Iimbalasane
Unyango lwemitha luqhele ukusetyenziswa ukunyanga umhlaza wamabele, kodwa amaxesha amaninzi iiseli zomhlaza zinokunganyangeki kunyango lwemitha. Ukutya / ukusetyenziswa kwe-Ellagic Acid ekudleni okufana namajikijolo, igromegranate kunye ne-walnuts (ezizityebi kule ngqungquthela ye-phenolic) okanye izongezo zineenzuzo ezininzi zempilo ezibandakanya imiphumo yokuchasana nomhlaza. I-Ellagic acid ikwaphucula impendulo yeradiotherapy kwiiseli zomhlaza wamabele ngaxeshanye ikhusela unomathotholo kwiiseli eziqhelekileyo: iyeza lendalo elinokubakho kwibele. umhlaza.
Yintoni iEllagic Acid?
I-Ellagic Acid yinto eyenzeka ngokwendalo ebizwa ngokuba yi-polyphenol eneempawu ezinamandla zokulwa ne-antioxidant, efumaneka kwiziqhamo nakwimifuno emininzi. Ikwafumaneka kwezorhwebo ngohlobo lwezongezelelo zokutya. I-Ellagic acid ine-anti-inflammatory kunye ne-anti-proliferative ifuthe kwaye inezibonelelo ezininzi zempilo.
Ukutya okuTyebileyo kwi-Ellagic Acid: I-Ellagic acid ifunyanwa ngokutya okwahlukeneyo kubandakanya iziqhamo ezinje ngeerabhisi, amaqunube, amaqunube amnyama, iicranberries kunye neerharnate. Okunye ukutya kubandakanya amandongomane athile emithi anje ngama-walnuts kunye nee-pecans nawo atyebile kwi-Ellagic acid.
Izibonelelo zezeMpilo ze-Ellagic Acid
Ezinye zeenzuzo ezinokubakho kwezempilo ze-Ellagic acid ezongezekayo zibandakanya iziphumo ezichasene nomhlaza, ukunciphisa iimpawu zezifo ezinganyangekiyo zemetabolism kubandakanya i-dyslipidemia, ukutyeba kakhulu (ngokusetyenziswa kwe-ellagic acid kwi-pomegranate extract) kunye nokutyeba okunxulumene ne-metabolic iingxaki ezinje nge-insulin ukumelana, uhlobo 2 isifo seswekile, kunye nesifo esinamafutha esingatyisi. (Inhae Kang okqhubekayo, Adv Nutr., 2016Izibonelelo ezongezelelekileyo zezempilo zokusebenzisa i-Ellagic Acid ikwabandakanya nokuphazamisa imibimbi yesikhumba kunye nokudumba okunxulunyaniswa nokuvezwa okungapheliyo kwe-UV. (UJi-Omncinci Bae okqhubekayo, Exp Dermatol., 2010)
I-Radiotherapy yoMhlaza weSifuba
Umhlaza webele lolona hlobo luqhelekileyo lomhlaza kwabasetyhini kwihlabathi liphela (https://www.wcrf.org). Ukusukela ngeyoMqungu yowama-2019, kukho ngaphezulu kwesigidi esi-3.1 sabasetyhini abanembali yomhlaza webele e-US kuphela, oko kubandakanya oomama abaqhubekayo okanye abagqityiweyo unyango. (Izibalo zomhlaza webele waseMelika; https://www.breastcancer.org). Unyango ngemitha okanye iRadiotherapy yenye yeendlela zoku umhlaza unyango ngaphandle kotyando kunye nechemotherapy kwaye isetyenziswa rhoqo ukunyanga amanqanaba okuqala omhlaza wamabele njengonyango lwasekhaya emva kotyando, ukunceda ukuthoba ithuba lokuba umhlaza ubuye. Unyango ngemitha lukwasetyenziswa xa umhlaza ubuyile kwaye unwenwele kwamanye amalungu afana nengqondo kunye namathambo, zidityaniswe nolunye unyango olufana nechemotherapy okanye i-immunotherapy.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-Ellagic Acid kunye neRadiotherapy kuMhlaza weSifuba
Unyango lwemitha lusebenza ngokubangela umonakalo kwiDNA ye umhlaza iiseli ngokusebenzisa amasuntswana ionizing amandla aphezulu. Nangona kunjalo, ikwabangela umonakalo onokubambisa kwiiseli ezingqongileyo eziqhelekileyo, ezingezizo zomhlaza, ezibangela iziphumo ebezingalindelekanga ezingafunekiyo nezibi. Ukongeza, ngokuvela ngokukhawuleza kweeseli zomhlaza, bahlala bephinda befaka oomatshini babo bangaphakathi kwaye balawule ukusinda kwiradiotherapy kwaye banganyangeki ngemitha. Ukuphucula amathuba okuphumelela unyango lweradiation kuye kwakho uphando oluninzi kwiikhompawundi radiosensitizer ukuba xa zidityaniswe unyango ngemitha kunokunceda ukufikelela umonakalo omkhulu ithumba lo gama kwangaxeshanye radioprotective iiseli non-zomhlaza. Ikhompawundi enye enjalo yendalo eye yabonisa ngovavanyo le propati imbini yokuba yiradiosensitizer kwiiseli zomhlaza wamabele kunye neradioprotective kwiiseli eziqhelekileyo yikhompawundi ye-phenolic ebizwa ngokuba yi-Ellagic Acid.
Uphononongo kwiiseli zomhlaza wamabele i-MCF-7 lubonise ukuba i-Ellagic Acid idibene nemitha yokwandisa ukufa kweeseli zomhlaza nge-50-62% ngelixa indibaniselwano efanayo yayikhusela kwiiseli eziqhelekileyo ze-NIH3T3. Indlela eyathi iEllagic Acid yasebenza ngayo ukuphucula ukusebenza kwemitha kwiiseli zomhlaza wamabele yaba kukuchaphazela kakubi i-mitochondria - iifektri zamandla zeeseli; ngokwandisa ipro cell-death; kunye nokunciphisa izinto ezixhasa ukusinda kwi umhlaza iseli. Uphononongo olunjalo lucebisa ukuba iikhompawundi zendalo ezifana ne-Ellagic Acid zinokusetyenziswa “ukuphucula unyango lweradiyo yomhlaza ngokwandisa ubutyhefu bethumba kunye nokunciphisa umonakalo oqhelekileyo weeseli obangelwa kumitha.” (I-Ahire V. et al, Isondlo kunye noMhlaza, 2017)
isiphelo
Ukongeza kwimpembelelo ye-radiosensitization kwiiseli zomhlaza, inani elikhulu lezifundo zesayensi ziye zaqaqambisa uninzi lweepropathi ezichasene nomhlaza ze-Ellagic Acid (efumaneka rhoqo kwiirharnate), ekubeni ikwazi ukunqanda ukwanda kweeseli zomhlaza, ukunceda ukukhuthaza Ukufa kweseli yomhlaza obizwa ngokuba yi-apoptosis, ukuthintela ukusasazeka komhlaza ngokuthintela ukukhula kwemithambo yegazi entsha kunye nokuhamba kunye nokuhlaselwa kweeseli zomhlaza ukuya kwamanye amalungu omzimba (UCeci C okqhubekayo, Izondlo, 2018; UZhang H et al, Umhlaza Biol Med., 2014). Kukho izilingo zeklinikhi eziqhubekayo kwizibonakaliso ezahlukeneyo zomhlaza (umhlaza webele (NCT03482401), umhlaza we-colorectal (NCT01916239), umhlaza wesifo seprotate (NCT03535675) kunye nabanye) ukuqinisekisa uncedo lwe-chemopreventive kunye nonyango lwe-Ellagic Acid kwizigulane ezinomhlaza, njengoko kubonwa kwiimodeli zokulinga umhlaza. Nangona esi songezelelo sendalo singeyotyhefu kwaye sikhuselekile, i-Ellagic acid kufuneka isetyenziswe kuphela ngokubonisana neengcali zokhathalelo lwempilo, kuba inamandla okunxibelelana namanye amachiza ngenxa yokuthintela i-enzymes ye-metabolizing yeziyobisi esibindini. Kwakhona, ukukhetha idosi eyongezelelweyo ye-Ellagic acid kunye nokuqulunqwa okune-solubility ephuculweyo kunye ne-bioavailability iyafuneka ukuze ufumane impembelelo yayo epheleleyo yonyango.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.