Muchidimbu
Kenza yemazamu yeMetastatic, inozivikanwawo sedanho IV kenza yemazamu, imhando yepamusoro yechirwere umo gomarara rakapararira kune dzimwe nzvimbo dzemuviri, senge mapfupa, mapapu, chiropa, kana uropi. Chikamu chidiki chete (6%) chevakadzi vanotanga vaonekwa kuti vane metastatic zamu kenza, nezviitiko zvakawanda zvinoitika semugumisiro wekudzokera shure mushure mekutanga kurapwa uye nguva yekuregererwa.
Pane musiyano mukuru pakati pegomarara rezamu negomarara rezamu remazamu; gomarara rezamu iamburera izwi remarudzi ese nematanho ecarcinoma inotangira munyama yezamu. Nekune rimwe divi, National Cancer Institute (NCI) inopawo ruzivo nezve metastatic cancer cancer uye akasiyana nhanho dzegomarara rezamu, kusanganisira tsananguro yegomarara rezamu remazamu sechikamu IV chechirwere, uko maseru egomarara akapararira kune dzimwe nhengo dzemuviri. .
Nepo gomarara rezamu remazamu richinyanya kuwanikwa muvakadzi, rinobatawo varume vashoma. Zvinoenderana neAmerican Cancer Society's Cancer Chokwadi uye Figures shumo kubva muna 2019, chiyero chemakore mashanu ekupona kwekenza yemazamu yemazamu isingasviki makumi matatu%.
Segar, Jennifer M et al. "Chidzidzo cheChikamu II cheIrinotecan uye Etoposide seKurapa kweRefractory Metastatic Breast Cancer." The oncologist vol. 24,12 (2019): 1512-e1267. doi:10.1634/theoncologist.2019-0516
Clinical Trial (NCT00693719): Irinotecan uye Etoposide muMetastatic Breast Cancer
- Paive nevakadzi makumi matatu nemumwe vakanyoreswa mune irwo ruoko, chikamu II kiriniki kutongwa, pakati pemakore makumi matatu nemasere kusvika makumi masere nemasere.
- 64% yevakadzi ava vaive nehutachiona hwakanaka uye HER2 mhando yakaipa yekenza yemazamu.
- Vakadzi vacho vakamborapwa nepakati nepakati peanenge mashanu ekurapwa uye vaive vatove vanopesana neamberi anthracycline, taxane uye capecitabine therapy.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Sayenzi Pfungwa yeChidzidzo
- Kufunga kuseri kwekutongwa kwaive kuyedza seti nyowani yemakemikari madhiragi ayo aive aratidzira zviitiko zvakanyorwa muvarwere vegomarara repazamu uye mubatanidzwa wacho wakaverengerwa mushe.
- Ose ari maviri Irinotecan neEtoposide zvakasikwa, zvinomera-zvakasimwa zvinoriumba modulators zve topoisomerase (TOP) enzyme isoforms. TOP enzymes inodiwa kuti DNA idzokorore uye kunyora, ese ari maviri maitiro akaomarara ekenza inokurumidza kenza. Kukanganisa TOP chiito kunokonzeresa DNA tambo kuputsa, DNA kukuvara uye induces sero kufa.
- Irinotecan ndeye TOP1 uye Etoposide ari TOP2 modulator. Chikonzero chekubatanidza zvese TOP1 uye TOP2 inhibitors ndeyekugadzirisa kumisikidza kumisikidza kweimwe isoform apo imwe yeiyo isoforms yakadzvanywa.
Clinical Trial Mhedzisiro
- Paive nevarwere makumi maviri nemana vaigona kuongororwa kuti zvinobudirira here izvi zverejimeni regirini yeIlinotecan neEtoposide. 24% yaive nemhinduro shoma uye 17% yaive nechirwere chakatsiga.
- Vese varwere ve31 vakaongororwa huturu uye 22 yeiyo 31 (71%) yakawana kurapwa kwakanangana negiredhi 3 uye 4 zviitiko zvakashata. Kazhinji huturu chaihwo hwaive neutropenia, ndiko kuvapo kwematanho asinganetsi neutrophil muropa ayo anogona kuwedzera kubatwa nezvirwere.
- Kudzidza kwakamiswa kare nekuti huturu hutoro hwakanga hwakanyanya uye hwakapfuura kushanda kwemubatanidzwa.
Metastatic Breast Cancer Symptoms
- Kurwadza kwepfupa kana kupfava: Inogona kupararira kumapfupa, ichikonzera marwadzo kana unyoro munzvimbo dzakakanganiswa.
- Kuneta: Kenza uye kurapwa kwegomarara kunogona kukonzera kuneta, izvo zvinogona kuve zvakanyanya uye zvinoramba zviripo.
- Kupfupika kwekufema: Gomarara rinopararira kumapapu rinogona kukonzera kupfupika kwekufema.
- Neurological zviratidzo: Gomarara rapararira kuuropi rinogona kukonzera zviratidzo zvetsinga zvakadai sekutemwa nemusoro, pfari, kana kuchinja kwekushanda kwepfungwa.
- Kurasikirwa nechido uye kuora muviri: Kurapa kenza uye kenza kunogona kukonzera kurasikirwa kwechido uye kuora muviri.
- Jaundice kana kuzvimba mudumbu kana gomarara rapararira kuchiropa.
Hupenyu hunotarisirwa hweumwe munhu ane metastatic cancer cancer inogona kusiyana zvichienderana nezvakati wandei zvakaita senzvimbo uye kupararira kwebundu.
Maererano neongororo, chiyero chemakore mashanu ekupona chiyero chekuti vangani vanhu vane rudzi urwu rwe kenza vachiri vapenyu mumakore mashanu apfuura mushure mekuwanikwa kwegomarara. Inoratidzwa sechikamu, zvichireva nhamba yevanhu kubva pazana vari vapenyu mushure memakore mashanu. Sekureva kweAmerican Cancer Society, mwero wemakore mashanu ekupona kwevakadzi vane metastatic cancer cancer ndeye 5%, nepo makore mashanu ekupona kwevarume vane 100%. Zvakakosha kuziva kuti idzi ndidzo nhamba dzese uye nyaya dzega dzinogona kusiyana.
Kurapa kweMetastatic Breast Cancer
Kurapa kwakaoma asi musanganiswa wechemotherapy ine chaiwo chemo mishonga ine zvimwe zvakanaka mukudzora gomarara. Iyo haigone kushandiswa zvakanyanya uye kwenguva yakareba nekuda kweiyo yakanyanya toxicity chimiro uye hupenyu hwehupenyu hunokanganisa kumurwere. Immunotherapy kurapwa ndiyo imwe sarudzo inogona kutariswa kune varwere vane metastatic kenza yemazamu; nzira yekurapa iyi inogona kubatsira immune system yemuviri kuziva uye kurwisa cancer maseru.
Kuongorora iyo mutation profile ye metastatic bundu inogona zvakare kubatsira kuona musanganiswa weakanyanya kunangwa nzira dzekurapa ine yakaderera mhedzisiro. Ngozi yekushandisa iyo chaiyo musanganiswa wetopoisomerase inhibitors Irinotecan uye Etoposide yakapfuura mabhenefiti uye inogona kusashandiswa mukurapa metastatic zamu. kanzira.
Sezvo yega yega metastatic cancer yemazamu yakasarudzika neyayo seti yekusiyana kwe genomic, nzira dzekurapa dzinoitwa zvinoenderana nevanooncologists. Pachine basa rinofanira kuitwa mukutsvaga nzira dzekurapa dzakavandudzwa uye dzakachengeteka kwairi. Gore rega rega, nemusi wa13 Gumiguru, zuva rekuziva nezvegomarara rezamu rezamu rinopembererwa kupa rutsigiro kune avo vakabatwa nechirwere ichi uye kuunganidza mari yetsvakiridzo yekuvandudza nzira dzekurapa.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.
References:
- Cancer.net (2022). Gomarara rezamu – Metastatic: Statistics.
- National Cancer Institute. (nd). Gomarara rezamu.
- American Cancer Society. (2021). Metastatic Breast Cancer.
- National Cancer Institute. (2021). Metastatic Breast Cancer.
- Cancer.net. (2022). Gomarara rezamu – Metastatic: Statistics.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.