Nā Meaʻai Soy a me ka maʻi ʻaʻai umauma

o ka Naauao

ʻO nā meaʻai soya nā kumu meaʻai nui o nā isoflavones e like me genistein, daidzein a me glycitein, e hana ana ma ke ʻano he phytoestrogens (nā mea kanu i hoʻokumu ʻia me ke ʻano like me ka estrogen). Nui maʻi ʻaʻai umauma he estrogen receptor (hormone receptor) maikaʻi a no laila hopohopo paha kekahi inā pili ka ʻai ʻana i nā meaʻai soya me ka piʻi nui ʻana o ka maʻi kanesa o ka umauma. Hōʻuluʻulu kēia blog i nā haʻawina like ʻole e loiloi ana i ka pilina ma waena o ka ʻai soy a me ka maʻi maʻi umauma. Hōʻike nā ʻike o kēia mau haʻawina ʻo ka ʻai ʻana i nā meaʻai soy i ka nui haʻahaʻa ʻaʻole e hoʻonui i ka pilikia o ka maʻi kanesa o ka umauma, akā ʻaʻole paha he koho palekana ka lawe ʻana i nā meaʻai soy.

Ua lilo kahi mea ʻai soya i ʻāpana o ka ʻaina ʻĀkia kuʻuna mai nā makahiki he nui a ua loaʻa i nā huahana soy ka kaulana a puni ka honua. Ma muli o ka nui o ka protein i loko, hoʻohana ʻia nā huahana soy ma ke ʻano he analogue olakino no kaʻiʻo a me nā hopena nutritional maʻamau no nā mea kanu. ʻO nā ʻano ʻano like ʻole o ka meaʻai soya me nā meaʻai soya ʻole ʻole e like me ka soybeans holoʻokoʻa, tofu, edamame a me ka waiū soy a me nā huahana soy fermented e like me ka soy sauce, fermented bean paste, miso, nattō, a me tempeh. 

Eia kekahi, ʻo nā meaʻai soy kekahi kumu meaʻai nui o isoflavones e like me genistein, daidzein a me glycitein. ʻO Isoflavones nā mea kanu kūlohelohe e hāʻule ana ma lalo o kahi ʻano o nā flavonoids e hōʻike ana i ka antioxidant, anticancer, antimicrobial, a me nā waiwai anti-inflammatory. Hana ʻo Isoflavones ma ke ʻano he phytoestrogens, ʻaʻohe mea ʻē aʻe akā nā mea kanu i hoʻokumu ʻia me ke ʻano like me ka estrogen. Ua aʻo ikaika ʻia ka hui ʻana o ka meaʻai soy me ka maʻi maʻi umauma no nā makahiki he nui. Ke nānā nei kēia blog i nā haʻawina like ʻole i loiloi i ka hui ʻana o nā meaʻai soy me ka umauma Ka maʻi 'aʻai.

ʻO ka hui ma waena o Soy Foods a me ka maʻi ʻaʻai umauma 

ʻO ka maʻi kanulau ʻo ia ka lua o nā kumu o ka make ʻana o ka maʻi ʻaʻai i nā wahine ma 2020. Ua hoʻonui iki ʻia ka hanana ʻana o ka maʻi ʻaʻai umauma e 0.3% i kēlā me kēia makahiki i kēia mau makahiki (Hawaiian Cancer Society). ʻO ka mea maʻamau i nā wahine ma waena o 20-59 mau makahiki. Hoʻohui ʻia, loaʻa i ka maʻi ʻaʻai umauma ka 30% o nā maʻi ʻaʻa wahine āpau (Ka helu helu maʻi ʻaʻai, 2020). Nui nā kanulau umauma he receptor estrogen (receptor hormone) maʻi maʻi umauma maikaʻi a e like me ka mea i ʻōlelo ʻia ma mua, loaʻa nā isoflavones i nā meaʻai soy e hana ma ke ʻano he phytoestrogens. No laila, makaʻu paha kekahi inā pili ka lawe ʻana o ka meaʻai soy me ka hoʻonui ʻana o ka maʻi kanesa o ka umauma (e like me ka estrogen receptor cancer cancer). E ʻike kākou i ka ʻōlelo a nā haʻawina.

Nā mea i loaʻa mai ka ʻike e pili ana i nā meaʻai soy a me ka maʻi ʻaʻai umauma 

1. Hoʻokomo ʻia ka soya a me ka maʻi maʻi ʻaʻai o ka umauma i nā wahine Kina

ʻO kahi loiloi hou i paʻi ʻia ma ka European Journal of Epidemiology i loiloi i ka pilina ma waena o ka lawe ʻana i ka soy a me ka makaʻu o ka maʻi kanesa o ka umauma. Ua hoʻohana nā kānaka noiʻi i ka ʻikepili mai kahi noiʻi cohort prospective nui i kapa ʻia ʻo China Kadoorie Biobank (CKB) cohort study no ke kālailai. Ua komo ka noiʻi ma luna o nā wahine he 300,000 ma waena o 30-79 mai 10 mau ʻāina a me nā ʻekekehana ʻokoʻa ma Kina. Ua kākau inoa ʻia kēia mau wahine ma waena o 2004 a me 2008, a ua ukali ʻia no ka hanana kanesa o ka umauma ma kahi o 10 mau makahiki. Hoʻohui ʻia, ua loaʻa i nā mea noiʻi nā kikoʻī o ka hoʻohana ʻana i ka soy mai nā nīnau nīnau pinepine i nā meaʻai i ka laina maʻamau, ʻelua mau resurveys a me ʻumikūmālua mau 24-h meaʻai hoʻomanaʻo. (Wei Y et al, Eur J Epidemiol. 2019)

Wahi a ka ʻikepili i hōʻiliʻili ʻia, ʻo ka ʻai ʻana o ka soy o kēia mau wahine he 9.4 mg / lā. 2289 ua hoʻomohala nā wahine i nā maʻi ʻōpū o ka umauma i ka manawa o 10 mau makahiki i hala. ʻIke piha ʻia i ka ʻikepili ʻaʻole i loaʻa kahi pilina koʻikoʻi ma waena o ka lawe ʻana i ka soy a me ka maʻi ʻaʻai umauma āpau. 

I kēia manawa, ua ʻimi a loaʻa nā mea noiʻi iā 8 i hoʻopaʻa ʻia i nā cohort prospective mua mai ka ʻāina ākea a hoʻokō ʻia ka meta-analysis meta-pane. Ua hōʻike ʻia ke anamanaʻo no kēlā me kēia 10 mg / lā hoʻonui i ka lawe ʻana i ka soy, aia he 3% hōʻemi o ka maʻi maʻi ʻaʻai umauma. (Wei Y et al, Eur J Epidemiol. 2019)

Kiʻi Ala:

Ua hoʻoholo ka poʻe noiʻi ʻaʻole pili ka lawe ʻana i ka soy i ka umauma maʻi 'aʻai i nā wahine Pākē. Ua ʻōlelo pū lākou i ka nui o ka ʻai ʻai soya i hāʻawi ʻia i nā pono kūpono o ka hōʻemi ʻana i ka maʻi ʻaʻai umauma.

2. Hoʻokomo ʻia ka Soy isoflavone Intake a me nā Hōʻailona Menopausal (MPS) i waena o nā wahine Kina me ka maʻi ʻaʻai o ka umauma pae mua.

I loko o kahi noiʻi hou, ua noiʻi nā kānaka noiʻi i ka hui ma waena isoflavone soy ʻai a me nā hōʻailona menopausal (MPS) i waena o nā wahine Kina i ʻike ʻia me ka maʻi ʻaʻai o ka umauma pae mua. Ua paʻi ʻia ke aʻo ʻana ma ka Ka Pepa ʻIa ʻIliʻi a me ka Hoʻōla ʻana i ka maʻi ʻaʻai ma ʻApelila 2020. Ua hoʻohana ʻia i ka nīnau nīnau e pili ana i ka ʻikepili mai ka 1462 poʻe maʻi maʻi umauma Pākē. ʻEkolu mau manawa manawa ukali i ka manawa o 5 mau makahiki ma hope o ka ʻike ʻana. (Lei YY et al, Hoʻomaʻi i ka maʻi ʻaʻai umauma. 2020)

Kiʻi Ala: 

ʻAʻole i hōʻike ka hopena i ka pilina ma waena o ka soy isoflavone i lawe ʻia a me nā hōʻailona menopausal ma waena o nā mea maʻi maʻi umauma Pākē.

3. ʻO Soy isoflavones a me ka maʻi ʻaʻai umauma ma Pre- a me Post-Menopausal Women mai nā ʻāina ʻAsia a me ke Komohana

ʻO kahi meta-analysis i paʻi ʻia ma ka puke pai ʻo PLoS One ma 2014 i loko o 30 mau noiʻi nānā e pili ana i nā wahine premenopausal a me 31 mau noiʻi e pili ana i nā wahine postmenopausal e ʻimi i ka hui o ka lawe ʻana i ka soy isoflavone me ka maʻi ʻaʻai umauma. ʻO nā haʻawina e pili ana i nā wahine premenopausal, 17 mau hana i hana ʻia ma nā ʻāina ʻAsia a 14 i hana ʻia ma nā ʻāina Komohana. ʻO nā haʻawina e pili ana i nā wahine postmenopausal, 18 mau hana i hana ʻia ma nā ʻāina ʻAsia a 14 i hana ʻia i nā ʻāina Komohana. (Chen M et al, PLoS Hoʻokahi. 2014) 

Kiʻi Ala:

Ua ʻike nā kānaka noiʻi he hiki i ka ʻai soy isoflavone ke hōʻemi i ka makaʻu o ka umauma maʻi ʻaʻai no nā wahine premenopausal a me post-menopausal ma nā ʻāina ʻAsia. Eia naʻe, ʻaʻole i loaʻa iā lākou nā hōʻike e hōʻike ana i ka pilina ma waena o ka soy isoflavoneʻai a me ka umauma maʻi ʻaʻai no ka premenopausal a me nā wahine post-menopausal ma nā ʻāina Komohana.

4. Hoʻokomo ʻia ka meaʻai soya a me ka hanana o ka haʻi o ka iwi i nā mea ola i ka maʻi ʻaʻai umauma

Ma kahi noiʻi noiʻi nui i kapa ʻia ʻo "The Shanghai Breast Cancer Survival Study", ua noiʻi nā mea noiʻi i ka ulu ʻana o ka haʻihaʻi iwi a me kona hui pū ʻana me ka ʻai soy i ka poʻe ola maʻi maʻi umauma. Ua komo ka haʻawina i ka ʻikepili mai 4139 pae 0-III umauma Ka maʻi 'aʻai nā maʻi, 1987 pre-menopausal a me 2152 postmenopausal maʻi. Ua helu ʻia ka ʻai ʻana i ka meaʻai soy ma 6 a me 18 mau mahina ma hope o ka hōʻoia ʻana. Eia kekahi, ua loiloi ʻia nā haʻihaʻi ma 18 mahina a ma 3, 5, a me 10 mau makahiki ma hope o ka hōʻoia ʻana.(Zheng N a me al, JNCI maʻi ʻaʻai Spectr. 2019) 

Nā ala nui:

Hōʻike nā ʻike mai ka noiʻi ʻana e hoʻonui ka ʻai ʻana o ka soy isoflavone i mea e hōʻemi ai i ka haki o nā iwi i nā mea maʻi pre-menopausal akā ʻaʻole i nā mea maʻi ma hope o ka menopausal.

5. Hoʻokomo ʻia ka soy isoflavones a me ka hoʻi ʻana o ka maʻi ʻaʻai umauma 

Ma kahi haʻawina i hana ʻia e Kang X et al., ua ʻimi lākou i nā pilina ma waena o ka ʻai ʻana o ka isoflavones soy a me ka hoʻi hou ʻana o ka maʻi maʻi umauma a me ka make. Ua hoʻohana ka haʻawina i ka ʻikepili pili nīnau mai 524 umauma Ka maʻi 'aʻai nā mea maʻi no ka nānā ʻana. Ua hana ʻia ke aʻo ʻana ma luna o nā maʻi i hana ʻia no ka maʻi kanesa o ka umauma ma waena o ʻAukake 2002 a me Iulai 2003. Ua loaʻa pū nā mea maʻi i ka adjuvant endocrine therapy ma ka Halemai Cancer o Harbin Medical University ma Kina. ʻO ka lōʻihi o ka mālama ʻana he 5.1 mau makahiki. Ua loiloi hou ʻia ke aʻo ʻana e ke kūlana receptor hormonal a me ka endocrine therapy. (Kang X et al, CMAJ. 2010).

Kiʻi Ala:

ʻO nā ʻike mai ka noiʻi ʻana i hōʻike ʻia ʻo ka nui o ka soy isoflavones ma ke ʻāpana o ka papaʻai e hoʻoliʻiliʻi ai i ka hoʻi hou ʻana o nā mea maʻi maʻi umauma post-menopausal i mea maikaʻi no ka receptor estrogen a me ka receptor progesterone, a me ka poʻe e loaʻa nei ka endocrine therapy. 

6. Nā Kākoʻo Soy Diet a me ka maʻi ʻaʻai o ka maʻi hānai i nā wahine Palani

ʻO kahi noiʻi i paʻi ʻia i kēia manawa ma ka The American Journal of Clinical Nutrition i ka makahiki 2019, ua ʻimi ʻia ka pilina ma waena o kaʻai soy supplement supplement a me ka maʻi maʻi ʻaʻai umauma. Ua komo ka noiʻi i ka ʻikepili o 76,442 mau wahine Palani mai ka INSERM (French National Institutes for Health and Medical Research) Etude Epidemiologique aupres de Femmes de la Mutuelle Generale de lʻEducation Nationale (E3N) cohort. ʻO nā wahine i komo i loko o ke aʻo ʻana he mau makahiki ma mua o 50 mau makahiki a hānau ʻia ma waena o 1925 a me 1950. Ua ukali ʻia lākou mai 2000 a 2011 me kahi manawa maʻamau o 11.2 mau makahiki. Hoʻohui ʻia, loiloi ʻia ka hoʻohana ʻana o ka soy supplement i kēlā me kēia 2-3 mau makahiki. (ʻO Touillaud M et al, Am J Clin Nutr. 2019)

Ua ʻike nā kānaka noiʻi ʻaʻohe hui nui ma waena o ka hoʻohana ʻana o ka soy dietary i kēia manawa a i hala paha (me ka isoflavones) a me ka makaʻu o ka umauma umauma. Eia nō naʻe, ke kālailai ʻia lākou i ka ʻikepili e ka estrogen receptor (ER) kūlana, ua ʻike ʻia aia ka haʻahaʻa o ka loaʻa ʻana o ka estrogen receptor positive (ER +) maʻi maʻi umauma a me ka nui o ka hopena o ka estrogen receptor maikaʻi (ER–) umauma maʻi ʻaʻai i kēia manawa. mea hoʻohana kōpō soy dietary. Ua hōʻike pū ʻia nā ʻike i loaʻa i nā wahine me ka moʻolelo ʻohana o ka maʻi ʻaʻai umauma ma kahi kiʻekiʻe o ka maʻi ʻaʻai ER. ʻO Premenopausal, nā wahine postmenopausal i hala koke aku nei a me nā wahine me ka ʻole o ka ʻohana o ka maʻi kanesa o ka umauma i loaʻa ka haʻahaʻa o ka maʻi maʻi ER + umauma.

Kiʻi Ala: 

Kuhi ʻia nā hopena o kēia noi ʻana aia he mau hui kūʻēʻē o nā meaʻai soy dietary me ka receptor estrogen maikaʻi a me ka hopena maʻi maʻi umauma ER-maikaʻi ʻole. Eia kekahi, ʻo nā wahine i loaʻa ka moʻolelo ʻohana o ka maʻi ʻaʻai umauma e ʻoi aku ke akahele i ka lawe ʻana i nā meaʻai soy dietary. 

7. Ka hopena o ka Soy Supplementation on Breast Cancer Risk Markers e like me Mammographic / Breast Density

Ua loiloi ʻia kahi noiʻi i 2015 i ka hopena o ka soy supplementation ma ka mammographic / ka nui o ka umauma ma 66 i mālama mua ʻia i nā maʻi maʻi maʻi maʻi a me nā wahine 29 kiʻekiʻe. ʻO ka nui o ka mamamographic, ka mea i ʻike ʻia me ka nui o ka umauma, ʻo ia ka pākēneka o nā kiko kiko o ka umauma holoʻokoʻa. ʻO ia kekahi o nā mea nui pilikia o ka maʻi ʻaʻai umauma. Ua komo i loko o ka noiʻi maʻi nā wahine 30 a 75 mau makahiki ʻo lākou:

• ua ʻike ʻia me ka maʻi ʻaʻai umauma a ua mālama ʻia a mālama ʻole ʻia paha me ka hae o ka mālama ʻana o ka hormone mālama a i ʻole kahi mea hōʻoki aromatase (AI) ma kahi o 6 mau mahina ma mua, me ka hōʻike ʻole o ka hoʻi hou ʻana. a i ʻole

• wahine hoʻoweliweli kiʻekiʻe me kahi ʻike BRCA1 / BRCA2 ka hoʻololi ʻana, a i ʻole ka moʻolelo ʻohana e kūlike me ka maʻi ʻaʻai umauma hoʻoilina.

Hoʻokaʻawale ʻia nā mea komo i nā hui 2. Loaʻa i ka hui mua i nā papa soy e loaʻa ana nā 50 mg isoflavones a me ka hui kaohi i loaʻa i nā papa placebo i loaʻa i ka microcrystalin cellulose. Loaʻa nā mammogram digital a me nā scram MRI o ka umauma ma ka palena haʻahaʻa (ma mua o ka hoʻopili ʻana) a me 12 mau mahina ma hope o kēlā me kēia lā 50 mg soy isoflavones papa a placebo papa supplementation. (Wu AH et al, Ka maʻi ʻaʻai Prev Res (Phila), 2015). 

Kiʻi Ala:

Ua loaʻa i ke anamanaʻo ka hoʻoliʻiliʻi iki o ka pākēneka mammographic density (ana ʻia e nā lakio o ka mahina 12 i nā pae pae laina) i ka hui i loaʻa i ka soy supplementation a me ka control group. Eia naʻe, ʻaʻole ʻokoʻa kēia mau hoʻololi i waena o nā ʻano lāʻau. Pēlā nō, ua hoʻohālikelike ʻia nā hopena i nā maʻi maʻi ʻaʻai umauma a me nā wahine kūpilikiʻi kiʻekiʻe. I ka hopena, ua ʻōlelo nā kānaka noiʻi ʻaʻole pili ka hoʻopili ʻana i ka soy isoflavone i ka nui o ka mammographic.

8. ʻO ke kai ʻōpio ʻōpio a me nā mākua makua kāne me ka maʻi ʻaʻai

I loko o kahi noiʻi i paʻi ʻia ma 2009, ua kālailai nā kānaka noiʻi i ka ʻike mai ka Shanghai Women Health Study e loiloi i ka hui ʻana o ka meaʻai soy ʻōpio a me nā mākua me ka pilikia o ka maʻi ʻaʻai. ʻO 73,223 ka wahine i hoʻopaʻa ʻia ma waena o 40-70 mau makahiki i hōʻiliʻili ʻia ma waena o 1996 a me 2000. Ua hoʻohana ʻia ka ʻike e pili ana i ka nīnau nīnau e loiloi ai i ka papaʻai i ka wā makua a me ka ʻōpio. Ua hōʻike ʻia nā hanana 592 o ka maʻi ʻaʻai umauma ma hope o ka ukali ʻana ma kahi o 7 mau makahiki. (Lee SA et al, Am J Clin Nutr. 2009)

Nā ala nui:

Ua hōʻike ʻia nā hopena o ke aʻo ʻana e hoʻemi ʻia ka hopena o ka maʻi ʻaʻai umauma ma waena o nā wahine premenopausal i ka lawe ʻana i ka soy kiʻekiʻe. ʻO nā wahine i hoʻopau i ka nui o nā meaʻai soya mau i ko lākou wā ʻōpio a me ko lākou wā makua ua hōʻemi i ka maka maʻi kanesa o ka umauma. Eia naʻe, ʻaʻole i loaʻa iā lākou kahi hui pū me ka meaʻai soya no ka maʻi ʻaʻai umauma postmenopausal.

He aha kā mākou e manaʻo ai mai kēia mau ʻimi?

Hōʻike kēia mau haʻawina ʻo ka ʻai ʻana i nā meaʻai soy i ka nui haʻahaʻa ʻaʻole e hoʻonui i ka pilikia o ka umauma Ka maʻi 'aʻai. Eia kekahi, ʻoi aku ka liʻiliʻi o nā haʻawina e hiki ke hoʻohaʻahaʻa i nā meaʻai soy i ka maʻi kanesa o ka umauma, ʻoi aku ka nui o nā wahine Kina/Asia. Hōʻike pū kekahi haʻawina ʻo kēia mau pōmaikaʻi ka mea nui i nā wahine e ʻai mau ana i nā meaʻai soya i ko lākou wā ʻōpio a me ke kanaka makua. Hiki i nā meaʻai soya ke hoʻemi i ke kiʻekiʻe o ka cholesterol a hoʻemi i ka pilikia o nā maʻi puʻuwai. Eia naʻe, ʻaʻole paha palekana e lawe i nā mea kōkua soya meaʻai, ʻo nā wahine hoʻi me ka moʻolelo ʻohana o ka maʻi ʻaʻai umauma. I ka hōʻuluʻulu, palekana a olakino hoʻi e lawe i ka nui o nā meaʻai soy ma ke ʻano he mahele o kā mākou papaʻai / meaʻai ma mua o ka lawe ʻana kumukanawai a. Hōʻalo i ka lawe kīʻaha soy ke ʻole e koi ʻia e kāu poʻe lawelawe mālama ola.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy e pili ana i ko lākou ola a nānā aku no nā hoʻoponopono ʻē aʻe no ka maʻi ʻaʻai ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

• Hoʻohana ʻia ka mea hoʻopihapiha meaʻai ma nā manawa o Chemotherapy Impact Survival Output no nā maʻi maʻi maʻi maʻi maʻi maʻi?
• ʻO Chemotherapy a me kāna ʻaoʻao-hopena i ka maʻi ʻaʻai
• Nā Meaʻai Kūlohelohe / Hoʻohui i kumu / hōʻino i ka maʻi ʻaʻai
• Hoʻonui i ka makaʻu o nā maʻi puʻuwai i nā mea ola maʻi umauma
• Nā Meaʻai Kāohi Kālepa e hōʻemi ai i ka makaʻu o ka maʻi ʻaʻai