o ka Naauao
Ua hōʻike ʻia kahi noiʻi lapaʻau e palekana ana e hoʻohana i ka soy isoflavone Genistein supplement me ka hoʻohui chemotherapy FOLFOX i ka mālama ʻana i nā mea maʻi maʻi maʻi metectatic colorectal cancer. Hoʻohui ʻia ʻo Genistein i nā mea hoʻopihapiha me ka chemotherapy i hiki i ka hoʻomaikaʻi ʻana i nā hopena olakino FOLFOX i nā mea maʻi maʻi maʻi metectatic colorectal.
Ka maʻi ʻaʻai Colorastal Metastatic
ʻAʻole maikaʻi ka wānana ʻana o ka Metastatic Colorectal Cancer (mCRC) me ka emi ʻana o 2% o ke ola 40 makahiki a ʻoi aku ka liʻiliʻi o 5 mau makahiki ma mua o 10%, ʻoiai nā koho lapaʻau chemotherapy hui pū ʻana. (AJCC Cancer Staging Handbook, 8th Edn).
ʻO ka Metastatic Colorectal Cancer Chemotherapy Regimens
ʻO ka metastatic Colorectal cancer regimens he 5-Fluorouracil me kahi lāʻau platinum Oxaliplatin, me ka mea antiangiogenic a ʻole ʻole (e kāohi i ke kūkulu ʻana i nā kīʻaha koko i ka ʻōpū) ʻo Bevacizumab (Avastin). ʻO nā regimens hou e like me FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) a me FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan) i hōʻike pū i nā hopena hoʻohiki.
Ma ʻaneʻi, e kūkākūkā mākou i nā regimens mCRC koʻikoʻi i loko o nā hoʻokolohua lapaʻau a manaʻo ʻia he kūpono e kūʻē i ka Metastatic Colorectal Cancer (mCRC).
ʻO ka maikaʻi o FOLFOXIRI i nā maʻi maʻi maʻi maʻi metastatic colorectal
Ua hoʻopaʻa ʻia nā haʻawina he nui i nā colorectal metastatic like ʻole Ka maʻi 'aʻai regimens a me ko lākou pono i nā maʻi mCRC. ʻO FOLFOXIRI kahi lāʻau lapaʻau hui mua mCRC e pili ana i ka fluorouracil, oxaliplatin, leucovorin a me nā hui lāʻau irinotecan. I ka hoʻokolokolo TRIBE, i paʻi ʻia ma 2020, ʻo ka hoʻokomo hou ʻana o FOLFOXIRI me ka bevacizumab i hopena i nā hopena ʻoi aku ka maikaʻi ma mua o FOLFIRI a me ka bevacizumab akā me ka manawa o ka nui o ka ʻawaʻawa ʻoi aku ka lōʻihi o ka chemotherapy i koi ʻia a ua ʻike ʻia nā hopena ʻino i loko o ia mau maʻi. (Glynne-Jones R, et al. ʻO ka Lancet Oncology, 2020). ʻO kēia hoʻolālā o ka hoʻohui ʻana i nā lāʻau lapaʻau maikaʻi akā cytotoxic me nā lāʻau antiangiogenic ua hāpai i kekahi mau hopohopo no ka poʻe oncologists e pili ana i ka palekana a me ka ʻona.
Nā kikoʻī o kahi Meta-analysis: XELOX vs. FOLFOX i ka Metastatic Colorectal Cancer
He haʻawina ma 2016 e Guo Y, et al. hoʻohālikelike i ka pono o ka capecitabine a me ka fluorouracil, ua hui pū ʻia kēlā me kēia me ka oxaliplatin, i nā maʻi mCRC i hui pū ʻia me ka chemotherapy (Guo, Yu et al. ʻImi maʻi maʻi, 2016).
- Ua hoʻohana ʻia ʻewalu randomized controlled trials (RCTs) no ka nānā ʻana e pili ana i nā maʻi 4,363 i ka huina.
- ʻO ka hopena mua o ke aʻo ʻana ʻo ia ka loiloi i ka palekana a me ka maikaʻi o nā regimens chemotherapy XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (fluorouracil plus oxaliplatin) i nā maʻi maʻi maʻi maʻi maʻi metastatic colorectal.
- ʻO ka huina o 2,194 mau maʻi i mālama ʻia me ka regimen o XELOX aʻo 2,169 mau maʻi i mālama ʻia me ka regimen FOLFOX.
Nā hualoaʻa o ka Meta-analysis: XELOX vs. FOLFOX i ka Metastatic Colorectal Cancer
- Ua ʻoi aku ka nui o ka maʻi o ka lima-wāwae, ka maʻi paʻi a me ka thrombocytopenia i ka hui XELOX akā ʻoi aku ka nui o ka neutropenia i ka hui FOLFOX.
- ʻOkoʻa nā ʻano mea ʻawaʻawa i loaʻa mai ka loiloi pooled no nā pūʻulu ʻelua akā koi ʻia ka noiʻi hou ʻana no kēia mea.
- ʻO ka maikaʻi o XELOX no nā maʻi mCRC e like me ka FOLFOX efficacy.
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
Pākuʻi Genistein no ka maʻi ʻaʻai
ʻO Genistein kahi isoflavone i loaʻa maoli i nā meaʻai e like me ka soy a me nā huahana soybean. ʻO Genistein loaʻa nō hoʻi ma ke ʻano o nā mea hoʻohui meaʻai a ua ʻike ʻia he nui nā pono olakino duets i kāna mau antioxidant, anti-inflammatory a me anti-cancer. ʻO kekahi o nā pono olakino maʻamau ʻē aʻe o nā mea hoʻohui genistein (ma kahi o nā waiwai anti-cancer) e komo pū:
- Hiki ke kōkua i ka hōʻemi ʻana i nā pae kō kō
- Hiki ke kōkua i ka hōʻemi ʻana i nā hōʻailona menopause
- Hiki ke kōkua i ka hoʻomaikaʻi ʻana i ke olakino puʻuwai
- Hiki ke hoʻoikaika i ka olakino iwi a me ka lolo
Ma kēia blog e kūkākūkā mākou inā he pono ka hoʻohana ʻana o Genistein supplement i ka metastatic colorectal Ka maʻi 'aʻai maʻi.
Hoʻohui Genistein Hoʻohana i ka maʻi ʻaʻai Colorectal
Ua hōʻike ʻia nā noiʻi he nui i kahi hui o ka makaʻu haʻahaʻa o nā maʻi ʻaʻai kala i nā lāhui hikina o ʻAsia e ʻai i ka papaʻai waiwai Soy. Nui a hewahewa nā noiʻi hoʻokolohua preclinical i hōʻike i ka anti-cancer waiwai o ka soy isoflavone Genistein, a me kona hiki ke hōʻemi i ka chemotherapy resistence i nā maʻi ʻaʻai maʻi maʻi. No laila, ua hoʻāʻo nā mea noiʻi ma ke Kula ʻo Kauka Icahn ma Mount Sinai, ma New York, i ka palekana a me ka pono o ka hoʻohana ʻana i ka soy isoflavone Genistein me ke kaulike o ka mālama ʻana me ka chemotherapy i kahi noiʻi maʻi mua i nā mea maʻi maʻi maʻi metastatic colorectal. (NCT01985763) (Pintova S et al, Cancer Chemotherapy & Pharmacol., 2019)
Nā kikoʻī o ka Haʻawina Haukino ma ka Genistein Supplement hoʻohana ma Colorectal Cancer
- He 13 mau maʻi me ka mCRC me ka mālama ʻole ʻana ma mua i mālama ʻia me ka hui pū ʻana o FOLFOX a me Genistein (N=10) a me FOLFOX + Bevacizumab + Genistein (N=3).
- ʻO ka hopena mua o ke aʻo ʻana e loiloi i ka palekana a me ke ahonui o ka hoʻohana ʻana iā Genistein me ka chemotherapy hui pū. ʻO ka hopena hope e nānā i ka pane holoʻokoʻa maikaʻi loa (BOR) ma hope o 6 pōʻaiapuni o ka chemotherapy.
- ʻO Genistein ma kahi mahele o 60 mg / lā, hāʻawi waha ʻia no 7 mau lā i kēlā me kēia 2 pule, e hoʻomaka ana i 4 mau lā ma mua o ka chemo a hoʻomau i nā lā 1-3 o ka chemo infusion. Ua ʻae kēia i nā mea noiʻi e nānā i nā hopena ʻaoʻao me Genistein wale nō a i ke alo o chemo.
Nā hopena o ka Haʻawina Haukino ma ka Genistein Supplement hoʻohana ma Colorectal Cancer
- ʻO ka hui pū ʻana o Genistein me chemotherapy i loaʻa kahi palekana a hoʻomanawanui hoʻi.
- ʻO nā hanana maikaʻi ʻole i hōʻike ʻia me Genistein wale nō he akahai loa, e like me ka headache, nausea a me nā uila wela.
- Ua hōʻike ʻia nā hanana maikaʻi ʻole i ka wā i hāʻawi ʻia ai ʻo Genistein me ka chemotherapy e pili ana i nā hopena chemotherapy, e like me ka neuropathy, ka luhi, ka maʻi pākī, eia nō naʻe, ʻaʻole i loaʻa i kekahi o nā mea maʻi ka hanana kūpilikiʻi loa o ka papa 4.
- Aia kahi hoʻomaikaʻi i ka pane maikaʻi maikaʻi loa (BOR) i kēia mau mCRC maʻi e lawe ana i ka chemotherapy me Genistein, ke hoʻohālikelike ʻia i nā mea i hōʻike ʻia no ka hoʻomaʻamaʻa chemotherapy wale nō i nā noiʻi mua. ʻO BOR ka 61.5% ma kēia noi vs. 38-49% i nā noiʻi mua me nā ʻano chemotherapy like. (Saltz LB et al, J Clin Oncol, 2008)
- ʻOiai ʻo ka metric ola manuahi holomua, e hōʻike ana i ka nui o ka manawa ʻaʻole i holomua ka tumo me ka lapaʻau, he median o 11.5 mau mahina me Genistein hui pū ʻia me 8 mau mahina no ka chemotherapy wale nō i hoʻokumu ʻia ma kahi noiʻi mua. (Saltz LB et al, J Clin Oncol., 2008)
Panina
ʻO kēia haʻawina, ʻoiai ma kahi liʻiliʻi loa o nā mea maʻi, hōʻike i ka hoʻohana ʻana soy isoflavone Genistein ua palekana a me ka hoʻohui pū ʻana i ka chemotherapy ʻaʻole ia i hoʻonui i ka ʻona o ka chemotherapy ma Colorectal Cancer. Eia hou, ʻo ka hoʻohana ʻana iā Genistein me ka hui pū me FOLFOX ka hiki ke hoʻomaikaʻi i ka pono o ka lāʻau a hōʻemi paha i nā hopena o ka chemotherapy. ʻO kēia mau mea i ʻike ʻia, ʻoiai e hoʻohiki, e pono e loiloi a hoʻopaʻa ʻia i loko o nā noi lāʻau ʻoi aku ka nui.
ʻO ka meaʻai āu e ʻai ai, a ʻo nā mea hoʻohui āu e lawe ai he hoʻoholo āu e hana ai. Pono kāu hoʻoholo e noʻonoʻo i ka hoʻololi ʻana o ka maʻi kanesa, ʻo ia ka maʻi kanesa, nā lāʻau hoʻomau a me nā mea hoʻohui, nā allergies, ʻike ola, ke kaumaha, ke kiʻekiʻe a me nā maʻamau.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi maʻi mai addon ma ka ʻimi pūnaewele. Hoʻokaʻawale ia i ka hoʻoholo ʻana no ʻoe e pili ana i ka ʻepekema molecular i hoʻokō ʻia e kā mākou ʻepekema a me nā ʻenekini polokalamu. ʻAʻole manaʻo inā makemake ʻoe e hoʻomaopopo i ke kumu o nā ala molekole biochemical i lalo a i ʻole - no ka hoʻolālā ʻana i ka meaʻai no ka maʻi kanesa e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.