Muchidimbu
Curcumin, yakabviswa kubva pamudzi weturmeric, yakadzidzwa zvakanyanya kune yayo anti-gomarara zvimiro zvine ruzivo rwemaserura maitiro ekuti inogona kubatsira sei kuwirirana nechaiyo chemotherapy. Curcumin kubva kuturmeric yakawedzera mhinduro yeFOLFOX chemotherapy kurapwa mune colorectal cancer varwere sekuratidzwa kwechikamu chechipiri chekiriniki kuyedzwa. Zvisinei, kenza varwere vanofanira kutora Curcumin supplements (yakanyanyisa curcumin yakatorwa kubva muturmeric) chete pasi pekutungamirirwa kwechiremba wehutano sezvo inogona kuwirirana nemamwe marapirwo akadai seTamoxifen.
Iyo Turmeric Spice
Turmeric inonhuwira yanga ichishandiswa zvakanyanya kwemazana emakore muAsia kwete chete sechinhu chakakosha muIndia chikafu asi muchinyakare Chinese mushonga uye Indian Ayurvedic mushonga, kurapa akasiyana siyana hutano. Munguva pfupi yapfuura pakave nekuferefetwa kwakakura pamusoro peanopesana nekenza zvivakwa zveakakosha anoshanda echinhu Curcumin, iripo muturmeric (curcuma longa). Curcumin inoburitswa kubva pamidzi yeTurmeric uye inozivikanwa neyero orenji pigment. Iko kune kuwanda kwezvidzidzo uye kucherechedzwa kwakaburitswa muzviuru zvevezera rakaongorora magazini pane ekurapa maitiro eCurcumin.
Curcumin kubva kuTurmeric spice ndeye phytochemical ine huwandu hwakakura-hukuru pane akawanda maseru maitiro, nzira, mapuroteni uye majini anosanganisira akasiyana kinases, cytokines, enzymes uye zvinyorwa zvinyorwa. Nekudaro Curcumin ine zvakawanda zvinodzivirira hutano zvinosanganisira antioxidant, anti-cancer, anti-inflammatory, antimicrobial, immunomodulatory, neuroprotective, uye dziviriro yakafararira kune dzakawanda nhengo uye masisitimu enhengo anosanganisira chiropa, itsvo, ganda nezvimwe (Kocaadam B et al, Crit. Rev. Chikafu Sci. Nutriti., 2015)
Mune ino blog isu tichapfupikisa iyo yekuyedza uye yekiriniki humbowo hwechemopreventive uye anticancer zvivakwa zveCurcumin, kiyi inoshanda yeiyo spice Turmeric. Iyo inowanikwa nyore, yakaderera mutengo uye yakaderera chepfu, yakasikwa phytochemical, yakasarudzwa seimwe yezvinhu zvinogona kuvimbisa zvinhu zviri kuyedzwa mumakiriniki ekuedzwa neUS National Cancer Institute.
Kunyangwe paine humbowo hwakasimba hwekuyedza uye hwehunyanzvi hweCurcumin's anticancer pharmacological kugona, iine nyaya dzekusatora zvakanaka uye kushomeka kwekuwanika mumuviri, muchimiro chayo. Izvi zvinogona kugadziriswa kuburikidza nekuumbwa kunosimudzira kuwanikwa kwayo. Pamusoro pezvo, kuburikidza nekubatana kwayo nezvinodhaka zvinogadzirisa enzymes uye vanotakura zvinodhaka, ine mikana yakakura yekudyidzana nemimwe mishonga. Nekudaro, pane kudikanwa kwezvakawanda zvakagadzirwa-zvakanaka zvekiriniki zvidzidzo zvekujekesa iwo chaiwo mamiriro uye musanganiswa umo Curcumin inogona kushandiswa. (Unlu A et al, JBUON, 2016)
Anti-Kuzvimba Zvivakwa zveCurcumin / Turmeric Ipa Anopa-Kenza Bhenefiti
Iyo yakakosha anti-kenza hunhu hweCurcumin / Turmeric inokonzerwa neayo-inopesana nekuzvimba uye immunomodulatory zvivakwa.
Gomarara rinoitika kana maseru edu achishandurwa nekuda kwekuchinja uye hurema hunokonzerwa nezvakakonzera zvakasiyana siyana zvinosanganisira mararamiro, chikafu, kushushikana, nharaunda uye zvakakonzerwa nemagene. Miviri yedu yakagadzirirwa nevarindi uye nzira dzekudzivirira pamatanho ehurongwa uye maseru. Yedu immune system yakagadzirirwa kuratidza chero chinhu chiri chekunze (hutachiona kana hutachiona hutachiona) kana chero chinhu chiri mukati momuviri chisina kujairika, uye chine mashandiro uye kubatika kwekufashukira kwekubvisa kusagadzikana. Kunyangwe padanho remaseru sezvo maseru anopatsanuka kuti akure, kuvandudzwa, kupora kwemaronda uye kumwe kushanda kwemuviri, isu tine cheki pamatanho ese kutanga nekutarisa kunyatsoita kwemessage mese muedu genome, iyo DNA. Iko kune izere DNA kukanganisa kwekuona uye kugadzirisa michina iyo inogara ichishanda kune ino maitiro.
Kana gomarara rikaitika, izvo zvidzidzo zvakabvumikisa kuti pane hurema padanho remaseru nemuchina wekugadzirisa weDNA unokonzeresa kukuvara kwemaseru uye kusanzwisisika, uye hurema hwesisitimu mumapurisa ekudzivirira masoja akaregeredza uye akatadza kuziva nekujekesa kusagadzikana. Nekudaro maseru asina kujairika anotenderwa kurarama uye maseru akasimba anobva atora sisitimu uye kubudirira uye kubudirira sezvo chirwere ichi chichienderera mberi.
Kuzvimba kuita kana muviri uchinge waona kuremara kana kusagadzikana uye uchitsvaga dziviriro yemuviri kuti igadzirise nyaya uye kubvisa dambudziko racho. Kunyanya, kusagadzikana kwese kunosanganisira autoimmune kusagadzikana, kushomeka kwekukanganisa uye kunyangwe kenza inokonzerwa nekusiyana kwakasiyana kwema immune system. Panyaya yekenza, immune system inobiwa kuti irege kuziva asi kutsigira zvisina kujairika maseru uye kubatsira mukukura kwavo.
Kune zvakawanda zvidzidzo zvakatemwa maseru enzira eanopokana-nekurwisa zviito zveCurcumin zvakaburitswa kubva kuTurmeric izvo zvinopa iyo yakakosha yekurwisa kenza kubatsirwa. Curcumin inoshandisa yayo inorwisa-kupisa zvivakwa kuburikidza nekudyidzana nevamiririri vazhinji vemuviri senge kudzvinyirira pro-kuzvimba transcript zvinhu zvakadai seNuclear factor kappa B (NFKB), inhibits pro-inflammatory cytokines, chemokines, prostaglandins uye kunyangwe iyo inoshanda oxygen mhando (ROS). Vazhinji vevarevereri ava vanobatanidzwa munzira dzinoverengeka dzekuratidzira maseru dzakanangana nekenza magumo senge kuwedzera kenza kukura (kuwanda), kuderedzwa maseru kufa (apoptosis), kumera kwakanyanya kwemitsipa yeropa mitsva (angiogenesis) uye kutsigira kupararira kwemasero emukenza asina kujairika kusvika zvimwe zvikamu zvemuviri (metastasis). Iyo immunomodulatory zvivakwa zveCurcumin hazvisi chete nekuda kwekuvharirwa kwemaseru mamorekuru zvinangwa asi zvakare zvinokwanisa kugadzirisa zvine mutsindo maseru ekudzivirira akadai macrophages, dendritic maseru, T-maseru uye B-lymphocyte, immune system yekudzivirira. (Giordano A uye Tommonaro G, Nutrients, 2019)
Ongororo Dzidzo paAnti-kenza Mhedzisiro yeTurmeric / Curcumin Mukenza
Iyo anti-cancer mhedzisiro yeCurcumin / Turmeric yakaferefetwa mumazhinji kenza maseru mitsara uye mhando dzemhuka. Curcumin yakaratidza zvinobatsira zvekudzora kenza maseru kukura mumhando dzekenza yeprostate, gomarara repazamu kusanganisira katatu kenza yemazamu, esophageal uye yemusoro nemutsipa kanzura, gomarara remapapu nevamwe vazhinji. (Unlu A et al, JBUON, 2016)
Pamusoro pezvo, pakave nezvidzidzo zvekuongorora kana Curcumin inogona kuwedzera kunzwisisika kwemakemikari ekurapa uye ekurapa nemwaranzi.
- Curcumin yakaratidzirwa kuwedzera kunzwisisika kwe5-fluorouracil mune colorectal cancer cancer mitsetse. (Shakibaei M et al, PLoS Imwe, 2014)
- Curcumin yakabviswa kubva kuTurmeric kuyedza yakawedzera kushanda kwecisplatin mumusoro nemutsipa uye ovarian cancer cancer. (Kumar B et al, PLoS Mumwe, 2014; Selvendiran K et al, Cancer Biol. Ther., 2011)
- Curcumin inonzi inowedzera kushanda kwepaclitaxel mumasero emukenza emuchibereko. (Sreekanth CN et al, Oncogene, 2011)
- Mune lymphoma, Curcumin yakaratidzirwa kusimudzira kunzwisisika kune radiation radiation. (Qiao Q et al, Anticancer Zvinodhaka, 2012)
- Mune squamous cell maseru emukenza maseru, Curcumin anobva kuTurmeric anonzi akawirirana nekemotherapy mushonga wevinorelbine. (Sen S et al, Biochem Biophys Res. Commun., 2005)
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Clinical Zvidzidzo Pamhedzisiro yeCurcumin muCancer
Curcumin ichiri kuongororwa mune dzakawanda zvirikuenderera mberi zvekiriniki zvidzidzo, zvese se monotherapy uye pamwe chete nemimwe mishonga.
- Mune colorectal cancer cancer kliniki yekudzidza, yemumuromo kugadzirwa kwecurcumin yakaongororwa. Paive nekushomeka kwehuturu neCurcumin, nepo vaviri vevarwere gumi nevashanu vakaratidza chirwere chakasimba mushure memwedzi miviri yekurapwa kweCurcumin. (Sharma RA et al, Clin Cancer Res., 2) Mune chimwe chikamu chechipiri chevarwere makumi mana nevana vane maronda ekenza yemakoloni, kushandiswa kweCurcumin kwemazuva makumi matatu kwakanzi kunoderedza huwandu hwezvironda ne15%. (Carroll RE et al, Cancer Prev. Res. (Phila), 2)
- Muchikamu chechipiri cheyedzo yeCurcumin yemumuromo yekuumbwa mune makumi maviri neshanu epancreatic kenza varwere, varwere vaviri vakaratidza kiriniki chiitiko chekiriniki nemurwere mumwe anonzi ane chirwere chakatsiga che> 25 mwedzi uye mumwe aine pfupi asi yakakosha bundu regression. (Dhillon N et al, Clin Cancer Res., 18)
- Chidzidzo chekiriniki mune chisingaperi myeloid leukemia (CML) varwere, kurapwa kweiyo mubatanidzwa weCurcumin pamwe neImatinib (muyero wekurapa mushonga weCML) yakaongororwa. Iko kusanganisa kwakaratidza kushanda zvirinani pane Imatinib chete. (Ghalaut VS et al, J Oncol. Pharm Dzidzira., 2012)
- Mune varwere vekenza yemazamu, Curcumin iri pasi pekuferefetwa mune monotherapy (NCT03980509) uye pamwe chete ne paclitaxel (NCT03072992). Iri kuongororwawo mune zvimwe zvidzidzo zvemakiriniki zvegomarara reprostate rine njodzi shoma, gomarara remuromo wechibereko, gomarara rependometrium, uterine sarcoma nevamwe. (Giordano A uye Tommonaro G, Nutrients, 2019)
- Chikamu chechangobva kuitika chechipiri chemakiriniki mune varwere vane metastatic colorectal cancer (NCT01490996) yakafananidza kupona kwevarwere vanowana mubatanidzwa chemotherapy FOLFOX (folinic acid / 5-fluorouracil / oxaliplatin kurapwa) pamwe uye pasina Curcumin zvinowedzera (kubva kuTurmeric). Kuwedzeredzwa kweCurcumin kune FOLFOX kwakawanikwa kuve kwakachengeteka uye kushivirira kune colorectal kenza varwere uye haina kuwedzera migumisiro yemhedzisiro yechemo. Pakuenderana nemitengo yemhinduro, iro Curcumin + FOLFOX boka raive nemhedzisiro iri nani yekupona pamwe nekufambira mberi kwemahara kurarama mazuva zana nemakumi maviri pakureba kupfuura boka reFOLFOX uye kupona kwese kuri kuwedzera zvakapetwa. (Howells LM et al, J Nutriti, 120) Kusanganisira Curcumin sechikamu checolorectal kanzuru yevarwere chikafu paunotora FOLFOX chemotherapy inogona kubatsira.
Kutaurirana kweCurcumin nemamwe Mishonga
Curcumin, kunyange ichizivikanwa sechinhu chinowanzochengetedzwa neFDA (Food and Drug Administration), ine humbowo hwekuti inokanganisa mushonga unogadzirisa cytochrome P450 enzymes. Nokudaro, ine mukana wekubatana nemamwe madhiragi uye kukanganisa kushanda kwemishonga. Pane zvidzidzo zvekudyidzana kwayo nemishonga inosanganisira antiplatelet mishonga, nezvimwe kenza uye chemotherapy zvinodhaka zvinosanganisira Tamoxifen, doxorubicin, cyclophosphamide, tacrolimus nevamwe. (Unlu A et al, JBUON, 2016)
Curcumin's antiplatelet pfuma inogona kuwedzera njodzi yekubuda ropa kana ichishandiswa nemaanticoagulants. Yayo antioxidant chivakwa inogona kukanganisa maitiro ekuita kwemakemikari madhiragi senge cyclophosphamide uye doxorubicin. (Yeung KS et al, Oncology J, Kubatanidza Oncol., 2018)
Curcumin kubva kuTurmeric inopindirana neTamoxifen kurapwa, iyo Standard yeKutarisira Hormone Yakanaka Checheche Checheche.
Mushonga wemumuromo Tamoxifen inogadziriswa mumuviri mune ayo pharmacologically anoshanda metabolites kuburikidza ne cytochrome P450 enzymes muchiropa. Endoxifen ndiyo kiriniki inoshanda yeTamoxifen, ndiyo muyananisi wakakosha wekubatsira kwetamoxifen therapy (Del Re M et al, Pharmacol Res., 2016). Zvimwe zvekare zvidzidzo zvakaitwa pamakonzo zvakaratidza kuti kune kudyidzana kwezvinodhaka-zvinodhaka pakati peCurcumin neTamoxifen. Curcumin inhibited iyo cytochrome P450 yakagadziriswa metabolism yekutendeuka kwetamoxifen kune fomu yayo inoshanda (Cho YA et al, Pharmazie, 2012). Chichangobva kuburitswa chinotarisirwa kiriniki yekudzidza (EudraCT 2016-004008-71 / NTR6149) kubva kuErasmus MC Cancer Institute muNetherlands, yakaedza kubatana uku pakati peCurcumin neTurmeric (ine kana isina piperine) uye kurapwa kweTamoxifen mune varwere vegomarara repazamu (Hussaarts KGAM et al, Cancers (Basel), 2019). Vatsvakurudzi vakaongorora mazinga eTamoxifen uye Endoxifen pamberi peCurcumin.
Mhedzisiro yacho yakaratidza kuti kusungwa kweiyo inoshanda metabolite Endoxifen yakaderera neCurcumin. Uku kuderera muEndoxifen kwaive kwakakosha. Naizvozvo, kana Curcumin yekuwedzera (kubva kuTurmeric) inotorwa pamwe chete neTamoxifen kurapwa kwekenza yemazamu, inogona kudzikisa kuwanda kwemushonga unoshanda pazasi pechikumbaridzo chekubudirira uye inogona kukanganisa kurapa kwechirwere.
mhedziso
Turmeric, iyo orenji-yeyero zvinonhuwira, yanga ichishandiswa kwemazana emakore, kunyangwe isati yamboonekwa chinhu chinoshanda cheCurcumin, kune ayo mazhinji mabhenefiti ehutano. Iyo inoshandiswa seanopokana-nekuzvimba uye kunyange kuiswa yakanangana nemaronda kuwedzera kurapa kwemaronda. Pini yeturmeric nemukaka unopisa rave zera remishonga inorwisa mabhakitiriya uye yekudzivirira mishonga inoshandiswa mudzimba nhasi, sekuenderana nehungwaru hwetsika. Icho chinongedzo che curry poda uye inowanzo uye zvakanyanya kushandiswa sechikamu cheIndia neAsia chikafu. Chipunu chemidzi yakasvibira uye yakakangwa muturimeri pamwe chete nemhiripiri nhema uye ndimu ndeimwezve mubatanidzwa unoshandiswa pachishandiswa nzira yekurwisa chirwere cheshuga, anti-arthritic, immune immune boosting. Nekudaro sekudya kwechisikirwo uye zvinonhuwira, turmeric inowanda uye zvakanyanya kudyiwa.
Nhasi, kune ese marudzi ese e-turmeric neCurcumin anotora, mahwendefa, macapsule, uye akasiyana mafomati anotengeswa mumusika, akatasva pane anozivikanwa hutano mabhenefiti. Nekudaro, Curcumin inozivikanwa kuva nehurombo hwekumwisa uye bioavailability mumuviri. Kana iripo ichisangana nepepuru nhema kana piperine kana bioperine, yakagadzirisa bioavailability. Zvigadzirwa zveCurcumin zvinoiswa semishonga yemakwenzi uye botanicals zvisina kunyatso kudzorwa semushonga. Naizvozvo, kunyangwe paine kuwanda kwezvigadzirwa zveCurcumin mumusika, mumwe anofanirwa kuziva nezvekusarudza chigadzirwa nechakakodzera kuumba uye kuwedzera mavara ekufanirwa kubva kuUSP, NSF nezvimwe, kuvimbisa iri nani chigadzirwa.
Sezvakatsanangurwa mubhurogu, kune zvakawanda zvekuyedza zvidzidzo mumasero mazhinji emukenza akasiyana uye mhando dzemhuka dzinoratidza kuti Curcumin haigone chete kudzivisa kukura kwegomarara uye mamwe magumo ekenza, asi zvakare vakadzvinyirira zvimiro zvehupenyu nenzira iyo Curcumin iri kushanda mukupa anti-cancer mabhenefiti. Kune zvimwe zvidzidzo zvemakiriniki izvo zvakaratidza kubatsirwa zvine mwero uye zvakaratidza kuvandudzika mukushanda kwezvinodhaka zvemamwe marapirwo egomarara anosanganisira chemotherapy uye kurapwa nemwaranzi, pamwe chete neCurcumin (kubva kuTurmeric).
Zvisinei, kusiyana nezvinodiwa zvakasimba zvezvidzidzo zvemishonga yekiriniki, kushandiswa kweCurcumin kuumbwa uye kuisa pfungwa kwave kusina kuwirirana uye kwakamisikidzwa kune dzakawanda zvidzidzo zvekiriniki. Pamusoro pezvo, nekuda kweiyo inozivikanwa yakaderera bioavailability nyaya yeyakasikwa Curcumin, mhedzisiro muzvidzidzo zvekiriniki haina kuve inonakidza uye inogutsa. Uyezve kune data pamusoro pekudyidzana kweCurcumin nemamwe marapirwo anogona kukanganisa kushanda kwemushonga. Saka nekuda kwezvikonzero zvese zviri pamusoro, kunze kwekushandisa turmeric muchikafu chedu uye kudya uye pamwe inokwanisa curcumin kuumbwa kweayo immune boosting zvivakwa, kushandiswa kweCurcumin ne. kenza varwere havakurudzirwi kunze kwekunge pasi pekutungamirirwa kwechiremba wehutano.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.