Iimbalasane
I-Mannitol, imveliso yendalo, isetyenziswa njenge-diuretic yokunyusa imveliso yokuchama kubantu abanesifo sezintso ezibi (iziphumo ebezingalindelekanga ze-chemo). Izifundo zonyango ziye zabonisa ukuba ukusebenzisa i-mannitol kunye ne-Cisplatin chemotherapy kunciphisa ukulimala kwezintso ze-Cisplatin, isiphumo esibi esibonwe kwisithathu sezigulana eziphathwe ngeCisplatin. Ukusetyenziswa kweMannitol kunye neCisplatin kunokuba nephroprotective.
Iimpembelelo zeCisplatin Chemotherapy
I-Cisplatin yichemotherapy esetyenziselwa ukunyanga amathumba amaninzi aqinileyo kunye nomgangatho wokhathalelo lomhlaza wesinyi, intloko kunye nentamo, iseli encinci kunye nemiphunga yeseli engeyincinci. i cancer, i-ovarian, i-cervical kunye ne-testicular cancers kunye nezinye ezininzi. I-Cisplatin iyasebenza ekupheliseni iiseli zomhlaza ngokubangela ukwanda koxinzelelo lwe-oxidative kunye nomonakalo we-DNA, ngaloo ndlela ibangela ukufa kweseli yomhlaza. Nangona kunjalo, ukusetyenziswa kweCisplatin kukwanxulunyaniswa neziphumo ebezingalindelekanga ezininzi ezingafunekiyo ezibandakanya ukuchasana nomzimba, ukugonywa okuphantsi, ukuphazamiseka kwesisu, isifo sentliziyo kunye neengxaki ezinzulu zezintso. Isinye kwisithathu sezigulana ezinyangwa ngeCisplatin zifumana ukonakala kwezintso emva konyango lokuqala.Yao X, okqhubekayo, Am J Med. Inzululwazi., 2007). Umonakalo wezintso okanye i-nephrotoxicity ebangelwa yiCisplatin iye yaqatshelwa njengesiganeko esibi esibalulekileyo (Owu, uGi-Su, et al. Electrolyte Blood Press, 2014). Esinye sezizathu eziphambili zokuba nephrotoxicity ephezulu neCisplatin kungenxa yokuba kukho ukuqokelelwa okukhulu kwesiyobisi kwizintso nto leyo ebangela ukonakala ngakumbi kwizintso.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Yintoni iMannitol?
IMannitol, ekwabizwa ngokuba siswekile yotywala, ifumaneka kwimithombo emininzi yendalo njengamakhowa, istrawberry, iseleri, itswele, amathanga kunye nolwelwe lwaselwandle. Ikwaqwalaselwa njengesithako esikhuselekileyo yi-FDA (Ukutya kunye noLawulo lweeDrug), kwaye liyinto esetyenziswa ngokubanzi kwiimveliso zonyango.
Izibonelelo / Ukusetyenziswa kweMannitol Supplements
Oku kulandelayo zezinye zeendlela eziqhelekileyo zokusetyenziswa kwemannitol:
- I-Mannitol ihlala isetyenziswa njenge-diuretic yokunyusa imveliso yokuchama kubantu abanesifo sezintso.
- IMannitol ikwasetyenziswa kumayeza amiselweyo ukunciphisa uxinzelelo kunye nokudumba kwingqondo.
- I-Mannitol inokunceda ukuphucula ukulawulwa kweswekile yegazi
Iziphumo ebezingalindelekanga zeziNcedisi zeMannitol
Ezi zilandelayo zezinye zeziphumo ebezingalindelekanga zesongezelelo se-mannitol:
- Ukuchama rhoqo
- Ukongeza kwenani lentliziyo
- Intloko
- Utywala
- emzimbeni
IMannitol yeCisplatin Chemo Iziphumo ebezingalunganga- Ukonzakala kwezintso
Enye indlela yokunciphisa iziphumo ebezingalindelekanga ze-chemo njenge-nephrotoxicity, xa inyangwa ngeCisplatin, ethe yavavanywa ngokwezonyango isebenzisa iMannitol kunye neCisplatin chemotherapy.
Kukho izifundo ezininzi apho kuvavanye isiphumo sokusetyenziswa kweMannitol kunye neCisplatin chemotherapy kwi-nephrotoxicity (chemo side-effect) yokumakisha njengamanqanaba e-serum creatinine:
- Uphononongo olwenziwayo oluvela kwiYunivesithi yaseMinnesota Health-Fairview inkqubo yahlalutya izigulane ze-313 eziphathwe nge-Cisplatin (i-95 iphathwe nge-mannitol kunye ne-218 ngaphandle), yafumanisa ukuba iqela elisebenzisayo i-Mannitol linomlinganiselo ophantsi wokunyuka kwinqanaba le-serum creatinine kuneqela elingazange lisebenzise. IMannitol. I-Nephrotoxicity yenzeke ngaphantsi kwezigulane ezifumana i-Mannitol kunezo zingazange - 6-8% kunye neMannitol vs. 17-23% ngaphandle kweMannitol (UWilliam RP Jr okqhubekayo, J Oncol Pharm Pract., 2017).
- Olunye uphononongo oluvela kwiYunivesithi yaseEmory lubandakanya ukuphononongwa kwetshathi yazo zonke izigulana ezifumana i-cisplatin ngemitha efanayo ye-squamous cell carcinoma yentloko nentamo. Uhlalutyo lwedatha kwizigulana ezili-139 (i-88 eneMannitol kunye ne-51 ene-saline yodwa) ibonakalise ukuba iqela leMannitol lalinyuke kancinci kwi-serum creatinine ebonisa nephrotoxicity esezantsi (UMcKibbin T okqhubekayo, Inkxaso kwiCancer Care, 2016).
- Isifundo esisodwa seziko esivela kwisibhedlele saseRigshospitalet kunye nesibhedlele saseHerlev, eDenmark, saqinisekisa iziphumo ze-nephroprotective zokusetyenziswa kweMannitol entloko nasentanyeni. umhlaza izigulane ezifumana unyango lwe-cisplatin kwiqela lezigulane ezingama-78 (IHagerstrom E, et al. Iiklinikhi zeMed Insights i-Oncol., 2019).
isiphelo
Ubungqina beklinikhi obungasentla buyakuxhasa ukusetyenziswa kwento ekhuselekileyo, yendalo njengemannitol, ukunciphisa i-cisplatin-induced ebalulekileyo kunye nesiphumo esibi se-nephrotoxicity umhlaza izigulane.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.