Vitamini C: Zakudya ndi Ubwino wa Khansa

Mfundo

Kutenga Vitamini C (ascorbic acid) zakudya / magwero olemera monga gawo la zakudya / zakudya zatsiku ndi tsiku kungachepetse chiopsezo cha khansa zina monga khansa ya m'mapapo ndi glioma. Mavitamini a Vitamini C amapezekanso ndi calcium kuti achepetse vuto la m'mimba. Vitamini C, nawonso, amathandizira kuyamwa kwa calcium ndi thupi lathu. Pankhani ya chithandizo cha khansa, kusowa kwa kuyamwa koyenera kwa Vitamini C kuchokera muzakudya zake zam'kamwa ndi zakudya / magwero kwakhala kochepera. Komabe, maphunziro osiyanasiyana akuwonetsa phindu la kulowa m'mitsempha ya Vitamini C khansa kuphatikiza kukonza magwiridwe antchito amankhwala, kuchepetsa kawopsedwe komanso kukonza moyo wa odwala khansa.

Vitamini C, yemwenso amadziwika kuti ascorbic acid, ndi wamphamvu antioxidant ndipo ndi imodzi mwazomwe zimagwiritsidwa ntchito kwambiri pochepetsa chitetezo chachilengedwe. Pokhala vitamini wofunikira, samapangidwa ndi thupi la munthu ndipo amapezeka kudzera mu chakudya chopatsa thanzi. Ndiwonso mavitamini osungunuka amadzi omwe amapezeka mumtengowu zipatso ndi ndiwo zamasamba. Kusakhala ndi Vitamini C (ascorbic acid) kudzera pazakudya / zakudya zopitilira miyezi itatu kumatha kubweretsa kusowa kwa Vitamini-C kotchedwa scurvy. 

Kutenga zakudya zabwino za Vitamini C (ascorbic acid) kuli ndi maubwino ambiri azaumoyo chifukwa cha antioxidant, anti-inflammatory, anti-cancer komanso mphamvu zolimbitsa thupi. Zimathandizira kukhalabe wathanzi komanso chitetezo champhamvu champhamvu, minofu yolumikizana, kutsitsa kuthamanga kwa magazi ndikuwongolera thanzi la mtima. Vitamini C amathandizira thupi kupanga collagen yomwe imathandizira kuchiritsa kwa bala. Mavitamini a Vitamini C amathandiza kuteteza maselo athu kuti asawonongeke chifukwa cha zopitilira muyeso zaulere. Zowonjezera zaulere ndimadzimadzi othandizira omwe thupi lathu limagaya chakudya. Izi zimapangidwanso chifukwa chazowonekera zachilengedwe monga kusuta ndudu, kuipitsa mpweya kapena cheza cha ultraviolet padzuwa.

Zakudya / Magwero a Vitamini C (Ascorbic Acid)

Titha kukwaniritsa zofunikira za Vitamini C wathu watsiku ndi tsiku pophatikiza Vitamini C (ascorbic acid) zipatso ndi ndiwo zamasamba zomwe timadya. Zakudya zapamwamba / magwero a Vitamini C (ascorbic acid) ndi awa: 

• Zipatso za zipatso monga malalanje, mandimu, zipatso zamphesa, pomelos, ndi mandimu. 
• gwafa
• Tsabola wobiriwira
• Tsabola wofiira
• Froberries
• Chipatso cha Kiwi
• papaya
• chinanazi
• Madzi a phwetekere
• Mbatata
• Burokoli
• Ma Cantaloupes
• Kabichi wofiira
• sipinachi

Vitamini C ndi Kutsekemera kwa calcium

Vitamini C mukamamwa limodzi ndi calcium, imathandizira kuyamwa kwa calcium. Phunziro la Morcos SR ndi al. adawonetsanso kuti Vitamini C / ascorbic acid, malalanje ndi tsabola zimathandizira kuyamwa kwa calcium yamatumbo. Akadziphatikiza, Vitamini C ndi calcium zimatha kukulitsa mphamvu ya mafupa.

Vitamini C / ascorbic acid ndi acidic mwachilengedwe. Zotsatira zake, kudya kwambiri zakudya / magwero a Vitamini C kapena Vitamini C wowonjezera kumatha kubweretsa zovuta m'mimba. Chifukwa chake, pamsika, zowonjezera mavitamini C zimapezekanso limodzi ndi calcium, ndipo zimagulitsidwa ngati zowonjezera za calcium ascorbate. Mavitamini a calcium ascorbate amakhala ndi calcium carbonate yomwe imatha kusokoneza mphamvu ya Ascorbic Acid / Vitamini C.

Analimbikitsa Dietary Allowance ya Vitamini C ndi 75 mg ya akazi achikulire ndi 90 mg ya amuna akulu. Pamene 30-180 mg wa Vitamini C amatengedwa pakamwa patsiku kudzera muzakudya ndi zowonjezera, 70-90% imayamwa. Komabe, polowa kwambiri kuposa 1g / tsiku, kuchuluka kwa mayamwidwe kumatsikira ochepera 50% (Robert A. Jacob & Gity Sotoudeh, Nutrition in Clinical Care, 2002).

Ubwino Wotenga Vitamini C (Aascorbic Acid) Zakudya Zolemera mu Khansa

Chifukwa cha thanzi lawo labwino, mayesero ambiri azachipatala adasanthula zakudya / magwero a Vitamini C kuti aphunzire zaubwino wawo wa khansa. Kafukufuku angapo adachitika kuti aphunzire mayanjano a Kudya kwa Vitamini C ali ndi chiopsezo cha khansa kapena kuti awone momwe amathandizira pa khansa 

Vuto la Vitamini C & Khansa

1. Kuyanjana ndi Chiwopsezo cha Khansa ya M'mapapo

Pakafukufuku wofalitsidwa mu 2014, ofufuzawo adasanthula kafukufuku wosiyanasiyana yemwe adawunika momwe mavitamini C (ascorbic acid) amadyera zakudya zowonjezera kapena zowonjezera komanso khansa ya m'mapapo. Kuti azindikire maphunzirowa, ofufuzawo adafufuza m'mabuku, makamaka Pubmed, Wan Fang Med Online ndi Web of Knowledge (Luo J et al, Sci Rep., 2014). Kusanthula kwa meta kunaphatikizanso zolemba 18 zosiyanasiyana zomwe zidalemba kafukufuku 21 wokhudza milandu ya khansa yamapapo 8938. Mwa izi, maphunziro 15 adachitika ku United States, 2 ku Netherlands, 2 ku China, 1 ku Canada ndi 1 ku Uruguay. Zolemba za 6 pa 18 zomwe zidagwiritsidwa ntchito pakuwunika meta zinali zochokera pakuwongolera zochitika / maphunziro azachipatala ndipo 12 idatengera maphunziro a anthu / gulu. 

Zotsatira zakusanthula zidawonetsa kuti kudya kwa vitamini C wambiri kumalumikizidwa kwambiri ndi kuchepa kwa chiopsezo cha khansa yamapapo, makamaka ku United States komanso maphunziro a gulu. Zotsatirazo sizinawonetse mphamvu yayikulu ya Vitamini C m'maphunziro ochokera ku 6-control-control / clinical articles.

Pakadali pano, ofufuzawo adasanthula mayankho a mayankho pogwiritsa ntchito chidziwitso kuchokera ku maphunziro a 14 kuphatikiza milandu ya 6607. Zotsatira za kafukufukuyu zidawonetsa kuti pakukula kwa 100 mg / tsiku lililonse pakudya Vitamini C, panali kuchepa kwa 7% pachiwopsezo chokhala ndi khansa yamapapo. (Luo J et al, Sci Rep., 2014).

Kutenga Kwakukulu:

Zotsatira izi zikuwonetsa kuti kudya kwambiri Vitamini C (ascorbic acid) zakudya zabwino kungakhale ndi mwayi wochepetsa khansa yamapapo.

2. Kuyanjana ndi Kuopsa kwa Khansa ya Ubongo (Glioma)

Pakafukufuku wofalitsidwa mu 2015, ofufuzawo adasanthula kafukufuku wosiyanasiyana yemwe adawunika momwe mavitamini C amadyera komanso glioma / khansa yaubongo. Pazofufuza zofunikira, ofufuzawo adasanthula zolemba m'mabuku, makamaka Pubmed and Web of Knowledge mpaka Juni 2014 (Zhou S et al, Neuroepidemiology., 2015). Kuwunikaku kunaphatikizanso zolemba 13 zomwe zidalemba kafukufuku 15 wokhudza milandu 3409 ya glioma yochokera ku United States, Australia, China, & Germany. Ofufuzawa adapeza mabungwe oteteza ku America komanso maphunziro owongolera milandu.

Kutenga Kwakukulu:

Zotsatira za kafukufukuyu zikuwonetsa kuti kudya kwa vitamini C kumachepetsa chiopsezo cha glioma, makamaka pakati pa anthu aku America. Komabe, maphunziro ena azachipatala amafunikira kuti atsimikizire zomwezi.

Zomwe Zimakhudza Khansa ndi Moyo Wabwino

Kuyesedwa kwamankhwala koyenera kogwiritsa ntchito mavitamini C am'mlomo / zowonjezera zakudya sikunapindulitse anthu omwe ali ndi khansa. Mavitamini C okwera kwambiri kuchokera pakamwa zowonjezera/ zakudya sizimayamwa bwino kuti zikwaniritse bwino kwambiri zomwe zimapezeka kudzera mu kulowetsedwa kwa Vitamini C chifukwa chake sizinapindule. Vitamini C wopatsidwa kudzera m'mitsempha adapezeka kuti akuwonetsa phindu mosiyana ndi momwe zimayambira pakamwa. Kulowetsedwa mkati mwa Vitamini C kumapezeka otetezedwa ndipo zitha kukonza magwiridwe antchito komanso kutsika poizoni mukamagwiritsa ntchito mankhwala a radiation ndi chemotherapy. Pakhala pali maphunziro ambiri azachipatala omwe amafufuza zaubwino wogwiritsa ntchito Vitamini C wambiri mu khansa zosiyanasiyana.

1. Ubwino ku Glioblastoma (Khansa ya Ubongo) Odwala omwe amathandizidwa ndi Radiation kapena TMZ chemo mankhwala

Kafukufuku wazachipatala yemwe adasindikizidwa mu 2019 adawunikira chitetezo komanso mphamvu yoperekera kulowetsedwa kwa pharmacological ascorbate (Vitamin C) limodzi ndi Radiation kapena chemotherapy TMZ mwa odwala a glioblastoma (khansa ya muubongo). Radiation ndi TMZ ndi mitundu iwiri yodziwika bwino yochizira glioblastoma (khansa yaubongo). Kafukufukuyu adawunika zambiri kuchokera ku ubongo 11 khansa odwala (Allen BG et al. Chipatala cha Cancer Res., 2019). 

Ofufuzawa adapeza kuti mavitamini C / ascorbate infusions opitilira muyeso amathandizira kupulumuka kwa odwala a glioblastoma kuyambira miyezi 12.7 mpaka miyezi 23, makamaka m'mitu yomwe inali ndi chidziwitso chodziwika bwino. Kuchuluka kwamitsempha yamavitamini C / ascorbate infusions kumachepetsa zovuta zoyipa za kutopa, nseru ndi zovuta zamatenda zomwe zimakhudzana ndi TMZ ndi mankhwala a radiation. Zotsatira zoyipa zokha zomwe zimakhudzana ndi kulowetsedwa kwa ascorbate / Vitamini C zomwe odwala adakumana nazo zinali zowumitsa pakamwa komanso kuzizira.

Kutenga Kwakukulu:

Zomwe apezazi zikuwonetsa kuti kupereka mankhwala otsekemera a Vitamini C / ascorbate infusions limodzi ndi Radiation therapy kapena TMZ mwa odwala a Glioblastoma atha kukhala otetezeka komanso ololera. Mlingo waukulu wa Vitamini C amathanso kukulitsa mphamvu yothandizirayo monga zikuwonekera pakukula kwa moyo wa odwala.

2. Ubwino mu Okalamba Acute Myeloid Leukemia Odwala omwe amathandizidwa ndi hypomethylating agent (HMA)

Ma Hypomethylating agents (HMA) amagwiritsidwa ntchito pochiza Acute Myeloid Leukemia ndi Myelodysplastic Syndromes (MDS). Komabe, kuchuluka kwa mayankho a mankhwala ena osokoneza bongo nthawi zambiri amakhala otsika, pafupifupi 35-45% yokha. (Welch JS et al, New Engl. J Med, 2016)

Mu posachedwapa phunziro yomwe idachitika ku China, ofufuzawo adasanthula momwe zimathandizira kuperekera Vitamini C wochepa kwambiri limodzi ndi HMA mwa odwala okalamba a myeloid leukemia (AML). Ofufuzawo adasanthula zotsatira zamankhwala za odwala 73 okalamba a AML omwe amalandila mavitamini C ochepa kwambiri ndi HMA kapena HMA okha. (Zhao H et al, Leuk Res., 2018)

Ofufuzawa adapeza kuti odwala omwe adatenga HMA iyi kuphatikiza ndi Vitamini C anali ndi chikhululukiro chokwanira kwambiri cha 79.92% poyerekeza ndi 44.11% mwa iwo omwe adatenga HMA okha. Anapezanso kuti kupulumuka kwapakatikati (OS) kunali miyezi 15.3 m'gululi lomwe lidalandira Vitamini C ndi HMA poyerekeza ndi miyezi 9.3 mgulu lomwe lidalandira HMA lokha. Adatsimikiza zomwe asayansi amatengera Vitamini C pazoyankha za HMA. Chifukwa chake, izi sizimangochitika mwangozi. 

Kutenga Kwakukulu:

Kutenga mlingo wochepa wa Vitamini C limodzi ndi mankhwala ena a HMA atha kukhala otetezeka komanso othandiza kwa okalamba a AML. Kuphatikiza apo, zikhozanso kupititsa patsogolo kupulumuka konse komanso kuyankha kwachipatala kwa odwala a AML omwe amathandizidwa ndi HMA. Zotsatira izi zikuwonetsa kuyanjana kwa Vitamini C wamitsempha komanso wothandizila kugwiritsira ntchito hypomethylating mu odwala a AML. 

3. Zokhudza Kutupa kwa Odwala Khansa

Kafukufuku wofalitsidwa mu 2012 adafufuza momwe mavitamini C amathandizira kwambiri pakatupa omwe ali ndi khansa. Kafukufukuyu anaphatikizira zambiri kuchokera kwa odwala 45 omwe amathandizidwa ku Riordan Clinic, Wichita, KS, United States. Odwalawa amapezeka kuti ali ndi khansa ya prostate, khansa ya m'mawere, khansa ya chikhodzodzo, khansa ya kapamba, khansa yam'mapapo, khansa ya chithokomiro, khansa yapakhungu kapena B-cell lymphoma. Anapatsidwa mankhwala okwanira a Vitamini C atalemba mankhwala ochiritsira. (Mikirova N et al, J Kumasulira Med. 2012)

Kutupa ndi mapuloteni okwera kwambiri a C-reactive (CRP) amathandizidwa ndi matenda osokoneza bongo ndikuchepetsa kupulumuka m'mitundu yambiri ya khansa. (Mikirova N et al, J Kumasulira Med. 2012) Zotsatira za kafukufukuyu zidawonetsa kuti Vitamini C wolowa m'mitsempha amatha kuchepetsa kwambiri zizindikilo zomwe zimawonjezera kutupa monga IL-1cy, IL-2, IL-8, TNF-α, chemokine eotaxin ndi CRP. Ofufuzawo apezanso kuti kuchepa kwa milingo ya CRP panthawi ya chithandizo cha Vitamini C kumayenderana ndi kuchepa kwa zotupa zochepa.

Kutenga Kwakukulu:

Zotsatirazi zikuwonetsa kuti mankhwala amtundu wa Vitamini C okwera kwambiri amatha kuchepetsa kutupa kwa odwala khansa.

4. Zomwe Zimakhudza Moyo Wodwala Khansa

Pakufufuza koyang'ana m'malo osiyanasiyana, ofufuzawo adawunikiranso momwe vitamini C wopitilira mulingo wambiri paumoyo wamunthu amakhalira. khansa odwala. Pa kafukufukuyu, ofufuzawo adawunika zambiri kuchokera kwa odwala omwe ali ndi khansa yomwe yangopezeka kumene omwe adalandira vitamini C wambiri m'mitsempha ngati chithandizo chothandizira. Deta yochokera kwa odwala 60 inapezedwa kuchokera ku mabungwe omwe akugwira nawo ntchito ku Japan pakati pa June ndi December 2010. Kusanthula kwa umoyo wa moyo kunkachitika pogwiritsa ntchito mafunso okhudzana ndi mafunso omwe anapezeka kale, komanso pa 2 ndi masabata a 4 a mlingo waukulu wa mankhwala a Vitamini C.

Kafukufukuyu adawonetsa kuti kuwongolera kwapakati pamitsempha ya Vitamini C kumathandizira kwambiri thanzi komanso thanzi la odwala padziko lonse lapansi. Anapezanso kusintha kwakuthupi, m'maganizo, mozindikira, komanso momwe amagwirira ntchito masabata anayi a Vitamini C oyang'anira. Zotsatira zake zidawonetsa mpumulo waukulu pazizindikiro monga kutopa, kupweteka, kusowa tulo komanso kudzimbidwa. (Hidenori Takahashi et al, Makonda a Zachilengedwe Zachilengedwe, 2012).

Kutenga Kwakukulu:

Zotsatirazi zikuwonetsa kuti kulowetsedwa kwamitsempha yochuluka ya Vitamini C kumatha kusintha moyo wa odwala khansa.

Kutsiliza

Mwachidule, zakudya za Vitamini C ndi antioxidants zabwino zomwe zimakhala ndi thanzi labwino ndipo ziyenera kukhala gawo lazakudya zathu zatsiku ndi tsiku. Vitamini C imathandizanso kuyamwa kwa kashiamu m'thupi lathu komanso kumalimbitsa mafupa. Yawonetsanso kuthekera kochepetsera chiopsezo chapadera khansa monga khansa ya m'mapapo ndi glioma. Pankhani ya chithandizo cha khansa, Vitamini C wapakamwa ndi wosakwanira chifukwa cha kuyamwa kocheperako. Komabe, kulowetsedwa kwa Vitamini C m'mitsempha kwawonetsa kuti kumathandizira kuchiza komanso kulekerera kwamankhwala enaake a chemotherapy. Izi zawonetsanso kuthekera kochulukitsa odwala ' khalidwe la moyo komanso kuchepa kwa kawopsedwe ka mankhwala a radiation ndi chemotherapy. Mavitamini apamwamba a vitamini C (ascorbate) infusions awonetsanso kuthekera kochepetsa poizoni wama chemotherapies ena mu khansa ya kapamba ndi yamchiberekero. (Welsh JL et al, Cancer Chemother Pharmacol., 2013; Ma Y et al, Sci. Tanthauzirani. Ndi., 2014).

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa komanso chithandizo chamankhwala zoyipa.

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