwaye zeziphi izongezo ozithathayo sisigqibo osenzayo. Isigqibo sakho kufuneka siquke uqwalaselo lotshintsho lwemfuza yomhlaza, nguwuphi umhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukungezwani komzimba, ulwazi lwendlela yokuphila, ubunzima, ubude kunye nemikhwa.
Ucwangciso lwesondlo somhlaza ovela kwi-addon alusekelwanga kukhangelo lwe-intanethi. Izenzela wena isigqibo ngokusekwe kwisayensi yeemolekyuli eziphunyezwe zizazinzulu zethu kunye neenjineli zesoftware. Nokuba uyakhathala na ukuqonda iindlela zemolekyuli zebhayoloji okanye hayi - kucwangciso lwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.