Iimbalasane
Uphononongo oluninzi lubonisa ukuba ukutya rhoqo ukutya okuneswekile eninzi kunokubangela okanye ukondla umhlaza. Olunye uphando lubonisa ukuba iswekile yokutya ephezulu (ukusuka kwi-beet yeswekile) ukusetyenziswa kunokuphazamisa iziphumo ezithile zonyango kwiintlobo ezithile zomhlaza. Iqela lophando liye lafumanisa iindlela zeselula kunye neendlela ezidibanisa amanqanaba aphezulu eshukela egazi afunyenwe kwisifo seswekile ekwandiseni umonakalo we-DNA, ngokwenza i-adducts ye-DNA (ukuguqulwa kweekhemikhali ze-DNA), ezibangela ukuguquka, isizathu esibangela umhlaza. Ke ngoko, abaguli abanomhlaza kufuneka bakuphephe ukutya rhoqo iswekile exineneyo. Nangona kunjalo, ukusika iswekile ngokupheleleyo ekutyeni kwethu akusiso isisombululo njengoko kushiya iiseli eziphilileyo ziphantsi kwamandla! Ukugcina indlela yokuphila ngokutya okunempilo kunye nokutya okuncitshisiweyo kweswekile (umzekelo: ukusuka kwi-sugar beet) kunye nokunyuka komsebenzi womzimba kunokunceda ekunciphiseni umngcipheko womhlaza okanye ukuyeka ukutya. umhlaza.
"Ngaba Iswekile Yondla Umhlaza?" “Ngaba Iswekile Inokubangela Umhlaza?” “Ngaba kufuneka ndinqumle iswekile ngokupheleleyo kwindlela enditya ngayo ukuze ndiyeke ukondla umhlaza wam?” "Ngaba abaguli abanomhlaza kufuneka bayiphephe iswekile?"
Le yeminye yemibuzo edla ngokuphendla kwi-intanethi iminyaka emininzi. Ngoko ke, zithini iimpendulo zale mibuzo? Kukho iinkcukacha ezininzi eziphikisanayo kunye neentsomi malunga noshukela kunye nomhlaza kwindawo yoluntu. Oku kuba yinkxalabo kwizigulane ezinomhlaza kunye neentsapho zabo ngelixa besenza isigqibo malunga nokutya kwezigulane. Kule bhlog, siya kushwankathela oko kuthethwa zizifundo malunga nokuxhamla phakathi kweswekile kunye umhlaza kunye neendlela zokubandakanya umlinganiselo ofanelekileyo weswekile njengenxalenye yokutya okunempilo.
Iswekile kunye noMhlaza
Iswekile ikho kuninzi lokutya esikuthatha mihla le kwifom enye okanye enye. I-Sucrose lolona hlobo luxhaphakileyo lweswekile esihlala silongeza kukutya kwethu njengeswekile yetafile. Itafile yeswekile iyenziwa okanye icoceke ifom ye-sucrose ekhutshwe kwizikhondo zezityalo zeswekile okanye i-beet yeswekile. I-Sucrose ikwafumaneka nakokunye ukutya kwendalo kubandakanya ubusi, iswekile yemaple sap kunye nemihla kodwa kufunyenwe ukuba ifumaneka ngeyona ndlela kugxilwe kuyo kummoba nakwiswekile. I-Sucrose incasa kamnandi kune-glucose, kodwa incinci kune-fructose. UFructose ukwaziwa ngokuba "sisiqhamo seswekile" kwaye ubukhulu becala sifumaneka kwiziqhamo. Ukongeza iswekile eninzi ecoliweyo ekhutshwe kwii-beet zeswekile kunye neeswekile akunampilo.
Iiseli zomzimba wethu zifuna amandla ukukhula nokukhula kwazo. Iswekile ngumthombo ophambili wamandla kwiiseli zethu. Uninzi lwecarbohydrate kunye neswekile yokutya okutyiwayo esikuthatha njengenxalenye yokutya kwethu kwemihla ngemihla okufana neenkozo kunye neenkozo, imifuno enesitatshi, iziqhamo, ubisi kunye neswekile yetafile (ekhutshwe kwiswekile beet) iyaqhekeka iswekile / iswekile yegazi emzimbeni wethu. Njengokuba iseli esempilweni ifuna amandla ukuze ikhule kwaye iphile, iiseli zomhlaza ezikhula ngokukhawuleza zifuna amandla amaninzi.
Iiseli zomhlaza zikhupha la mandla kwigazi leswekile / iswekile eyenziwe kwi-carbohydrate okanye kukutya okusekwe kwiswekile / kukutya. Ukusetyenziswa kakhulu kweswekile kunyuke ngokukhawuleza kwihlabathi liphela. Oku kunegalelo elibonakalayo ekutyebeni kakhulu kunye nokutyeba kakhulu okunokuqhuba nomhlaza. Ngapha koko, ukutyeba kakhulu sesinye sezona zinto ziphambili zomngcipheko womhlaza Umbuzo wokuba iswekile iyondla okanye ibangela umhlaza uvela koku.
Izifundo ezahlukeneyo / uhlalutyo lwenziwe ngabaphandi kwihlabathi liphela ukuvavanya umanyano phakathi kokusetyenziswa kokutya okuneswekile okuninzi okunje ngeziselo ezinencasa kunye nomngcipheko womhlaza. Iziphumo zophando oluninzi zidityaniswe apha ngezantsi. Makhe sibone ukuba zithini iingcali!
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Ngaba ukuthatha iziselo ezineswekile kunye nokutya kungabangela / kunesifo somhlaza?
Umbutho wokuSetyenziswa kweziselo eziShukela kunye nomngcipheko womhlaza webele
Uhlalutyo lwe-meta lwakutsha nje olusebenzise idatha evela kwiFrench NutriNet-Santé cohort Study ebandakanya abathathi-nxaxheba be-1,01,257 abaneminyaka eyi-18 nangaphezulu. Uphononongo luvavanye umanyano phakathi kokusetyenziswa kweziselo ezineswekile ezinjengeeswekile ezinotywala kunye ne-100% yeencindi zeziqhamo, kunye neziselo ezenziwe ngobumnandi kunye nomhlaza osekwe kwidatha yemibuzo esekwe. (IChazelas E okqhubekayo, BMJ., 2019)
Uphononongo lucebise ukuba abo banesiselo esandayo sokusela iziselo ezineswekile bangama-18% amathuba okuphuhlisa umhlaza jikelele kunye neepesenti ezingama-22 amathuba okuba nomhlaza webele xa kuthelekiswa nabo bangakhange basebenzise iziselo ezineswekile. Nangona kunjalo, abaphandi bacebisa ngakumbi ukuba kwenziwe izifundo ezinokwenzeka zokuseka lo mbutho.
Uphononongo olufanayo lwenziwa kuvavanyo lwedatha ukusuka kuma-10,713 aneminyaka ephakathi, abantu baseSpain ababhinqileyo abavela eSeguimiento Universidad de Navarra (SUN) isifundo seqela elineminyaka yobudala engama-33, ababengenayo imbali yomhlaza wamabele. Uphononongo luvavanye umanyano phakathi kokusetyenziswa kweswekile-iziselo ezinencasa kunye neziganeko zomhlaza wamabele. Emva kokulandelwa kweminyaka eli-10, 100 zezehlo zomhlaza wamabele zaxelwa. (I-Romanos-Nanclares A et al, i-Eur J Nutriti., 2019)
Olu phononongo lufumanise ukuba xa kuthelekiswa no-zero okanye kunqabile ukusetyenziswa kwesiselo esinxilisayo, ukusetyenziswa rhoqo kweswekile ezinotywala kunokudityaniswa neziganeko eziphezulu zomhlaza wamabele, ngakumbi kubafazi abasemva kwemiphunga. Baye bafumanisa ukuba kwakungekho nxulumana phakathi kokutya iziselo ezineswekile kunye nesifo somhlaza wamabele kwizigulo zangaphambi kokuya exesheni. Nangona kunjalo, abaphandi bacebise ukuba kwenziwe izifundo ezikhulu ezenzelwe ukuxhasa ezi ziphumo. Ngayiphi na imeko, kungcono ukuba izigulana ezinomhlaza zithintele ukusela rhoqo, ukutya okuneswekile eninzi.
Umbutho wokuSetyenziswa kweeSuars ezijolise kwiZifo zeCancer Prostate
Uphononongo lwamva nje luhlalutye idatha yamadoda angama-22,720 avela kwiProstate, Lung, Colorectal, kunye ne-Ovarian (PLCO) Isilingo sovavanyo lomhlaza ababhalise phakathi kwe-1993-2001. umngcipheko womhlaza. Emva kokulandelwa okuphakathi kweminyaka eli-9, amadoda angama-1996 afunyaniswa enesifo somhlaza webele. (Miles FL okqhubekayo, Br J Nutriti., 2018)
Uphononongo lufumanise ukuba ukwanda kokusetyenziswa kweswekile kwiziselo ezineswekile zinxulunyaniswa nomngcipheko owandayo womhlaza wamadlala emadodeni athe atya amanqanaba aphezulu eswekile. Uphononongo lucebise ukuba ukunciphisa umyinge weswekile kwiziselo kunokuba kubalulekile ekunciphiseni umngcipheko womhlaza webele. Izigulana ezinomhlaza wamatyambo kusenokufuneka ziphephe ukutya kakhulu iswekile.
Umanyano lweSwekile yokuTya kunye noMhlaza wePancreatic
Uphononongo lwamva nje lwenze uhlalutyo olufanayo kusetyenziswa idatha esekwe kwimibuzo evela kubathathi-nxaxheba abangama-477,199 ababandakanyiwe kuphando lwaseYurophu olujolise kuphando lweCancer and Nutrition cohort, uninzi lwabo yayingabafazi abaneminyaka yobudala engama-51. Ngexesha lokulandela iminyaka eyi-11.6, i-865 yomhlaza wepancreatic yaxelwa. (Navarrete-Muñoz EM okqhubekayo, Am J Clin Nutr. 2016)
Ngokungafaniyo nesifundo sangaphambili, olu phononongo lufumanise ukuba isiselo esipheleleyo sokusela isenokungadibani nomngcipheko wepancreatic cancer. Uphononongo lufumanise ukuba incindi kunye nokusetyenziswa kwencindi kunokunxulunyaniswa nokwehla kancinci komngcipheko womhlaza wepancreatic. Izigulana ezinomhlaza wepancreatic kungafuneka zithintele ukusela kakhulu kwiziselo ezineswekile egxile kakhulu.
Umbutho wamanqanaba eswekile yeGazi ePhakamileyo kunye neziPhumo zoNyango kwizigulana ezinomhlaza weColorectal
Kuphononongo olwenziwe ngabaphandi baseTaiwan, bahlalutya idatha ukusuka kwisigaba se-157 senqanaba lesithathu sezigulana ezinomhlaza ezahlelwa ngokwamaqela ama-2 ngokwamanqanaba eswekile yegazi- elinye iqela elinamanqanaba eswekile yegazi ⩾126 mg / dl kunye nelinye ngegazi amanqanaba eswekile <126 mg / dl. Isifundo sithelekise iziphumo zokusinda kunye nokunyanga kwe-oxaliplatin kunyango kula maqela mabini. Baye benza nezifundo ze-vitro ukuvavanya ifuthe leziyobisi ezichaseneyo nesifo seswekile ekwandeni kweseli emva kokuhambisa iswekile. (Yang IP okqhubekayo, Ther Adv Med Oncol., 2019)
Ukongezwa kweGlucose kwandise ukwanda kweseli yomhlaza kwi-vitro. Ikwabonakalise ukuba ukulawulwa kwesiyobisi esichasene nesifo seswekile esibizwa ngokuba yi-metformin kunokuguqula ukwanda kweseli kunye nokwandisa ubuntununtunu bonyango lwe-oxaliplatin. Uphononongo kumaqela amabini ezigulana acebise ukuba iswekile ephezulu yegazi inokunxulunyaniswa neziganeko eziphezulu zokuphinda ubuye esi sifo. Baye bagqiba kwelokuba abaguli abanesifo somhlaza esinqanaba lesithathu kunye namanqanaba eswekile yegazi aphezulu anokubonakalisa ukungalunganga kwaye banokukhulisa ukunganyangeki kunyango lwe-oxaliplatin ngexesha elifutshane.
Iziphumo ezivela kolu phononongo zibonisa ukuba iswekile ephezulu yegazi inokuchaphazela iziphumo zonyango lwe-oxaliplatin kwizigulana ezinomhlaza weColorectal. Yiyo loo nto izigulana ezinomhlaza ongalunganga ezifumana olu nyango kungafuneka zithintele ukutya okuneswekile egxile kakhulu.
Nguwuphi umanyano phakathi kweswekile kunye nomhlaza?
Isifo seswekile ngubhubhane wehlabathi onabantu abangaphezu kwezigidi ezingama-30 baseMelika nangaphezulu kwezigidi ezingama-400 zabantu abachaphazeleka sesi sifo. Ngokwentlangano yezempilo yehlabathi, ukuxhaphaka kwesifo seswekile kuyanda ngokukhawuleza kumazwe asezantsi anengeniso ephakathi, le meko inxulunyaniswa nokutya okungenampilo, ukunqongophala kwemisebenzi yomzimba kunye nokutyeba kakhulu. Kukho izifundo ezininzi kunye nohlalutyo lwe-meta olubonisa unxibelelwano olomeleleyo phakathi kweswekile kunye nokwanda komngcipheko womhlaza, kodwa bekusoloko kungacacanga ukuba kutheni le nto kunjalo. Ugqirha John Termini kunye neqela lakhe abavela kwisiXeko seThemba, iziko lophando lomhlaza eCarlifonia, baphonononge lo mbutho kwaye bakwazi ukudibanisa i-hyperglycemia (inqanaba leswekile ephezulu) kumonakalo we-DNA, unobangela ophambili wokukhula kweenguqu ezinokukhokelela kumhlaza. UGqr Termini wazisa iziphumo zakhe kunyaka ophelileyo kwintlanganiso ye-2019 American Chemical Society.
Phambi kokuba singene kule mpumelelo ingakholelekiyo, kufuneka sifumane ukuqonda okusisiseko kwamagama asisiseko kunye nemisebenzi ukuze sikuqonde ngokupheleleyo ukubaluleka kophando lukaGqr Termini. Njengabantu, sifumana amandla ekufuneka imizimba yethu isebenze ngokutya ukutya, okuthi xa kusophulwe, kukhuphe iswekile okanye iswekile yegazi emzimbeni. Nangona kunjalo, ukuze umzimba uguqule le glucose ibe ngamandla, isebenzisa i-insulin, ihomoni eveliswe kwi-pancreas, ukufumana iswekile ifunxwe ziiseli kunye nezicubu zomzimba. Abantu abafunyaniswe ukuba banesifo seswekile banamanqanaba asezantsi e-insulin kunye nobuntununtunu emzimbeni wabo, nto leyo ekhokelela ekubeni iswekile eninzi ihlale egazini, eyaziwa njenge-hyperglycemia kwaye inokukhokelela kwingxaki ezininzi zempilo. Olunye uluvo lokuba uqonde kukuba umhlaza ubangelwa kukutshintsha kweeseli ngenxa yomonakalo we-DNA, okhokelela kukungalawulwa nokungalawulwa kwesahlulo seseli esasazeka emzimbeni.
Isishwankathelo seziphumo zikaGqr Termini kunye nemiboniso kwinqaku le-ASCO (American Society of Clinical Oncology) Intatheli yeposi, uCaroline Helwick, uHelwick ubhala ukuba uGqr Termini kunye noogxa bakhe bafumene “ukuba iswekile ephezulu yonyusa ubukho beDNA. IDNA enokunyanzeliswa ukuba iphelele ”(IHelwick C, i-ASCO Post, i-2019). Iqela lifumene ukuba amanqanaba aphezulu e-glucose yegazi ayinakukwenza kuphela oku kuguqulwa kweekhemikhali zeDNA (i-DNA Addics) kodwa nokuthintela ukulungiswa kwazo. I-DNA adducts inokukhokelela kwi-miscoding DNA ngexesha lokuphindaphinda okanye ukuguqulelwa kwiiprotheni (ezikhokelela kwiinguqu ze-DNA), okanye zide zibangele ikhefu le-strand eliphazamisa yonke i-architecture ye-DNA. Inkqubo yokulungiswa kwe-DNA yendalo ekufanele ilungise naziphi na iimpazamo kwi-DNA ngexesha lokuphindaphinda kwe-DNA, iphinde iphazamiseke kukwenziwa kwee-adducts ze-DNA. UGqr Termini kunye neqela lakhe baye bachonga i-adduct kunye neeprotheni ezibandakanyeka ngokuthe ngqo kwinkqubo ngenxa yokunyuka kwe-glucose egazini. Ukuqonda okuqhelekileyo kwanda umhlaza Umngcipheko kwisifo seswekile wawunxulunyaniswa nokungasebenzi kakuhle kwehomoni, kodwa uphando lukaGqr Termini luchaza indlela ukungasebenzi kakuhle kwehomoni ekhokelela kukungalingani kweglucose kunye namanqanaba aphezulu eswekile / iswekile egazini abangela umonakalo weDNA onyuse umngcipheko womhlaza kubantu abanesifo seswekile.
Inyathelo elilandelayo, abaphandi abohlukeneyo esele beqalisile ukusebenza kulo, yindlela yokusebenzisa olu lwazi lokuphumelela ukunciphisa kakhulu umhlaza kumazinga ehlabathi. "Kwithiyori, iyeza elinciphisa amanqanaba eswekile linokunceda ekulweni umhlaza" ngokulambisa "iiseli ezinobungozi zife" (Helwick C, ASCO Post, 2019). I-Termini kunye nabanye abaphandi abaninzi baphonononga iziphumo ezichasene nomhlaza kwichiza lesifo seswekile elisetyenziswa kakhulu ekuthiwa yi-metformin, esetyenziselwa ukulawula nokuthoba amanqanaba eswekile yegazi. Izifundo ezininzi zovavanyo kwiimodeli ezininzi zomhlaza zibonise ukuba i-metformin inesakhono sokulawula iindlela ezithile zeselula eziqhuba ukulungiswa kwe-DNA.
Zithini ezi zifundo- ngaba iswekile ibangela okanye ityisa umhlaza?
Kukho idatha ephikisanayo malunga nobudlelwane phakathi kokutya kokutya kweswekile kunye nomngcipheko womhlaza. Nangona kunjalo, uninzi lophononongo lubonisa ukuba ukusetyenziswa kweswekile kwimiyinge ethintelweyo akunakubangela / ukondla umhlaza. Olu phononongo lukwaqaqambisa ukuba ukutya rhoqo okuneswekile eninzi kunokunyusa iswekile yegazi ukuya kwinqanaba eliphezulu kakhulu okukhokelela ekutyebeni okugqithisileyo kunye nokutyeba akusempilweni kwaye kunokunyusa umngcipheko womhlaza. Ukutya rhoqo ukutya okuneswekile okugxininiswe kakhulu (kuquka iswekile etafileni evela kwibhiti yeswekile) kunokubangela/ukutya umhlaza. Olunye uphando lukwabonisa ukuba ukusetyenziswa kokutya okuneswekile ephezulu kunokuphazamisa iziphumo ezithile zonyango ngokuthe ngqo umhlaza iintlobo.
Ngaba kufuneka sinqumle iswekile ngokupheleleyo kukutya kwethu ukukhusela umhlaza?
Ukusika zonke iintlobo zeswekile ekudleni kunokuba yindlela efanelekileyo yokuthintela umhlaza, njengoko iiseli eziqhelekileyo ezisempilweni zifuna amandla ukuze zikhule kwaye zisinde. Nangona kunjalo, ukugcina itsheki koku kulandelayo kunokusinceda sihlale sisempilweni!
- Kuphephe ukutya rhoqo iswekile eneswekile, iziselo ezineswekile eneswekile, iziselo ezineswekile eninzi ezibandakanya iziselo ezithile kunye nokusela amanzi amaninzi.
- Thatha nje izixa ezifanelekileyo zeswekile njengenxalenye yokutya kwethu ngokuba neziqhamo ezipheleleyo endaweni yokongeza ngokwahlukeneyo itafile yeswekile (ekhutshwe kwiswekile yesithombo sebhitrudi) okanye ezinye iintlobo zeswekile kukutya kwethu. Thintela umyinge weswekile yetafile (osuka kwi-beet yeswekile) kwiziselo zakho ezinje ngeti, ikofu, ubisi, ijusi yelime njalo njalo.
- Ukunciphisa ukusetyenziswa kokutya okwenziweyo kunye neziqhamo kunye nemifuno.
- Gwema ukutya okuneswekile kunye nokutya okunamafutha kwaye ugcine itsheki kubunzima bakho, kuba ukutyeba yenye yezona zinto zibangela umhlaza.
- Thatha isondlo somhlaza somntu esixhasa unyango lwakho kunye umhlaza.
- Kunye nokutya okusempilweni, yenza umthambo rhoqo ukuze uhlale usempilweni kwaye uphephe ukutyeba.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.