Amandla Okwelapha weQuercetin kuCancer

Amaphuzu avelele

I-Quercetin iyi-flavonoid yemvelo ekhona ekudleni okuhlukahlukene okufana nezithelo ezinemibala nemifino futhi inezinzuzo eziningi zezempilo ngenxa ye-antioxidant eqinile, anti-cancer, anti-inflammatory, antiviral kanye ne-antibacterial properties. Izifundo ezehlukene zokuhlola nezezilwane zibonise izinzuzo ezingaba khona zokwelapha ze-quercetin (etholakala ngokudla/izithasiselo) ezinhlotsheni ezithile zomdlavuza ezifana ne-pancreatic, ibele, i-ovary, isibindi, i-glioblastoma, umdlavuza wendlala yesinye kanye nomdlavuza wamaphaphu, kanye nokwenza ngcono ukusebenza kahle kwe-chemotherapies ethile kanye okunye umdlavuza ukwelashwa. Izivivinyo ezinkulu zomtholampilo zidinga ukwenziwa ukuze kuqinisekiswe lezi zinzuzo kubantu. Futhi, ukusetshenziswa ngokweqile kwe-quercetin kungaholela emiphumeleni engathandeki njengokungasebenzi kahle kwegilo.

Kuyini iQuercetin?

I-Quercetin iyi-flavonoid eyenzeka ngokwemvelo etholakala ngokuningi ekudleni okugcwele okunomsoco kubandakanya: 

• Izithelo ezinemibala efana nama-apula, amagilebhisi namajikijolo
• Ama-anyanisi abomvu
• Ama-teas
• amajikijolo
• Iwayini elibomvu
• Imifino eluhlaza
• utamatisi
• I-broccoli

Inezakhi ezinamandla zokulwa ne-antioxidant, anti-inflammatory, anti-virus kanye ne-antibacterial.

Izinzuzo Zezempilo zeQuercetin

Ukuba yi-antioxidant enamandla, i-quercetin kanye nokudla okunothile kwe-quercetin kubhekwa njengezinzuzo eziningi zezempilo. Ezinye izinzuzo zezempilo ze-quercetin zifaka:

• Kunganciphisa izifo zenhliziyo
• Kunganciphisa ukuvuvukala
• Kunganciphisa izimpawu zokuguga
• Kunganciphisa ubungozi bokutheleleka ngokuphefumula nangamathumbu
• Kunganciphisa umfutho wegazi
• Kunganciphisa ukungezwani komzimba

Imiphumela Emibi yeQuercetin

Okulandelayo eminye yemiphumela emibi ejwayelekile ye-quercetin lapho isetshenziswa ngomlomo:

• Ukuba ndikindiki ezingalweni nasemilenzeni
• bekhanda

Ukuphathwa okufakwayo komthamo ophakeme kakhulu we-quercetin kungaba nemiphumela emibi ethile kwabanye abantu abanjengo:

• Ukuqhuma nokujuluka
• I-nausea nokuhlanza
• Ukuphefumula ubunzima
• Ukulimala kwezinso

Omunye umphumela ohlangothini ongaba khona ohlotshaniswa nokudla ngokweqile kwe-quercetin ukuthi kungaphazamisa ukusebenza kwe-thyroid. Ngaphandle kwemiphumela emibi njengokungasebenzi kahle kwe-thyroid, ukuthatha i-quercetin nakho kungazenza zibe zimbi izimo kulabo abanezinkinga zezinso.

Izakhiwo Zokulwa Nomdlavuza weQuercetin

I-flavonoid quercetin ibonakala njenge-ejenti ethembisayo yokulwa nomdlavuza ngokususelwe kokutholakele kusuka kumamodeli amaningi wezilwane zasendlini kanye nezifundo ezimbalwa zasemtholampilo kanye nokubuka. Ngezansi kunezibonelo zezinye zalezi zifundo eziqhakambisa izinzuzo ezingaba khona zokulwa nomdlavuza ze-quercetin.

Umthelela Wokusebenzisa iQuercetin kanye Nezinye Izithako noma Ukwelashwa Komdlavuza

I-Quercetin kanye neCurcumin kunganciphisa ama-Adenomas ezigulini ezine-Familial Adenomatous Polyposis - Clinical Study

Ucwaningo oluncane lomtholampilo olwenziwe ngabaphenyi baseCleveland Clinic eFlorida, e-United States luhlolisise ukusebenza kwenhlanganisela yezithako zokudla ezongezwa i-curcumin ne-quercetin ukunciphisa ama-adenomas ezigulini ezi-5 ezine-Familial adenomatous polyposis, isimo sefa lapho kutholakala khona ama-polyps amaningi kukholoni noma kunxande, ngaleyo ndlela kwande amathuba okuthi umdlavuza colorectal. Ucwaningo luthole ukuthi inani nosayizi wama-polyps kwehle kuzo zonke iziguli ezinamaphesenti anciphe ngo-60.4% kanye no-50.9%, ngokulandelana, ngemuva kwezinyanga eziyisithupha zokwelashwa nge-curcumin ne-quercetin. (UMarcia Cruz-Correa et al, uClin Gastroenterol Hepatol., 6)

I-Quercetin ingathuthukisa ukusebenza kweTemozolomide Ekuvimbeleni Amaseli E-Human Glioblastoma- Ucwaningo Lokuhlola

Ucwaningo lwelabhoratri olwenziwe ngabaphenyi lwakha isibhedlela i-Changshu Traditional Chinese Medical Hospital kanye ne-Second Affiliated Hospital yaseSoochow University e-China lathola ukuthi ukusetshenziswa kwe-quercetin kanye ne-temozolomide, okuyindlela ejwayelekile yokwelashwa ngamakhemikhali okunakekela izicubu zobuchopho, kuthuthukise kakhulu umthelela we-Temozolomide wokuvimbela amaseli womdlavuza womuntu we-glioblastoma / ubuchopho futhi wacindezela ukusinda kweseli le-glioblastoma. (UDong-Ping Sang et al, Acta Pharmacol Sin., 2014)

I-Quercetin ingathuthukisa imiphumela elwa nomdlavuza ye-Doxorubicin kumaseli womdlavuza wesibindi - Isifundo sokuhlola

Olunye ucwaningo lwelabhoratri olwenziwe ngabaphenyi baseZhejiang University eChina luveze ukuthi ukusetshenziswa kwequercetin kungathuthukisa imiphumela elwa nomdlavuza ye-doxorubicin chemotherapy kumaseli womdlavuza wesibindi ngenkathi ivikela amangqamuzana ejwayelekile esibindi. (UGuanyu Wang et al, i-PLoS One., 2012)

I-Quercetin kanye neCisplatin Chemotherapy kungathuthukisa i-Apoptosis / Ukufa Kwamaseli Amaseli Omdlavuza Womlomo - Ucwaningo Lokuhlola

Ocwaningweni olwenziwe ngabaphenyi abavela eGuangdong Provincial Centre for Disease Control and Prevention, eSun Yat-sen University naseSouth China Institute of Environmental Sciences - eGuangzhou eChina, bahlole umthelela wokusebenzisa i-quercetin kanye neCisplatin chemotherapy ku-Oral Squamous yabantu Imigqa yeSeli Carcinoma Cell (OSCCs) kanye namagundane abangelwa umdlavuza womlomo. Ucwaningo luthole ukuthi ukuhlanganiswa kwe-quercetin ne-cisplatin kuthuthukise ukufa kwamaseli / i-apoptosis kumaseli womdlavuza womlomo womuntu kanye nokuvimbela ukukhula komdlavuza kumagundane, kuphakamisa amandla okwelashwa kwe-quercetin ne-cisplatin inhlanganisela ye-Oral Cancer. (Xin Li et al, J Cancer., 2019)

Ukusebenzisa i-Quercetin ku-Ovarian Cancer Refractory ku-Cisplatin Chemotherapy kungasiza - Isifundo Somtholampilo

Esivivinyweni somtholampilo esincane sesigaba soku-1 esenziwe abacwaningi baseNyuvesi yaseBirmingham, e-UK, isiguli esinomdlavuza wesibeletho esasingaphenduli ekwelashweni kwe-cisplatin sanikezwa izifundo ezimbili ze-quercetin, okuthunyelwe inani leprotein CA 125 (umdlavuza i-antigen 125 - esetshenziswa njengophawu lomdlavuza we-ovarian) egazini lehle kakhulu lisuka ku-295 kuya ku-55 amayunithi / ml. (DR Ferry et al, Clin Cancer Res. 1996)

I-Quercetin Supplement kanye neResveratrol bangazuza ekuphatheni iProstate Cancer neColon Cancer - Preclinical Study

Ucwaningo olwenziwe ngabaphenyi base-University of Wisconsin kanye noWilliam S. Middleton VA Medical Center eWisconsin e-United States ngemodeli yegundane (transgenic adenocarcinoma of the mouse prostate -TRAMP) ebukisisa kahle igciwane lesifo somdlavuza womuntu, ukuthi inhlanganisela ye-quercetin kanye ne-resveratrol supplements, ama-antioxidants amabili atholakala kakhulu kumagilebhisi, abe nezinzuzo zokulwa nomdlavuza kule modeli yegundane lomdlavuza wesinye. (UChandra K Singh et al, Cancers (Basel)., 2020)

Olunye ucwaningo olwenziwe ngabaphenyi baseTexas A&M University, e-United States bathole ukuthi inhlanganisela yeResveratrol futhi i-quercetin ingaba nomsebenzi we-anticancer kumaseli womdlavuza wekoloni. (U-Armando Del Follo-Martinez et al, I-Cancer Cancer., 2013)

I-Quercetin ingathuthukisa ukusebenza kokwelapha kwe-Fluorouracil ekwelashweni komdlavuza wesibindi - Ucwaningo lokuhlola

Ucwaningo lwelabhoratri olwenziwe yiKurume University, eJapan luthole ukuthi ukwelashwa okuhlanganisiwe ne-quercetin ne-fluorouracil (5-FU) kungaholela ekutheni kube nomthelela owengeziwe noma wokuvimbela ukwanda kwesifo somdlavuza wesibindi. (UToru Hisaka et al, i-Anticancer Res. 2020)

Ukusetshenziswa kweQuercetin kanye Nengozi Yomdlavuza

Ukudla kwe-Quercetin kunganciphisa ubungozi be-Non-Cardia Cancer Gastric

Abaphenyi abavela eKarolinska Institutet eSweden bahlaziye idatha yocwaningo olukhulu olususelwa kubantu baseSweden olubandakanya amacala omdlavuza wesisu angu-505 kanye nezilawuli eziyi-1116 zokuhlola ukuhlangana phakathi kwe-quercetin kanye nobungozi bezinhlobo ezahlukahlukene zomdlavuza wesisu ezifana ne-cardia kanye ne-non-cardia subtypes yomdlavuza wesisu . Ucwaningo luthole ukuthi ukudla okuphezulu okudla i-quercetin kunciphise kakhulu ubungozi be-noncardia gastric adenocarcinoma, ikakhulukazi kubantu ababhemayo besifazane. (AM Ekström et al, Ann Oncol., 2011)

Ukuthatha ukudla okunothile kwe-quercetin kungasiza ekunciphiseni ubungozi bemidlavuza njengomdlavuza wesisu.

Izifundo Zokuhlola Emandleni Okulwa Nomdlavuza weQuercetin

Izifundo eziningi zaselabhorethri zenziwe abacwaningi abavela ezingxenyeni ezahlukene zomhlaba ukuthola ukuthi ukudla okucebile kwe-quercetin / izithasiselo zinemiphumela yokulwa nomdlavuza ezinhlotsheni ezahlukene ze zomdlavuza. Ngezansi ezinye izibonelo zocwaningo lwakamuva lwaselabhorethri noma izifundo zangaphambi komtholampilo ezihlole amandla okulwa nomdlavuza e-Quercetin.

Umdlavuza Wesibindi: Ucwaningo olwenziwe ngabaphenyi baseKurume University eJapan luveze ukuthi i-quercetin ingavimbela ukwanda kwamangqamuzana omdlavuza wesibindi ngokudala ukufa kwe-apoptosis / cell kanye nokuboshwa komjikelezo weseli. (UToru Hisaka et al, i-Anticancer Res., 2020)

Umdlavuza Wamaphaphu: Ucwaningo olwenziwe yiHubei University of Medicine, eChina luqhakambise ukuthi i-quercetin ingavimbela ukwanda nokwanda komdlavuza kolayini bamangqamuzana omdlavuza we-Non-Small Cell Lung Cancer. (UYan Dong et al, Med Sci Monit ,. 2020)

Umdlavuza weProstate: Ucwaningo olwenziwe ngabaphenyi base-University of Madras e-India kanye ne-Pukyong National University eSouth Korea luthole ukuthi i-quercetin inganciphisa ukusinda kwamangqamuzana omdlavuza wendlala yemfashini ezinhlobonhlobo zezilwane, futhi ingavimbela namaprotheni abhebhethekayo nawaphikisana ne-apoptotic, akhombisa izinzuzo ezingaba khona izithako ze-quercetin ekuvimbeleni ubungozi bomdlavuza wendlala yabesilisa. (G Sharmila et al, Clin Nutr., 2014)

Umdlavuza We-Ovarian: Ucwaningo olwenziwe ngabaphenyi base-University of Madras, e-India luqhakambise ukuthi i-Quercetin inamandla okuvimbela ukukhula kwesifo somdlavuza we-ovarian womuntu. (UDhanaraj Teekaraman et al, Chem Biol Interact., 2019)

Umdlavuza Webele: Ocwaningweni lwelebhu olwenziwe ngabaphenyi abavela e-University of Madras eNdiya, baveze ukuthi ukusebenzisa iQuercetin kungasiza ekunciphiseni i-Apoptosis noma i-Cell death kumaBele Cancer Cells. (ISanthalakshmi Ranganathan et al, PLoS One., 2015)

Umdlavuza wePancreatic: Abaphenyi abavela kuDavid Geffen School of Medicine e-UCLA, e-US bahlola ukusebenza kahle kokuphathwa ngomlomo kwe-quercetin kumodeli yegundane lomdlavuza wepancreatic bathola ukuthi i-quercetin iyakwazi ukuvimbela ukukhula kwezimila zepancreatic kwimodeli yegundane. (U-Eliane Angst et al, amaPancreas., 2013)

Isiphetho

Izifundo ezehlukene ze-preclinical kanye nezaselabhorethri zibonise izinzuzo ezingaba khona/ezingenzeka zokudla okucebile nge-quercetin nezithako ekwelapheni okuthile. umdlavuza izinhlobo ezifana ne-pancreatic, ibele, i-ovarian, isibindi, i-glioblastoma, i-prostate kanye nomdlavuza wamaphaphu, kanye nokuthuthukisa ukusebenza kahle kokwelashwa kwe-chemotherapies ethile kanye nezinye izindlela zokwelapha zomdlavuza. Izivivinyo ezinkulu zomtholampilo kufanele zenziwe ukuze kuqinisekiswe lezi zinzuzo zokulwa nomdlavuza ze-quercetin kubantu.

I-Quercetin ine-antioxidant enamandla, elwa nomdlavuza, elwa nokuvuvukala, elwa namagciwane nezakhiwo ezilwa namagciwane. Izinhlobonhlobo zezinzuzo zezempilo ze-quercetin zingatholakala ngokufaka ukudla okwehlukahlukene okunjengezithelo zemibala nemifino egcwele imifino njengengxenye yokudla. Izithako ze-Quercetin zivame ukuhlanganiswa namanye ama-bioactive compounds afana no-Vitamin C noma i-Bromelain ukuthuthukisa ukumuncwa kwawo namandla. Kodwa-ke, ukudla ngokweqile i-quercetin kungaholela emiphumeleni emibi eminingi kubandakanya ukuphazamiseka nokusebenza kahle kwe-thyroid. Gwema ukusebenzisa izithasiselo ze-quercetin ngaphandle kokuholwa ngabasebenzi bakho bezempilo ukuze uhlale kude nemiphumela emibi njengokungasebenzi kahle kwe-thyroid nokusebenzisana nokwelashwa okuqhubekayo.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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