Amaphuzu avelele
I-Apigenin, isithasiselo semvelo esivela ezitshalweni esitholakala kwimifino ejwayelekile, izithelo, amakhambi neziphuzo kuye kwaziwa ukuthi kunezinzuzo ezehlukene zezempilo ngenxa yemiphumela yazo elwa nomdlavuza kanye nemiphumela yokulwa nokuvuvukala. Izifundo eziningi zaselabhorethri zikhombisile ukuthi i-Apigenin ingasiza kanjani ekuvimbeleni amangqamuzana omdlavuza nokuthi angahlangana kanjani ne-chemotherapy ethize ezinhlotsheni zomdlavuza ezifana ne-prostate, i-pancreatic, isisu kanye neminye imidlavuza.
Isishayo sokuxilonga umdlavuza yisigameko esishintsha impilo esiholela umuntu ukuthi aphinde avakashele futhi aguqule indlela yakhe yokuphila kanye nokukhetha kokudla. Naphezu kweqiniso lokuthi i-chemotherapy isengenye yezindlela zokwelapha ezingcono kakhulu zokwelapha umdlavuza, iziguli ziyaziqaphela izindaba eziningi ezihlobene ne-chemo ikakhulukazi imiphumela emibi kakhulu kanye nomthelela wekhwalithi yokuphila. Isiguli somdlavuza sibheka noma yiziphi izindlela kanye nazo zonke ezinye izindlela zokwelapha ngamakhemikhali, ukuze sithuthukise 'amathuba aso empumelelo'. Enye inketho enjalo ukungeza izithasiselo zemvelo nezamakhambi eziye zasetshenziswa emithini yesintu emhlabeni wonke, ukuze ziqinise amasosha omzimba kanye nezakhiwo zokuphulukisa (ikhambi lemvelo lomdlavuza). I-modus operandi yabaningi umdlavuza Iziguli ziwukukhetha okungahleliwe kwalezi zitshalo ezitholwe yimikhiqizo yemvelo enemiphumela yokulwa nomdlavuza eziqala ukuyithatha, ngombono wokuthi kuzobasiza ukubhekana kangcono nemiphumela engemihle ngaphandle kokwengeza umthwalo wobuthi futhi bathuthukise amathuba abo okungabi nawo umdlavuza. ukusinda. Omunye umkhiqizo onjalo wemvelo i-flavonoid ebizwa ngokuthi i-Apigenin.
I-Apigenin nemithombo yayo yokudla
I-Apigenin iyi-flavonoid yokudla (i-flavone) etholakala ezitshalweni eziningi, izithelo, imifino neziphuzo ezibandakanya:
- I-Chamomile itiye
- parsley
- isilimo esidliwayo esinamagatsha anamanzi
- Isipinashi
- Usuku
- emhlophe
- spearmint
- Basil
- oregano
- Fenugreek
- Ugaliki
- Iwayini elibomvu
I-Apigenin idlala indima ebalulekile ekwelashweni ngamakhambi aseChina.
Ukusetshenziswa Okushiwo / Izinzuzo Zezempilo ze-Apigenin
Njengemikhiqizo eminingi yemvelo esetshenziswa ngokwesiko, kuyaziwa ukuthi i-Apigenin inemisebenzi enamandla elwa nokuvuvukala, i-antioxidant, antibacterial kanye ne-antiviral ngakho-ke ithathwa njengezinzuzo eziningi zezempilo. Ezinye izinzuzo zokusetshenziswa / zezempilo ze-Apigenein zifaka:
- Kunganciphisa ukucindezeleka / ukukhathazeka nokuqwasha (ukulala)
- Kungaba nemiphumela elwa nesifo sikashukela
- Kwangathi kungasebenza umphumela we-neuroprotective
- Kungaba nezindawo ezilwa nomdlavuza
- Kungasiza ukunciphisa umfutho wegazi
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Imiphumela Yokulwa Nomdlavuza / Izinzuzo ze-Apigenin
Ucwaningo olunzulu olwenziwe ezinhlobonhlobo ze umdlavuza imigqa yamaseli namamodeli ezilwane asebenzisa i-Apigenin abonise imiphumela yawo yokulwa nomdlavuza. Ubuhle be-flavonoid njenge-Apigenin ukuthi ayikwazi nje ukusiza ezinyathelweni zokuvimbela umdlavuza ukunciphisa ingozi engaba khona yesikhathi esizayo yokuthuthukisa isimila, kodwa futhi iyakwazi ukusebenza ngokubambisana namanye ama-chemotherapies ukuthuthukisa ukusebenza kahle komuthi (UJan et al, Cell Biosci., 2017).
Zimbalwa Izibonelo Zokulwa Nomdlavuza we-Apigenin
Ezinye zezibonelo ze umdlavuza izenzo zokuvimbela i-Apigenin kanye nokusebenzisana kwayo ne-chemotherapy ezinhlotsheni ezithile zomdlavuza kugqanyiswe ngezansi.
Umphumela we-Apigenin Emdlavuzeni Wamathumbu
Endabeni yomdlavuza wamathumbu, i-Apigenin yatholwa ibanga ukufa kweseli futhi yavimbela ukukhula kwemithambo yegazi emisha esiza ukuthi isimila sikhule. Ngaphezu kwalokho, u-Apigenin wenza imvelo yesimila yaba nobutha ngokunciphisa ukutholwa kweglucose ngamangqamuzana omdlavuza, ukuphazamisa ukulungiswa kabusha kwe-matrix ngaphandle nangaphandle kweseli lomdlavuza, nokuvikela izinqubo ezikhuthaza ukuqhubeka komdlavuza nokusabalala (ULefort EC et al, iMol Nutrut Res Res., 2013).
Umphumela wokuthatha i-Apigenin kanye neGemcitabine Chemotherapy yePancreatic Cancer - Izifundo Zokuhlola
- Ucwaningo lwelabhoratri olwenziwe ngabaphenyi abavela eSeoul National University College of Medicine eKorea lwathola ukuthi i-apigenin ithuthukisa ukusebenza kwe-anti-tumor ye-gemcitabine kumdlavuza we-pancreatic. (U-Lee SH et al, uCancer Lett., 2008)
- Olunye ucwaningo olwenziwe ngabaphenyi abavela eFeinberg School of Medicine eChicago luye lwathola nokuthi ukusebenzisa i-apigenin kanye ne-gemcitabine kuvimbela ukukhula kwamangqamuzana omdlavuza wepancreatic futhi kwafa umdlavuza wesifo somdlavuza (apoptosis). (UStrouch MJ et al, AmaPancreas, 2009)
Ngamafuphi, izifundo eziningi ezisebenzisa amasiko namaseli ezinhlobonhlobo zezilwane zathola ukuthi i-Apigenin yenze ukuthi ukusebenza kwe-gemcitabine chemotherapy kube nzima ukwelapha umdlavuza wepancreatic.
Umphumela wokuthatha i-Apigenin kanye neCisplatin Chemotherapy - Ucwaningo Lokuhlola
Ocwaningweni olwenziwe ngabaphenyi baseTrakya University eTurkey, i-Apigenin uma ihlanganiswe nomuthi we-chemo iCisplatin ithuthukise kakhulu umthelela wayo we-cytotoxic kumaseli womdlavuza wendlala (umphumela wokulwa nomdlavuza we-Apigenin), kanye nezinqubo zamangqamuzana ezenziwa yi-Apigenin. (U-Erdogan S et al, Biomed Pharmacother., 2017).
Isiphetho
Ucwaningo oluhlukile lokuhlola luphakamisa amandla/izinzuzo zokulwa nomdlavuza ze-apigenin. Nokho, imiphumela evela kulezi zifundo zokuhlola ayiqinisekiswanga ekuhlolweni kwabantu. Futhi, ngesexwayiso, iqiniso lokuthi umkhiqizo wemvelo onjenge-Apigenin uyakwazi ukuba nomthelela ojule kangaka ezingeni lamaselula liphinde lisho ukuthi lingaba nemiphumela emibi ekwelashweni komdlavuza womuntu uma lisetshenziswa nenhlanganisela engalungile yezidakamizwa ze-chemo. Ukwengeza, i-Apigenin ukuba i-antioxidant ingaphazamisa izidakamizwa ze-chemo ezisebenzisa indlela yokwandisa ukulimala kwe-oxidative kumaseli omdlavuza uma ithathwa kanyekanye ne-chemo, kuyilapho ucwaningo lubonise ukuthi ukwelashwa kwangaphambili nge-Apigenin ngaphambi kwe-chemo kube nomthelela ongcono. Ngakho-ke, kusemqoka ukuthi umdlavuza iziguli zihlale zithintana nochwepheshe bazo bezempilo ngokudla kwazo kanye nokusebenzisa izithasiselo zemvelo lapho zelashwa ngamakhemikhali kunokukhetha okungahleliwe okusekelwe ezincomo ezivela emndenini nakubangane.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.