Mfundo
Mlingo waukulu kwambiri wa Ascorbic Acid (Vitamini C) woperekedwa kudzera m'mitsempha pamodzi ndi mankhwala ophatikizika monga FOLFOX ndi FOLFIRI, m'matenda a khansa yam'mimba kapena am'mimba, amatha kupatsidwa chitetezo popanda zowonjezerapo poizoni. Kutenga kuchuluka kwa Vitamini C kapena kuphatikiza zakudya zopatsa Vitamini C ngati gawo la Zakudya za odwala khansa Kuphatikizidwa ndi chemotherapy kumatha kuyankha bwino ndikuchepetsa zotsatirapo zoyipa za khansa ya colorectal kapena m'mimba. khansa.
Vitamini C / Ascorbic Acid
Ascorbic Acid (Vitamini C) ndi antioxidant yomwe imagwiritsidwa ntchito kwambiri komanso yogwiritsidwa ntchito kwambiri ndi chitetezo chamthupi. Komabe, udindo wake mu khansa kupewa ndi kuchiza anthu akhala akukangana. Ngakhale umboni wina wosonyeza kuti kudya zakudya zolemera za Vitamini C kumachepetsa chiopsezo cha khansa, umboni wochokera ku mayesero osakanikirana, osakanikirana ndi oral ascorbate sanasonyeze phindu lililonse. Koma posachedwapa preclinical maphunziro ndi mkulu kwambiri mlingo ascorbic asidi kukhudzana ndi mtsempha kulowetsedwa kusankha anapha maselo a khansa, ndipo anasonyeza synergistic zotsatira ndi cytotoxic mankhwala. Mlingo wapamwamba kwambiri wa ascorbic acid ukhoza kutheka ndi kulowetsedwa kwa mtsempha ndipo pa mlingo uwu, ascorbic acid akhoza kukhala ndi zotsatira za okosijeni, zomwe zimayambitsa kuwonongeka kwa DNA, zomwe zingayambitse imfa ya maselo a khansa. Kuonjezera apo, pali umboni woyambirira wachipatala wosonyeza kuti mlingo waukulu wa ascorbic acid ukhoza kuperekedwa mosamala pamodzi ndi mankhwala a cytotoxic monga gemcitabine, paclitaxel ndi carboplatin.Ma Y et al, Sci. Tanthauzirani. Ndi., 2014; Welsh JL et al, Cancer Chemother Pharmacol, 2013)
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Kugwiritsa ntchito Vitamini C / Ascorbic Acid limodzi ndi Chemotherapy mu Metastatic Colorectal ndi Gastric Cancer
Kuwunika chitetezo ndi mlingo waukulu wololera (MTD) wa ascorbic acid/Vitamini C womwe ungaperekedwe limodzi ndi mankhwala ophatikizika a cytotoxic chemotherapy monga FOLFOX ndi FOLFIRI, ofufuza ochokera ku Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University ku China. adachita mayeso achipatala a Phase 1 (NCT02969681) mu metastatic colorectal (mCRC) kapena m'mimba. khansa (mGC) odwala. FOLFOX ndi mankhwala amphamvu a chemotherapy omwe ali ndi mankhwala atatu: leucovorin (Folinic acid), Fluorouracil ndi oxaliplatin. Mu regimen ya FOLFIRI, 3 mankhwala a cytotoxic - Folinic acid, Fluorouracil, Irinotecan ndi Cetuximab amagwiritsidwa ntchito. (Wang F et al. Khansa ya BMC, 2019)
Odwala 36 achi China adayesedwa ndi kuchuluka kwa mankhwala osokoneza bongo a ascorbic acid kuchokera ku 0.2-1.5 g / kg kwa kulowetsedwa kwa ola limodzi, kamodzi patsiku, kwa masiku 3-1, komanso ZOKHUDZA kapena FOLFIRI mu kuzungulira kwa masiku 14, mpaka MTD itakwaniritsidwa. Mwa odwala 36 omwe adalembetsa, 24 (23 yokhala ndi mCRC ndi 1 yokhala ndi mGC) adayesedwa poyankha chotupa. Yankho labwino kwambiri limaphatikizapo kuyankha pang'ono mwa odwala khumi ndi anayi (58.35%), matenda okhazikika mwa asanu ndi anayi (37.5%), omwe ali ndi chiwopsezo cha 95.8%. Ofufuzawo ananena kuti palibe MTD yomwe idafikiridwa ndipo sanapeze poizoni wochepetsera mlingo wopezeka pakukula kwa mlingo. Zotsatira zoyipa zomwe zimadza chifukwa cha kuchuluka kwa ascorbic acid zimaphatikizapo kupweteka mutu, kupepuka, pakamwa pouma komanso poyizoni wam'mimba chifukwa cholowetsedwa m'mitsempha. Kafukufukuyu adawonetsanso kuchepa kwa mafuta m'mafupa komanso m'mimba poyizoni yokhudzana ndi chemotherapy regimens pomwe ascorbic acid idaperekedwa limodzi ndi chemotherapy.
Zotsatira za kafukufukuyu zikusonyeza kuti "ascorbic acid / Vitamini C pa 1.5 g / kg kamodzi patsiku masiku atatu motsatizana atha kuthandizidwa bwino ndi FOLFOX kapena FOLFIRI chemotherapy m'masiku 14." (Wang F et al. Khansa ya BMC, 2019)
Kutsiliza
Mlingo waukulu wa Vitamini C ndi/kapena zakudya / zakudya zokhala ndi Vitamini C woperekedwa limodzi ndi mankhwala amphamvu atha kuwongolera kuyankha ndikuchepetsa zotsatira zoyipa za khansa yapakhungu kapena m'mimba. khansa.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kulosera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe khansa ndi zotsatira zake zokhudzana ndi chithandizo.