Mfundo
Kafukufuku wachipatala wasonyeza kuti kugwiritsa ntchito (kulowetsedwa) kwa mlingo waukulu wa ascorbate (vitamini C) kumatha kupititsa patsogolo kupulumuka kwa odwala khansa ya muubongo (GBM) omwe ali ndi vuto losazindikira. Kulowetsedwa kwa Vitamini C (ndipo mwinamwake zowonjezera) zoperekedwa pamodzi ndi muyezo wa chisamaliro cha radiation ndi mankhwala a Temozolomide a ubongo. khansa ilinso ndi mphamvu yochepetsera zotsatira zake, motero kumapangitsa moyo wa wodwalayo kukhala wabwino.
Khansa ya Ubongo - Glioblastoma
Glioblastoma (GBM) ndi khansa yoyamba muubongo. Njira yothandizira chisamaliro cha GBM imaphatikizaponso kuphatikiza kwa chotupa cha muubongo komwe kumatsatiridwa ndi ma radiation omwewo (RT) ndi chithandizo cha temozolomide (TMZ). Nthawi zambiri, izi zimatsatiridwa ndi ma radiation owonjezera a ma adjuvant a TMZ. Ngakhale kutukuka kwa mankhwala a khansa yatsopano komanso kupita patsogolo kwa chithandizo chamankhwala, kufalikira kwa odwala omwe ali ndi GBM kukupitilizabe kukhumudwitsa, ndikupulumuka kwa miyezi 14-16 ndi zaka 5 zosakwana 10%. (Stupp R et al, Lancet Oncol., 2009; Gilbert MR et al, New Engl. J Med, 2014)
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Vitamini C / Ascorbic Acid Gwiritsani Ntchito Khansa ya Ubongo
Maphunziro a preclinical komanso mayesero azachipatala mu zina khansa zisonyezo zidawonetsa phindu logwiritsa ntchito mlingo waukulu wa Vitamini C kuti ukhale wotetezeka komanso kuti ukhale wothandiza komanso wochepetsera kawopsedwe akagwiritsidwa ntchito limodzi ndi ma radiation ndi mankhwala a chemotherapy.
Choyamba pa kafukufuku wamankhwala amunthu chidachitika kwa odwala 11 omwe adapezeka ndi GBM ndi department of Radiation Oncology ku chipatala cha University of Iowa, kuti awone chitetezo ndi momwe angayambitsire kulowetsedwa kwa mankhwala, kuperekedwa limodzi ndi chithandizo chamankhwala cha GBM. (Allen BG et al. Chipatala cha Cancer Res., 2019Mlingo waukulu wa ascorbate umalowetsedwa katatu pasabata pamankhwala azachipatala za RT / TMZ komanso kawiri mlungu uliwonse mkati mwa ma adjuvant a TMZ. Mwa maphunziro 3 mu phunziroli, 11 mwa iwo sanadziwitse bwino kutengera mtundu wa enzyme yawo ya MGMT, chomwe chimadziwika kuti sichingayankhidwe ku TMZ. Mbiri yakale ikuwonetsa kuti odwala a GBM opanda MGMT omwe amalimbikitsa methylation amakhala ndi moyo miyezi 8 yokha pomwe omvera omwe sanapange MGMT omwe amapititsa patsogolo methylation amakhala ndi moyo miyezi 12 pomwe maphunziro a 23 akadali amoyo. Zotsatira zoyipa zokha zomwe anthuwa adakumana nazo zinali mkamwa wouma komanso kuzizira komwe kumalumikizidwa ndi kulowetsedwa kwa ascorbate, pomwe zovuta zina zoyipa za kutopa, mseru komanso zovuta zoyipa zam'magazi zokhudzana ndi TMZ ndi RT zidachepetsedwa.
Kutsiliza
Kafukufukuyu akuwonetsa kuti kupatsa odwala Vitamini C kapena ascorbate mu khansa yaubongo (GBM) omwe amathandizidwa ndi mankhwala a RT / TMZ ali ndi mwayi wopititsa patsogolo kupulumuka, makamaka m'maphunziro omwe ali ndi chizindikiritso cha MGMT chomwe chimadziwika kuti sichidziwika bwino . Kafukufukuyu akuwonetsa kuti kulowetsedwa kwa pharmacological ascorbate sikungopititsa patsogolo kulekerera kwa ma RT ndi TMZ, koma kuthekera kokulitsa moyo wa odwala ndikuchepetsa poizoni wa mankhwala a radiation ndi chemotherapy. Kulowetsedwa kwambiri kwa vitamini C (ascorbate) kwawonetsanso lonjezo pochepetsa poizoni wa chemotherapies monga gemcitabine, carboplatin ndi paclitaxel mu khansa ya kapamba ndi yamchiberekero. (Welsh JL et al, Cancer Chemother Pharmacol., 2013; Ma Y et al, Sci. Tanthauzirani. Ndi., 2014) Ofufuzawa akuwonetsa kuti zotsatira za kafukufuku wawo pa gulu laling'ono kwambiri ili la odwala akadali akulonjeza mokwanira kuti akuyenera kufufuzanso zachipatala pa zotsatira za kulowetsedwa kwa Vitamini C ndi zowonjezera mu ubongo. khansa.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.