Ukutya kweFlavonoid kunye neziBonelelo kwiCancer

Iimbalasane

Izifundo ezahlukeneyo zibonisa ukuba i-flavonoids inoluhlu lweenzuzo zezempilo kubandakanya iipropathi zokulwa umhlaza kunye neentsholongwane kwaye zifumaneka kukutya okwahlukeneyo kubandakanya iziqhamo (ezinje ngee-cranberries, iiblueberries, amaqunube amnyama, i-bilberries, ii-apile ezine-fiber njl.njl.), Imifuno kunye iziselo. Ke, kubandakanya ukutya okutyebileyo kwe-flavonoid njengenxalenye yokutya kwethu kwemihla ngemihla kuya kuba luncedo. Nangona kunjalo, ngaphambi kokuba uthathe naziphi na izongezo ze-flavonoid, abaguli abanomhlaza kufuneka baxoxe rhoqo nabaqeqeshi babo bezempilo.

Yintoni i-flavonoids?

I-Flavonoids liqela le-bioactive phenolic compounds kunye ne-subset ye-phytonutrients efumaneka kakhulu kukutya kwezityalo ezahlukeneyo. I-Flavonoids zikhona kwiintlobo ezahlukeneyo zeziqhamo, imifuno, amandongomane, iimbewu, iziqholo, iinkozo, ixolo, iingcambu, iziqu, iintyatyambo nokunye ukutya kwezityalo kunye neziselo ezinje ngeti kunye newayini. Ngokusetyenziswa okunyukayo kwe-flavonoids ngokuthatha iziqhamo kunye nokutya okunesityebi semifuno, izifundo ezahlukeneyo zenziwe kwihlabathi liphela ukuvavanya izibonelelo zempilo ezinokubakho kunye neempawu zokulwa nomhlaza.

Iiklasi ezahlukeneyo zeFlavonoids kunye neMithombo yokutya

Ngokusekwe kubume beekhemikhali ze-flavonoids, zahlelwa kwezi nkqutyana zilandelayo.

1. I-Anthocyanins
2. IiChalcones
3. Iiflavanones
4. Iiflavones
5. IiFlavonols
6. I-Flavan-3-ols
7. Ii-isoflavones

Anthocyanins-I-Flavonoid Subclass kunye neMithombo yokutya

I-Anthocyanins zii-pigment ezijongene nokubonelela ngemibala kwiintyatyambo nakwiziqhamo zezityalo. Ziyaziwa ngokuba neempawu ezomeleleyo zokulwa ne-antioxidant. I-flavonoid Anthocyanins isetyenziswa ngokubanzi kushishino lokutya ngenxa yezibonelelo zayo zempilo kunye nozinzo. 

Eminye yemizekelo ye-anthocyanins yile:

• Delphinidin
• ICyanidin 
• I-Pelargonidin
• Malvidin 
• Peonidin kunye
• IPetunidin

Imithombo yokutya yeAnthocyanin flavonoids: I-Anthocyanins ifumaneka kakhulu kulusu lwangaphandle lweziqhamo / amajikijolo kunye neemveliso zeberry kubandakanya:

• imidiliya ebomvu
• Iidiliya zemerlot
• Isiselo somdiliya esibomvu
• ICranberries
• Iikhrantshi ezimnyama
• Iirasberries
• Ierberberries
• aluhlaza
• Bilberries kunye 
• Amaqunube amnyama

I-Chalcones-I-Flavonoid Subclass kunye neMithombo yokutya

I-Chalcones lolunye udidi lwe-flavonoids. Ziyaziwa ngokuba zii-flavonoids zechungechunge oluvulekileyo. I-Chalcones kunye nezinye zazo zinezibonelelo ezininzi zesondlo kunye ne-biological. I-chalcones zokutya zibonakala zinomsebenzi ngokuchasene neeseli zomhlaza, zibonisa ukuba banokuba neepropathi ezichasene nomhlaza. I-Chalcones yaziwa ngokuba ne-antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, kunye neepropathi zokuzikhusela emzimbeni. 

Eminye yemizekelo yee-chalcones zezi:

• IArbutin 
• I-Phloridzin 
• Phloretin kunye 
• I-Chalconaringenin

I-flavonoids, iiChalcones, zifumaneka ngokutya okwahlukeneyo njengoku:

• Iitumato zasegadini
• IiShallots
• Iimbotyi ziyahluma
• Amapheya
• Ierberberries
• Iibherebheri
• Licorice kunye
• iimveliso ezithile zengqolowa

I-Flavanones-I-Flavonoid Subclass kunye neMithombo yokutya

I-Flavanones, ekwabizwa ngokuba yi-dihydroflavones, yenye into ebalulekileyo ye-flavonoids ene-antioxidant eyomeleleyo kunye neepropathi ezikhululekileyo zokuqhekeza. I-Flavanones inika incasa ekrakra kwixolo kunye nejusi yeziqhamo zesitrasi. Ezi flavonoids zesitrasi zikwabonisa iipropathi ezichaseneyo nokudumba kwaye zisebenza njengegazi elinciphisa lipid kunye neearhente zokunciphisa i-cholesterol.

Eminye yemizekelo yeeflavanones yile:

• UEliodictyol
• Hesperetin kunye
• INaringenin

I-flavonoids, iFlavanones, zifumaneka kakhulu ekutyeni okufana nazo zonke iziqhamo zesitrasi kubandakanya:

• Oranges
• eHeidelberg
• Iilamuni kunye
• Iidiliya

I-Flavones- I-Flavonoid Subclass kunye neMithombo yokutya

I-Flavones yindawo engaphantsi kwee-flavonoids ezikhoyo kumagqabi, iintyatyambo kunye neziqhamo njenge-glucosides. Ziyi-pigment kwizityalo eziluhlaza okwesibhakabhaka namhlophe. I-Flavones ikwasebenza njengemithi yokubulala izitshabalalisi yendalo kwizityalo, inika ukhuseleko kwizinambuzane nakwizifo zokungunda. Iiflavones ziyaziwa ngokuba neepropathi zokulwa ne-antioxidant kunye ne-anti-inflammatory. 

Eminye yemizekelo yeencasa yile:

• Apigenin
• I-Luteolin
• IBaicalein
• IChrysin
• IsiTangeritin
• Inobiletin
• I-Sinensetin

I-flavonoids, i-Flavones, ubukhulu becala zikhona kukutya okufana:

• isileri
• parsley
• obomvu
• iqhosha
• Peppermint
• iginkgo biloba

I-Flavonols-Isiseko seFlavonoid kunye neMithombo yokutya

I-Flavonols, enye i-subclass ye-flavonoids kunye neebhloko zokwakha zeproanthocyanins, zifumaneka kwiintlobo ezahlukeneyo zeziqhamo kunye nemifuno. I-Flavonols yaziwa ngokuba nezibonelelo ezininzi zempilo kubandakanya amandla e-antioxidant kunye nokunciphisa umngcipheko wesifo se-vascular. 

Eminye yemizekelo ye flavonols ibandakanya:

• Fisetin 
• Quercetin
• Imyricetin 
• Rutin
• IKaempferol
• Isorhamnetin

I-flavonoids, i-Flavonols, ubukhulu becala zikhona kukutya okufana:

• Anyanisi
• Kale
• iitumato
• IiApile
• Amagilebhisi
• Iibhere
• Iti
• Isiselo somdiliya esibomvu

I-Flavan-3-ols -I-Flavonoid Subclass kunye neMithombo yokutya

I-Flavan-3-ols zezona flavonoids ziphambili zeti zinoluhlu olubanzi lwezibonelelo zezempilo. I-Flavan-3-ols yaziwa ngokuba ne-antioxidant, anti-inflammatory kunye ne-anti-cancer properties. 

Eminye yemizekelo ye-flavan-3-ols ibandakanya:

• ICatechins kunye neziphumo zazo zegalati: (+) - Catechin, (-) - Epicatechin, (-) - Epigallocatechin, (+) - Gallocatechin
• Iifaflavins, iThearubigins
• Iproanthocyanidins

I-flavonoids, i-Flavan-3-ols, ubukhulu becala zikhona kukutya okufana:

• itiye emnyama
• iti eluhlaza
• Iti emhlophe
• oolongwe iti
• IiApile
• iimveliso zecocoa
• iidiliya ezimfusa
• imidiliya ebomvu
• Isiselo somdiliya esibomvu
• iiblueberries
• strawberries

Isoflavones-Isiseko seFlavonoid kunye neMithombo yokutya

I-Isoflavonoids lelinye iqela le-flavonoids kwaye ezinye zazo ngamanye amaxesha zibizwa ngokuba zii-phytoestrogens ngenxa yomsebenzi wazo we-estrogenic. I-Isoflavones zinxulunyaniswa neempawu zonyango kubandakanya i-anticancer, antioxidant, kunye neepropathi zokukhusela ngenxa yokusebenza kwe-estrogen receptor inhibition.

Eminye yemizekelo yee-isoflavones yile:

• I-genistein
• Daidzein
• Glycitein
• Biochanin A
• Ifomononetin

Phakathi kwezi, isoflavones ezifana genistein kunye daidzein zezona phytoestrogens ethandwa.

I-flavonoids, isoflavones, ubukhulu becala zikhona ekutyeni okufana:

• Iimbotyi zesoya
• Ukutya kwesoy kunye neemveliso
• Izityalo ezinemidumba

Ezinye i-isoflavonoids zinokubakho kwii-microbes. 

Iipropathi zokulwa nomhlaza zeFlavonoids ezikhoyo kwiziqhamo, imifuno kunye neziselo

I-Flavonoids yaziwa ngokuba neenzuzo ezininzi zempilo ngenxa ye-antioxidant kunye ne-anti-inflammatory properties. Ezinye zezibonelelo zezempilo zokutya okunotyebileyo kwe-flavonoid zidweliswe apha ngezantsi.

• Ukubandakanya ii-flavonoids kwisidlo sethu kunokunceda ukulawula uxinzelelo lwegazi oluphezulu.
• I-Flavonoids inokunceda ukunciphisa imeko yokuhlaselwa yintliziyo okanye ukubetha.
• I-Flavonoids inokunceda ekunciphiseni umngcipheko wesifo seswekile.
• Olunye uphononongo luxele ukuba i-flavonoids inokuphucula ukwakheka kwethambo kunye nokuthintela ukubonwa kwethambo.
• I-Flavonoids inokuphucula ukuqonda kubantu abadala.

Kunye nazo zonke izibonelelo zempilo esele zikhankanyiwe, ii-flavonoids ezifumaneka ngokutya ezifana neziqhamo, imifuno kunye neziselo ziyaziwa ngokuba neempawu zokulwa nomhlaza. I-Flavonoids inokukhangela ii-radicals zasimahla ezinokonakalisa ii-macromolecule ezifana ne-DNA. Oku kunokunceda kulungiso lwe-DNA kwaye kuthintele i-angiogenesis kunye nokuhlasela kwethumba.

Siza kusondeza kwezinye zezifundo ezenziweyo ukuvavanya iipropathi zokulwa umhlaza ezimbalwa ze-flavonoids / i-flavonoid yokutya okunotye kubandakanya iziqhamo, imifuno kunye neziselo. Masibone ukuba zithini ezi zifundo!

Ukusetyenziswa kweSoy Isoflavone Genistein kunye neChemotherapy kwiMetastatic Colorectal Cancer

I-Metastatic Colorectal Cancer ine-prognosis engalunganga ngokusinda kweminyaka emi-2 engaphantsi kwama-40% kunye neminyaka emi-5 yokuphila engaphantsi kwe-10%, ngaphandle kwendibaniselwano enobundlongondlongo yonyango lwe-chemotherapy (AJCC Cancer Staging Handbook, 8th Edn). Izifundo ezahlukeneyo zibonakalisile ukuba abantu baseMpuma Asia abadla ukutya okunotyebileyo okunxulunyaniswa nomngcipheko omncinci wee-cancer ezingafaniyo. Izifundo ezininzi zovavanyo lwaphambi kokubonisa zikwabonisa iipropathi ezichasene nomhlaza zesoya isoflavone Genistein, kunye nokukwazi kwayo ukunciphisa ukumelana nekhemotherapy kwiiseli zomhlaza.  

Abaphandi kwiSikolo seIcahn of Medicine kwiNtaba yeSinayi, eNew York, bavavanya ukhuseleko kunye nokusebenza kokutya i-isoflavone Genistein kunye nomgangatho wokunyanga indibaniselwano ngekhemotherapy kwisifundo esinokubakho kwiklinikhi kwizigulana ezinomhlaza weColorectal Cancer (NCT01985763) (Pintova S et al , Umhlaza Chemotherapy kunye neFarmacol., 2019). Uphononongo lubandakanya abaguli abali-13 abanesifo somhlaza we-metastatic colorectal ngaphandle konyango lwangaphambili, kunye nezigulana ezili-10 ziphathwe ngokudityaniswa kwe-FOLFOX chemotherapy kunye noGenistein kunye nezigulana ezi-3 ziphathwe nge-FOLFOX + Bevacizumab kunye noGenistein. Ukudibanisa uGenistein nale chemotherapies kwafunyanwa kukhuselekile kwaye kunyamezeleka.

Kwakukho ukuphucuka kweyona mpendulo ibalaseleyo (i-BOR) kwezi zigulana zinomhlaza we-metastatic colorectal ezithatha i-chemotherapy kunye no-Genistein, xa kuthelekiswa nezo zixeliweyo zonyango lwe-chemotherapy kuphela kwizifundo zangaphambili. I-BOR yayiyi-61.5% kolu phando xa kuthelekiswa ne-38-49% kwizifundo zangaphambili kunye nonyango olufanayo lwe-chemotherapy. (I-Saltz LB okqhubekayo, J Clin Oncol, 2008) Nokuba inkqubela phambili yasimahla yemetrikhi yokusinda, ebonisa ixesha elingaqhubekanga ngalo ithumba kunyango, yayiliphakathi leenyanga ezili-11.5 ngokudityaniswa kukaGenistein kolu phononongo xa kuthelekiswa ne-8. iinyanga zekhemotherapy kuphela ngokusekwe kuphando lwangaphambili. (I-Saltz LB okqhubekayo, J Clin Oncol., 2008)

Uphononongo lubonisa ukuba kunokukhuseleka ukusebenzisa isoyoflavone Genistein isongezo kunye nokudityaniswa kwekhemotherapy i-FOLFOX kunyango lomhlaza we-metastatic colorectal cancer. Ukudibanisa uGenistein kunye ne-chemotherapy kunamandla okuphucula iziphumo zonyango. Nangona kunjalo, ezi ziphumo, nangona zithembisa, ziya kufuna ukuvavanywa kwizifundo ezikhulu zeklinikhi.

Ukusetyenziswa kwe-flavonol Fisetin kwiColorectal Cancer

I-flavonol-I-Fisetin yiarhente yokufaka imibala efumaneka ngokwendalo kwizityalo nakwimifuno emininzi kubandakanya amaqunube, iiapile ezinefayibha ezityebileyo kunye neediliya. Kuyaziwa ngokuba nezibonelelo ezahlukeneyo zempilo ezinje nge-neuroprotective, anti-inflammatory, kunye ne-anti-carcinogenic. Izifundo ezahlukeneyo zenziwe ukuvavanya isiphumo seFisetin kwiziphumo zekhemotherapy kwizigulana ezinomhlaza.

Uphononongo lweklinikhi lwenziwe ngo-2018 ngabaphandi abavela e-Iran ukuze bafunde iziphumo zokuncedisa i-fisetin kwizinto ezinxulumene nokuvuvukala kunye nokusasazeka komhlaza (i-metastasis), kwizigulana ezinomhlaza weColorectal ezifumana i-adjuvant chemotherapy (Farsad-Naeimi A okqhubekayo, Ukutya Funct. 2018). Olu phononongo lubandakanya abaguli abangama-37 abaneminyaka engama-55 ukuya kwengama-15 ubudala, abathi bangeniswa kwiSebe le-Oncology kwiYunivesithi yaseTabriz yezeNzululwazi yezoNyango, eIran, benesifo somhlaza webakala II okanye lesithathu, benobomi obungaphezulu kweenyanga ezintathu. I-Oxaliplatin kunye ne-capecitabine yayiyirejimeni yonyango lwe-chemotherapy. Kwizigulana ezingama-3, izigulana ezili-37 zikwafumene i-18 mg ye-fisetin kwiiveki ezisi-100 zilandelelana. 

Uphononongo lufumanise ukuba iqela elisebenzisa isongezelelo se-fisetin lalinokuncitshiswa okubonakalayo komhlaza ophembelela umhlaza kwi-IL-8 xa kuthelekiswa neqela lolawulo. Uphononongo lukwabonakalise ukuba ukongezwa kweFisetin kunciphise amanqanaba ezinye izinto zokukrala kunye neemetastasis ezifana ne-hs-CRP kunye neMMP-7.

Olu vavanyo lincinci lweklinikhi lubonisa isibonelelo esinokubakho se-fisetin ekunciphiseni ukumakisha komhlaza kwizigulana ezinomhlaza xa zinikwa ikhemotherapy yazo.

Ukusetyenziswa kweFlavan-3-ol Epigallocatechin-3-gallate (EGCG) kwizigulana ezinomhlaza we-Esophageal ziphathwe ngonyango lweRadiation

I-Epigallocatechin-3-gallate (EGCG) yi-flavonoid / flavan-3-ol eneempawu ezinamandla zokulwa ne-antioxidant kunye ne-anti-inflammatory. Isetyenziselwa ukunciphisa umngcipheko wee-cancer ezithile kunye nokunciphisa iziphumo ezithile zechemotherapy. Sesinye sezona zithako zininzi zifumaneka kwiti eluhlaza kwaye ikwafumaneka kumhlophe, kwi-oolong, nakwiitayi ezimnyama.

Kwisigaba sesibini sonyango esenziwe yiShandong Cancer Hospital kunye neZiko lase China, idatha kwizigulana ezingama-51 zibandakanyiwe, apho izigulana ezingama-22 zafumana unyango olufanayo lwe-chemoradiation (izigulana ezili-14 zaphathwa nge-docetaxel + cisplatin elandelwa yi-radiotherapy kunye ne-8 nge-fluorouracil + cisplatin elandelwa yi-radiotherapy) kunye nezigulana ezingama-29 zafumana unyango ngemitha. Abaguli babejongwa ngeveki nge-radiation esophagitis (i-ARIE). (Xiaoling Li okqhubekayo, Ijenali yokutya kweyeza, i-2019).

Uphononongo lufumanise ukuba ukongezwa kwe-EGCG kunciphise i-esophagitis / ukuginya ubunzima kwizigulana ezinomhlaza wokunyanga ophathwa ngonyango lwe-radiation ngaphandle kokuchaphazela kakubi ukusebenza konyango lwemitha. 

Iipropathi zokulwa nomhlaza ze-Apigenin

I-Apigenin ifumaneka ngokwendalo kwiintlobo ngeentlobo zemifuno, imifuno kunye neziqhamo kubandakanya iseleri, itswele, iidiliya, iidiliya, iiapile, i-chamomile, i-spearmint, i-basil, i-oregano. I-Apigenin ineempawu zokulwa ne-antioxidant kunye ne-anti-inflammatory kunye ne-antibacterial properties. Izifundo ezahlukeneyo zangaphambi kweklinikhi ezenziwe kwiintlobo ezahlukeneyo zomhlaza weseli kunye neemodeli zezilwanyana zisebenzisa i-Apigenin zikwabonakalisile iziphumo zokulwa nomhlaza. I-Flavonoids efana ne-Apigenin iyanceda kumanyathelo othintelo lomhlaza ukunciphisa umngcipheko onokubakho wokukhula kwesisu kodwa iyakwazi ukusebenza ngokudibeneyo nezinye iichemotherapies ukuphucula ukusebenza kwesiyobisi (Yan okqhubekayo, Iseli Biosci., 2017).

Kwizifundo ezahlukeneyo zisebenzisa inkcubeko yeeseli kunye neemodeli zezilwanyana, i-Apigenin iphucule ukusebenza kwe-gemcitabine chemotherapy ngenye indlela enzima ukunyanga umhlaza wepancreatic (Lee SH et al, Cancer Lett., 2008; Strouch MJ et al, Pancreas, 2009). Kwesinye isifundo nge-prostate umhlaza iiseli, i-Apigenin xa idityaniswe neyeza lekhemotherapy iCisplatin iphucule kakhulu isiphumo sayo se-cytotoxic. (Erdogan S et al, Biomed Pharmacother., 2017). Ezi zifundo zibonisa ukuba i-Apigenin efunyenwe kwiziqhamo ezahlukeneyo, imifuno kunye nemifuno inamandla okulwa nomhlaza.

Iimpawu zomlo wokulwa nomhlaza we-Flavonoid kunye ne-Fiber yee-apile ezizityebi 

Ii-apula zityebile kwiindidi ze-antioxidants, kubandakanya i-flavonoids ezinje nge-quercetin kunye ne-catechin. Ama-apile nawo atyebile kwifayibha, iivithamini, kunye neeminerali, zonke ezi zinto zinceda impilo. Iimpawu ze-antioxidant zezi phytochemicals kunye nefayibha kwii-apile zinokukhusela i-DNA kumonakalo we-oxidative. Izifundo ezahlukeneyo zenziwa ukuvavanya isiphumo sokusetyenziswa kweapile enefinonoid / ivithamin / ifayibha kumngcipheko womhlaza. 

Uhlalutyo lwemeta lwezifundo ezahlukeneyo zokuqwalaselwa ezichongiweyo ngophando loncwadi kwi-PubMed, iWebhu yeSayensi kunye ne-Embase yogcino-lwazi lufumene ukuba ukusetyenziswa okuphezulu kwe-flavonoid / ivithamin / i-apula ecebileyo yefayibha yayanyaniswa nomngcipheko oncitshisiweyo wemiphunga. umhlaza.(URoberto Fabiani et al, i-Public Health Nutr., 2016) Izifundo ezimbalwa zokulawulwa kwamatyala nazo zifumene umngcipheko oncitshisiweyo we-colorectal, isifuba kunye ne-digestive tract tract cancers ngokunyuka kokusetyenziswa kwama-apula. Iipropathi ezichasene nomhlaza we-apula, nangona kunjalo, azinakubalelwa kwi-flavonoids yodwa, njengoko inokuthi ibe ngenxa yezondlo ezifana neevithamini, iiminerali kunye neefayibha. Iifibers zokutya (ezikwafumaneka kwii-apula) ziyaziwa ukunciphisa umngcipheko we-colon cancers. (Yu Ma et al, Medicine (Baltimore), 2018)

Izibonelelo zezempilo zeCranberry ezinotyebileyo zeCranberries

I-Cranberries ingumthombo olungileyo wezinto eziphilayo ezibandakanya ii-flavonoids ezinjenge-anthocyanins, iivithamini kunye ne-antioxidants kwaye banezibonelelo ezahlukeneyo zempilo. Enye yeenzuzo ezinkulu zempilo zeCranberry zokukhupha umgubo kukuba kunciphisa usulelo lomchamo (UTIs). Izibonelelo zempilo yeProanthocyanidin efumaneka kwi-cranberries zibandakanya ukuthintela ukukhula kweebhaktiriya ezibangela ukwenziwa kwamacwecwe, imingxunya kunye namanqanaba okuqala esifo seentsini. iipropathi zokulwa umhlaza.

Kuphononongo lwe-placebo oluyimfama olulawulwa kabini, abaphandi baphande izibonelelo zempilo ze-cranberries ngokuvavanya iimpembelelo zokusetyenziswa kwe-cranberry kwixabiso leprostate ethile ye-antigen (PSA) kunye namanye amanqaku kumadoda anomhlaza wesibeletho ngaphambi kwe-radical prostatectomy. (UVladimir Umfundi okqhubekayo, iBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub., 2016) Uphononongo lufumanise ukuba ukusetyenziswa kwemihla ngemihla kwesiqhamo se-cranberry esenziwe ngophungule kunciphise i-serum PSA kwizigulana ezinomhlaza wedlala lobudoda nge-22.5%. Abaphandi bagqibe kwelokuba esi sibonelelo sempilo kunokwenzeka ngenxa yeepropathi zezinto eziphilayo ze-cranberries ezilawula ukubonakaliswa kohlobo lwe-androgen-ephendula, edlala indima ebalulekileyo kuphuhliso kunye nokuqhubela phambili komhlaza webala.

isiphelo

Uphononongo olwahlukileyo lubonisa ukuba i-flavonoids inoluhlu lweenzuzo zempilo ezibandakanya ukulwa nomhlaza kwaye zifumaneka kwiindidi zokutya ezibandakanya iziqhamo (ezifana nefayibha etyebileyo. apples, iidiliya, i-cranberries, i-blueberries), imifuno (efana neetumato, izityalo ze-leguminous) kunye neziselo (ezifana neti kunye newayini ebomvu). Ukuthatha ukutya okutyebileyo kwe-flavonoid njengenxalenye yokutya kwethu kwansuku zonke kuya kuba luncedo. Nangona kunjalo, ngaphambi kokubandakanya nayiphi na izongezo ze-flavonoid okanye igxile njengenxalenye ye Ukutya kwesigulana somhlaza, Umntu kufuneka axoxe ngayo neengcali zokhathalelo lwempilo. 

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.

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