Iimbalasane
I-Curcumin, ekhutshwe kwingcambu ye-turmeric, ifundwe ngokubanzi kwiipropati zayo zokulwa nomhlaza kunye nokuqonda kwiindlela zeselula zendlela enokunceda ngayo ukudibanisa kunye ne-chemotherapy ethile. I-Curcumin evela kwi-turmeric iphucule impendulo yonyango lwe-FOLFOX lwe-chemotherapy kwizigulana ezinomhlaza we-colorectal njengoko kugxininiswe sisigaba sesi-II solingo lwezonyango. Nangona kunjalo, umhlaza izigulane kufuneka zithathe izongezelelo ze-Curcumin (i-curcumin egxininisiweyo ekhutshwe kwi-turmeric) kuphela phantsi kwesikhokelo somsebenzi wezempilo njengoko inokusebenzisana nolunye unyango olufana ne-Tamoxifen.
Ispice seTurmeric
I-Turmeric sisiqholo esisetyenziswe ngokubanzi kwiinkulungwane ze-Asiya kungekuphela njengesithako esiphambili kwi-cuisine yase-India kodwa kunyango lwesiTshayina nakweyeza lase-Indian Ayurvedic, ukunyanga iingxaki zempilo ezahlukeneyo. Kutshanje kuye kwakho uphando olunzulu malunga neempawu zokulwa umhlaza zesithako esisebenzayo seCurcumin, ekhoyo kwi-turmeric (curcuma longa). ICurcumin ikhutshwe kwiingcambu zeTurmeric kwaye ibonakaliswa ngombala o-orenji omthubi. Kukho intaphane yezifundo kunye nokuqwalaselwa okupapashwe kumawakawaka oolindixesha abajongwa ngoontanga kunyango lweCurcumin.
I-Curcumin evela kwi-Turmeric spice yipytochemical enefuthe elibanzi kwiinkqubo ezininzi zeselula, iindlela, iiproteni kunye nemfuza kubandakanya ii-kinase ezahlukeneyo, ii-cytokines, ii-enzymes kunye nezinto ezikhutshelweyo. Yiyo loo nto iCurcumin inezinto ezininzi zokukhusela impilo kubandakanya i-antioxidant, anti-cancer, anti-inflammatory, antimicrobial, immunomodulatory, neuroprotective, kunye nokukhuselwa okubanzi kumalungu amaninzi nakwiinkqubo zamalungu kubandakanya isibindi, izintso, ulusu njl. (Kocaadam B et al, Umgxeki. Ukutya iSci. Nutr., 2015)
Kule bhulogi siza kushwankathela ubungqina bovavanyo kunye neeklinikhi kwiipropathi zekhemopreventive kunye ne-anticancer yeCurcumin, eyona nto iphambili kwi-spice Turmeric. Ifikeleleka ngokulula, ixabiso eliphantsi kunye nobuthi obuphantsi, iphytochemical yendalo, ekhethwe njengenye yezinto ezinokuthembisa ezivavanywa kuvavanyo lwezonyango yi-US National Cancer Institute.
Ngaphandle kobungqina obomeleleyo bokulinga kunye nobuchwephesha bobuchwephesha obunokubakho kwiCurcumin, inemicimbi yokufunxa okungalunganga kunye nokufumaneka okuphantsi emzimbeni, ngakwimo yayo yendalo. Oku kunokuqwalaselwa ngokwenziwa kwezinto ezithi ziphucule ukungafumaneki kwayo. Ukongeza, ngokunxibelelana kwayo neziyobisi ze-enzymes kunye nabathuthi beziyobisi, inamandla aphezulu okusebenzisana namanye amachiza. Ngenxa yoko, kukho imfuneko yezifundo zeklinikhi eziyilwe kakuhle zokuchaza iimeko ezichanekileyo kunye nokudityaniswa apho iCurcumin inokusetyenziswa khona. (Unlu A okqhubekayo, JBUON, 2016)
Iipropathi ezichasene nokuvuvukala kweCurcumin / iTurmeric zibonelela ngeZibonelelo eziLwa noMhlaza
Iimpawu eziphambili zokulwa nomhlaza zeCurcumin / iTurmeric kungenxa yeempawu zayo ezichaseneyo nokudumba kunye ne-immunomodulatory.
Umhlaza wenzeka xa iiseli zethu ziguqulwa ngenxa yotshintsho kunye neziphene ezibangelwa zizizathu ezininzi ezahlukeneyo kubandakanya indlela yokuphila, ukutya, uxinzelelo, okusingqongileyo kunye neemeko zofuzo. Imizimba yethu iyilelwe ngoonogada kunye neendlela zokuzikhusela kumanqanaba enkqubo kunye neeselfowuni. Amajoni ethu omzimba ayilelwe ukuchonga nantoni na eyangaphandle (intsholongwane okanye intsholongwane) okanye nantoni na emzimbeni engaqhelekanga, kwaye ineenkqubo kunye nokuhamba komsebenzi webhayoloji ukucacisa okungaqhelekanga. Nokuba kwinqanaba leselula njengoko iiseli zahlulahlulwe ukukhula, ukuvuselelwa, ukupholisa amanxeba kunye nokunye ukusebenza komzimba, sijonga kuwo onke amanqanaba siqala ngokujonga ukuchaneka komyalezo oyintloko kwi-genome yethu, iDNA. Kukho wonke umonakalo we-DNA wokujonga kunye nokulungisa oomatshini abahlala besebenza kule nkqubo.
Xa umhlaza usenzeka, uphononongo luqinisekisile ukuba kukho isiphako kwinqanaba leeselfowuni kunye noomatshini bokulungisa i-DNA obangela ukonakala okungaphezulu kweselfowuni kunye nokungaqhelekanga, kunye nokusilela kwenkqubo yamajoni omzimba athe akahoya kwaye akakwazanga ukuwucacisa ukungaqheleki. Yiyo loo nto iiseli ezingaqhelekanga zivunyelwe ukuba zisinde kwaye iiseli ezikhohlakeleyo zithathe inkqubo kwaye zichume kwaye zichume njengoko isifo siqhubeka.
Ukuvuvukala yinkqubo xa umzimba usamkela ngokwendalo isiphene okanye ukungaqheleki kwaye uphinda ufumane ukhuselo lomzimba ukujongana nomcimbi nokucoca ingxaki. Kakhulu, zonke iingxaki kubandakanya ukuphazamiseka komzimba, ukuphazamiseka komzimba kunye nomhlaza ngenxa yokungasebenzi kakuhle kwamajoni omzimba. Kwimeko yomhlaza, amajoni omzimba athinjelwa ukuba angaqapheli kodwa axhase iiseli ezingaqhelekanga kunye noncedo ekukhuleni kwawo.
Zininzi izifundo ezifumanise iindlela zeselfowuni yezenzo ezichasene nokudumba kweCurcumin ekhutshwe kwiTurmeric ebonelela ngoncedo oluphambili lokulwa nomhlaza. ICurcumin isebenzisa iipropathi zayo ezichaseneyo nokudumba ngokudibana nabalamli abaninzi bomzimba njengokuthintela ukuvuvukala okunje ngeNuclear factor kappa B (NFKB), inhibit cytokines pro-inflammatory, chemokines, prostaglandins and even the reactive oxygen (ROS). Uninzi lwaba bathetheleli babandakanyeka kwiindlela ezininzi zokubonisa iiseli ezinxulunyaniswa nokuphela komhlaza njengokukhula komhlaza okugqithileyo (ukwanda), ukunciphisa ukufa kweseli (apoptosis), ukuhluma okugqithileyo kwemithambo yegazi (angiogenesis) kunye nokuxhasa ukusasazeka kweeseli zomhlaza ezingaqhelekanga amanye amalungu omzimba (metastasis). Iipropathi ze-immunomodulatory zeCurcumin azibangelwa kuphela kukuthintela iithagethi zeseli kodwa zikwanakho ukumodareyitha iiseli zomzimba ezinje nge-macrophages, iiseli zedendritic, iiseli ze-T kunye ne-B-lymphocyte, inkqubo yokuzikhusela komzimba. (UGiordano A kunye noTommonaro G, iiNutrients, 2019)
Izifundo zovavanyo kwiZiphumo ezichasene nomhlaza zeTurmeric / Curcumin kuMhlaza
Iziphumo ezichasene nomhlaza zeCurcumin / iTurmeric ziphandwe kwimigca yeseli yomhlaza kunye neemodeli zezilwanyana. ICurcumin ibonakalise iziphumo eziluncedo zokunciphisa ukukhula komhlaza kwiseli kwiimodeli zomhlaza wedlala lobudoda, umhlaza wamabele kubandakanya umhlaza wamabele ongahlali kathathu, umqala kunye nomhlaza wentloko nentamo, umhlaza wemiphunga nabanye abaninzi. (Unlu A okqhubekayo, JBUON, 2016)
Ukongeza, kuye kwakho izifundo zokuvavanya ukuba ngaba iCurcumin inokuphucula ubuntununtunu bamachiza ekhemotherapy kunye nonyango lwemitha.
- I-Curcumin yaboniswa ukuba inyuse ubuntununtunu be-5-fluorouracil kwimigca yeseli yomhlaza. (Shakibaei M okqhubekayo, PLoS One, 2014)
- ICurcumin ekhutshwe kwiTurmeric ngokuzama ukuphucula ukusebenza kwe-cisplatin entloko nasentanyeni kunye neeseli zomhlaza we-ovari. (Kumar B okqhubekayo, PLoS One, 2014; Selvendiran K okqhubekayo, Cancer Biol. Ther., 2011)
- I-Curcumin kwathiwa yonyusa ukusebenza kwe-paclitaxel kwiiseli zomhlaza womlomo wesibeleko. (ISreekanth CN okqhubekayo, Oncogene, 2011)
- Kwi-lymphoma, iCurcumin yaboniswa ukuphucula ubuntununtunu kunyango lwe-radiation. (Qiao Q okqhubekayo, iziyobisi zeAnticancer, 2012)
- Kwiiseli ezinomhlaza weseli yomhlaza wemiphunga, uCurcumin ovela eTurmeric waxelwa ukuba uyadibana neyeza chemotherapy vinorelbine. (USen S okqhubekayo, iBiochem Biophys Res. IKhomishini., 2005)
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izifundo zoNyango ngeZiphumo zeCurcumin kuMhlaza
ICurcumin isaphandwa kwizifundo ezininzi eziqhubekayo zeklinikhi, zombini njenge-monotherapy kunye nokudibanisa namanye amachiza.
- Kwisifundo seklinikhi somhlaza ongacacanga, uvavanyo lomlomo lwe-curcumin lwavavanywa. Kwakukho ukungabikho kwetyhefu kunye neCurcumin, ngelixa i-2 yezigulana ze-15 ibonakalisa isifo esizinzileyo emva kweenyanga ezimbini zonyango lweCurcumin. (USharma RA okqhubekayo, iCancer Cancer Res., 2) Kwesinye isigaba sesibini sokufunda kwizigulana ezingama-2004 ezinezilonda zomhlaza wekolon, ukusetyenziswa kweCurcumin kangangeentsuku ezingama-44 kwaxelwa ukunciphisa inani lezilonda nge30%. (UCarroll RE okqhubekayo, iCancer Prev. Res. (Phila), 40)
- Kwilingo lesibini lesilingo sokuqulunqwa komlomo kweCurcumin kwizigulana ezingama-25 zomhlaza wepancreatic, izigulana ezibini zibonise imisebenzi yezonyango kunye nesigulana esinye esichaze ukuba sinezifo ezizinzileyo> kwiinyanga ezili-18 kwaye esinye sinesifo esibuhlungu esifutshane kodwa esibalulekileyo. (UDhillon N okqhubekayo, kwiCancer Cancer Res., 2008)
- Isifundo seklinikhi kwizigulana ezingapheliyo ze-myeloid leukemia (CML), isiphumo sonyango sokudityaniswa kweCurcumin kunye ne-Imatinib (umgangatho wokunyanga iziyobisi kwi-CML) kuvavanywe. Umdibaniso ubonise ukusebenza okungcono kune-Imatinib kuphela. (IGhalaut VS okqhubekayo, J Oncol. Ukuziqhelanisa neFarm, 2012)
- Kwizigulana ezinomhlaza wamabele, iCurcumin iphantsi kophando kwi-monotherapy (NCT03980509) kwaye ngokudibeneyo ne-paclitaxel (NCT03072992). Iyavavanywa nakwezinye izifundo zeklinikhi yomhlaza wedlala lobuchwephesha, umhlaza womlomo wesibeleko, umhlaza we-endometrium, isibeletho sarcoma nabanye. (UGiordano A kunye noTommonaro G, iiNutrients, 2019)
- Uphononongo lwakutshanje lwesigaba II seklinikhi kwizigulana ezinomhlaza we-metastatic colorectal cancer (NCT01490996) xa kuthelekiswa ukusinda okupheleleyo kwezigulana ezifumana indibaniselwano ye-chemotherapy FOLFOX (folinic acid / 5-fluorouracil / oxaliplatin treatment) kunye nangaphandle kwezincedisi zeCurcumin (ezivela kwiTurmeric). Ukongezwa kweCurcumin kwi-FOLFOX kwafunyanwa kukhuselekile kwaye kuyanyamezeleka kwizigulana ezinomhlaza kwaye azizenzakalisi iziphumo ebezingalindelekanga ze-chemo. Ngokwezinga lokuphendula, iqela leCurcumin + le-FOLFOX lalinesiphumo esingcono sokusinda kunye nokuqhubela phambili kokuphila simahla iintsuku ezingama-120 ubude kuneqela le-FOLFOX kunye nokusinda ngokubanzi kungaphezulu kokuphindwe kabini. (I-Howells LM okqhubekayo, J Nutriti, 2019) Kubandakanya iCurcumin njengenxalenye yecolorectal Ukutya kwabaguli abanomhlaza xa uthatha i-FOLFOX chemotherapy kunokuba luncedo.
Ukudibana kweCurcumin kunye nezinye iziyobisi
I-Curcumin, nangona ibonwa njengento ekhuselekileyo ngokubanzi yi-FDA (Ukutya kunye noLawulo lweDrugs), inobungqina bokuba ichaphazela i-drug metabolizing cytochrome P450 enzymes. Ke ngoko, inamandla okunxibelelana namanye amachiza kwaye iphazamise ukusebenza kwechiza. Kukho izifundo ngonxibelelwano lwayo kunye namachiza abandakanya iziyobisi ze-antiplatelet, kunye nezinye umhlaza kunye neziyobisi ze-chemotherapy ezibandakanya i-Tamoxifen, i-doxorubicin, i-cyclophosphamide, i-tacrolimus kunye nabanye. (Unlu A et al, JBUON, 2016)
Ipropathi ye-antiplatelet yeCurcumin inokunyusa umngcipheko wokopha xa isetyenziswa nee-anticoagulants. Ipropathi yayo ye-antioxidant inokuphazamisa indlela yokusebenza kwamachiza e-chemotherapy njenge-cyclophosphamide kunye ne-doxorubicin. (Yeung KS okqhubekayo, Oncology J, Ukudibanisa i-Oncol., 2018)
I-Curcumin evela kwiTurmeric inxibelelana nonyango lweTamoxifen, uMgangatho woKhathalelo lweHormone Positive Breast Cancer
Ichiza lomlomo iTamoxifen lixutywe emzimbeni kwii-metabolites zalo ezisebenzayo ze-cytochrome P450 enzymes esibindini. I-Endoxifen yimetabolite esebenzayo yekliniki yeTamoxifen, ngoyena mlamli uphambili wokusebenza kwonyango lwe-tamoxifen (Del Re M et al, Pharmacol Res., 2016). Olunye uphando lwangaphambili olwenziwe kwiigundane lubonise ukuba kukho ukuhlangana kweziyobisi phakathi kweCurcumin kunye neTamoxifen. ICurcumin ithintele i-cytochrome P450 mediated metabolism of tamoxifen's conversion to its form (Cho YA et al, Pharmazie, 2012). Uphando olusandula kupapashwa oluzayo (EudraCT 2016-004008-71 / NTR6149) oluvela e-Erasmus MC Cancer Institute eNetherlands, luvavanye olu nxibelelwano phakathi kweCurcumin evela eTurmeric (kunye okanye ngaphandle kwepiperine) kunye nonyango lweTamoxifen kwizigulana ezinomhlaza wamabele (I-Hussaarts KGAM okqhubekayo, umhlaza (iBasel), 2019). Abaphandi bavavanye amanqanaba eTamoxifen kunye ne-Endoxifen phambi kweCurcumin.
Iziphumo zibonise ukuba uxinzelelo lwe-metabolite esebenzayo ye-Endoxifen yehle ngeCurcumin. Oku kuncipha kwi-Endoxifen kwakubalulekile ngokwezibalo. Ke ngoko, ukuba isongezelelo seCurcumin (esivela kwiTurmeric) sithathwa kunye nonyango lweTamoxifen somhlaza wamabele, inokuhlisa uxinzelelo lwechiza elisebenzayo elingaphantsi komqobo walo wokusebenza kakuhle kwaye linokuphazamisa ifuthe lonyango lwechiza.
isiphelo
I-Turmeric, i-spice e-orenji etyheli, ibisetyenziswa kangangeenkulungwane, nangaphambi kokuba kuchongwe into esebenzayo yeCurcumin, ngenxa yezibonelelo zayo ezininzi zezempilo. Isetyenziswa njengeyeza lokudumba kwaye isetyenziswe ngokuthe ngqo kumanxeba ukuphucula ukuphola kwenxeba. Ipinki ye-turmeric enobisi olushushu ibiyiminyaka ubudala ye-antibacterial kunye ne-immune yokunyusa iyeza elisetyenziswa kumakhaya namhlanje, ngokobulumko bendabuko. Ingumxube we-curry powder kwaye iqhelekileyo kwaye isetyenziswa ngokubanzi njengenxalenye ye-Indian kunye ne-Asia cuisines. I-spoonful ye-green and grated turmeric root kunye ne-pepper emnyama kunye ne-lemon enye enye inhlanganisela eqhelekileyo esetyenziselwa rhoqo kwisifo sayo sesifo sikashukela, i-anti-arthritic, i-immune boosting effect. Ngenxa yoko njengokutya kwendalo kunye nesipayisi, iturmeric isetyenziswa ngokubanzi kwaye isetyenziswa kakhulu.
Namhlanje, kukho zonke iintlobo zeeturmeric kunye neCurcumin izicatshulwa, iipilisi, iifomsile, kunye neendlela ezahlukeneyo ezithengiswa kwimarike, zikhwela kwizibonelelo zempilo ezaziwayo. Nangona kunjalo, iCurcumin yaziwa ngokuba nokufunxwa okungalunganga kunye nokufumaneka komzimba emzimbeni. Xa ikho ngokudibeneyo nepepile emnyama okanye i-piperine okanye i-bioperine, iphucule ukungafumaneki. Iimveliso zeCurcumin zihlelwa njengeeherbals kunye neebotanicals ezingalawulwa ngokungqongqo njengeziyobisi. Ke ngoko, ngaphandle kobuninzi beemveliso zeCurcumin kwintengiso, umntu kufuneka aqonde ngokukhetha imveliso kunye nokuqulunqwa okufanelekileyo kunye neelebheli zokufumana isiqinisekiso kwi-USP, NSF njl, ukuqinisekisa umgangatho ongcono wemveliso.
Njengoko kucacisiwe kwibhlog, zininzi izifundo zovavanyo kwiiseli ezahlukeneyo zomhlaza kunye neemodeli zezilwanyana ezibonisa indlela iCurcumin engakwaziyo ngayo ukuthintela ukukhula komhlaza kunye nezinye iziphelo zomhlaza, kodwa ikwenze nomatshini ukukopisha imigaqo yebhayoloji yendlela iCurcumin isebenza ekuboneleleni ngezibonelelo ezichasene nomhlaza. Kukho ezinye izifundo zeklinikhi ezibonise isibonelelo esithobekileyo kwaye zibonise ukuphucuka kokusebenza kweziyobisi ezithile zonyango lomhlaza kubandakanya ichemotherapy kunye nonyango lwemitha, ngokudibeneyo neCurcumin (evela kwiTurmeric).
Nangona kunjalo, ngokungafaniyo neemfuno ezingqongqo kwizifundo zamachiza eklinikhi, ukusetyenziswa kweCurcumin formulations kunye nogxininiso aluzange luhambelane kwaye lubekwe emgangathweni kwizifundo ezininzi zeklinikhi. Ukongezelela, ngenxa yomcimbi owaziwayo ophantsi we-bioavailability we-Curcumin yendalo, iziphumo kwizifundo zeklinikhi azizange zibe mnandi kwaye zikholise. Ngaphezu koko kukho idatha ekusebenzisaneni kwe-Curcumin kunye nolunye unyango olunokuthi lube nefuthe ekusebenzeni kwechiza. Ngenxa yoko ngenxa yazo zonke ezi zizathu zingasentla, ngaphandle kokusebenzisa i-turmeric ekutyeni nasekutyeni kwethu kwaye mhlawumbi ukwakhiwa kwe-curcumin efanelekileyo kwiipropati zayo zokunyusa umzimba, ukusetyenziswa kwe-Curcumin ngu. umhlaza izigulane azikhuthazwa ngaphandle kokuba phantsi kwesikhokelo somsebenzi wezempilo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.