Izibonelelo zoNyango lweMilk / Silymarin kuMhlaza

Iimbalasane

I-Milk Thistle Extract / i-Silymarin kunye necandelo layo eliphambili i-Silibinin ineenzuzo ezininzi zempilo ezinomdla ngenxa ye-antioxidant, i-anti-inflammatory kunye ne-anti-cancer properties. Izifundo ezahlukeneyo ze-vitro / in vivo kunye nezilwanyana ziye zaphanda ngezibonelelo zempilo ze-milk thistle extract kunye nokukwazi kwayo ukuthintela iintlobo zomhlaza kwaye zifumene iziphumo ezithembisayo. Zimbalwa izilingo zabantu eziye zacebisa ukuba i-milk thistle kunye nezithako zayo ezisebenzayo zinokuba luncedo ekunciphiseni ezinye zeziphumo ebezingalindelekanga ze-chemotherapy kunye ne-radiotherapy efana ne-cardiotoxicity, i-hepatotoxicity kunye ne-edema yobuchopho kwezinye iindawo. umhlaza iintlobo eziphathwa ngekhemo ethile.

Yintoni ubisi lwamakhaka?

Inkunkuma yobisi sisityalo esidubula iintyatyambo ebesikhe sasetyenziswa kangangeenkulungwane njengeyeza lendalo lokunyanga ukuphazamiseka kwesibindi kunye ne-bile ikakhulu kumazwe aseYurophu. Inkunkuma yobisi ikwafumaneka njengesongezelelo sokutya. Inkunkuma yobisi ifumene igama layo kulwelo lobisi oluphuma emagqabini xa aphukile. 

Izithako eziphambili zeMilki yobisi

Ezona ndawo ziphambili zembewu yobisi eyomileyo zii-flavonolignans (izinto zendalo ezenziwe yinxalenye ye-flavonoid kunye nenxalenye ye-lignan) ebandakanya:

• Isilibinin (silybin)
• Isosilybin
• USilychristin
• USilydianin.

Umxube wezi flavonolignans ziveliswe kwimbewu ye thistle yobisi ngokudibeneyo yaziwa njenge Silymarin. I-Silibinin ekwabizwa ngokuba yi-silybin, yeyona ndawo iphambili yesilymarin. USilymarin unezinto zokulwa neentsholongwane. I-Milk Thistle / i-Silymarin iyafumaneka njengesongezelelo sokutya kwaye isetyenziswa rhoqo kwiipropathi zayo eziluncedo ekunyangeni ukuphazamiseka kwesibindi. Uninzi lwezincedisi zikwimilinganiselo esemgangathweni ngokusekwe kumxholo wabo we-silibinin. Kukwakho nemixube ekhethekileyo ye-silymarin okanye i-silibinin ekhoyo enokonyusa ukubakho kokufumaneka ngokudibanisa ne-phosphatidylcholine.

IziBonelelo eziBanzi zezeMpilo zeMisi yobisi

Izifundo ezininzi zezilwanyana kunye nezifundo ezimbalwa zeklinikhi ezenziweyo ukuvavanya izibonelelo zobisi lobisi. Ezinye zezibonelelo zezempilo zengqolowa yobisi zezi:

1. Ngamana unokunceda kwiingxaki zesibindi kubandakanya i-cirrhosis, i-jaundice, i-hepatitis
2. Ngamana unokunceda kwiingxaki ze-Gall bladder
3. Xa ithathwa ngokudibanisa nonyango oluqhelekileyo, inokusiphucula isifo seswekile
4. Ngamana unokunceda ukuphucula amanqanaba e-cholesterol kwizigulana ezinesifo seswekile
5. Ngamana unokunceda ngokutshisa kunye nokugaya ukutya
6. Ngamana unokunceda ekuthinteleni umhlaza

Izibonelelo zoMisi wobisi kwiCancer

Kule minyaka ingamashumi amabini idlulileyo, kuye kwakho umdla okhulayo ekuqondeni izibonelelo zeklinikhi ze-milk thistle kumhlaza. Ezinye zezifundo ze-in vitro/in vivo/yezilwanyana/abantu ezivavanye usetyenziso/iziphumo zobisi thistle umhlaza zishwankathelwa ngezantsi:

KwiVitro / KwiVivo / kwizifundo zezilwanyana

1. Ngamana angathintela ukukhula komhlaza wepancreatic kunye nokunciphisa umhlaza wepancreatic onomdla wecachexia / ubuthathaka

Izifundo ze-in vitro zibonise ukuba ubisi lwameva olusebenzayo lwe-silibinin lunokuthintela ukukhula kwesifo somhlaza wepancreatic ngendlela exhomekeke kwidosi. Olunye kwizifundo ze-vivo lukwacebisa ukuba i-silibinin inciphisa ukukhula kwethumba kunye nokwanda komhlaza wepancreatic kwaye inokunceda ukuthintela ukulahleka kobunzima bomzimba kunye nesihlunu. (I-Shukla SK okqhubekayo, i-Oncotarget., 2015)

Ngamafutshane, in vitro kunye nezifundo zezilwanyana zicebisa ukuba ubisi lwameva / i-silibinin inokuzuza ekunciphiseni ukukhula komhlaza wepancreatic kunye nomhlaza wepancreatic-indened cachexia / ubuthathaka. Uvavanyo lwezonyango luyafuneka ukumisela okufanayo ebantwini. 

2. Ngamana angathintela ukukhula komhlaza webele

Izifundo ze-in vitro zibonise ukuba i-silibinin inqanda ukukhula komhlaza webele kwaye yenza ukuba i-apoptosis / ukufa kweseli kwiiseli zomhlaza wamabele. Iziphumo ezivela kwizifundo ezahlukeneyo zibonisa ukuba i-silibinin ineempawu ezifanelekileyo zomhlaza webele. (UTiwari P okqhubekayo, uCancer Invest., 2011)

3. Ngamana Anokuthintela Ukukhula Komhlaza Webala Lesibeletho

Kwesinye isifundo, iziphumo ezichasene nomhlaza ze-Silibinin zavavanywa kunyango oludibeneyo kunye ne-DOX / Adriamycin. Kolu phando, iiseli zeprostate carcinoma zanyangwa nge-silibinin kunye ne-DOX ngokudibeneyo.Iziphumo zabonisa ukuba indibaniselwano ye-silibinin-DOX ikhokelele kuthintelo lokukhula kwiiseli eziphathwayo. (UPrabha Tiwari kunye noKaushala Prasad Mishra, uMda woPhando lweCancer., 62)

4. Ngamana anganqanda uMhlaza wolusu

Izifundo ezininzi ziye zenziwa ukuvavanya iimpembelelo zeMilk Thistle esebenzayo yeSilibinin kumhlaza wesikhumba. Iziphumo ezifunyenwe kwezi zifundo ze-vitro zibonise ukuba unyango lwe-Silibinin lunokuba neziphumo zokuthintela iiseli zomhlaza wolusu lomntu. Uphononongo lwe-vivo lufumanise ukuba uSilibinin unokuthintela umhlaza wolusu obangelwa yimitha ye-UVB kwaye unokunceda ekulungiseni umonakalo we-DNA owenziwe nge-UV kulusu lwegundane. (Prabha Tiwari kunye noKaushala Prasad Mishra, Imida yoPhando lweCancer., 2015)

Olu phononongo luyathembisa kwaye lucebisa ukuba ubisi thistle/silibinin lunokukhuseleka kwaye luzuze ulusu umhlaza.

5. Ngamana angathintela umhlaza wecolorectal cancer

Olunye uphononongo lwe-in vitro lubonise ukuba i-Silibinin inokubangela ukubhubha kweseli kwiiseli zomhlaza eziluhlaza. Izifundo ze-in vitro zikwafumanise ukuba unyango lwe-Silibinin lwe-24h lunokunciphisa ukukhula kweeseli zomhlaza nge-30-49%. (UPrabha Tiwari kunye noKaushala Prasad Mishra, uMda woPhando lweCancer., 2015)

Izibonelelo zeMilk Thistle / Silibinin nazo zavavanywa ngokudibeneyo nezinye iindlela zonyango ezinje nge-histone-deacetylase (HDAC) inhibitors. Umdibaniso ubonise ukungqinelana kweeseli kwiiseli ezimibala.

6. Isenokuthintela umhlaza wemiphunga

Izifundo ze-in vitro zibonise ukuba i-Silibinin inokuba nefuthe kuthintelo kwimigca yeseli yomhlaza wemiphunga yomntu. Izifundo zikwabonakalise ukuba iSilibinin ngokudibeneyo ne-DOX inqanda ukukhula komhlaza wesifo somhlaza wamaphaphu kwi-vitro. I-Silibinin kunye ne-indole-3-carbinol ikwabangele ifuthe elinamandla lokulwa ne-antiproliferative kuneearhente ezizezinye. (UPrabha Tiwari kunye noKaushala Prasad Mishra, uMda woPhando lweCancer., 2015)

Ezi ziphumo zibonisa ukuba i-Milk Thistle esebenzayo ye-Silibinin inokuba nesibonelelo sonyango ngokuchasene nomhlaza wemiphunga.

7. Ngamana angathintela umhlaza wesinyi

Izifundo ze-in vitro zibonise ukuba i-Silibinin yenze ukuba i-apoptosis / ukufa kweseli kweeseli zomhlaza wesinyi somntu. Izifundo zikwabonakalise ukuba uSilibinin unokucinezela ukufuduka kunye nokusasazeka kweeseli zomhlaza wesinyi. (UPrabha Tiwari kunye noKaushala Prasad Mishra, uMda woPhando lweCancer., 2015)

8. Isengathintela umhlaza wesibeleko

Izifundo ze-in vitro zibonise ukuba i-silibinin inokuthintela ukukhula kweeseli zomhlaza we-ovari yomntu, kwaye ikwenze ukuba i-apoptosis / ukufa kweseli. Izifundo zikwafumanise ukuba i-Silibinin inokuphucula ubuntununtunu beeseli zomhlaza we-ovari kwi-PTX (Onxal). I-Silibinin xa isetyenziswa ngokudibeneyo ne-PTX (i-Onxal) inokuphucula i-apoptosis / ukufa kweseli. (UPrabha Tiwari kunye noKaushala Prasad Mishra, uMda woPhando lweCancer., 2015)

Ezi ziphumo zibonisa ukuba i-silibinin inokusetyenziswa njengenxalenye yonyango oludibeneyo olunxamnye nomhlaza we-ovari.

9. Ngamana angathintela uMhlaza woMlomo weSibeleko

Izifundo zibonisa ukuba i-Silibinin inokuthintela ukwanda kweeseli zomlomo wesibeleko. Ukongeza, i-silibinin kunye ne-MET, iarhente eyaziwayo yesifo seswekile, ibonisa ukungqinelana kokuthintela iiseli zomhlaza womlomo wesibeleko kunye nokufa kweseli. Ke, i-silibinin inokusebenza njengearhente yokuthintela umhlaza ngokuchasene nomhlaza womlomo wesibeleko. Izifundo ezongezelelekileyo kufuneka ziphonononge amathuba okuphucula iindlela zonyango ezichasene nomhlaza womlomo wesibeleko.

Izifundo zeKlinikhi kuBantu

Makhe sijonge kwizifundo ezahlukeneyo zeklinikhi ukuqonda ukuba ingaba kubandakanya inkunkuma yobisi njengenxalenye ye Ukutya kwabaguli abanomhlaza iluncedo okanye akunjalo.

1. Izibonelelo zoMila wobisi ekunciphiseni i-Cardiotoxicity kwi-Acute Lymphoblastic Leukemia yaBantwana inyangwa nge-DOX (Adriamycin)

I-Silymarin, enye yezona zinto ziphambili ezenziwayo zobisi lobisi, ibonakalisiwe kuvavanyo lokuba nefuthe le-cardioprotective xa inikwa kunye ne-DOX. USilymarin unokunciphisa uxinzelelo lwe-oxidative, oyena nobangela we-cardiotoxicity. I-antioxidant kwaye inganciphisa ukonakala kweembrane kunye neeproteni ngohlobo olusebenzayo, olwenziwe njengenxalenye yendlela yokusebenza kwe-DOX, ngokuthintela ukupheliswa koomatshini bendalo be-antioxidant beeseli ezisempilweni. (URoskovic A okqhubekayo, iiMolekyuli 2011)

Isifundo seklinikhi esivela kwiYunivesithi yaseTanta e-Egypt sivavanye isiphumo se-cardioprotective sika-Silymarin ovela kwi-Milk Thistle kubantwana abane-Acute Lymphoblastic Leukemia (BONKE), abanyangwa nge-DOX. Uphononongo lusebenzise idatha ukusuka kubantwana abangama-80 BONKE, ngaphandle kwezigulana ezingama-40 zanyangwa nge-DOX kunye noSilymarin kwi-420 mg / ngosuku kwaye i-40 eseleyo yaphathwa kuphela nge-DOX (iqela le-placebo). Uphononongo lufumanise ukuba kwiqela laseSilymarin, bekukho 'ukuncipha kwangaphambi kokuphazamiseka kwemisebenzi ye-ventricular systolic' kwiqela le-placebo. Olu phononongo lweklinikhi, nangona linenani elincinci labo BONKE abantwana, libonelela ngesiqinisekiso seziphumo zentliziyo zikaSilymarin njengoko kubonisiwe kwiimodeli zezifo zovavanyo. (I-Adel A Hagag okqhubekayo, Ukuchaphazela iiThagethi zoSetyenziso lweziyobisi., 2019)

2. Izibonelelo zobisi lobisi ekunciphiseni ukuTyhefu kwesibindi kwi-Acute Lymphoblastic Leukemia yaBantwana inyangwa ngeChemotherapy

Unyango lwabantwana abane-lymphoblastic leukemia (BONKE) besebenzisa amayeza e-chemotherapy bahlala bephazamiseka ngenxa ye-hepatotoxicity / isibindi sobutyhefu esibangelwa ngamachiza e-chemotherapy. Le conundrum yokuphelisa umhlaza usebenzisa amayeza e-chemotherapy ngokuchasene nokujongana neziphumo ezibi kwaye ngamanye amaxesha ezingenakuphinda zichaphazeleke kwezi ziyobisi yingxaki eqhubekayo kuluntu lomhlaza. Yiyo loo nto kukho imizamo eqhubekayo yokufumana iindlela ezinokunceda ukunciphisa okanye ukukhusela isiguli kwiziphumo ebezingalindelekanga ezibi.

Kwisifundo seklinikhi, abantwana abane-acute lymphoblastic leukemia (BONKE) abantwana abane-hepatic toxicity banokunyangwa nge-chemotherapy yodwa (i-placebo) okanye indibaniselwano yobisi lwethikhisi ene-80 mg ye-silibinin kunye ne-chemotherapy (MTX / 6-MP / VCR) ngomlomo ( Iqela lobisi lobisi) kangangeentsuku ezingama-28. I-50 yabantwana yabhaliswa ukusuka ngoMeyi 2002 ukuya ku-Agasti 2005 kolu phando, ngezifundo ezingama-26 kwiqela le-placebo kunye nama-24 kwiqela leMilk Thistle. Ngama-49 kubantwana abangama-50 abaye bavavanyelwa isifundo. Ityhefu yesibindi yajongwa ngalo lonke ixesha lonyango. (U-EJ Ladas okqhubekayo, uMhlaza. 2010)

Iziphumo ezivela kolu phononongo zicebise ukuba ukuthatha iMilk Thistle kunye ne-chemotherapy ngabo BONKE abaguli kunokunxulunyaniswa nokwehliswa okubalulekileyo kwityhefu yesibindi. Olu phononongo alufumananga zinetyhefu ezingalindelekanga, isidingo sokunciphisa iidosi zekhemotherapy, okanye nakuphi na ukulibaziseka kunyango ngexesha lokuxhaswa kwamakhaka wobisi. Izifundo zikwabonakalisile ukuba ubisi lwameva aluzange luchaphazele ukusebenza kweearhente zekhemotherapy ezisetyenziselwa LONKE unyango. 

Abaphandi nangona kunjalo bacebisa izifundo ezizayo ukuze bafumane elona dose lisebenzayo le Milk Thistle kunye nefuthe layo kwi-hepatotoxicity / isibindi sotyhefu kunye nokusinda ngaphandle kwe-leukemia.

3. Izibonelelo zoMdumba wobisi iSilibinin esebenzayo yokunciphisa i-edema yengqondo kwizigulana ezinomhlaza wemiphunga ezinesifo sobuchopho seMetastasis.

Uphononongo lucebisa ukuba ukusetyenziswa kwe-milk thistle active silibinin-based nutraceutical ebizwa iLegasil® inokuphucula i-Brain Metastasis evela kwi-NSCLC/izigulane zomhlaza wemiphunga eziqhubele phambili kunyango lwasemva konyango ngeradiotherapy kunye nechemotherapy. Iziphumo zolu phando zikwabonisa ukuba ulawulo lwe-silibinin lunokunciphisa kakhulu i-edema yengqondo. Nangona kunjalo, ezi ziphumo zokuthintela i-silibinin kwi-metastasis yobuchopho ayinakuchaphazela ukukhula kwethumba kwimiphunga. umhlaza izigulane. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Izibonelelo zobisi lobisi ekunciphiseni ukuTyhefu kwesibindi kumguli womhlaza wamabele

Isifundo esapapashwa kwisigulana somhlaza wamabele esanyangwa ngeendlela ezintlanu zonyango zonyango kunye nokusilela kwesibindi okuqhubekayo. Ingxelo ichaze ukuba iziphumo zovavanyo lwesibindi ziye zonakala kumanqanaba okusongela ubomi emva konyango lwemijikelezo emine. Isigulana emva koko songezwa nge-Silibinin-based nutraceutical egama lingu-Legasil® post apho uphuculo lweklinikhi kunye nesibindi kwaqwalaselwa khona, nto leyo eyanceda isigulana ukuba siqhubeke nokunyanga ngamayeza anyangayo. (UBosch-Barrera J et al, iAnticancer Res., 5)

Olu pho nonongo lubonise ukuba kunokwenzeka ukuba uncedo lweklinikhi lwe-silibinin ekunciphiseni ubuthi besibindi kwizigulane zomhlaza wesifuba eziphathwe nge-chemotherapy.

5. Izibonelelo zoMila wobisi ekuphuculeni iziPhumo zokuSinda kwiBongo Izigulana zeMetastatic ezinyangwa ngeRadiotherapy

Izifundo zibonisa ukuba ubisi lwameva lunokunceda izigulana zengqondo ezifumana unyango lweradiotherapy. Uphononongo lweklinikhi lubandakanya idatha evela kwizigulana ezine-metastases yengqondo ezanyangwa nge-radiotherapy yodwa okanye i-radiotherapy kunye ne-omega 3 fatty acids kunye ne-silymarin. Uphononongo lufumanise ukuba abaguli abathatha i-omega 3 fatty acids kunye ne-silymarin banamaxesha okusinda kunye ne-radionecrosis. (I-Gramaglia A et al, iAnticancer Res., 1999)

isiphelo

Ubisi lweNkunkuma / iSilymarin kunye neyona nto iphambili kuyo iSilibinin inezibonelelo ezininzi zempilo ngenxa yeempawu zayo zokulwa nokudumba kunye nokulwa nomhlaza. Ubisi lwameva acatshulweyo / uSilymarin uhlala engenazo iziphumo ebezingalindelekanga ezininzi xa ethathwa ngomlomo ngobungakanani obuchanekileyo. Nangona kunjalo, kwabanye abantu, ukuthatha ubisi lwenkunkuma kunokukhokelela kurhudo, isicaphucaphu, irhasi yamathumbu, ukudumba, ukugcwala okanye iintlungu, kunye nelahleko lokutya. Kwakhona, ekubeni ubisi lwenkunkuma lunokunciphisa izinga leswekile yegazi kubantu abanesifo seswekile, amayeza eswekile anokulungiswa. Ukukhutshwa kobisi lobisi kunokuba neempembelelo ze-estrogenic ezinokuthi zenze mandundu iimeko ezinobuzaza behomoni, kubandakanya iintlobo ezithile zomhlaza wamabele.

Izifundo ezahlukeneyo ze-invitro/invivo kunye nezilwanyana ziye zaphanda ngezibonelelo zempilo ze-milk thistle extract kunye nokukwazi kwayo ukuthintela iintlobo zomhlaza. Iziphumo ezithembisayo ziye zaxelwa luninzi lwezi zifundo zibonisa iziphumo ezikhuselayo ze-milk thistle kwiintlobo ezithile zomhlaza. Izilingo ezimbalwa zabantu zikwaxhasa ukuba i-milk thistle kunye nezithako zayo ezisebenzayo zinokuba luncedo ekunciphiseni ezinye zeziphumo ebezingalindelekanga ze-chemotherapy kunye ne-radiotherapy efana ne-cardiotoxicity, i-hepatotoxicity kunye ne-edema yobuchopho kwiintlobo ezithile zomhlaza ezinyangwa nge-chemo ethile. Nangona kunjalo, ukuthatha isongezelelo sendalo esifana ne-milk thistle extract ngokungakhethiyo nayo nayiphi na ichemotherapy kuyo nayiphi na umhlaza ayikhuthazwa njengoko inokubangela ukusebenzisana kakubi kwe-herb-drug. Ke, umntu kufuneka asoloko edibana nogqirha wabo ngaphambi kokuba athathe nasiphi na isongezelelo sendalo kunye nechemotherapy.

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.

• Ubisi olunameva olusebenzayo uSilymarin unciphisa iDoxorubicin-indased Cardiotoxicity kuBantwana abane-leukemia
• Ubisi, iimveliso zobisi kunye nomngcipheko womhlaza
• Ukutya / iziXhobo zeNdalo zinxibelelana njani neChemotherapy kwiCancer?
• Umbutho odidayo wokusetyenziswa kweVitamin E yokuNcedisa kunye noMhlaza weBongo
• Ukutya kweLacto-Ovo yemifuno kunye nomngcipheko womhlaza