Iimbalasane
Umhlaza webele we-Metastatic, okwaziwa ngokuba yinqanaba le-IV lomhlaza webele, luhlobo oluphambili lwesi sifo apho umhlaza usasazeke kwamanye amalungu omzimba, njengamathambo, imiphunga, isibindi okanye ingqondo. Kuphela yipesenti encinci (6%) yabasetyhini abaye bafumanisa ukuba banebele ye-metastatic umhlaza, kunye neemeko ezininzi ezenzekayo ngenxa yokubuyela emva konyango lwangaphambili kunye nexesha lokuxolelwa.
Kukho umahluko omkhulu phakathi komhlaza wamabele kunye nomhlaza wamabele we-metastatic; umhlaza wamabele ligama le-ambrela lazo zonke iintlobo kunye nezigaba ze-carcinoma ezivela kwizicubu zebele. Kwelinye icala, iNational Cancer Institute (NCI) ikwabonelela ngolwazi malunga nomhlaza webele we-metastatic kunye nezigaba ezahlukeneyo zomhlaza wamabele, kubandakanya nenkcazo yomhlaza webele we-metastatic njengenqanaba le-IV lesi sifo, apho iiseli zomhlaza ziye zasasazeka kwezinye iindawo zomzimba. .
Ngelixa umhlaza webele we-metastatic uxhaphake kakhulu kubasetyhini, ukwachaphazela inani elincinci lamadoda. Ngokwengxelo yeCancer Cancer Society yaseMelika kunye nengxelo yamanani ukusuka ngo-2019, izinga lokusinda leminyaka emi-5 kumhlaza wamabele we-metastatic lingaphantsi kwama-30%.
Segar, uJennifer M et al. "Uphononongo lweSigaba sesi-II se-Irinotecan kunye ne-Etoposide njengoNyango lwe-Refractory Metastatic Breast Cancer." I-oncologist Umqulu 24,12 (2019): 1512-e1267. doi:10.1634/theoncologist.2019-0516
Uvavanyo lweKlinikhi (NCT00693719): Irinotecan kunye ne-Etoposide kwi-Metastatic Breast Cancer
- Kwakukho abantu ababhinqileyo abangama-31 ababhalise kulengalo inye, inqanaba lesibini lokuvavanywa kweklinikhi, phakathi kweminyaka engama-36-84 yeminyaka.
- I-64% yaba bafazi yayine-hormone elungileyo kunye nohlobo lwe-HER2 olubi lomhlaza webele.
- Abafazi babephathwe nge-median ye-5 yangaphambi konyango kwaye babesele benganyangeki kwi-anthracycline, irhafu kunye nonyango lwe-capecitabine.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Isiseko seNzululwazi kuPhando
- Isizathu emva kwetyala yayikukuzama iseti entsha yamachiza e-chemotherapy awaye bonisa umsebenzi obhaliweyo kwizigulana ezinomhlaza wamabele kwaye indibaniselwano yaqinisekiswa ngokuthe ngqo.
- Zombini i-Irinotecan kunye ne-Etoposide zizinto zendalo, ezivela kwizityalo eziyimodulators ye-topoisomerase (TOP) enzyme isoforms. Ii-enzyme ze-TOP ziyafuneka ukuphindaphindeka kunye nokubhalwa kwe-DNA, zombini iinkqubo ezibaluleke kakhulu kwiseli yomhlaza ekhula ngokukhawuleza. Ukuphazamisa isenzo se-TOP kubangela ukuqhekeka kwe-DNA strand, ukonakala kwe-DNA kunye nokufa kweseli.
- I-Irinotecan yi-TOP1 kunye ne-Etoposide imodyuli ye-TOP2. Isizathu sokudibanisa zombini i-TOP1 kunye ne-TOP2 inhibitors kukujongana nokunyanzeliswa kwesinye isoform xa enye ye-isoform icinezelwe.
Iziphumo zovavanyo lweklinikhi
- Kwakukho izigulana ezingama-24 ezinokuthi zivavanywe ngokusebenza kwale ndlela yokudibanisa ye-Irinotecan kunye ne-Etoposide. I-17% yayineempendulo ezithile kwaye i-38% yayinezifo ezizinzileyo.
- Zonke izigulana ze-31 zavavanywa ukuba zinetyhefu kwaye i-22 ye-31 (71%) yafumana unyango olunxulumene nebanga lesi-3 kunye neziganeko ezibi ezi-4. Eyona ityhefu ixhaphakileyo yayiyi-neutropenia, obubukho bamanqanaba asezantsi ngokungaqhelekanga e-neutrophils egazini elinokunyusa usulelo kwizifo.
- Uphononongo lwapheliswa kwangoko kuba umthwalo wetyhefu wawunzima kwaye ukongamela ukusebenza kwendibaniselwano.
Iimpawu zeMetastatic Breast Cancer
- Ubuhlungu bethambo okanye ububele: Iyakwazi ukusasazeka emathanjeni, kubangela intlungu okanye ububele kwiindawo ezichaphazelekayo.
- Ukukhathala: Umhlaza kunye nonyango lomhlaza lunokubangela ukudinwa, okunokuba nzima kwaye kuqhubeke.
- Ukuphefumula okufutshane: Umhlaza osasazeka kwimiphunga unokubangela ukuphefumula okufutshane.
- Iimpawu ze-Neurological: Umhlaza oye wasasazeka kwingqondo unokubangela iimpawu ze-neurological ezifana nentloko, ukuxhuzula, okanye utshintsho ekusebenzeni kwengqondo.
- Ukulahlekelwa ngumdla kunye nokunciphisa umzimba: Umhlaza kunye nonyango lomhlaza lunokubangela ukulahlekelwa ngumdla kunye nokunciphisa umzimba.
- Ijaundice okanye ukudumba kwesisu xa umhlaza unwenwele esibindini.
Ubomi obulindelekileyo bomntu onomhlaza webele we-metastatic bunokwahluka ngokuxhomekeke kwizinto ezininzi njengendawo kunye nokusasazeka kwethumba.
Ngokophononongo, izinga lokusinda leminyaka emi-5 ngumlinganiselo wokuba bangaphi abantu abanolu hlobo umhlaza basaphila kule minyaka mi-5 idlulileyo emva kokuba umhlaza ufunyenwe. Ichazwa njengepesenti, oku kuthetha ukuba inani labantu kwi-100 eliphilayo emva kweminyaka emi-5. Ngokutsho kwe-American Cancer Society, izinga lokusinda kweminyaka emi-5 kwabasetyhini abanomhlaza webele we-metastatic yi-29%, ngelixa izinga lokusinda leminyaka emi-5 kumadoda angama-22%. Kubalulekile ukuqaphela ukuba ezi ziinkcukacha-manani jikelele kwaye iimeko zomntu ngamnye zinokwahluka.
Unyango lweMetastatic Breast Cancer
Unyango luntsonkothile kodwa indibaniselwano yechemotherapy kunye namachiza athile ekhemo inezibonelelo ezithile ekulawuleni umhlaza. Ayinakusetyenziswa kakhulu kwaye ixesha elide ngenxa yeprofayili yetyhefu enzima kunye nomgangatho wempembelelo yobomi kwisigulane. Unyango lwe-Immunotherapy lolunye ukhetho olunokuthi luthathelwe ingqalelo kwizigulane ezinomhlaza webele we-metastatic; le ndlela yonyango inokunceda amajoni omzimba aqaphele kwaye ahlasele iiseli zomhlaza.
Ukuvavanya iprofayili yoguqulo lwe-metastatic tumor kunokunceda ukuchonga indibaniselwano yeendlela zonyango ezijolise ngakumbi ezineziphumo ebezingalindelekanga ezisezantsi. Umngcipheko wokusebenzisa indibaniselwano ethile ye-topoisomerase inhibitors i-Irinotecan kunye ne-Etoposide igqithise izibonelelo kwaye ayinakusetyenziswa ekunyangeni ibele le-metastatic. i cancer.
Kuba wonke umhlaza webele we-metastatic wahlukile kunye neseti yawo yokwahluka kwe-genomic, ukhetho lonyango lwenzelwe umntu ngokufanelekileyo zii-oncologists. Usekho umsebenzi ekufuneka wenziwe ekufumaneni iindlela zonyango eziphuculweyo nezikhuselekileyo kulo. Rhoqo ngonyaka, ngomhla we-13 ka-Okthobha, usuku lokwazisa ngomhlaza webele we-metastatic lubhiyozelwa ukunika inkxaso kwabo bachaphazelekayo sesi sifo kunye nokunyusa imali yophando lokuphuhlisa iindlela zonyango eziphuculweyo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.
Iingxelo:
- Cancer.net (2022). Umhlaza wamabele – Metastatic: Iinkcukacha-manani.
- Iziko lomhlaza leSizwe. (nd). Umhlaza webele.
- Umbutho womhlaza waseMelika. (2021). Umhlaza wamabele weMetastatic.
- Iziko lomhlaza leSizwe. (2021). Umhlaza wamabele weMetastatic.
- Cancer.net. (2022). Umhlaza wamabele – Metastatic: Iinkcukacha-manani.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.