ʻO Chemotherapy a me kāna ʻaoʻao-hopena i ka maʻi ʻaʻai

o ka Naauao

ʻO Chemotherapy ka mea nui o ka mālama ʻana i ka maʻi ʻaʻai a me ka lālani mua o ke koho ʻana no ka nui o nā maʻi ʻino e kākoʻo ʻia e nā alakaʻi alakaʻi a me nā hōʻike. Eia nō naʻe, me ka holomua o ka olakino a me ka hoʻomaikaʻi ʻana i ka nui o ka poʻe i loaʻa i ka maʻi ʻaʻai i loko o nā makahiki i hala aku nei, ʻo ka wā pōkole a me nā hopena ʻaoʻao lōʻihi o ka chemotherapy e lilo i mea hopohopo nui no nā mea maʻi a me nā kauka. Ke koho ʻana i ka meaʻai kūpono kūpono a me nā mea hoʻopili pono hiki ke kōkua i ka hōʻemi ʻana i kekahi o kēia mau hopena ʻaoʻao.

He aha kā Chemotherapy?

He ʻano kemotherapy Ka maʻi 'aʻai ka lāʻau lapaʻau e hoʻohana ai i nā lāʻau e hoʻopau i nā pūnaewele maʻi maʻi e puʻunaue wikiwiki ana. ʻO ia hoʻi ke koho lāʻau lapaʻau mua no ka hapa nui o nā maʻi maʻi e like me ke kākoʻo ʻia e nā alakaʻi a me nā hōʻike.

ʻAʻole i hoʻokumu ʻia ʻo Chemotherapy no kāna hoʻohana i kēia manawa i ka mālama ʻana i ka maʻi ʻaʻai. I ka ʻoiaʻiʻo, ua ʻike ʻia i ka wā o ke Kaua Honua ʻelua i ka wā i ʻike ai ka poʻe noiʻi ua make ke kinoea mākeke nitrogen i ka nui o nā hunaola keʻokeʻo. Ua hoʻonāukiuki hou kēia i ka noiʻi inā hiki iā ia ke hoʻopau i ka ulu ʻana o nā ʻāpana wikiwiki a me nā mutating cancer cells. Ma o ka noiʻi hou aʻe, hoʻokolohua, a me ka hoʻokolohua hoʻokolohua, ua ulu ka chemotherapy i mea i kēia lā.

Loaʻa i nā lāʻau chemotherapy ʻokoʻa nā ʻano hana o ka hana i hoʻohana ʻia no ka māka ʻana i nā ʻano maʻi ʻaʻai. Kauoha ʻia kēia mau lāʻau chemotherapy:

• ma mua o ke kaha ʻana e hōʻemi i ka nui o kahi tumo nui;
• e hoʻolōʻihi i ka ulu ʻana o nā hunaola maʻi ʻaʻai;
• e mālama i ka maʻi ʻaʻai i metastasize a hoʻolaha ma nā ʻāpana like ʻole o ke kino; a i ʻole
• e hoʻopau a hoʻomaʻemaʻe i nā hunaola āpau āpau a ulu wikiwiki e pale i ka hoʻi hou ʻana i ka wā e hiki mai ana.

I kēia lā, ʻoi aku ma mua o 100 mau lāʻau chemotherapy i ʻae ʻia a loaʻa i ka mākeke no nā ʻano maʻi ʻaʻai like ʻole. ʻO nā ʻāpana ʻokoʻa o nā lāʻau chemotherapy e komo pū me nā ʻākena alkylating, antimetabolites, alkaloids mea kanu, antibiotic antitumor a me nā mea hoʻopale topoisomerase. Lawe ka oncologist i kahi hoʻoholo i kahi lāʻau chemotherapy e hoʻohana ai no ka mālama ʻana i ka mea maʻi maʻi maʻi maʻi e pili ana i nā kumu like ʻole. Pākuʻi ʻia kēia mau mea:

• ʻano a me ke kahua o ka maʻi ʻaʻai
• kahi o ka maʻi ʻaʻai
• nā kūlana olakino e kū nei o ka mea maʻi
• ka makahiki hoʻomanawanui a me ke olakino laulā

Nā Chemotherapy Side-Effects

ʻOiai nā holomua o ke olakino a me ka hoʻomaikaʻi ʻana i ka helu o ka poʻe i ola i ka maʻi ʻaʻai i loko o nā makahiki i hala aku nei, nā hopena ʻaoʻao o kūʻē i ke kanesa Noho ka chemotherapy i kumu nui o ka hopohopo no nā mea maʻi a me nā kauka. Kaukaʻi ʻia i ka ʻano a me ka laulā o ka mālama ʻana, hiki i ka chemotherapy ke kumu i nā hopena ʻino a ʻino hoʻi. Hiki i kēia mau hopena ke hopena i ka maikaʻi o ke ola o ka mea maʻi maʻi.

Nā ʻaoʻao ʻaoʻao pōkole

Hoʻopilikia ka Chemotherapy i nā hunaola e māhele wikiwiki nei. ʻO nā ʻāpana ʻokoʻa o ko mākou kino kahi e hoʻokaʻawale pinepine ai nā hunaola olakino maʻamau i ka chemotherapy. ʻO ka lauoho, ka waha, ka ʻili, nā ʻōpū a me ka iwi iwi ka mea e laha pinepine ʻia e nā lāʻau chemotherapy.

ʻO nā hopena ʻaoʻao pōkole o ka chemotherapy i ʻike ʻia i nā mea maʻi ʻaʻai e like me:

• pau ka lauoho
• nausea a me ka luaʻi
• ka nele o kaʻai
• constipation a i ʻole kaulike
• luhi
• Kanikani'āʻula. 
• pilikia hanu
• loli ka ʻili
• nā ʻōuli like flu
• Pain
• esophagitis (ʻōhū o ka esophagus e alakaʻi ana i ka ʻānai ʻana i nā pilikia)
• ʻeha nā waha
• nā pilikia o ka hakuʻala a me ka ʻai
• anemia (hoʻemi ʻia ka helu o nā hunaola ʻulaʻula)
• maʻiʻaʻai
• pilikia pili koko
• hoʻonui i ke kahe a me ka ʻeha
• neutropenia (ke kūlana ma muli o ka pae haʻahaʻa o nā neutrophil, kahi ʻano o nā hunaola keokeo)

Hiki ke hoʻololi i kēia mau ʻaoʻao i kēlā me kēia kanaka a mai chemo a chemo. No ka mea hoʻomanawanui hoʻokahi, ʻokoʻa paha nā hopena ʻaoʻao a puni ka papa o kā lākou chemotherapy. ʻO ka hapa nui o kēia mau hopena e hoʻopili i ke kino a me ke olakino manaʻo o nā maʻi maʻi maʻi. 

Nā hopena ʻaoʻao lōʻihi

Me ka hoʻohana ākea o nā chemotherapy i nā hui like ʻole o nā maʻi ʻaʻai, nā mea ʻona e pili ana i kēia mau chemotherapies hoʻokumu maikaʻi e like me chemotherapies ma muli o ka platinum hoʻomau e hoʻonui. No laila, me nā holomua olakino a pau, ʻo ka hapa nui o nā mea ola o ka maʻi ʻaʻai ke hoʻopau ʻana me nā hopena o ka hopena lōʻihi o kēia mau chemotherapy, ʻoiai he mau makahiki ma hope o ka hoʻomaʻamaʻa. E like me ka National Pediatric Cancer Foundation, ua manaʻo ʻia ʻoi aku ma mua o 95% o nā mea i loaʻa i ka maʻi ʻaʻa kamaliʻi e loaʻa kahi pilikia pili i ke olakino i ka manawa o 45 mau makahiki, a he hopena paha ia no kā lākou lapaʻau maʻi maʻi mua (https: //nationalpcf.org/fact-about-childhood-cancer/). 

Ua mālama ʻia nā ʻano noiʻi like ʻole e pili ana i nā maʻi ʻaʻai a me nā mea pakele o nā ʻano maʻi ʻaʻai like ʻole e like me ka maʻi ʻaʻai umauma, maʻi ʻaʻai prostate a me ka lymphoma e loiloi ai i ka hopena o nā hopena lōʻihi o kā lākou mālama maʻi maʻi maʻi. ʻO nā noiʻi loiloi e loiloi ana i kēia mau hopena chemotherapy i nā mea i pakele i ka maʻi ʻaʻa e hōʻuluʻulu ʻia ma lalo.

Nā aʻo e pili ana i nā hopena ʻaoʻao lōʻihi o Chemotherapy

Pilikia o nā maʻi ʻelua

Me ka hoʻomaʻamaʻa hou ʻana o ka maʻi ʻaʻai me ka hoʻohana ʻana i ka chemotherapy a i ʻole ka radiotherapy, ʻoiai ua hoʻomaikaʻi ke ola o nā tumors paʻa, ua hoʻonui ʻia ka makaʻu o nā maʻi ʻelua i hoʻokomo ʻia e kahi lāʻau (ʻo kekahi o nā hopena chemotherapy lōʻihi). Hōʻike nā haʻawina ʻokoʻa i ka nui o nā lāʻau chemotherapy e hoʻonui ai i ka makaʻu o ka loaʻa ʻana i ka maʻi ʻaʻai ʻelua ma hope o ka loaʻa ʻole o ka maʻi ʻaʻai no kekahi manawa. 

ʻO kahi noiʻi i hana ʻia e ka National Cancer Institute ua kālailai loa ʻia i ka ʻikepili ma luna o 700,000 mau maʻi me nā tumors maʻi ʻaʻai paʻa. Ua hoʻomaka mua kēia mau maʻi i ka chemotherapy mai 2000-2013 a ua ola no hoʻokahi makahiki ma hope o ka ʻike ʻana. Ua ʻelemakule lākou ma waena o 1 a me 20. Ua ʻike nā mea noiʻi ʻo ka makaʻu o ka therapy e pili ana i ka myelodysplastic syndrome (tMDS) a me ka leukemia myeloid huehue (AML) "ua hoʻonui ʻia mai ka 84 pā a ʻoi aku ma mua o 1.5-pā no 10 o 22 mau ʻano maʻi ʻaʻai paʻa i ʻimi ʻia" . (Morton L et al, JAMA Oncology. Dek. 20, 2018) 

Ua hana hou ʻia kahi noiʻi ʻē aʻe e nā kānaka noiʻi mai ke Kula Nui Lapaʻau o ke Kulanui o Minnesota ma kahi o 20,000 i pakele i ka maʻi ʻaʻai kamaliʻi. Ua ʻike mua ʻia kēia mau mea i koe me ka maʻi ʻaʻai i ka wā ma lalo o 21 mau makahiki, ma waena o 1970-1999 a ua mālama ʻia me chemotherapy / radiotherapy a chemotherapy pū me ka radiation radiation. Ua hōʻike ʻia kahi noiʻi i nā mea pakele i mālama ʻia me ka chemotherapy wale nō, ʻo ia hoʻi ka poʻe i mālama ʻia me nā koina hōʻemi kiʻekiʻe o ka platinum a me nā ʻākena alkylating, he 2.8-pelu i hoʻonui i ka makaʻu o ka maʻi ʻaʻai maʻi ma hope e hoʻohālikelike ʻia me ka lehulehu. (Turcotte LM et al, J Clin Oncol., 2019) 

Ua lawe ʻia kekahi noiʻi noiʻi a paʻi ʻia ma 2016 i loiloi i ka ʻikepili mai 3,768 wahine leukemia kamaliʻi a i ʻole nā ​​mea ola i ka maʻi ʻaʻai sarcoma me ka ʻole o ka mōʻaukala radiotherapy. ʻO nā mea ola i ka maʻi ʻaʻai i mālama mua ʻia me ka hoʻonui ʻia ʻana o ka cyclophosphamide a i ʻole nā ​​anthracyclines. Ua ʻike ʻia ka noiʻi ua pili nui kēia mau mea i koe me ka makaʻu o ka ulu ʻana i ka maʻi ʻaʻai umauma. (Henderson TO et al., J Clin Oncol., 2016)

Ma kahi noiʻi ʻokoʻa, ua ʻike ʻia ʻo ka poʻe me Hodgkin's Lymphoma ʻoi aku ka nui o ka makaʻu o ka hoʻomohala ʻana i kahi maʻi ʻaʻai ʻelua ma hope o ka radiotherapy. ʻO Hodgkin's Lymphoma kahi maʻi ʻaʻai o ka ʻōnaehana lymphatic kahi ʻāpana o ke kino pale o ke kino. (Petrakova K et al, Int J Clin Practice. 2018)

Eia nō naʻe, ʻoi aku ka kiʻekiʻe o ka helu kūleʻa mua no nā wahine me ka maʻi ʻaʻai umauma, ua hoʻonui nui ʻia ka makaʻu o ka hoʻomōloli ʻana i nā tumors maʻi lua o ka maʻi (Wei JL et al, Int J Clin Oncol. 2019).

Kūkulu kēia mau noiʻi i nā maʻi ʻōpio i mālama ʻia me nā koina kumulative kiʻekiʻe o ka chemotherapy e like me cyclophosphamide a i ʻole anthracyclines ke kū nei i ka nui o ka hopena o ka hopena lōʻihi o ka hoʻomohala ʻana i nā maʻi ʻē aʻe.  

Pilikia o nā maʻi puʻuwai

ʻO kahi hopena ʻē aʻe o ka chemotherapy ka maʻi maʻi maʻi a i ʻole ka maʻi puʻuwai. Hōʻike nā haʻawina ʻē aʻe he nui ka nui o ka hōʻino ʻole o ka puʻuwai i nā mea i pakele i ka maʻi ʻaʻai umauma, mau makahiki ma hope o ka ʻike mua a me ka mālama ʻana i kā lākou maʻi ʻaʻai. ʻO ke kūpikipiki ʻole o ka puʻuwai kahi kūlana maʻi mau i hiki ke hiki ʻole i ka puʻuwai ke pauma pono i ke koko a puni ke kino.

I loko o kahi noiʻi i hala iho nei, ua nānā nā kānaka noiʻi Kōlea i ke alapine o ka hanana a me nā mea pōpilikia e pili pū ana me ka puʻuwai puʻuwai congestive (CHF) i nā maʻi maʻi maʻi umauma i ola ma mua o 2 mau makahiki ma hope o ka ʻike maʻi ʻaʻai. Ua mālama ʻia ka noiʻi me ka National Health Data Database o Kōlea Hema a ua komo pū ka ʻikepili mai ka huina o 91,227 mau maʻi i loaʻa i nā maʻi ʻaʻai umauma ma waena o 2007 a me 2013. Ua ʻike nā kānaka noiʻi:

• ʻoi aku ka nui o nā pilikia o ka puʻuwai puʻuwai congestive i nā mea ola i ka maʻi ʻaʻai umauma, keu hoʻi i nā ʻōpio i pakele ma mua o 50 mau makahiki, ma mua o nā kaohi. 
• ʻo ka poʻe i loaʻa i ka maʻi ʻaʻai i mālama mua ʻia me nā lāʻau chemotherapy e like me antracyclines (epirubicin a i ʻole doxorubicin) a me nā taxan (docetaxel a i ʻole paclitaxel) i hōʻike i kahi makaʻu kiʻekiʻe loa o nā maʻi puʻuwai (Lee J et al, Ka maʻi ʻaʻai, 2020). 

I kahi noiʻi ʻokoʻa i hana ʻia e Paulista State University (UNESP), Brazil, ua loiloi nā mea noiʻi i nā mea pilikia e pili ana i nā pilikia puʻuwai i nā poʻe i loaʻa i ka maʻi ʻaʻai umauma postmenopausal. Ua hoʻohālikelike lākou i ka ʻikepili mai ka poʻe i pakele i ka maʻi ʻaʻai umauma 96 i hala ma mua o 45 mau makahiki me 192 mau wahine postmenopausal i loaʻa ʻole i ka maʻi ʻaʻai umauma. Ua hoʻoholo ʻia ua hoʻopaʻa ʻia nā wahine postmenopausal ka mea i pakele i ka maʻi ʻaʻai umauma i ʻoi aku ka ikaika o ka hui pū ʻana me nā mea pilikia no ka maʻi puʻuwai a hoʻonui i ka momona o ka ʻōpū i hoʻohālikelike ʻia me nā wahine postmenopausal me ka ʻole o ka mōʻaukala o ka umauma maʻi (Buttros DAB et al, Menopause, 2019).

I kahi noiʻi i paʻi ʻia e Dr Carolyn Larsel a me ka hui mai Mayo Clinic, ʻAmelika Hui Pū ʻIa, ua kālailai lākou i ka ʻikepili mai ka 900+ umauma maʻi ʻaʻai a i ʻole nā ​​mea maʻi lymphoma mai Olmsted County, ʻAmelika Hui Pū ʻIa. Ua ʻike nā kānaka noiʻi ʻo ka maʻi kanesa o ka umauma a me nā mea maʻi lymphoma ma ka hoʻonui nui ʻana o ka puʻuwai o ka puʻuwai ma hope o ka makahiki mua o ka hōʻoia ʻana i hoʻomau ʻia a 20 mau makahiki. Ua ʻike pū ʻia ka noiʻi ʻana ua hoʻomālua ka poʻe maʻi i mālama ʻia me Doxorubicin i ka hopena o ka puʻuwai puʻuwai ke hoʻohālikelike ʻia i nā ʻano lāʻau ʻē aʻe. (Carolyn Larsen et al, Pai no ka American College of Cardiology, Malaki 2018)

Hoʻokumu kēia mau hopena i ka ʻoiaʻiʻo hiki i kekahi mau maʻi maʻi maʻi maʻi ke hoʻonui i ka hopena o nā hopena ʻaoʻao o ka hoʻomohala ʻana i nā pilikia o ka puʻuwai i nā mea ola o ka maʻi ʻaʻai i mau makahiki he nui ma hope o ka ʻike a me ka lāʻau.

Nā Pilikia o nā Maʻi Lung

Hoʻokumu pū ʻia nā maʻi puʻu a i ʻole nā ​​pilikia pulmonary ma ke ʻano he hopena hopena lōʻihi o ka chemotherapy. Hōʻike nā haʻawina ʻokoʻa i nā poʻe i loaʻa i ka maʻi ʻaʻa kamaliʻi i kahi kiʻekiʻe o nā maʻi maʻi / kūpilikiʻi e like me ka uha mau, ka hānō a me ka nūpepa hoʻi e like me nā mākua a ʻoi aku ka nui o ka makaʻi ke mālama ʻia me ka radiation i ka wā ʻōpio.

I loko o kahi noiʻi i paʻi ʻia e ka American Cancer Society, ua kālailai nā kānaka noiʻi i ka ʻikepili mai kahi Study Cancer Survivor Study e ana i kēlā me kēia kanaka i ola ma kahi o ʻelima mau makahiki ma hope o ka ʻike ʻōpio ʻana i nā maʻi ʻaʻai e like me leukemia, malignancies a me nā neuroblastomas. Ma muli o ka ʻikepili mai nā maʻi he 14,000, ua ʻike nā kānaka noiʻi ma ka makahiki 45, ʻo ka nui o nā maʻi pulmonary he 29.6% no nā mea pakele a me 26.5% no ko lākou kaikaina. Ua hoʻoholo lākou he nui ka pilikia o ka pulmonary / lung ma waena o nā poʻe i pakele i ka maʻi ʻaʻa kamaliʻi a hiki ke hoʻopili i nā hana o kēlā me kēia lā. (Dietz AC et al, Ka maʻi ʻaʻai, 2016).

Ma kahi noiʻi ʻē aʻe i hana ʻia e nā mea noiʻi mai ke Kulanui ʻo Columbia ma New York, ua hana lākou i kahi loiloi like e pili ana i ka ʻikepili mai nā keiki 61 i loaʻa i ka radiation radiation a ua hoʻokolohua ʻia kahi hana pulmonary. Ua loaʻa iā lākou kahi hoʻopili pololei e hōʻike ana i ka maikaʻi o ka pulmonary / lung i waena o nā poʻe i loaʻa i ka maʻi ʻaʻai pediatric i loaʻa i ka radiation i ka māmā ma ke ʻano he ʻāpana o kā lākou hoʻoponopono mālama. Ua ʻike pū ka poʻe noiʻi he nui ka makaʻu o ka hoʻomohala ʻana i ka maʻi pulmonary / lung i ka wā i hana ʻia ai ka lāʻau i ka wā ʻōpio ma muli o ka ulu ʻole o ka ulu (Fatima Khan et al, Advances in Radiation Oncology, 2019).

ʻO ka ʻike ʻana i nā pilikia o nā hana hōʻeuʻeu e like me chemotherapy, hiki i ke kaiāulu olakino ke hoʻonui hou aʻe i ka mālama ʻana i ka maʻi ʻaʻai i nā keiki e hōʻalo i kēia mau hopena maikaʻi ʻole i ka wā e hiki mai ana. Pono e nānā pono i nā hōʻailona o nā pilikia pulmonary a pono e hana i nā ʻanuʻu e pale aku ai iā lākou. 

Ka makaʻu o ka hahau ma hope

Ke hōʻike nei i ka ʻikepili mai ka helu o nā noiʻi olakino kūʻokoʻa e hōʻike ana i ka poʻe i loaʻa i ka maʻi ʻaʻai i hana i nā radiation radiation a i ʻole nā ​​chemotherapy lapaʻau e hoʻonui i ka hopena o nā hopena ʻaoʻao o ka hahau hope. 

I kahi noiʻi i hana ʻia e nā mea noiʻi ma Kōlea Hema, ua nānā lākou i ka ʻikepili o 20,707 maʻi maʻi ʻaʻai mai ka National National Insurance Insurance Service National Sample Cohort database ma waena o 2002-2015. Ua loaʻa iā lākou kahi hui maikaʻi o kahi kiʻekiʻe o ka maʻi stroke i nā maʻi maʻi maʻi ke hoʻohālikelike ʻia i nā maʻi maʻi ʻole. Hoʻohui kūʻokoʻa ʻia ka mālama ʻana me Chemotherapy me ka nui o ka maʻi ahulau. ʻOi aku ka kiʻekiʻe o ka makaʻikaʻi i nā poʻe maʻi me nā maʻi ʻino o nā ʻōnaehana digestive, nā maʻi ʻeha a me nā mea ʻē aʻe e like me ka maʻi ʻaʻai umauma a me nā maʻi ʻino o nā kāne a me nā wahine hānau keiki. Ua hoʻopau ka noiʻi ʻana ua piʻi ka makaʻu o ka maʻi ahulau i nā mea maʻi ʻaʻai ma 3 mau makahiki ma hope o ka ʻike a hoʻomau ʻia kēia pilikia a hiki i ka 7 mau makahiki o ka ukali. (Jang HS et al, Ma mua. Neurol, 2019)

Ua aʻo ʻia e ke kula ʻo Xiangya School of Public Health, ke Kulanui o South South, Kina, kahi meta-analysis o 12 i hoʻopukapuka ʻia kūʻokoʻa retrospective i hoʻopaʻa ʻia ma waena o 1990 a 2017, me 57,881 ka nui o nā maʻi, i mālama ʻia me ka radiation radiation. Ua hōʻike ʻia ke anamanaʻo i kahi kūlana kiʻekiʻe aʻe o ka hahau ma hope o ka poʻe i loaʻa i ka maʻi ʻaʻai i hāʻawi ʻia i ka radiation therapy ke hoʻohālikelike ʻia me ka poʻe i mālama ʻole ʻia me ka radiation radiation. Ua ʻike lākou he ʻoi aku ka kiʻekiʻe o ka pilikia ma ka radiotherapy i mālama ʻia i nā mea maʻi me ka lymphoma o Hodgkin a me ke poʻo, ka ʻāʻī, ka lolo a i ʻole nā ​​maʻi maʻi nasopharyngeal. Ua ʻoi aku ka kiʻekiʻe o kēia hui o radiation radiation a me ka hahau ʻana i nā mea maʻi ma mua o 40 mau makahiki ke hoʻohālikelike ʻia i nā mea maʻi kahiko. (Huang R, et al, Nā Neurol i Mua., 2019).

Ua hōʻike ʻia nā ʻike mai kēia mau noiʻi hoʻokolohua i ka nui o ka makaʻu o ka hahau hope ʻana i nā poʻe i loaʻa i ka maʻi ʻaʻai i mālama ʻia me ka radiation radiation a chemotherapy paha.

Ka makaʻu o Osteoporosis

ʻO Osteoporosis kahi hopena lōʻihi ʻē aʻe i ʻike ʻia i nā mea maʻi ʻaʻai a me nā mea ola i loaʻa i nā lāʻau e like me chemotherapy a me ka hormone therapy. ʻO ka Osteoporosis kahi ʻano olakino kahi e hoʻemi ʻia ai ka iwi iwi, a nāwaliwali ka iwi a palupalu. Hōʻike nā noiʻi he nui nā mea maʻi a me nā mea ola o nā ʻano maʻi ʻaʻai e like me ka maʻi ʻaʻai umauma, maʻi ʻaʻai prostate a me ka lymphoma i ka nui o ka maka o ka osteoporosis.

ʻO kahi noiʻi i alakaʻi ʻia e nā mea noiʻi mai Johns Hopkins Bloomberg School of Public Health, Baltimore, ʻAmelika Hui Pū ʻIa, i loiloi i ka nui o nā hanana pohō e like me ka osteoporosis a me ka osteopenia i ka 211 pakele maʻi maʻi umauma. Ua ʻike ʻia ka poʻe i koe i ka maʻi ʻaʻai umauma me ka maʻi ʻaʻai ma ka makahiki 47 mau makahiki. Ua hoʻohālikelike nā kānaka noiʻi i ka ʻikepili mai nā mea pakele maʻi ʻaʻai umauma me 567 mau wahine ʻaʻohe maʻi ʻaʻai. Ua ʻike ʻia ua anamanaʻo aia he 68% ʻoi aku ka nui o ka makaʻi o ka osteoporosis i ka poʻe i loaʻa i ka maʻi ʻaʻai umauma i ka hoʻohālikelike ʻia me nā wahine ʻaʻohe maʻi ʻaʻai. Kūlana nui nā hopena i nā mea i mālama ʻia me nā mea kāohi aromatase wale nō, a i ʻole ka hui pū ʻana o nā chemotherapy a me nā aromatase a me Tamoxifen. (Cody Ramin et al, Nānā i ka maʻi ʻaʻai umauma, 2018)

I loko o kahi noiʻi hoʻokolohua ʻē aʻe, ua kālailai ʻia ka ʻikepili mai 2589 mau maʻi Denemaka i ʻike ʻia me ka lymphoma B-cell diffuse nui a i ʻole follicular lymphoma. Ua mālama nui ʻia nā mea maʻi lymphoma me nā steroid e like me prednisolone ma waena o 2000 a me 2012. Hoʻohālikelike ʻia ka ʻikepili mai nā maʻi maʻi ʻaukā me nā kumumanaʻo o ka mana he 12,945 e loiloi i nā hanana o nā hanana pohō e like me nā hanana osteoporotic. Ua ʻike ʻia ke anamanaʻo i loaʻa i nā mea maʻi lymphoma ka nui o ka hopena o nā hanana pohō o ka iwi ke hoʻohālikelike ʻia me ka kaohi, me nā makahiki he 5 a me 10 mau makahiki i loaʻa he 10.0% a me 16.3% no nā mea maʻi lymphoma i hoʻohālikelike ʻia me 6.8% a me 13.5% no ka kaohi. (Baech J et al, Leuk Lymphoma., 2020)

Hōʻike kēia mau hopena i nā maʻi maʻi ʻaʻai a me nā mea ola i loaʻa i nā lāʻau e like me nā mea hōʻoki aromatase, chemotherapy, hormone therapy e like me Tamoxifen a i ʻole ka hui pū ʻana o kēia mau mea, aia i ka nui o nā kūlana o ka iwi-lilo.

Ka mālama ʻana i nā ʻaoʻao Chemotherapy ma o ke koho ʻana i nā mea kōkua kūpono / meaʻai kūpono

Hiki ke hoʻemi a mālama ʻia paha kekahi o nā ʻaoʻao ʻaoʻao o ka chemotherapy e ka lawe ʻana i ka nā meaʻai kūpono / nā mea kōkua kūpono me ka lāʻau. Pākuʻi a nā meaʻai, inā koho ʻepekema, hiki ke hoʻomaikaʻi i nā pane chemotherapy a hoʻemi i ko lākou ʻaoʻao-hopena i nā maʻi maʻi maʻi. Eia naʻe, koho wale ʻia o ka meaʻai kino a hiki i nā mea hoʻopihapiha meaʻai hoʻomāinoino i nā hopena ʻaoʻao.

ʻImi ʻia nā hōʻike noiʻi / hōʻike ʻokoʻa i kākoʻo i nā pono o kahi meaʻai / kōkua kikoʻī i ka hōʻemi ʻana i kahi ʻaoʻao chemo kikoʻī i kahi ʻano maʻi ʻaʻai i hōʻuluʻulu ʻia ma lalo. 

1. Ua mālama ʻia kahi ʻimi noiʻi hoʻokolohua pae II e nā mea noiʻi ma ka Halemai ʻo Shandong Cancer a me Institute ma Kina i hiki i ka EGCG supplementation ke hoʻemi i ka ale ʻana i nā pilikia / esophagitis me ka hopena maikaʻi ʻole i ka pono o chemoradiation a i ʻole radiation therapy ma ka maʻi ʻaʻai esophageal. (Xiaoling Li et al, Ka Nūpepa o nā Meaʻai Medicinal, 2019)
2. Ua hōʻike ʻia kahi noiʻi makapō hoʻokahi i hana ʻia ma ke poʻo a me ka ʻāʻī maʻi maʻi ʻōpio i hoʻohālikelike ʻia i ka pūʻulu hoʻomalu, ma kahi o 30% o nā maʻi i ʻike ʻole i ka mucositis oral 3 (ʻeha waha) ke hoʻohui ʻia me ka jelly aliʻi. (Miyata Y et al, Int J Mol Sci., 2018).
3. Ua mālama ʻia kahi noiʻi i mālama ʻia e nā mea noiʻi mai ke Kulanui o Medical Science o Shahrekord ma Iran e hiki ai i ka lycopene ke hoʻokō pono i ka hoʻoliʻiliʻi ʻana i nā pilikia ma muli o ka nephrotoxicity i hoʻokomo ʻia e cisplatin (nā pilikia pākī) ma o ka hoʻopili ʻana i kekahi mau hōʻailona o ka hana renal. (Mahmoodnia L et al, J Nepropathol., 2017)
4. Ua hōʻike ʻia kahi noiʻi lapaʻau mai ke Kulanui ʻo Tanta i ʻAigupita i kēlā hoʻohana ʻana o ʻO Milk Thistle e hana nei iā Silymarin me nā Doxorubicin pono i nā keiki me ka leukemia lymphoblastic huikau (ALL) ma o ka hōʻemi ʻana i ka cardiotoxicity i hoʻokomo ʻia e Doxorubicin. (Hagag AA et al, Infect Disord Drug Target., 2019)
5. ʻO kahi noiʻi waena i hana ʻia e Rigshospitalet a me ka haukapila Herlev, Denmark ma 78 mau maʻi i loaʻa e hoʻohana ʻo Mannitol i nā maʻi maʻi poʻo a me ka ʻāʻī e loaʻa ana i ka cisplatin therapy hiki ke hoʻēmi i ka ʻeha puʻuwai i hoʻokomo ʻia e Cisplatin.Hagerstrom E, et al, ʻO Clin Med Insights Oncol., 2019).
6. ʻO kahi noiʻi i hana ʻia ma ke Kulanui ʻo Alexandria ma ʻAigupita ua ʻike ʻia ka lawe ʻana nā hua ʻeleʻele waiwai i Thymoquinone a me chemotherapy e hoʻoliʻiliʻi i ka hanana o febrile neutropenia (nā keena koko keʻokeʻo haʻahaʻa) i nā keiki me nā tumors lolo. (Mousa HFM et al, Keiki hopohopo a ke keiki., 2017)

Panina

I ka hōʻuluʻulu ʻana, hiki i ka mālama ʻana me ka chemotherapy hiki ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā hopena ʻaoʻao pōkole a me ka wā lōʻihi e pili ana i nā pilikia o ka puʻuwai, nā maʻi ʻāmāmā, nā kūlana iwi, ka lua. maʻi pū a me ka hahau i kekahi mau makahiki ma hope o ka lapaau ana. No laila, ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, he mea nui ia e aʻo i nā mea maʻi maʻi maʻi e pili ana i nā hopena maikaʻi ʻole i hiki i kēia mau lāʻau lapaʻau ke loaʻa i ko lākou olakino a me ka maikaʻi o ke ola. ʻO ka nānā ʻana i ka pōʻino-pōmaikaʻi o ka mālama ʻana i ka maʻi kanesa no nā keiki a me nā ʻōpio makua e makemake i ka mālama ʻana e ka palena ʻana i nā lāʻau cumulative o chemotherapy a me ka noʻonoʻo ʻana i nā koho a ʻoi paha i koho ʻia e hōʻemi i ka hopena o nā hopena ʻino i ka wā e hiki mai ana. ʻO ke koho ʻana i nā meaʻai kūpono kūpono a me nā mea hoʻopili pono hiki ke kōkua i ka hoʻopau ʻana i kekahi o kēia mau hopena ʻaoʻao.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

Hana pinepine nā mea maʻi maʻi maʻi i nā hopena chemotherapy ʻokoʻa e pili ana i ko lākou ola a nānā aku no nā hoʻoponopono ʻē aʻe no ka maʻi ʻaʻai. ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

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