Yimuphi umdlavuza ongazuza ngokufaka Ikhofi ekudleni kwabo?

Amaphuzu avelele

Ikhofi laziwa kabanzi ngezinzuzo zalo zezempilo futhi livame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kwekhofi ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, Ikhofi lingase lizuzise labo abane-Primary Cervical Neuroendocrine Tumor abathola i-Docetaxel, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Fibromatosis. Ngaphezu kwalokho, nakuba Ikhofi lingasiza abantu abanesici esiyingozi sofuzo “TERT”, angeke liphakanyiswe kulabo abasengozini yofuzo ehlukile “ATM”. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwekhofi esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi ikhofi liyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana nekhofi esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uyaphakama: Ingabe kufanele ufake Ikhofi ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle Ikhofi uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ATM? Ingabe kunenzuzo ukufaka Ikhofi ekudleni kwakho uma kutholakala ukuthi une-Primary Fibromatosis, noma uma ukuxilongwa kwakho kuyi-Primary Cervical Neuroendocrine Tumor? Ngaphezu kwalokho, ukusebenzisa kwakho Ikhofi kufanele kulungiswe kanjani uma welashwa nge-Docetaxel noma uma uhlelo lwakho lokwelapha lusuka ku-Docetaxel luye kwiRadiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'Ikhofi lingokwemvelo, ngakho lihlala lizuzisa' noma 'Ikhofi lithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka Ikhofi ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana nekhofi ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangele izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Cervical Neuroendocrine Tumor noma Primary Fibromatosis, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengekhofi. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-TERT inemithelela efanayo ye-biochemical pathway njengoguquko ku-ATM? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Cervical Neuroendocrine Tumor ilingana ne-Primary Fibromatosis? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Docetaxel? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Ikhofi – Isengezo Esinomsoco

Isithasiselo Ikhofi sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Lauric Acid, i-L-histidine, i-Chlorogenic Acid, i-D-aspartic Acid ne-L-phenylalanine, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Carbohydrate Metabolism, i-JAK-STAT Signaling, Ukulungiswa KweDNA kanye ne-Oncogenic Cancer Epigenetics, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengekhofi, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa Ikhofi lomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweKofi akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo Zekhofi

Ukubhekana nombuzo othi 'Kufanele ngiligweme nini Ikhofi esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo zekhofi kuyehluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithasiselo ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi ikhofi lifanelekile yini noma kufanele ligwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo Zekhofi zizozizuzisa Iziguli Eziyinhloko ze-Fibromatosis ezelashwa ngeRadiation?

I-Primary Fibromatosis ibonakala ngokuguqulwa kofuzo okuthile, okuyi-CTNNB1, KDR ne-CIC, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-JAK-STAT Signaling, i-Adherens junction, i-Androgen Signaling, i-Angiogenesis kanye ne-RAS-RAF Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo Sekhofi, esithinta Ukusayinwa kwe-JAK-STAT, kungase kungabi inketho efanele esimweni se-Primary Fibromatosis lapho sithola I-Radiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Zekhofi zizozizuzisa Iziguli Eziyinhloko Ze-Cervical Neuroendocrine Tumor ezelashwa nge-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ibonakala ngokuguqulwa kwezakhi zofuzo ezithile, njenge-ABHD6, STOX1 kanye ne-PDZD4, okuholela ekushintsheni kwezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Carbohydrate Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Docetaxel, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo Sekhofi siyinketho enengqondo yalabo abane-Primary Cervical Neuroendocrine Tumor ebhekene ne-Docetaxel. Lokhu kungenxa yokuthi Ikhofi lithonya izindlela ezifana ne-Carbohydrate Metabolism, engase ivimbele izici eziqhuba I-Primary Cervical Neuroendocrine Tumor noma izuzise ukusebenza kahle kwe-Docetaxel.

3. Ingabe Izithasiselo Zekhofi Ziphephile Kubantu Abanempilo Enempilo Nge-ATM Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ATM luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ATM kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana nokulungiswa kwe-DNA, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza ukuguqulwa kwezakhi zofuzo ku-ATM okuhlobene nengozi eyengeziwe Ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwekhofi eyengeziwe. Lokhu kungenxa yokuthi isengezo Ikhofi sithonya izindlela ezifana nokulungiswa kwe-DNA, okungaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ATM kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Zekhofi Ziphephile Kubantu Abanempilo Enempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Oncogenic Cancer Epigenetics kanye ne-DNA Repair, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ehambisana Nomdlavuza Wegazi, cabanga ukufaka izithasiselo zekhofi ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Oncogenic Cancer Epigenetics, zizuze ngokunikeza usizo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana neKofi, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• I-Chlorogenic acid ivimbela ukulimala kwesibindi se-cholestatic okubangelwa i-α-naphthylisothiocyanate: ukubandakanyeka kwe-STAT3 ne-NFκB yokulawula ukusayina.
• I-genomics yomtholampilo edidiyelwe yomdlavuza we-metastatic.
• I-STAT3: I-Novel Molecular Mediator of Resistance to Chemoradiotherapy.
• cBioPortal for Cancer Genomics
• [Imiphumela ye-tizanidine, isinqamuli semisipha esimaphakathi, phezu kokukhalipha komgogodla].