Muchidimbu
Yakanyanya yakakwira dosi Ascorbic Acid (Vitamin C) inopihwa musinga pamwe pamwe nekubatana chemotherapy senge FOLFOX uye FOLFIRI, mune metastatic colorectal kana gastric kenza varwere, inogona kupihwa zvakachengeteka pasina chero yakawedzera huturu. Kutora yakakwira dose Vitamin C kana kusanganisira Vitamin C zvakapfuma zvekudya sechikamu che kanzuru yevarwere chikafu pamwe chete nechemotherapy inogona kuvandudza kupindurwa kwese uye kuderedza chemotherapy inosanganiswa nemhedzisiro mu colorectal cancer kana gastric. kenza.
Vhitamini C / Ascorbic Acid
Ascorbic Acid (Vitamin C) inowanzoshandiswa uye yakashandiswa zvakanyanya antioxidant uye yakasikwa immune immune booster. Zvisinei, basa rayo mu kenza kudzivirira uye kurapwa kwave kune nharo. Nepo humwe humbowo hweanecdotal hwakaratidza kuti kudya Vitamin C chikafu chakapfuma kwakaderedza njodzi yekenza, humbowo hunobva mukupindira, randomized clinical trials with oral ascorbate hauna kuratidza chero rubatsiro. Asi munguva pfupi yapfuura zvidzidzo zvepreclinical zvine yakanyanya kukwirisa dose ascorbic acid kuratidzwa ne intravenous infusion inouraya cancer maseru, uye yakaratidza synergistic mhedzisiro necytotoxic mishonga. Yakanyanya kukwira yeascorbic acid inogona kuwanikwa chete nekupinzwa mutsinga uye panguva iyi, ascorbic acid inogona kuva nepro-oxidant mhedzisiro, inokonzera kuwedzera kweDNA kukuvadzwa, izvo zvinogona kukonzera kenza kufa. Pamusoro pezvo, kune humbowo hwekutanga hwekiriniki hunowedzera hunoratidza kuti yakanyanya dose ascorbic acid inogona kupihwa zvakachengeteka pamwe nemishonga yecytotoxic yakadai segemcitabine, paclitaxel uye carboplatin.Ma Y et al, Sci. Dudziro. Med., 2014; Welsh JL et al, Cancer Chemother Pharmacol, 2013)
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Uchishandisa Vitamin C / Ascorbic Acid pamwe neChemotherapy muMetastatic Colorectal uye Gastric Cancer
Kuongorora kuchengetedzeka uye yakanyanya kushivirira dosi (MTD) yeascorbic acid / Vitamin C iyo inogona kupihwa pamwe nemubatanidzwa cytotoxic chemotherapy regimens senge FOLFOX neFOLFIRI, vaongorori kubva kuCollaborative Innovation Center yeCancer Medicine, Sun Yat-sen University kuChina. akaita anotarisirwa Phase 1 kiriniki yekuedza (NCT02969681) mune metastatic colorectal (mCRC) kana gastric kenza (mGC) varwere. FOLFOX musanganiswa wechemotherapy unosanganisira 3 mishonga: leucovorin (Folinic acid), Fluorouracil uye oxaliplatin. Muchirongwa cheFOLFIRI, 4 cytotoxic zvinodhaka - Folinic acid, Fluorouracil, Irinotecan uye Cetuximab inoshandiswa. (Wang F et al, BMC Kenza, 2019)
36 varwere veChinese vakaedzwa nedosi kukwira kweiyo intravenous ascorbic acid kubva ku0.2-1.5 g / kg kwe3 yekumisikidzwa kweawa, kamwe chete pazuva, kwemazuva 1-3, pamwe FOLFOX kana FOLFIRI mune yegumi nemana kutenderera, kudzamara MTD yawanikwa. Pakati pevarwere makumi matatu nevatanhatu vakanyoresa, 14 (36 ine mCRC uye 24 ine mGC) vakaongororwa kuti vapindure bundu. Mhinduro yepamusoro yakazara yaisanganisira kupindura zvishoma muvarwere gumi nemana (23%), chirwere chakatsiga muzvipfumbamwe (1%), nechirwere chekudzivirira chirwere che58.35%. Vatsvakurudzi vakataura kuti pakange pasina MTD yakasvika uye havana kuwana chero hutachiona-hunotapudza huturu hwakaonekwa pane kuwedzera kwedosi. Iwo akanyanya kuwanda mhedzisiro-mhedzisiro anokonzerwa neepamusoro-dhizaini ascorbic acid yaisanganisira musoro, kureruka-musoro, mukanwa wakaoma uye humwe hutumbu hwemudumbu nekuda kwekuiswa infravenous infusion. Ichi chidzidzo chakaratidzawo kuderera kwemupfupa wakashata wemudumbu uye huturu hwehutachiona hwakabatana nemakemikari marimeni apo yakakwira dosi ascorbic acid yakapihwa pamwe nekemotherapy.
Zvakawanikwa zvechidzidzo ichi zvakaratidza "kuti ascorbic acid / Vitamin C pa1.5 g / kg kamwe pazuva pazuva kwemazuva matatu akateedzana anogona kupihwa zvakachengeteka pamwe neFOLFOX kana FOLFIRI chemotherapy mukutenderera kwemazuva gumi nemana." (Wang F et al, BMC Kenza, 2019)
mhedziso
Yakakwira vhitamini C uye / kana chikafu / chikafu chakapfuma muVitamin C chinopihwa pamwe nechemotherapy chinogona kuvandudza mhinduro yese uye kuderedza chemotherapy inoenderana nemhedzisiro mugomarara remukati kana gastric. kenza.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kudzivisa kufungidzira uye kusarudzika kusarudzwa) ndiyo yakanyanya kunaka mushonga we kenza uye kurapa kwakabatana nemhedzisiro.