Iimbalasane
ICurcumin sisona sixhobo siphambili esisebenzayo sesiqholo esiqhelekileyo seTurmeric. I-Piperine, eyona nto iphambili yepelepele emnyama ihlala ifakwa kwiifomathi zeCurcumin zokuphucula ukufumaneka kwayo. Izigulana ezininzi ezinomhlaza wamabele zinyangwa ngomgangatho wokhathalelo lwehomoni olubizwa ngokuba yiTamoxifen. Kunye nonyango oluqhelekileyo lonyango, abaguli abanomhlaza wamabele bahlala bejonga izongezo zendalo ezinje ngeCurcumin (evela kwiTurmeric) eneempawu ezomeleleyo zokulwa nokudumba, i-antioxidant kunye nepropathi yomhlaza ukuze kuphuculwe amajoni omzimba, ukusebenza konyango, umgangatho wobomi okanye ukunciphisa iziphumo ebezingalindelekanga zonyango. Nangona kunjalo, ezinye zezi zongezelelo zinokuphela zenzakalisa unyango. Isifundo seklinikhi ekuxoxwe ngaso kule bhlog kufumanise unxibelelwano olungafunekiyo phakathi konyango lweziyobisi lweTamoxifen kunye neCurcumin ekhutshwe kwiTurmeric. Ukuthatha isongezelelo seCurcumin ngelixa unyango lweTamoxifen lunokunciphisa amanqanaba emetabolite esebenzayo yeTamoxifen kwaye iphazamise ifuthe lonyango lweziyobisi kwizigulana ezinomhlaza wamabele. Yiyo loo nto umntu kufuneka aphephe ukuquka izongezo zeCurcumin njengenxalenye yesifuba Ukutya kwabaguli abanomhlaza ukuba ufumana unyango lwe-Tamoxifen. Kwakhona, kubalulekile ukwenza isondlo kumntu ngokuthe ngqo umhlaza kunye nonyango lokufumana inzuzo ephezulu kwisondlo kwaye ukhuseleke.
I-Tamoxifen yoMhlaza weSifuba
Umhlaza webele ngowona mhlaza ufunyanwa ngesiqhelo kwaye sesinye sezizathu eziphambili zokufa kwabantu abanxulumene nomhlaza kwihlabathi liphela. Enye yezona zinto zixhaphakileyo zomhlaza wamabele kukuxhomekeka kwehomoni yesini, i-estrogen (ER) kunye neprogesterone (PR) yokwamkela kunye nokukhula kwesidermal ukukhula komntu 2 (ERBB2, ekwabizwa ngokuba yi-HER2) engalunganga- (ER + / PR + / HER2- subtype) . Ihommone subtype enesifo somhlaza wamabele ine-prognosis elungileyo enesilinganiso sokusinda seminyaka emi-5 kakhulu se-94-99% (I-Waks kunye ne Winer, JAMA, 2019). Izigulana ezifunyaniswe zinehomoni zomhlaza wamabele zinyangwa ngonyango lwe-endocrine olufana neTamoxifen kuthintelo lomhlaza wamabele kunye nokuphinda, emva kotyando lwabo kunye nonyango lwe-chemo-radiation. I-Tamoxifen isebenza njengemodyuli ekhethiweyo ye-estrogen receptor (SERM), apho inqanda i-hormone receptors kwizicubu zomhlaza webele ukunciphisa ukusinda komhlaza. umhlaza iiseli kunye nokunciphisa umngcipheko wokuphinda ubuyele.
I-Curcumin- Isithako esisebenzayo seTurmeric
Ukuxilongwa komhlaza kuzisa utshintsho olukhulu kubomi babantu kubandakanywa imeko ekusetyenzisweni kwezongezelelo zendalo ezivela kwizityalo ezaziwa ngokuba neepropathi ezichasene nomhlaza, ukukhuthaza ukhuseleko kunye nokuba sempilweni jikelele. Iziphumo zophando lwamva nje zibonise ukuba ngaphezulu kwe-80% yezigulana ezinomhlaza zisebenzisa izongezo kubandakanya amayeza ahambelanayo kunye namanye (URichardson MA okqhubekayo, J Clin Oncol., 2000). I-Curcumin, isithako esisebenzayo esivela kwi-curry spice turmeric, sesinye songezo sendalo esidumileyo phakathi kwabaguli abanomhlaza kunye nabasindileyo anti-umhlaza kwaye ezichasayo iipropati. Ke ngoko, amathuba okuba izigulana ezinomhlaza wamabele zithathe izongezo zeCurcumin (ekhutshwe kwiTurmeric) ngelixa unyango lweTamoxifen luphezulu. ICurcumin yaziwa ngokuba nokufunxeka okungalunganga emzimbeni kwaye ke ihlala isetyenziswa ekwakhiweni kwepiperine, icandelo lepepile emnyama, enceda ukwandisa ukungafumaneki kwayo kakhulu (UShoba G et al, Planta Med, 1998).
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
ICurcumin (evela kwiTurmeric) kunye nokuNxibelelana kweziyobisi kweTamoxifen kuMhlaza weSifuba
Ichiza lomlomo iTamoxifen lixutywe emzimbeni kwii-metabolites zalo ezisebenzayo ze-cytochrome P450 enzymes esibindini. I-Endoxifen yimetabolite esebenzayo yekliniki yeTamoxifen, ngoyena mlamli uphambili wokusebenza kwonyango lwe-tamoxifen (Del Re M et al, Pharmacol Res., 2016). Olunye uphononongo lwangaphambili olwenziwe kwiigundane lubonise ukuba kukho ukuhlangana kweziyobisi phakathi kweCurcumin (ukusuka kwiTurmeric) kunye neTamoxifen kuba iCurcumin ithintele i-cytochrome P450 mediated metabolism of tamoxifen conversion to its form (Cho YA okqhubekayo, Pharmazie, 2012). Uphononongo olusandula kupapashwa oluzayo (EudraCT 2016-004008-71 / NTR6149) oluvela e-Erasmus MC Cancer Institute eNetherlands, kuvavanye olu nxibelelwano phakathi kweCurcumin kunye neTamoxifen kwizigulana ezinomhlaza wamabele (I-Hussaarts KGAM okqhubekayo, umhlaza (iBasel), 2019).
Kolu phononongo bavavanya isiphumo se-Curcumin yodwa kunye ne-Curcumin kunye ne-bio-enhancer Piperine xa ithathwa ngaxeshanye ne-Tamoxifen kwi-16 yesifuba esivavanyiweyo. umhlaza izigulane. Izigulane zanikwa i-Tamoxifen kwiintsuku ze-28 ngaphambi kophando ukuze kuqinisekiswe amanqanaba azinzileyo e-Tamoxifen kuzo zonke izifundo. Izigulane zaye zalawulwa imijikelo ye-3 kwii-2 amaqela ahlukeneyo ngokulandelelana ngokulandelelana kwemijikelezo. I-Tamoxifen inikwe kwi-dose eqhubekayo ye-20-30 mg ngexesha lemijikelezo ye-3. Imijikelezo ye-3 yayiquka i-Tamoxifen yodwa, i-Tamoxifen kunye ne-1200 mg Curcumin ethathwe kathathu imihla ngemihla, okanye i-Tamoxifen kunye ne-1200 mg Curcumin kunye ne-10 mg yePiperine ethathwe kathathu imihla ngemihla. Amanqanaba e-Tamoxifen kunye ne-Endoxifen afaniswa kunye nangaphandle kwe-Curcumin yedwa kunye nokongezwa kwe-bio-enhancer Piperine.
Olu phononongo lubonise ukuba uxinzelelo lwe-metabolite esebenzayo ye-Endoxifen yehle ngeCurcumin kwaye yancipha ngakumbi ngeCurcumin kunye nePiperine ithathwa kunye. Oku kuncipha kwi-Endoxifen kwakubalulekile ngokwezibalo.
isiphelo
Isishwankathelo, ukuba isongezelelo seCurcumin sithathiwe kunye nonyango lweTamoxifen, sinokuhlisa uxinzelelo lwechiza elisebenzayo elingaphantsi komqobo walo wokusebenza ngokukuko kwaye linokuphazamisa ifuthe lonyango lwechiza. Izifundo ezinje ngezi azinakuhoywa, nangona inani elincinci lezigulana ezinomhlaza wamabele, kwaye zinika isilumkiso kwabasetyhini abathatha i-tamoxifen ukuba bakhethe izongezo zendalo abazithathayo ngononophelo, ezingaphazamisiyo ukusebenza komhlaza weziyobisi (ifuthe lonyango) nakweyiphi na indlela. Ngokusekwe kobu bungqina, iCurcumin ibonakala ngathi ayisosongezo esifanelekileyo sokuthathwa kunye neTamoxifen njengoko iphazamisa ukusebenza ngempumelelo kwonyango.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.