Amaphuzu avelele
I-Curcumin, ekhishwe empandeni ye-turmeric, iye yacwaningwa kabanzi ngezindawo zayo zokulwa nomdlavuza ngemininingwane yezindlela zamaselula zokuthi ingasiza kanjani ukuvumelanisa nge-chemotherapy ethile. I-Curcumin evela ku-turmeric ithuthukise impendulo yokwelashwa ngamakhemikhali kwe-FOLFOX ezigulini ezinomdlavuza we-colorectal njengoba kuqokonyiswe ukuhlolwa komtholampilo kwesigaba II. Nokho, umdlavuza iziguli kufanele zithathe izithako ze-Curcumin (i-curcumin egxilile ekhishwe ku-turmeric) kuphela ngaphansi kwesiqondiso somsebenzi wezempilo njengoba ingase ihlanganyele nezinye izindlela zokwelapha ezifana ne-Tamoxifen.
Isinongo seTurmeric
I-Turmeric yisinongo esasetshenziswa kabanzi amakhulu eminyaka e-Asia hhayi njengesithako esiyinhloko ekudleni kwaseNdiya kepha emithini yendabuko yamaShayina nasemithini yase-Indian Ayurvedic, ukwelapha izinkinga ezahlukahlukene zezempilo. Muva nje kube nocwaningo olunzulu ngezindawo ezilwa nomdlavuza zesithako esisebenzayo esibalulekile iCurcumin, esikhona nge-turmeric (curcuma longa). ICurcumin ikhishwe ezimpandeni zeTurmeric futhi ibonakaliswa ngombala ophuzi owolintshi. Kunenqwaba yezifundo nokubukwa okushicilelwe ezinkulungwaneni zamaphephabhuku abukezwe ontanga ngezinto zokwelapha zeCurcumin.
ICurcumin evela kusinongo seTurmeric iyi-phytochemical enomthelela obanzi ezinqubweni eziningi zamaselula, izindlela, amaprotheni nezakhi zofuzo kufaka phakathi ama-kinase ahlukene, ama-cytokines, ama-enzyme nezici zokubhala. Ngakho-ke iCurcumin inezinto eziningi ezivikela impilo kubandakanya i-antioxidant, anti-cancer, anti-inflammatory, antimicrobial, immunomodulatory, neuroprotective, kanye nokuvikelwa okubanzi ezithweni eziningi nasezinhlelweni zezitho kubandakanya isibindi, izinso, isikhumba njll. (Kocaadam B et al, Crit. UMfu Food Sci. Nutr., 2015)
Kule bhulogi sizofingqa ubufakazi bokuhlola nobemitholampilo bezakhiwo ze-chemopreventive and anticancer of Curcumin, ukhiye osebenzayo we-spice Turmeric. Kuyindlela efinyeleleka kalula, ephansi futhi enobuthi obuphansi, i-phytochemical yemvelo, ekhethwe njengenye yezinto ezingathembisa ukuvivinywa ekuhlolweni kwemitholampilo yi-US National Cancer Institute.
Ngaphandle kobufakazi obuqinile bokuhlola nobokusebenza kwamandla we-Curcumin's anticancer pharmacological, inezinkinga zokumuncwa okungekuhle kanye nokutholakala okuphansi emzimbeni, ngendlela yayo yemvelo. Lokhu kungabhekiswa ngokwakhiwa okuthuthukisa ukutholakala kwayo. Ngokwengeziwe, ngokusebenzisana kwayo nezidakamizwa ezisebenzisa i-enzyme kanye nabathuthi bezidakamizwa, inamandla amakhulu okusebenzisana nezinye izidakamizwa. Ngakho-ke, kunesidingo semfundo eyenzelwe kahle yomtholampilo yokuchaza izimo eziqondile kanye nenhlanganisela lapho i-Curcumin ingasetshenziswa khona. (Unlu A et al, JBUON, 2016)
Izakhiwo Zokulwa Nokuvuvukala kweCurcumin / Turmeric Nikeza Izinzuzo Zokulwa Nomdlavuza
Izici ezibalulekile zokulwa nomdlavuza weCurcumin / Turmeric kungenxa yezakhiwo zayo ezilwa nokuvuvukala nezokuzivikela komzimba.
Umdlavuza wenzeka lapho amangqamuzana ethu eguqulwa ngenxa yezinguquko nokukhubazeka okubangelwa izimbangela eziningi ezahlukahlukene kubandakanya indlela yokuphila, ukudla, ingcindezi, imvelo kanye nezici zofuzo. Imizimba yethu yakhelwe ngonogada nezindlela zokuzivikela emazingeni e-systemic namaselula. Amasosha ethu omzimba aklanyelwe ukukhomba noma yini engaphandle (ukutheleleka ngamagciwane noma igciwane) noma yini ngaphakathi emzimbeni engajwayelekile, futhi enezinqubo kanye nokugeleza kokusebenza kwezinto eziphilayo ukukhipha konke okungajwayelekile. Ngisho nasezingeni lamangqamuzana njengoba amaseli ehlukana ukukhula, ukuvuselelwa, ukuphulukiswa kwamanxeba nokunye ukusebenza komzimba okujwayelekile, sinokuhlola kuwo wonke amazinga siqala ngokubheka ukunemba komlayezo oyinhloko ku-genome yethu, i-DNA. Kukhona yonke imishini yokuzwa nokulungisa i-DNA yemishini esebenza njalo kule nqubo.
Lapho umdlavuza wenzeka, izifundo ziqinisekisile ukuthi kukhona ukukhubazeka ezingeni lamaselula ngemishini yokulungisa i-DNA edala ukulimala okungaphezulu kwamaselula nokungajwayelekile, kanye nenkinga ehlelekile kumasosha omzimba wamaphoyisa anganakiwe futhi angakwazi ukubona nokusula ukungajwayelekile. Ngakho-ke amangqamuzana angajwayelekile avunyelwe ukusinda futhi amangqamuzana anamandla abe esethatha uhlelo futhi achuma futhi achume njengoba isifo siqhubeka.
Ukuvuvukala kuyinqubo lapho umzimba ngokwemvelo ubona ukukhubazeka noma ukungajwayelekile futhi uqasha izivikeli mzimba zomzimba ukubhekana nenkinga nokususa inkinga. Ngokuyinhloko, konke ukuphazamiseka okubandakanya ukuphazamiseka komzimba, ukuphazamiseka okwehlayo kanye nomdlavuza kungenxa yokungasebenzi kahle kwesistimu yomzimba. Endabeni yomdlavuza, amasosha omzimba ayadunwa ukuze angaqapheli kepha asekele amangqamuzana angajwayelekile futhi asize ekukhuleni kwawo.
Kunezifundo eziningi ezinqume izindlela zeselula zezenzo ezilwa nokuvuvukala zeCurcumin ezikhishwe kwiTurmeric ezinikeza inzuzo ebalulekile yokulwa nomdlavuza. ICurcumin isebenzisa izakhiwo zayo ezilwa nokuvuvukala ngokusebenzisana nabalamuli abaningana bokuzivikela emzimbeni njengokuvimbela izinto zokubhala ezinamandla okuvuvukala njengeNuclear factor kappa B (NFKB), ivimbela ama-cytokines ahlasela ukuvuvukala, amakhemikhali, ama-prostaglandin kanye nezinhlobo zomoya-mpilo ezisebenzayo (ROS). Iningi lalaba balamuli liyabandakanyeka ezindleleni zokusayina eziningi zamangqamuzana ezihambisana nezimpawu zomdlavuza ezinjengokukhula komdlavuza ngokweqile (ukwanda), ukunciphisa ukufa kwamaseli (apoptosis), ukuhluma ngokweqile kwemithambo yegazi emisha (angiogenesis) nokuxhasa ukusabalala kwamangqamuzana omdlavuza angajwayelekile ezinye izitho zomzimba (metastasis). Izici ze-immunomodulatory zeCurcumin azibangelwa kuphela ukuvinjelwa kwezinhloso zamangqamuzana eselula kepha futhi zikwazi ukulinganisa ngempumelelo amaseli omzimba afana nama-macrophage, amaseli we-dendritic, ama-T-cell nama-B-lymphocyte, uhlelo lokuzivikela lomzimba. (UGiordano A noTommonaro G, amaNutrients, 2019)
Izifundo Zokuhlola Ngemiphumela Elwa Nomdlavuza YeTurmeric / Curcumin In Cancer
Imiphumela yokulwa nomdlavuza yeCurcumin / Turmeric iphenyiwe emigqeni eminingi yamangqamuzana omdlavuza nakumamodeli wezilwane. ICurcumin ikhombise imiphumela ezuzisayo yokunciphisa ukukhula komdlavuza kumamodeli womdlavuza wendlala yabesilisa, umdlavuza webele kubandakanya umdlavuza webele omubi ophindwe kathathu, umdlavuza wekhanda nowentamo, umdlavuza wamaphaphu nabanye abaningi. (Unlu A et al, JBUON, 2016)
Ngokwengeziwe, kube nezifundo zokuhlola ukuthi iCurcumin ingakhulisa ukuzwela kwezidakamizwa zamakhemikhali kanye nokwelashwa ngemisebe.
- I-Curcumin ikhonjiswe ukuthi ikhulisa ukuzwela kwe-5-fluorouracil emigqeni yamangqamuzana omdlavuza onobuhle. (Shakibaei M et al, PLoS One, 2014)
- ICurcumin ekhishwe eTurmeric ngokuzama ithuthukise ukusebenza kwe-cisplatin ekhanda nasentanyeni nasemangqamuzaneni omdlavuza we-ovari. (Kumar B et al, PLoS One, 2014; Selvendiran K et al, Cancer Biol. Ther., 2011)
- ICurcumin kubikwe ukuthi yandisa ukusebenza kwe-paclitaxel kumaseli womdlavuza womlomo wesibeletho. (Sreekanth CN et al, Oncogene, 2011)
- Kwi-lymphoma, iCurcumin ikhonjiswe ukukhulisa ukuzwela ekwelashweni ngemisebe. (UQiao Q et al, Izidakamizwa ze-Anticancer, 2012)
- Emangqamuzaneni omdlavuza wamangqamuzana amangqamuzana, i-Curcumin evela eTurmeric kubikwe ukuthi ihambisana nomuthi we-chemotherapy i-vinorelbine. (USen S et al, iBiochem Biophys Res. IKhomishini., 2005)
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Izifundo Zomtholampilo Ngomthelela WeCurcumin kuCancer
ICurcumin isacwaningwa ezifundweni eziningi eziqhubekayo zomtholampilo, zombili njenge-monotherapy futhi zihlangene nezinye izidakamizwa.
- Esifundweni somtholampilo onomdlavuza obumbala, ukwakheka komlomo kwe-curcumin kwahlolwa. Kube bungekho ubuthi ngeCurcumin, kuyilapho eziguli ezimbili kwezingu-2 zikhombise izifo ezizinzile ngemuva kwezinyanga ezimbili zokwelashwa kweCurcumin. (Sharma RA et al, Clin Cancer Res., 15) Kwesinye isigaba sesibili sokuhlolwa kweziguli ezingama-2 ezinezilonda zomdlavuza wamakholoni, ukusetshenziswa kweCurcumin izinsuku ezingama-2004 kubikwe ukuthi kwehlisa inani lezilonda ngo-44%. (UCarroll RE et al, Cancer Prev. Res. (Phila), 30)
- Esivivinyweni sesigaba II sokwakheka ngomlomo kweCurcumin ezigulini zomdlavuza ze-pancreatic ezingama-25 ezithuthukile, iziguli ezimbili zikhombise umsebenzi wemitholampilo wesiguli ngesiguli esisodwa okubikwa ukuthi sinezifo ezizinzile> izinyanga eziyi-18 kanti esinye sinesifo esifushane kodwa esibalulekile sokuhlehla kwesimila. (UDhillon N et al, iCancer Cancer Res., 2008)
- Ucwaningo lomtholampilo lweziguli ezingama-myeloid leukemia (CML) ezingalapheki, umphumela wokwelashwa kwenhlanganisela yeCurcumin kanye ne-Imatinib (umuthi ojwayelekile wokunakekelwa kwe-CML) wahlolwa. Inhlanganisela ikhombise ukusebenza kangcono kune-Imatinib iyodwa. (UGhalaut VS et al, J Oncol. Pharm Pract., 2012)
- Ezigulini zomdlavuza webele, uCurcumin uphenywa nge-monotherapy (NCT03980509) futhi ngokuhlanganiswa ne-paclitaxel (NCT03072992). Kuyabuye kuhlolwe nakwezinye izifundo zokwelashwa ngomdlavuza wesibeletho onobungozi obuphansi, umdlavuza wesibeletho, umdlavuza we-endometrial, i-uterine sarcoma nezinye. (UGiordano A noTommonaro G, amaNutrients, 2019)
- Ucwaningo lwakamuva lwesigaba II somtholampilo ezigulini ezinomdlavuza we-metastatic colorectal (NCT01490996) uqhathanise ukusinda okuphelele kweziguli ezithola inhlanganisela ye-chemotherapy FOLFOX (folinic acid / 5-fluorouracil / oxaliplatin treatment) nangaphandle kwezithako zeCurcumin (ezivela eTurmeric). Ukungezwa kweCurcumin ku-FOLFOX kutholakale kuphephile futhi kubekezeleleka kwiziguli ezinomdlavuza ongaconsi phansi futhi akuzange kubhebhethekise imiphumela emibi ye-chemo. Ngokuya ngamazinga okuphendula, iqembu leCurcumin + FOLFOX libe nomphumela wokusinda ongcono kakhulu ngokuqhubeka kwamahhala okuqhubeka kube yizinsuku eziyi-120 ubude kuneqembu leFOLFOX nokusinda okuphelele kuphindwe kabili. (Howells LM et al, J Nutr, 2019) Kubandakanya iCurcumin njengengxenye ye-colorectal Ukudla kweziguli ezinomdlavuza lapho ukuthatha i-FOLFOX chemotherapy kungasiza.
Ukusebenzisana kweCurcumin nezinye Izidakamizwa
I-Curcumin, nakuba iqashelwa njengesithako esiphephile ngokuvamile yi-FDA (Ukulawulwa Kokudla Nezidakamizwa), inobufakazi bokuthi ithinta umuthi ohlanganisa ama-enzyme e-cytochrome P450. Ngakho-ke, inamandla okusebenzelana nezidakamizwa ezithile futhi iphazamise ukusebenza komuthi. Kukhona izifundo ekusebenzisaneni kwayo nezidakamizwa ezihlanganisa izidakamizwa ze-antiplatelet, nezinye umdlavuza kanye nezidakamizwa ze-chemotherapy ezihlanganisa i-Tamoxifen, i-doxorubicin, i-cyclophosphamide, i-tacrolimus nezinye. (Unlu A et al, JBUON, 2016)
Impahla yeCurcumin antiplatelet ingakhuphula ubungozi bokuphuma kwegazi lapho isetshenziswa ngama-anticoagulants. Impahla yayo ye-antioxidant ingaphazamisa ukusebenza kwesidakamizwa se-chemotherapy njenge-cyclophosphamide ne-doxorubicin. (Yeung KS et al, Oncology J, Integrative Oncol., 2018)
UCurcumin ovela eTurmeric uxhumana nokwelashwa kweTamoxifen, Izinga Lokunakekelwa KweHormone Positive Breast Cancer
Isidakamizwa somlomo i-Tamoxifen sihlanganiswa emzimbeni sibe yimetabolites yayo esebenzayo ekhemisi ngokusebenzisa ama-enzyme e-cytochrome P450 esibindi. I-Endoxifen yi-metabolite esebenzayo yomtholampilo yeTamoxifen, lowo ngumlamuleli oyinhloko wokusebenza kokwelapha kwe-tamoxifen (Del Re M et al, Pharmacol Res., 2016). Olunye ucwaningo lwangaphambilini olwenziwe kumagundane lwalukhombisile ukuthi kunokusebenzisana kwezidakamizwa phakathi kweCurcumin neTamoxifen. ICurcumin ivimbele i-cytochrome P450 mediated metabolism of the tamoxifen's conversion to its form active (Cho YA et al, Pharmazie, 2012). Ucwaningo lomtholampilo olusanda kushicilelwa (i-EudraCT 2016-004008-71 / NTR6149) oluvela e-Erasmus MC Cancer Institute eNetherlands, luhlole lokhu kusebenzisana phakathi kweCurcumin kusuka eTurmeric (nge-piperine noma ngaphandle kwayo) nokwelashwa kweTamoxifen ezigulini zomdlavuza webele (IHussaarts KGAM et al, Cancers (Basel), 2019). Abaphenyi bahlole amazinga weTamoxifen ne-Endoxifen phambi kweCurcumin.
Imiphumela ikhombise ukuthi ukugxila kwe-metabolite esebenzayo ye-Endoxifen kwehle ngeCurcumin. Lokhu kwehla kwe-Endoxifen kwakubalulekile ngokwezibalo. Ngakho-ke, uma isithasiselo seCurcumin (esivela eTurmeric) sithathwa kanye nokwelashwa kweTamoxifen komdlavuza webele, kunganciphisa ukugxila kwesidakamizwa esisebenzayo ngaphansi komkhawulo waso wokusebenza kahle futhi okungaphazamisa umthelela wokwelashwa komuthi.
Isiphetho
I-Turmeric, isinongo esiphuzi esiphuzi okusawolintshi, ibisetshenziswa amakhulu eminyaka, ngisho nangaphambi kokuba kutholakale isithako sayo esisebenzayo iCurcumin, ngezinzuzo zayo eziningi zezempilo. Isetshenziswa njenge-anti-inflammatory futhi isetshenziswe ngqo emanxebeni ukuthuthukisa ukuphulukiswa kwesilonda. Ingcosana ye-turmeric enebisi elishisayo bekuyikhambi elidala lokulwa namagciwane nokuvikela amasosha omzimba okusetshenziswa emakhaya namuhla, njengokuhlakanipha kwendabuko. Kuyisithako se-curry powder futhi isetshenziswa kakhulu futhi kabanzi njengengxenye yokudla kwaseNdiya nase-Asia. Isipuni sempande ye-turmeric eluhlaza kanye ne-grated kanye nopelepele omnyama nolamula kungenye inhlanganisela ejwayelekile esetshenziswa ngokwesisekelo somphumela wayo wokulwa nesifo sikashukela, anti-arthritic, nomphumela wokuqinisa amasosha omzimba. Ngakho-ke njengokudla kwemvelo nezinongo, i-turmeric isetshenziswa kakhulu futhi isetshenziswa kakhulu.
Namuhla, kukhona zonke izinhlobo zokukhishwa kwe-turmeric ne-Curcumin, amaphilisi, ama-capsule, kanye nokwakheka okuhlukahlukene okuthengiswa emakethe, kugibele izinzuzo zezempilo ezaziwayo. Kodwa-ke, iCurcumin yaziwa njengokumuncwa okubi kanye nokutholakala komzimba emzimbeni. Lapho ikhona ngokuhlanganiswa nepelepele emnyama noma i-piperine noma i-bioperine, ithuthukise ukutholakala kwe-bioavailability. Imikhiqizo yeCurcumin ihlukaniswa njengemithi yokwelapha kanye ne-botanicals engalawulwa ngokuqinile njengezidakamizwa. Ngakho-ke, yize kunenqwaba yemikhiqizo yeCurcumin emakethe, umuntu kudingeka azi ukuthi ukhetha umkhiqizo onokwakheka okulungile nokwengeza amalebuli eziqu ezivela ku-USP, NSF njll, ukuqinisekisa ikhwalithi engcono yomkhiqizo.
Njengoba kuningiliziwe kubhulogi, kunezifundo eziningi zokuhlola kumaseli amaningi omdlavuza ahlukahlukene kanye namamodeli ezilwane akhombisa ukuthi iCurcumin ayikwazi kanjani ukuvimbela kuphela ukukhula komdlavuza nezinye iziphetho zomdlavuza, kepha futhi ihlukumeze ngomqondo izilinganiso zebhayoloji zendlela iCurcumin usebenza ukuhlinzeka ngezinzuzo zokulwa nomdlavuza. Kunezifundo ezithile zomtholampilo ezikhombise inzuzo enesizotha futhi ekhombise ukuthuthuka ekusebenzeni kwezidakamizwa kwemithi ethile yokwelapha umdlavuza kufaka phakathi i-chemotherapy kanye nokwelashwa ngemisebe, ngokuhlangana neCurcumin (evela eTurmeric).
Kodwa-ke, ngokungafani nezidingo eziqinile zezifundo zezidakamizwa zomtholampilo, ukusetshenziswa kwe-Curcumin formulations kanye nokugxila akuzange kuhambisane futhi kumiswe kuzo zonke izifundo eziningi zomtholampilo. Ukwengeza, ngenxa yendaba ephansi eyaziwayo ye-bioavailability ye-Curcumin yemvelo, imiphumela yezifundo zomtholampilo ayizange ibe yinto emangalisa kakhulu futhi ekholisayo. Ngaphezu kwalokho kunedatha yokusebenzisana kwe-Curcumin nezinye izindlela zokwelapha ezingaba nomthelela ekusebenzeni komuthi. Ngakho-ke ngenxa yazo zonke izizathu ezingenhla, ngaphandle kokusebenzisa i-turmeric ekudleni nasekudleni kwethu futhi mhlawumbe ukwakheka okufanelekile kwe-curcumin yezakhiwo zayo zokuqinisa amasosha omzimba, ukusetshenziswa kwe-Curcumin ngu. umdlavuza iziguli azituswa ngaphandle uma ngaphansi kokuqondiswa ngumsebenzi wezempilo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.