Amaphuzu avelele
Izigameko zomdlavuza kapopopo zikhula ngo-2% unyaka ngamunye eqenjini elincane. Ukuhlaziywa kwedatha yezokudla etholwe ezigulini eziyi-1171 ezinomdlavuza we-metastatic colorectal ezibhaliswe ocwaningweni olukhulu lweqembu olubizwa ngeCancer and Leukemia Group B (Alliance)/SWOG 80405 ucwaningo, luthole ukuthi ukusetshenziswa nsuku zonke kwezinkomishi ezimbalwa zekhofi (ecebile nge-caffeine noma i-decaffeinated) ingase ihlotshaniswe nokuphila okuthuthukisiwe, ukufa okuncishisiwe kanye nokuqhubeka komdlavuza. Kodwa-ke, lokhu kuhlotshaniswa akubona ubudlelwano bembangela-nomphumela futhi akwanele ukuncoma ikhofi kuziguli ezinomdlavuza we-metastatic colorectal/colon.
Ikhofi neCaffeine
Ikhofi ngesinye seziphuzo ezidume kakhulu emhlabeni jikelele. Kuyaziwa ukuthi iqukethe izingxenye eziningi ze-phytochemical, enye yazo i-caffeine. Izigidi zabantu emhlabeni wonke zijabulela iziphuzo ezine-caffeine nokudla okufana nekhofi, amasoda, iziphuzo ezibandayo, itiye, iziphuzo zezempilo kanye noshokoledi. I-caffeine iyaziwa ukuthi ine-antioxidant kanye ne-anti-inflammatory properties. I-caffeine ingase futhi yandise ukuzwela kwe-insulin kwezicubu. I-Kahweol, enye ingxenye yekhofi nayo inemiphumela elwa nokuvuvukala kanye ne-proapoptotic enganciphisa ukuqhubeka komdlavuza.
Emashumini ambalwa edlule, abacwaningi bathole intshisekelo yokuqonda umthelela wezempilo wokuphuza ikhofi nokuthi ngabe ukuphuza uKofi ocebile nge-caffeine angasiza emisebenzini yokulwa nomdlavuza. Iningi lezifundo zokuhlola zikuthole ukuthi akulimazi.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ikhofi leColorectal / Colon Cancer
I-Cancer Colorectal
Umdlavuza ocwengekileyo ngumdlavuza wesithathu ovela kakhulu emadodeni futhi owesibili owenzeka kakhulu kubantu besifazane (iWorld Cancer Research Fund). Owesilisa oyedwa kwabangu-1 nowesifazane oyedwa kwabangu-23 babhekwa njengabasengozini yokuba nomdlavuza wobala (American Cancer Society). Ngokwezibalo zezinga lezigameko ezivela kuNational Cancer Institute, kuzoba namacala omdlavuza osolula asanda kutholakala e-United States ngonyaka ka-1, okubandakanya umdlavuza wamakholoni angu-25 namacala omdlavuza wamanqamu angama-1,47,950. (URebecca L Siegel et al, CA Cancer J Clin., 2020) Ukwengeza, izehlakalo zomdlavuza wamakholoni nazo zikhuphuke ngo-104,610% unyaka nonyaka eqenjini elincane elineminyaka engaphansi kweminyaka engama-43,340 okungenzeka ukuthi kubangelwa ukuhlolwa okuncane okujwayelekile kuleli qembu ngenxa ukungabi nezimpawu, indlela yokuphila engenampilo nokudla okunamafutha aphezulu, ukudla okune-fiber ephansi. Izifundo eziningana zokuhlola nezokuhlola zibuye ziphakamise ukuxhumana phakathi kwezici zokudla nezindlela zokuphila kanye nezigameko nokufa kwamanomdlavuza e-colon.
Ukuphuza Ikhofi Kuthuthukisa Ukusinda Ezigulini Ezinomdlavuza Ocacile
Ikhofi iqukethe izinto eziningi ezibalulekile njenge-caffeine enezenzo zokulwa ne-antioxidant kanye ne-anti-inflammatory futhi ivame ukufundelwa ukuhlola izakhiwo zazo ezilwa nomdlavuza. Ukuphikiswa kwe-insulin kuthathwa njengokuthinta kabi imiphumela yeCancer Colon. I-caffeine ingabuye izwakalise izicubu emiphumeleni ye-insulin futhi yehlise amazinga e-insulin egazini, indlela engenzeka yokunciphisa ingozi yomdlavuza.
Izifundo ezahlukahlukene zokubuka phambilini ziphakamise ukuhlangana phakathi kokuphuza ikhofi (ikhofi eline-caffeine ne-decaffeine) kanye nengozi yomdlavuza wekoloni kanye nemiphumela yomdlavuza. Kodwa-ke, okutholakele kulezi zifundo kuhlanganisiwe. Ocwaningweni lwakamuva olushicilelwe ephephabhukwini iJAMA Oncology, abacwaningi abavela eDana-Farber Cancer Institute naseHarvard Medical School eBoston nakwezinye izikhungo e-United States bahlole ukuhlangana kokusetshenziswa kwekhofi nokuqhubekela phambili kwezifo nokufa iziguli ezinomdlavuza ophakeme noma we-metastatic colorectal. (UChristopher Mackintosh et al, JAMA Oncol., 2020)
Ukuhlola kwenziwe kususelwa kudatha evela ezigulini zesilisa eziyi-1171, ezineminyaka yobudala engama-59, ezibhalise ocwaningweni olukhulu lweqembu lokubuka olubizwa ngeCancer and Leukemia Group B (Alliance)/SWOG 80405, ucwaningo lwesigaba sesi-3 somtholampilo olwathi kuqhathanise ukungezwa kwezidakamizwa i-cetuximab kanye/noma i-bevacizumab ekwelapheni ngamakhemikhali okujwayelekile ezigulini ezinomdlavuza we-colorectal owawungazange ulashwe ngaphambilini, owawuthuthuke endaweni noma we-metastatic. Idatha yezokudla yaqoqwa kusukela ngo-Okthoba 27, 2005, kuya kuJanuwari 18, 2018 etholwe kuhlu lwemibuzo lokudla olugcwaliswe iziguli ngesikhathi sokubhaliswa kwazo. Abacwaningi bahlaziya futhi bahlobanisa le datha yezokudla (ephinde yafaka phakathi ulwazi olucebile nge-caffeine ikhofi noma ukusetshenziswa kwekhofi eline-decaffeinated) nemiphumela ngesikhathi sokwelashwa komdlavuza, kusukela ngoMeyi 1 kuya ku-Agasti 31, 2018.
Ucwaningo luthole ukuthi ukwanda kwenkomishi eyodwa ngosuku kungahambisana nengozi encishisiwe yokuqhubeka komdlavuza nokufa. Ucwaningo luphinde lwathola ukuthi ababambiqhaza abaphuza izinkomishi zekhofi ezi-1 kuya kwezi-2 ngosuku babe nengozi encishisiwe yokufa uma kuqhathaniswa nalabo abangaphuzi ikhofi. Ngokwengeziwe, abacwaningi bathole ukuthi labo abaphuza izinkomishi ezingaphezu kwezine ngosuku babenezinga elingama-3% lokunyuka kokuphila okuphelele futhi ama-36% andise amathuba okuqhubeka okusinda mahhala, uma kuqhathaniswa nalabo abangaphuzanga ikhofi. Lezi zinzuzo ngomdlavuza wekoloni zabonwa kuzo zombili ikhofi eline-caffeine ne-decaffeine.
Isiphetho
Njengoba izehlakalo zomdlavuza wekoloni senyuke ngo-2% unyaka ngamunye eqenjini elincane, abacwaningi bebefuna amakhambi emvelo ukusiza ukuthuthukisa imiphumela yokwelashwa nokuphila kulezi ziguli. Okutholwe kulolu cwaningo lokubheka kuveze ngokucacile ukuhlobana okuhle phakathi kokusetshenziswa kwekhofi nokuphila kanye nengozi encishisiwe yokuqhubeka kwesifo nokufa ezigulini ezinomdlavuza we-colorectal/colon othuthukile noma we-metastatic. Kodwa-ke, lokhu kuhlotshaniswa akufanele kuthathwe njengobudlelwane bembangela-nomphumela futhi akwanele ukuncoma ikhofi kuziguli zomdlavuza we-metastatic colorectal/colon. Abacwaningi baphinde baphakamisa ucwaningo olwengeziwe ukuze kutholakale izindlela eziyisisekelo zebhayoloji. Baphinde bagqamisa ukulinganiselwa kocwaningo njengokungacabangeli ezinye izici ezibalulekile ezingabanjwanga esivivinyweni ezihlanganisa imikhuba yokulala, ukuqashwa, ukuvivinya umzimba okungahlobene nokuzivocavoca okuzinikele, noma izinguquko ekuphuzweni kwekhofi ngemva kokuxilongwa komdlavuza wekoloni. Ukwengeza, njengoba iziguli eziningi eziphuze ikhofi ngesikhathi sokwelashwa komdlavuza kungenzeka ziliphuze ngaphambi kokuxilongwa kwazo, bekungacaci ukuthi ikhofi abaphuzayo baba nomdlavuza ongenalo ulaka, noma ukuthi ikhofi libe nomthelela ngqo kumathumba asebenzayo. Kunoma ikuphi, ukuphuza inkomishi yekhofi akubonakali kuyingozi futhi kungase kungabangeli le midlavuza ethuthukisiwe njengomdlavuza wekoloni!
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.