Nderipi gomarara raizobatsirwa nekubatanidza Genistein mukudya kwavo?

Muchidimbu

Genistein inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweGenistein kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Genistein inogona kubatsira avo vane Primary Basal Cell Carcinoma vari pasi peVismodegib, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Urethral Squamous Cell Carcinoma. Uyezve, nepo Genistein inogona kubatsira vanhu vane genetic risk factor "ALK", inogona kunge isingakurudzirwe kune avo vane imwe genetic ngozi "JAK2". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweGenistein kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, njodzi dzemajini, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Genistein iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, ichitarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda muzvokudya / zvinowedzera seGenistein panzvimbo yekuongorora imwe neimwe inoshanda inosanganiswa zvakasiyana kana kuifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kubatanidza Genistein mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Genistein kana iwe uine genetic predisposition kune cancer yakabatana neiyo ALK gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuJAK2 gene? Zvinobatsira here kuisa Genistein mukudya kwako kana wabatwa nePrimary Urethral Squamous Cell Carcinoma, kana kuti chirwere chako chiri Primary Basal Cell Carcinoma? Uyezve, manwiro ako eGenistein anofanira kugadziriswa sei kana uri kurapwa neVismodegib kana chirongwa chako chekurapa chichibva kuVismodegib kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Genistein ndeyechisikigo, saka zvinogara zvichibatsira' kana 'Genistein inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Genistein mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seGenistein mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana waonekwa kuti une imwe mhando yegomarara, sePrimary Basal Cell Carcinoma kana Primary Urethral Squamous Cell Carcinoma, nzira dzekurapa dzinoda kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe chete nezvinhu zvakaita sezera uye murume kana mukadzi. ”

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, seGenistein. Ko genetic njodzi yegomarara kubva mukushandurwa muALK ine zvakafanana biochemical nzira nzira sekuchinja muJAK2? Kubva pakuona kwekudya, njodzi inosanganisirwa nePrimary Basal Cell Carcinoma inoenzana nePrimary Urethral Squamous Cell Carcinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRadiation sekune avo vanogamuchira Vismodegib? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Genistein - A Nutritional Supplement

Iyo yekuwedzera Genistein inotenderedza huwandu hwezvinhu zvinoshanda, kusanganisira Genistein, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Oncogenic Cancer Epigenetics, DNA Repair uye Hematopoiesis, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seGenistein, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Genistein yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweGenistein haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Genistein Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivisa Genistein mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eGenistein anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Genistein yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Genistein Supplements ichabatsira here Primary Urethral Squamous Cell Carcinoma Varwere vari kurapwa neRadiation?

Yekutanga Urethral Squamous Cell Carcinoma inoratidzwa nekumwe genetic mutations, iyo BLM, BRCA1 uye CTCF, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Androgen Signaling uye DNA Repair. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Genistein yekuwedzera, iyo inobata iyo DNA Kugadziridza, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Urethral Squamous Cell Carcinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Genistein Supplements ichabatsira Varwere veBasal Cell Carcinoma vari pasi peVismodegib Treatment?

Primary Basal Cell Carcinoma inotaridzwa neiyo chaiyo genetic mutations, yakadai sePTCH1, CSMD3 uye CSMD1, izvo zvinoguma nekuchinja mune biochemical pathways, kunyanya Oncogenic Cancer Epigenetics. Kushanda kwekurapa cancer, seVismodegib, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Genistein yekuwedzera isarudzo ine musoro kune avo vane Primary Basal Cell Carcinoma iri pasi peVismodegib. Izvi zvinodaro nekuti Genistein inokanganisa nzira dzakadai seOncogenic Cancer Epigenetics, inogona kuvharisa zvinhu zvinotyaira Primary Basal Cell Carcinoma kana kubatsira kushanda kweVismodegib.

3. Ko Genistein Supplements Yakachengeteka Kune Vanhu Vane Utano Vane JAK2 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo JAK2 gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muJAK2 gene inokanganisa nzira dzebiochemical kana maitirwo, akadai seHematopoiesis, Cytokine Signaling, JAK-STAT Signaling uye Immune Checkpoints, idzo dzakananga kana zvisina kunanga kutyaira cancer padanho remamorekuru. Kana genetic panel ikaratidza shanduko muJAK2 ine chekuita nenjodzi yakawedzera yeMyeloproliferative Neoplasms, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kweGenistein. Izvi zvinodaro nekuti kuwedzera Genistein kunopesvedzera nzira senge Hematopoiesis, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo JAK2 mutation uye ane hukama nekenza mamiriro.

4. Ko Genistein Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

ALK inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muALK kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira DNA Repair uye Growth Factor Signaling, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ichiratidza shanduko muALK yakabatana neCentral Nervous System, funga kuisa Genistein zvinowedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira dzakaita seDNA Repair, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane ALK mutations uye zvinetso zvehutano zvine chokuita.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seGenistein, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Iyo Molecular Landscape yeRecurrent uye Metastatic Head uye Neck Cancers: Insights Kubva kune Precision Oncology Sequencing Platform.
• BRCA1 uye BRCA2 sema molecular targets for phytochemicals indole-3-carbinol uye genistein mumazamu nekenza yeprostate.
• cBioPortal yeCancer Genomics
• Peroxisome proliferator-activated receptor gamma (PPARgamma) sechinangwa che molecular ye soy phytoestrogen genistein.
• Monosodium urate uye karusiyamu pyrophosphate makristasi anosiyanisa iyo yekukurudzira-mhinduro yekubatanidza kutevedzana kwevanhu neutrophils.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• BRCA1 kutaura kunodzoreredza kuramba kwemwaranzi muBRCA1-yakakanganisika cancer maseru kuburikidza nekusimudzira kwekunyora-kwakabatana DNA kugadzirisa.