Iinkonzo kunye ne-Cons of Selenium Supplement Use in Cancer

Iimbalasane

I-Selenium, iminerali ebalulekileyo, efunyenwe ngokutya kwethu, yinxalenye yenkqubo ye-antioxidant yomzimba. Ukusetyenziswa kwe-Selenium supplement kunokuba neenzuzo zempilo ezifana nokunciphisa izehlo kunye nokufa kwabantu abaninzi umhlaza iintlobo kunye nokunciphisa iziphumo ebezingalindelekanga eziyityhefu zechemotherapy. Nangona kunjalo, amanqanaba aphezulu e-Selenium anokuba ne-downsides / side-effects njengokukhuthaza ukukhula kwethumba kunye nokusasazeka kwiintlobo ezithile zomhlaza.

Selenium

Uninzi lwezimbiwa esizityayo mihla le kwaye zibalulekile kwimisebenzi yethu esisiseko yomzimba aziviwa ngabantu. Enye yezona zimbiwa zibalulekileyo yiSelenium. I-Selenium sisondlo esibalulekileyo kwimpilo yabantu ngenxa yendima eyidlalayo ekukhuseleni umzimba ngokuchasene nomonakalo we-oxidative kunye nosulelo. Inani le-selenium efumaneka kukutya kwendalo lixhomekeke kubungakanani be-selenium ekhoyo emhlabeni ngexesha lokukhula ngoko ke iyahluka phakathi kokutya okwahlukeneyo okuvela kwimimandla eyahlukeneyo. Nangona kunjalo, umntu uhlala ekwazi ukuzalisekisa iimfuno zabo ze-selenium ngokutya amantongomane eBrazil, ukutya kwaselwandle, inyama kunye neenkozo.

Uphononongo lwamva nje lwezenzululwazi lubonise ukuba ukongeza kwiinzuzo zempilo ngokubanzi, into efana neselenium inokudlala indima entle kuyo umhlaza unyango. Kodwa njengazo zonke iimveliso zendalo, ezi zibonelelo azisebenzi kuwo onke amalungu abemi. Ke ngoko, nalu uluhlu lweenzuzo kunye neengozi zento i-selenium enokuyenza kumzimba womntu.

Izibonelelo zezeMpilo zokuSebenzisa iZongezelelo zeSelenium kwiCancer

Oku kulandelayo zezibonelelo zezempilo zeSelenium kwiCancer.

1. I-Selenium yinto ebalulekileyo yeenkqubo zokulwa ne-antioxidant emzimbeni onceda ekukhuseleni umzimba kwii-radicals zamahhala (UZoidis E, et al, Antioxidants (Basel), 2018; IBellinger FP okqhubekayo, Biochem J. 2009).

• Iiradicals zasimahla ziveliswa ziinkqubo ezahlukeneyo zemetabolic emzimbeni kwaye ziyingozi ukuba zakhiwe ngesixa esikhulu kuba zinokubangela uxinzelelo lwe-oxidative kwaye zikhokelele kuguquko lwe-DNA, ezinokuthi zikhokelele kwiziphazamiso ezahlukeneyo kubandakanya umhlaza, izifo zentliziyo, ukungasebenzi komzimba kunye nokuphazamiseka kwemithambo-luvo.

2. Ukusetyenziswa kwe-Selenium Supplement inamandla okunciphisa kakhulu iziganeko kunye nokufa kokuphindaphindiweyo umhlaza iintlobo.

• Ukongezwa kwe-200mcg / ngemini kuncitshiswe izehlo zomhlaza webala le-Prostate ngama-50%, izehlo zomhlaza wemiphunga nge-30%, kunye neziganeko zomhlaza omnyama nge-54% (Ndikhokele okqhubekayo, iNutrition kunye neCancer, 2008).

3. Izongezo zeSelenium zingakhokelela kumanqanaba osulelo asezantsi kakhulu kwizigulana ezingenaHodgkin's Lymphoma

• Olunye uphononongo lubonise ukuba iipesenti ezingama-67 zezigulana ezine-chemo zodwa zifumene usulelo kodwa ziyi-20% kuphela yezigulana ezine-chemo kunye ne-selenium ezosulelekileyo (UAsfour IA okqhubekayo, iBiol Trace Elem Res., 2006).

4. I-Selenium ibonakalise amandla okunciphisa kunye nokuchasana neziphumo ebezingalindelekanga ezinokunyangwa ngamachiza kwizigulana ezinomhlaza

• Iyakwazi ukunciphisa ichiza elithile le-chemo elibangelwe nephrotoxicity kunye noxinzelelo lomongo wethambo (U-Hu YJ okqhubekayo, BiolTrace Elem Res., 1997kunye nokunciphisa i-radiation ebangelwa yityhefu yobunzima bokuginya (dysphagia) (UBüntzel J et al, iAnticancer Res., 2010)

5. Kubantu abangafunyaniswanga ukuba banomhlaza, i-selenium inokomeleza ukhuseleko lwabo ekuphuhliseni umhlaza ngokwandisa ukusebenza kweeseli ezibulalayo zendalo (UBüntzel J et al, iAnticancer Res., 2010)

Izinto ezinokubakho ezantsi okanye iziphumo ebezingalindelekanga zeSelenium Supplement Use kuCancer

Ezi zilandelayo zezinye zeziphumo ebezingalindelekanga / ukwehla kokusebenzisa izongezo zeSelenium kwiCancer.

1. Ngokusekwe kwisigulana semfuza ngasinye kunye nohlobo lomhlaza, iSelenium inokuphikisa amayeza e-chemo kwaye incede ithumba ekukhuleni kwayo.

• Ukongezwa kwe-Selenium kubonisiwe ukuqhubela phambili amathumba e-mesothelioma (URose AH okqhubekayo, Am J Pathol., 2014)

2. Iimpuku ezondliweyo ngeSodium Selenite zikhokelele kwimetastasis egqithisileyo (ukusasazeka) kweeseli zomhlazaU-Chen YC okqhubekayo, Umhlaza we-Int J., 2013)

3. Zonke izibonelelo ezichasene nomhlaza ze-selenium zinokusebenza kuphela ukuba amanqanaba e-selenium kwisigulana sele ephantsi. Ukuxhaswa kwe-Selenium yezigulana esele zine-selenium eyaneleyo emzimbeni wazo kunokukhokelela kumngcipheko okhulayo wohlobo lwe-2 Diabetes (URayman MP okqhubekayo, Lancet. 2012)

isiphelo

Izongezo zeSelenium zineenzuzo zezempilo zombini kunye neziphumo ebezingalindelekanga. Ngelixa ukusetyenziswa kwe-selenium kunciphise izehlo kunye nokufa kwabantu abaninzi umhlaza iintlobo kunye neziphumo ebezingalindelekanga ezithile eziyityhefu ezithile zonyango lwekhemotherapies, ukugqithisela kwamanqanaba eSelenium kunokuba nee-downsides / side-effects ezifana nokukhuthaza ukukhula kwethumba kunye nokusasazeka kwiintlobo ezithile zomhlaza.

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) lolona nyango lwendalo olungcono lomhlaza kunye nokunxulumene nonyango imiphumela.

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