Amaphuzu avelele
Umdlavuza wezingane onjenge-leukemia owelashwa ngemithamo ephezulu yokwenyuka kwamakhemikhali afana ne-cyclophosphamides kanye ne-anthracyclines, ubhekene nengozi eyengeziwe yokuthola umdlavuza olandelayo / wesibili. Umdlavuza wesibili / wesibili kulabo abasinde kumdlavuza wezingane ujwayelekile umphumela wesikhathi eside we-chemotherapy.
Umdlavuza Wezingane
Umdlavuza wezingane kwenzeka ezinganeni, intsha kanye nabantu abadala. Umdlavuza ovame kakhulu ezinganeni i-leukemia, umdlavuza wegazi. Ezinye izinhlobo zomdlavuza ezifana ne-lymphoma, izimila zobuchopho, ama-sarcoma nezinye izimila eziqinile nazo zingenzeka. Ngenxa yokwelashwa okuthuthukisiwe, bangaphezu kuka-80% abasinde kumdlavuza wezingane e-US. Ukwelashwa kuncike ohlotsheni lomdlavuza kodwa kungabandakanya ukuhlinzwa, imiphumela emibi yokwelashwa ngamakhemikhali, ukwelashwa ngemisebe futhi muva nje ngisho nokwelashwa kwamasosha omzimba. Kodwa-ke, ngokweNational Pediatric Cancer Foundation, balinganisela ukuthi ngaphezu kwe-95% yabasinde bomdlavuza wezingane bazoba nenkinga ebalulekile ehlobene nempilo lapho sebeneminyaka engama-45 ubudala, okungaba umphumela wokwelashwa kwabo komdlavuza ngaphambilini.https://nationalpcf.org/facts-about-childhood-cancer/).
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Umdlavuza Wesibili Kwabasindile Komdlavuza Wezingane
Ngokutholakala kwenani elikhulu labasindile bomdlavuza, abacwaningi abavela e-University of Minnesota Medical School bahlole inhlangano yabasindile bomdlavuza wezingane abaphathwa ngamakhemikhali ngezigameko ze-neoplasm (SMN) ebulalayo elandelayo njengengxenye yocwaningo lokusinda komdlavuza wezingane (ITurcotte LM et al, J Clin Oncol., 2019). Bahlolisise ama-SMN kwabasindile abaqale batholakala benomdlavuza besengaphansi kweminyaka engama-21 ubudala, phakathi kuka-1970-1999. Imininingwane ebalulekile yabantu besifundo nokutholakele kokuhlaziywa kwabo yile:
- Iminyaka ephakathi kokutholakala kokutholakala kwaba yiminyaka eyi-7ye kanye neminyaka ephakathi kokulandelwa kokugcina kwaba yiminyaka eyi-31.8.
- Bahlolisise ukusinda kwabantwana abangaphezu kuka-20,000 XNUMX abaphathwa ngamakhemikhali kuphela, i-chemotherapy kanye ne-radiation therapy, i-radiation therapy iyodwa noma cha.
- Abasinda ebuntwaneni abaphathwa ngamakhemikhali kuphela babenobungozi obungu-2.8 obandayo be-SMN.
- Izinga lezehlakalo ze-SMN laliphezulu kulabo abasinda ebuntwaneni abaphathwa ngemithi ye-platinum. Ngokwengeziwe, kuma-alkylating agents (Isib. I-Cyclophosphamide) ne-anthracyclines (Isib. I-Doxorubicin), kwakukhona ubudlelwano bokuphendula ngomthamo obubonwa phakathi kwemithamo ephezulu yalezi chemotherapy nokwanda komdlavuza webele.
Ubungozi Bomdlavuza Wesibili Webele ku-Leukemia noma eSurcoma Survivors
Kokunye ukuhlaziywa kwaphambilini njengengxenye yocwaningo lokusinda komdlavuza wezingane ebandakanya i-leukemia yabantwana besifazane engu-3,768 noma umdlavuza we-sarcoma Abasindile abelashwa ngemithamo ekhulayo yokwelashwa ngamakhemikhali njenge-cyclophosphamide noma i-anthracyclines, kutholakale ukuthi bahlotshaniswa kakhulu nengozi yokuba nomdlavuza webele oyinhloko wesibili / wesibili. Kube nokugoqeka okungu-5.3 no-4.1 fold kwandisa amathuba okuba nomdlavuza webele wesibili oyinhloko / wesibili kuma-sarcoma kanye nabasindile be-leukemia ngokulandelana. (UHenderson TO et al., J Clin Oncol., 2016)
Ubungozi Bomdlavuza Wesikhumba Osezingeni Eliphezulu Kwabasindile Komdlavuza Wezingane abake bathola i-Radiotherapy
Ngokusho kokutholwe kolunye ucwaningo olubizwa nge-DCOG-LATER cohort study obekubandakanya abantu abangama-5843 baseDutch abasinde kumdlavuza wezingane okwatholakala ukuthi banezinhlobo ezahlukene zomdlavuza. zomdlavuza phakathi kuka-1963 no-2001, abasindile abake belashwa nge-radiotherapy baba nengozi eyengeziwe yomdlavuza wesikhumba wesibili Ucwaningo lwathola cishe izikhathi ezingama-30 ukwanda kwengozi ye-basal cell carcinomas kulaba abasindile. Lokhu kubuye kuncike kubukhulu bendawo yesikhumba evezwe ngesikhathi sokwelashwa. (Jop C Teepen et al, J Natl Umdlavuza Inst., 2019)
Isiphetho
Kafushane, abasinde kumdlavuza wezingane abalashwe ngemithamo ephezulu enqwabelene ye-chemotherapy efana ne-cyclophosphamide noma i-anthracyclines yomdlavuza onjengoleukemia babhekene nengozi eyengeziwe yokuthola umdlavuza wesibili/wesibili (umphumela omude we-chemotherapy wesikhathi eside). Ngakho-ke, ukuhlaziywa kwengozi-inzuzo ye umdlavuza Ukwelashwa kwezingane kanye nabantu abadala abasebasha kufanele kuthande ukwelapha ngokunciphisa imithamo enqwabelene yokwelapha ngamakhemikhali kanye nokucatshangelwa kwezinye izindlela zokwelapha eziqondiswe kakhulu ukuze kuncishiswe ingozi yokuba nomdlavuza obulalayo olandelayo esikhathini esizayo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.