Vitamini C imathandizira kuyankha kwa Decitabine mwa odwala a Acute Myeloid Leukemia

Mfundo

Kafukufuku waposachedwa ku China wodwala okalamba a Acute Myeloid Leukemia (AML) adawonetsa izi Vitamini C wowonjezera/ kulowetsedwa kumawonjezera kukhudzidwa kwa mankhwala a hypomethylating Decitabine (Dacogen) kuchokera ku 44% mpaka 80% mwa izi. khansa odwala. Chifukwa chake, kuphatikiza kwa Vitamini C wambiri komanso / kapena zakudya zokhala ndi Vitamini C ndi Decitabine zitha kukhala njira yabwino yopititsira patsogolo kuyankha kwa odwala okalamba a Leukemia (AML).

Vitamini C / Ascorbic Acid

Vitamini C ndi antioxidant wamphamvu komanso imalimbikitsa chitetezo chamthupi. Amadziwikanso kuti ascorbic acid. Vitamini C ndi vitamini wofunikira, chifukwa chake amapezeka kudzera mu chakudya chopatsa thanzi. Vitamini C amapezeka zipatso ndi ndiwo zamasamba zambiri. Kusadya Vitamini C kumatha kubweretsa kuchepa kwa Vitamini-C wotchedwa scurvy.

Zakudya Zakudya za Vitamini C

Zotsatirazi ndi zina mwa zakudya zomwe zili ndi Vitamini C: 

• Zipatso za zipatso monga malalanje, mandimu, zipatso zamphesa, pomelos, ndi mandimu. 
• gwafa
• Tsabola wobiriwira
• Tsabola wofiira
• Froberries
• Chipatso cha Kiwi
• papaya
• chinanazi
• Madzi a phwetekere
• Mbatata
• Burokoli
• Ma Cantaloupes
• Kabichi wofiira
• sipinachi

Acute Myeloid Leukemia (AML) ndi Decitabine / Dacogen

Pali mankhwala apadera a chemo omwe amagwiritsidwa ntchito pazowonetsa zosiyanasiyana za khansa. Decitabine/Dacogen ndi amodzi mwa mankhwala a chemo omwe amagwiritsidwa ntchito pochiza acute myeloid leukemia (AML), osowa koma ovuta. khansa wa magazi ndi m`mafupa. Khansa ya m’magazi imapangitsa kuti maselo oyera a m’magazi akule mofulumira komanso mosadziwika bwino, ndipo amatulutsa mitundu ina ya maselo a magazi monga maselo ofiira a m’magazi amene amanyamula mpweya ndi mapulateleti omwe amathandiza kutsekeka kwa magazi. Ngakhale maselo oyera amagazi osadziwika bwino sangathe kuchita ntchito yawo yanthawi zonse yolimbana ndi matenda ndipo kuchuluka kwawo kosadziwika bwino kumayamba kukhudza ziwalo zina. 'Acute AML' ikufotokoza kukula msanga kwa mtundu wa khansa iyi. Chifukwa chake matendawa amapita patsogolo mwachangu ndipo amakhala ndi zotulukapo zoyipa ndikukhala ndi moyo wapakatikati kwa chaka chimodzi chokha (Klepin HD, Chipatala cha Geriatr Med. 2016).

Chimodzi mwa zifukwa zomwe zimayambitsa chitukuko cha khansa zambiri komanso khansa ya m'magazi makamaka ndikuti chitetezo, njira zowongolera zolakwika mkati mwa selo, motsogozedwa ndi majini opondereza chotupa mu DNA, zimazimitsidwa kudzera pakusintha kosintha kotchedwa methylation. Kusintha kwa methylation kumeneku kumagwiritsidwa ntchito mwachilengedwe kusindikiza kukumbukira kwapadera kwa majini ndi ntchito zomwe zimayatsa kapena kuzimitsa magawo osiyanasiyana akukula kwa maselo omwe akuchita ntchito zapadera. Ma cell a khansa amasankha masinthidwe a methylation ndikuigwiritsa ntchito mopitilira muyeso kuti azimitse majini opondereza chotupa omwe amawalola kuti apitilize kubwereza mosayang'aniridwa komanso mosadziletsa.

Vitamini C imathandizira kuyankha kwa Decitabine mu Odwala Leukemia

Imodzi mwa chemotherapy ya AML ndi gulu la mankhwala omwe amatchedwa 'hypomethylating agents' HMA omwe amaletsa kusintha kwa methylation kuti kuyambitsanso kwa majeremusi opatsirana chotupa kuti athe kuyambitsa khansa ya m'magazi. Decitabine ndi imodzi mwa mankhwala a HMA omwe amagwiritsidwa ntchito pa AML. Mankhwala a HMA amagwiritsidwa ntchito kwa odwala okalamba a AML omwe ali ndi zaka zopitilira 65 ndipo sangathe kupirira mankhwala amwano omwe amagwiritsidwa ntchito kwambiri ku AML. Zomwe amayankhira mankhwalawa amakhala otsika, pafupifupi 35-45% yokha (Welch JS et al, Engl J Med Watsopano. 2016). Kafukufuku waposachedwa ku China, adayesa momwe kuperekera mavitamini C ophatikizira ndi Decitabine kwa odwala khansa okalamba omwe ali ndi Acute Myeloid Leukemia pakati pa gulu lomwe limangotenga Decitabine ndi gulu lina lomwe lidatenga Decitabine ndi Vitamin C. Zotsatira zawo zidawonetsa kuti kulowetsedwa kwa Vitamini C alinso ndi mgwirizano ndi Decitabine popeza odwala khansa ya AML omwe adalandira mankhwalawa anali ndi kuchotsera kwathunthu kwa 79.92% poyerekeza ndi 44.11% mwa iwo omwe alibe Vitamini C supplementation (Zhao H et al, Leuk Res. 2018). Malingaliro asayansi amomwe Vitamini C adasinthira mayankho a Decitabine adatsimikizika ndipo sizinangochitika mwangozi. Zakudya zomwe zili ndi Vitamini C zitha kukhala zabwino pakuthandizira kuyankha kwamankhwala odwala Leukemia omwe amathandizidwa ndi Decitabine.

Kutsiliza

Ngakhale Vitamini C amadya nthawi zambiri ngati gawo la chakudya chamagulu, kafukufukuyu wasonyeza kuti kuphatikiza kwa Vitamini C wambiri kuphatikiza Decitabine kumatha kusintha moyo wa okalamba omwe ali ndi Acute Myeloid Leukemia. Vitamini C amatha kupezeka mwachilengedwe mumitengo ya citrus ndi masamba amadyera osiyanasiyana monga sipinachi ndi letesi kapena opezeka kuchokera ku mavitamini othandizira mavitamini omwe angagulidwe pakauntala. Kuphatikiza Vitamini C monga gawo la chakudyacho kungapindulitse odwala khansa ya m'magazi powongolera mayankho achire (Decitabine). Izi zikuwonetsa kuti zinthu zachilengedwe zomwe zasankhidwa mwasayansi zitha kuthandizira chemotherapy kuti athandizire kukhala wodwalayo.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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