Muchidimbu
Chidzidzo chekiriniki chakaratidza kuti zvakachengeteka kushandisa iyo soy isoflavone Genistein yekuwedzera pamwe nekubatana chemotherapy FOLFOX mukurapa kwemasastatic colorectal cancer varwere. Kubatanidza Genistein kuwedzera kudya ne chemotherapy kune mukana wekuvandudza iyo FOLFOX chemotherapy kurapwa mhedzisiro mune metastatic colorectal kenza varwere.
Metastatic Colorectal Kenza
Metastatic Colorectal Cancer (mCRC) ine fungidziro isina kunaka ine makore maviri ekurarama ari pasi pe2% uye makore mashanu ekurarama ari pasi pegumi muzana, zvisinei nehutsinye hwakanyanya hwekusanganisa chemotherapy marapirwo. (AJCC Cancer Staging Handbook, 40th Edn).
Metastatic Colorectal Cancer Chemotherapy Regimens
Metastatic Colorectal cancer regimens inosanganisira 5-Fluorouracil pamwe neplatinamu mushonga Oxaliplatin, ine kana isina antiangiogenic (inodzivisa kuumbwa kwetsinga dzeropa kune bundu) mumiririri Bevacizumab (Avastin). Mishonga mitsva inosanganisira FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) uye FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan varwere) vakaratidzawo m proCmisi migumisiro.
Pano, tichakurukura ane mukurumbira mCRC regimens ari mukiriniki miedzo uye anoonekwa seanoshanda kurwisa Metastatic Colorectal Cancer (mCRC).
Kubudirira kweFOLFOXIRI muMetastatic Colorectal Cancer Varwere
Zvidzidzo zvakawanda zvakatarisa pane akasiyana metastatic colorectal kenza regimens uye kushanda kwavo mumCRC varwere. FOLFOXIRI ndeyekutanga-mutsara musanganiswa kurapa mCRC iyo inosanganisira fluorouracil, oxaliplatin, leucovorin uye irinotecan mishonga misanganiswa. Muyedzo yeTRIBE, ichangobva kuburitswa muna 2020, kudzoserwa kweFOLFOXIRI ine bevacizumab kwakaguma nemhedzisiro iri nani pane FOLFIRI pamwe nebevacizumab asi nemukana wehupfu hwepamusoro senge nguva yakakura yechemotherapy yaidiwa uye akati wandei acute mhedzisiro akaonekwa muvarwere vakadaro. (Glynne-Jones R, nevamwe. Iyo Lancet Oncology, 2020) Iri zano rekubatanidza rinoshanda asi cytotoxic zvinodhaka ne antiangiogenic mishonga rakasimudza zvimwe zvinonetsa kune oncologists maererano nekuchengetedza uye chepfu.
Tsanangudzo yeMeta-analysis: XELOX vs. FOLFOX muMetastatic Colorectal Cancer
Chidzidzo muna 2016 naGuo Y, et al. akaenzanisa kushanda kwe capecitabine uye fluorouracil, imwe neimwe yakasanganiswa neoxaliplatin, mumCRC varwere pamwe chete nekemotherapy (Guo, Yu nevamwe. Kuongorora kenza, 2016).
- Eight randomized controlled trials (RCTs) yakashandiswa kuongororwa kunosanganisira varwere ve4,363 pamwe chete.
- Mhedziso yekutanga yekudzidza kwaiva kuongorora kuchengetedzwa uye kushanda kwekemotherapy regimens XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (fluorouracil plus oxaliplatin) mune metastatic colorectal cancer varwere.
- Varwere vanosvika 2,194 vakarapwa nechirongwa cheXELOX nepo varwere 2,169 vakarapwa nechirongwa cheFOLFOX.
Mibairo yeMeta-analysis: XELOX vs. FOLFOX muMetastatic Colorectal Cancer
- XELOX boka raiva nepamusoro-soro ye-hand-foot syndrome, diarrhea uye thrombocytopenia nepo FOLFOX boka raiva nepamusoro-soro yeutropenia chete.
- Iyo toxicity profiles yakawanikwa kubva muongororo yakabatanidzwa yemapoka ese aive akasiyana asi kumwe kutsvagisa nezvenyaya iyi kunodiwa.
- Kushanda kweXELOX kune mCRC varwere kwakafanana neFOLFOX kushanda.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Genistein Supplements yeCancer
Genistein isoflavone inongowanikwa muzvokudya zvakaita sesoya uye soya bhinzi. Genistein inowanikwawo nenzira yezvokudya zvinowedzera uye inozivikanwa kuva nehuwandu hwehutano hunobatsira nekuda kweiyo antioxidant, anti-inflammatory uye anti-cancer properties. Mamwe emamwe mabhenefiti ehutano egenistein ekuwedzera (kuwedzera kune anti-cancer zvivakwa) anosanganisira:
- Inogona kubatsira kudzikisa mashuga eropa
- Inogona kubatsira kudzikisa zviratidzo zvekuguma kuenda kumwedzi
- Inogona kubatsira kusimudzira hutano hwemwoyo
- Inogona kusimudzira hutano hwepfupa nehuropi
Mune ino blog tichakurukura kana Genistein yekuwedzera kushandiswa ine mabhenefiti mune metastatic colorectal kenza varwere.
Genistein Supplement Use muColorectal Kenza
Ongororo dzakawanda dzakaratidza kushamwaridzana kwenjodzi yakaderera yemakondomu akaomarara kumabvazuva kweAsia vanhu vanodya chikafu cheSoy-chakapfuma. Kune akawanda epamberi eongororo yekuyedza iyo yakaratidza anti-cancer zvimiro zve soy isoflavone Genistein, uye kugona kwayo kudzora chemotherapy kuramba mumasero ekenza. Nekudaro, vaongorori veIcahn Chikoro cheMishonga paGomo reSinai, muNew York, vakaedza kuchengetedzeka nekubudirira kwekushandisa soy isoflavone Genistein pamwe neyakajairika yekutarisirwa kusanganisa chemotherapy mune inotarisirwa kiriniki yekudzidza mune metastatic colorectal cancer varwere. (NDD01985763) (Pintova S et al, Cancer Chemotherapy & Pharmacol., 2019)
Tsanangudzo yeClinical Study paGenistein Supplement shandisa muColorectal Cancer
- Paiva nevarwere gumi nevatatu vane mCRC vasina kurapwa kwekare vakabatwa nekubatanidzwa kweFOLFOX neGenistein (N = 13) uye FOLFOX + Bevacizumab + Genistein (N = 10).
- Yekutanga yekupedzisira yekudzidza yaive yekuongorora kuchengetedzeka uye kushivirira kwekushandisa Genistein pamwe neakasanganiswa chemotherapy. Iyo yekupedzisira yekupedzisira yaive yekuongorora yakanakisa yakazara mhinduro (BOR) mushure mematanhatu matanhatu emakemotherapy.
- Genistein pachiyero che60 mg / zuva, akapihwa nemuromo kwemazuva manomwe vhiki mbiri dzese, kutanga mazuva mana pamberi pechemo uye kuenderera kuburikidza nemazuva 7-2 echichemo infusion. Izvi zvakabvumira vaongorori kuti vaongorore mhedzisiro-mhedzisiro naGenistein chete uye pamberi pechemo.
Mhedzisiro yeClinical Study paGenistein Supplement shandisa muColorectal Cancer
- Iko kusanganiswa kweGenistein nekemotherapy kwakawanikwa kuve kwakachengeteka uye kushivirira.
- Zviitiko zvakashata zvakataurwa naGenistein chete zvaive zvinyoro kwazvo, senge kutemwa nemusoro, kuda kurutsa uye kupisa kunopisa.
- Zviitiko zvakashata zvakataurwa apo Genistein akapihwa pamwe nekemotherapy zvaive zvine chekuita nekemotherapy mhedzisiro-mhedzisiro, senge neuropathy, kuneta, manyoka, zvisinei, hapana mumwe wevarwere akawana chiitiko chakakomba kwazvo chegiredhi rechina.
- Paive nekuvandudzwa mune yakanakisa mhinduro (BOR) mune aya mCRC varwere vanotora chemotherapy pamwe naGenistein, kana ichienzaniswa neavo vakanzi chemotherapy kurapwa kwega muzvidzidzo zvekare. BOR yaive 61.5% muchidzidzo ichi vs. 38-49% muzvidzidzo zvakapfuura zvine mishonga yakafanana yekemotherapy. (Saltz LB nevamwe, J Clin Oncol, 2008)
- Kunyangwe kufambira mberi kwemahara kwekupona kwemahara, izvo zvinoratidza huwandu hwenguva iyo bundu harina kufambira mberi nekurapwa, yaive median yemwedzi gumi nemashanu neGenistein mubatanidzwa vs. 11.5 mwedzi yekemotherapy chete zvichibva pachidzidzo chekutanga. (Saltz LB et al, J Clin Oncol., 2008)
mhedziso
Ichi chidzidzo, kunyangwe chiri padiki kwazvo nhamba yevarwere, chinoratidza kushandisa soy isoflavone Genistein kuwedzera pamwe nekubatana chemotherapy kwaive kwakachengeteka uye hakuna kuwedzera huturu hwechemotherapy muColorectal Cancer. Mukuwedzera, kushandisa Genistein pamwe chete neFOLFOX ine mikana yekuvandudza kushanda kwehutano uye zvichida kuderedza migumisiro yechirwere chemotherapy. Izvi zvakawanikwa, kunyange zvichinyatso kuvimbisa, zvinoda kuongororwa uye kusimbiswa muzvidzidzo zvakakura zvemakiriniki.
Chikafu chipi chaunodya, uye izvo zvinowedzera zvaunotora isarudzo yaunoita. Sarudzo yako inofanirwa kusanganisira kutariswa kwegomarara jena kuchinja, iro gomarara, kurapwa kunoramba kuripo uye kuwedzera, chero allergies, ruzivo rwemararamiro, huremu, kureba uye maitiro.
Kuronga kwekudya kwegomarara kubva kuaddon hakuna kubva pakutsvaga painternet. Inoita otomatiki sarudzo yekukuitira iwe zvichienderana nesainzi yemamorekuru inoshandiswa nemasaenzi edu uye mainjiniya esoftware. Zvisineyi nekuti une hanya nekunzwisisa aripasi biochemical molecular nzira kana kwete - yekudya kuronga kwegomarara ndiko kunzwisisa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.