Amaphuzu avelele
Ukwelashwa ngemisebe kuvame ukusetshenziselwa ukwelapha umdlavuza webele, kodwa izikhathi eziningi amangqamuzana omdlavuza angakwazi ukumelana nokwelashwa ngemisebe. Ukuthathwa/ukusetshenziswa kwe-Ellagic Acid ekudleni okufana namajikijolo, ihalananda nama-walnuts (okucebile kule nhlanganisela ye-phenolic) noma izithasiselo kunezinzuzo eziningi zezempilo ezingaba khona kuhlanganise nemiphumela yokulwa nomdlavuza. I-Ellagic acid iphinde ithuthukise ukusabela kwe-radiotherapy kumaseli omdlavuza webele ngesikhathi esifanayo njengoba ivikela umsakazo kumaseli ajwayelekile: ikhambi lemvelo elingase libe khona. umdlavuza.
Yini i-Ellagic Acid?
I-Ellagic Acid yinto eyenzeka ngokwemvelo ebizwa nge-polyphenol enezakhiwo eziqinile ze-antioxidant, etholakala kwizithelo nemifino eminingi. Iphinde itholakale ngokuthengisa ngendlela yezithako zokudla. I-Ellagic acid inemiphumela elwa nokuvuvukala kanye nokulwa nokwanda futhi inezinzuzo eziningi zezempilo.
Ukudla okunothile ku-Ellagic Acid: I-Ellagic acid ivame ukutholakala ekudleni okuhlukahlukene okubandakanya izithelo ezinjengamajikijolo, ama-strawberry, amajikijolo, ama-cranberries, namapomegranati. Okunye ukudla okubandakanya amantongomane athile ezihlahla njengama-walnuts nama-pecans nakho kunothile ku-Ellagic acid.
Izinzuzo Zezempilo ze-Ellagic Acid
Ezinye izinzuzo ezingaba khona zezempilo zezithako ze-Ellagic acid zifaka imiphumela yokulwa nomdlavuza, ukunciphisa izimpawu zezifo ezingapheli zemetabolism kubandakanya i-dyslipidemia, ukukhuluphala ngokweqile (ngokusetshenziswa kwe-ellagic acid ephuma kupomegranate) kanye nezinkinga ezihlobene nokukhuluphala ngokweqile njengokuqina kwe-insulin, uhlobo 2 isifo sikashukela, nesifo esingesona esinotshwala esinamafutha. (U-Inhae Kang et al, u-Adv Nutr., 2016) Izinzuzo ezingeziwe zezempilo zokudla i-Ellagic Acid nazo zifaka phakathi ukuphazamisa umbimbi wesikhumba nokuvuvukala okuhambisana nokuvezwa okungapheli kwe-UV. (UJi-Young Bae et al, Exp Dermatol., 2010)
I-Radiotherapy Yomdlavuza Webele
Umdlavuza wesibeletho uhlobo lomdlavuza oluvame kakhulu kwabesifazane emhlabeni jikelele (https://www.wcrf.org). Kusukela ngoJanuwari 2019, kunabesifazane abangaphezu kwezigidi eziyi-3.1 abanomlando womdlavuza webele e-US kuphela, okubandakanya abesifazane abaqhubeka nokwelashwa okuqhubekayo noma okuqediwe. (Izibalo Zomdlavuza Webele wase-US; https://www.breastcancer.org). I-radiation therapy noma iRadiotherapy ingenye yezindlela zokwelashwa umdlavuza ukwelashwa ngaphandle kokuhlinzwa nokwelashwa ngamakhemikhali futhi isetshenziswa njalo ukwelapha izigaba zokuqala zomdlavuza webele njengendlela yokwelapha yasendaweni ngemva kokuhlinzwa, ukusiza ukwehlisa ithuba lokuthi umdlavuza uzobuya. Ukwelapha ngemisebe kuyasetshenziswa futhi lapho umdlavuza usubuyile futhi usudlulele kwezinye izitho ezinjengobuchopho namathambo, kuhlanganiswe nezinye izindlela zokwelapha ezifana nokwelapha ngamakhemikhali noma i-immunotherapy.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
I-Ellagic Acid neRadiotherapy kuMdlavuza Webele
Ukwelashwa ngemisebe kusebenza ngokudala umonakalo ku-DNA ye umdlavuza amaseli ngokusebenzisa izinhlayiya eziphezulu ze-ionizing zamandla. Kodwa-ke, iphinde ibangele ukulimala okubanjiswayo kumaseli azungezile ajwayelekile, angewona awomdlavuza, okubangela imiphumela engemihle engadingeki futhi enzima. Ukwengeza, ngesimo esikhula ngokushesha samangqamuzana omdlavuza, ahlala ehlanganisa kabusha imishini yawo yangaphakathi futhi akwazi ukusinda ekwelashweni kwe-radiotherapy futhi angazweli emisebeni. Ukuze kuthuthukiswe amathuba empumelelo yokwelashwa ngemisebe kube nocwaningo oluningi ngezinhlanganisela ze-radiosensitizer okuthi uma kuhlanganiswa nokwelashwa ngemisebe kungasiza ekuzuzeni ukulimala okukhulu kwesimila kuyilapho ngesikhathi esifanayo kube yi-radioprotective yamangqamuzana angewona awomdlavuza. Enye inhlanganisela enjalo yemvelo eye yabonisa ngokuhlola le mpahla embaxambili yokuba i-radiosensitizer kumaseli omdlavuza webele kanye ne-radioprotective kumaseli avamile yinhlanganisela ye-phenolic ebizwa nge-Ellagic Acid.
Ucwaningo lwamangqamuzana omdlavuza webele i-MCF-7 lubonise ukuthi i-Ellagic Acid ihlanganiswe nemisebe inyusa ukufa kwamangqamuzana omdlavuza ngo-50-62% kuyilapho inhlanganisela efanayo yayivikela kumaseli avamile i-NIH3T3. Indlela i-Ellagic Acid esebenze ngayo ukuthuthukisa ukusebenza kahle kwemisebe kumangqamuzana omdlavuza wamabele kwaba ngokuthinta kabi i-mitochondria - izimboni zamandla zamangqamuzana; ngokwandisa i-pro cell-death; kanye nokunciphisa izici ezisekela ukusinda ku umdlavuza iseli. Ucwaningo olunjalo luphakamisa ukuthi izinhlanganisela zemvelo ezifana ne-Ellagic Acid zingasetshenziswa “ukuthuthukisa i-radiotherapy yomdlavuza ngokwandisa ubuthi besimila nokunciphisa ukulimala kwamangqamuzana okuvamile okubangelwa ukushiswa kwemisebe.” (U-Ahire V. et al, Nutrition kanye Nomdlavuza, 2017)
Isiphetho
Ngaphezu komthelela we-radiosensitization kumaseli womdlavuza, inqwaba yezifundo zesayensi nazo ziqhakambise izindawo eziningi zokulwa nomdlavuza ze-Ellagic Acid (evame ukutholakala kumapomegranati), ekubeni ikwazi ukunqanda ukwanda kwamangqamuzana omdlavuza, ukusiza ukwenza ukufa kweseli lomdlavuza okubizwa nge-apoptosis, ukuvimbela ukusabalala komdlavuza ngokuvimba ukukhula kwemithambo yegazi emisha kanye nokufuduka nokuhlaselwa kwamangqamuzana omdlavuza kuye kwezinye izingxenye zomzimba (UCeci C et al, Amakhemikhali, i-2018; UZhang H et al, I-Cancer Biol Med., 2014). Kukhona izivivinyo zomtholampilo eziqhubekayo ezinkomba ezahlukene zomdlavuza (umdlavuza webele (NCT03482401), umdlavuza we-colorectal (NCT01916239), umdlavuza wendlala yesinye (NCT03535675) nezinye) ukuze kuqinisekiswe izinzuzo ze-chemopreventive kanye nokwelashwa kwe-Ellagic Acid ezigulini ezinomdlavuza, njengoba kubonakala kumamodeli wokuhlola umdlavuza. Naphezu kokuba lesi sengezo semvelo singenabo ubuthi futhi siphephile, i-Ellagic acid kufanele isetshenziswe kuphela ngokubonisana nochwepheshe bezokunakekelwa kwempilo, ngoba inamandla okusebenzelana nemithi ethile ngenxa yokuvinjwa kwama-enzyme e-metabolizing esibindini. Futhi, ukukhetha umthamo ofanele we-Ellagic acid kanye nokwakheka okunokuncibilika okuthuthukisiwe nokutholakala kwe-bioavailability kuyadingeka ukuze kutholwe umthelela wayo ophelele wokwelapha.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.