Iimbalasane
Iimveliso zendalo / izongezo zokutya xa zikhethwe ngokwesayensi zinokuzuza kwaye zincedisane neempendulo ze-chemo kumhlaza othile ngeendlela ezininzi ezibandakanya: ukuqinisa iindlela zokuva amachiza, ukuthintela iindlela zokuchasa ichiza kunye nokuphucula i-bioavailability yeziyobisi. Ukongezelela, umntu kufuneka akuphephe ukuthatha nayiphi na imveliso yeNdalo / izongezo zokutya ezisebenzisana ne-chemotherapy (i-chemo) ngelixa ufumana unyango lokulwa nomhlaza. Ke, iimveliso zendalo ezikhethiweyo ngokwesayensi / izongezo zokutya zinokuzuza impendulo ye-chemo ngaphandle kokunyusa umthwalo wetyhefu umhlaza. Kuphephe ukusetyenziswa ngokungakhethiyo kweemveliso zendalo kunye ne-chemo ukuze uhlale kude nokunxibelelana okungafunekiyo.
Iimveliso zeNdalo / izincedisi kunye neChemo
Ngaba azininzi iziyobisi ezivela kwizityalo? -Ngokuphononongwa ngo-2016, ukusukela kwiminyaka yoo-1940 ukuya kowama-2014, kumachiza omhlaza ali-175 avunyiweyo ngelixesha, ama-85 (49%) yayiziimveliso zendalo okanye zivela ngqo kwizityalo (INewman kunye neCragg, J Nat. Ukuvelisa., 2016).
Ngeziphumo ebezingalindelekanga ezaziwayo ze-chemotherapy, umhlaza Izigulana zihlala zijonge iindlela ezongezelelweyo zokuphucula impilo yazo kunye nokuthatha ichemotherapy emiselweyo. Kukho umdla ohlaziyiweyo ekusetyenzisweni kwemveliso yezityalo njengeyeza njengenye indlela, ekhuselekileyo nengenatyhefu kunye nechemotherapy eqhelekileyo (iyeza lendalo lomhlaza). Kwaye ngaphandle kwento yokuba kukho inani elikhulu lovavanyo kunye nezifundo zeklinikhi zeemveliso ezahlukeneyo zendalo / izongezo zokutya kunye nokusetyenziswa kwazo ngokubanzi kumayeza esintu, abantu kunye namanye amayeza, kukho ukungakholelwa ngokubanzi phakathi koogqirha kunye noogqirha malunga nokusetyenziswa kwabo kunye neenzuzo. Izimvo zisukela ekuthandabuzeni okupheleleyo kwaye oku kungahambisani nenzululwazi kwaye kudidi lwe-oyile yenyoka, ukuya kwiziphumo zabo ngokuba yi-placebo okanye ingabalulekanga ukucebisa ukusetyenziswa kwazo.
Nangona kunjalo, uphononongo luhlalutye idatha yovavanyo kunyango olusebenzayo lweemveliso ze-anticancer zendalo ezingama-650 xa kuthelekiswa namachiza angama-88 avunyiweyo okulwa umhlaza kwaye kwafunyaniswa ukuba iipesenti ezingama-25 zeemveliso zendalo zinefuthe lonyango olufanayo nenqanaba lamandla eziyobisi kunye nenye i-33% yeemveliso zendalo zazingaphakathi kuluhlu oluphindwe kalishumi kwinqanaba leepotency zamachiza (UQin C okqhubekayo, PLoS One., 2012). Olu datha lubonisa ukuba uninzi lweemveliso zendalo / izongezo ngeendlela zazo ezahlukeneyo zokusasaza ngokusebenzisa iithagethi ezininzi kunye neendlela zendlela yokusebenza efanayo kunyango lweziyobisi ze-anticancer eziphandwe kakhulu kwaye zavavanywa ngeendlela ezithile. Amachiza avunyiweyo anemithwalo ephezulu yetyhefu engenakho ukubakho kwiimveliso zendalo ngenxa yendlela ebanzi neyasasazeka ngakumbi yokusebenza, kungoko ukuxhasa i-chemotherapy ukuba ikhethwe ngokwesayensi.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Zisinceda njani iimveliso zeNdalo okanye iziXhobo zokuTya ekuPhenduleni ngeChemo kwiCancer?
Ukuchongwa kweyona mveliso ilungileyo yendalo okanye izongezo zokutya oza kuzithatha ngexesha le-chemotherapy (chemo) kubaluleke kakhulu. Ezona ndlela zine ziphambili apho iimveliso zendalo okanye izongezo zokutya ezikhethwe ngokwenzululwazi zinokuxhamla kwaye zincede i-chemotherapy zezi:
- Ngokwandisa i-chemotherapy bioavailability kwiseli, kwindawo yokusebenza: Amachiza amaninzi ayathuthwa kwaye anokumpontshelwa ngaphandle kweseli ngeeproteni ezithile zothutho lwamachiza. Iimveliso zendalo xa zikhethwe ngokuchanekileyo zinokunceda ekuthinteleni ukuthunyelwa ngaphandle kweziyobisi kunye nokwandisa ukungenisa kweziyobisi kwiseli yomhlaza, ngaloo ndlela zenza ukuba ichemotherapy ibe ngaphakathi umhlaza iseli elide, ukwenza umsebenzi wayo wokubulala iseli yomhlaza.
- Ngokwandisa iindlela zokwenza i-chemotherapy sensitizing pathways: Amachiza aneendlela ezithile ezenziwayo zokuthintela okanye zokuvula ii-enzymes ezithile okanye iindlela zomnatha weseli yomhlaza. Iimveliso ezikhethwe ngokufanelekileyo zendalo zinokuba nefuthe elongezelelekileyo kwizenzo zazo ekujolise kuzo ezininzi ukumodareyitha abalawuli abaninzi, amahlakani kunye neziphumo zethagethi ephambili yekhemotherapy ethile.
- Ngokunciphisa i-chemotherapy yokukhusela okanye ukumelana neyeza: Iseli lomhlaza lifunda ukuphepha uhlaselo lwe-chemotherapy ngokwenza iindlela ezihambelanayo zokusinda ezithintela ukuba i-chemotherapy isebenze. Iimveliso zendalo zinokukhethwa ngokusekwe kukuqonda kweendlela ezichaseneyo zekhemotherapy ezahlukeneyo ukunqanda ezi ndlela kunye nokuphucula impendulo.
- Ngokuthintela nakuphi na ukongezwa kokutya-i-chemotherapy (chemo) yokunxibelelana ngexesha lonyango: Iimveliso zendalo / izongezo zokutya ezifana neTurmeric / Curcumin, iti eluhlaza, isicatshulwa segalikhi, iSt John's wort yaziwa ngokuba namandla okulwa nomhlaza. Yiyo loo nto zisetyenziswa ngokungekho mthethweni ukunyusa isiphumo se-chemotherapy kunye nokoyisa isiphumo setyhefu. (NCBI) Enye yezinto ezixhalabisayo ngokusetyenziswa ngokungakhethiyo kweemveliso zeNdalo / isongezelelo sokutya kukuba inokuphazamisana nesiphumo sonyango lweChemotherapy yokulwa ne umhlaza iiseli. Iimveliso zendalo / isongezelelo sokutya siphazamisa idosi yechemotherapy ngokuguqula ukufunxa. I-supplement inokunxibelelana ne-chemotherapy ngokusebenzisa i-supplement-drugs (CYP) indlela yokusebenzisana. Ezinye zentsebenziswano ezaziwayo-kakuhle zezongezelelo zezi:
- Icandelo leti eluhlaza (i-Epigallocatechin gallate) linxibelelana ne-chemotherapies ezinjengeBortezomib kunye ne-fluorouracil. (UJinping Qiao okqhubekayo, Ukutya Chem Toxicol., 2011; Ukudibanisa iB Igolide okqhubekayo, Igazi., 2009)
- I-St. John's wort inciphisa ukubakho kwe-Imatinib kunye ne-Irinotecan. (UReginald F Frye okqhubekayo, kwiKlinikhi ye-Pharmacol Ther., 2004; URon HJ Mathijssen okqhubekayo, J Natl Cancer Inst., 2002)
- Ukutya okanye ukongezwa kokutya I-Turmeric kufuneka ithintelwe ngelixa ikwi-Doxorubicin kunye neCyclophosphamide unyango njengoko inciphisa amandla abo okulwa nomhlaza wamabele. (USivagurunathan Somasundaram okqhubekayo, iCancer Res. 2002)
isiphelo
Ngazo naziphi na izenzo ezincedisayo, izenzo ezichasayo okanye ngokuphakamisa i-intracellular bioavailability ye-chemotherapy okanye ukuphepha nayiphi na intsebenziswano kunye ne-chemotherapy, iimveliso zendalo ezikhethiweyo okanye izongezo zokutya zinganceda ukuphucula iimpendulo ze-chemotherapy ngaphandle kokunyusa umthwalo wesifo somhlaza. Yiyo loo nto ukuba nolwazi lokuba loluphi uncedo oluza kuthatha okanye ukunqanda ngexesha le-chemotherapy kubaluleke kakhulu ekwandiseni amandla okulwa nomhlaza we-chemotherapy (chemo). Ukusetyenziswa okungahleliwe kwayo nayiphi na imveliso yendalo kufuneka ithintelwe njengoko inokuba yingozi kwaye inokuphazamisa i-chemotherapy.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ngokusekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye ukhetho olungakhethiyoOlona nyango lwendalo olulungileyo lomhlaza kunye neziphumo ebezingalindelekanga zonyango.