Kodi Berberine Ingachepetse Kuopsa Kwa Khansa Yoyenera?

Mfundo

Kafukufuku wachipatala wopangidwa bwino wasonyeza kuti chithandizo / kugwiritsa ntchito mankhwala opangidwa ndi zomera omwe amachokera ku Berberine mwa anthu omwe achotsedwa m'matumbo adenomas (polyps) ndi otetezeka popanda zotsatirapo zoyipa ndipo amathandiza kuchepetsa kubwereza kwa ma polyps. Chifukwa chake, kugwiritsa ntchito / kuchiza kwa berberine mulingo woyenera kungathandize poteteza colorectal adenoma (kupanga ma polyps m'matumbo) ndi colorectal. khansa.

Chifukwa cha kuchuluka kwa anthu okalamba, matenda a khansa akuchulukirachulukira, ndipo mosasamala kanthu za kupita patsogolo ndi njira zatsopano zochizira khansa, matendawa amatha kupitilira njira zonse zochiritsira odwala ambiri. Njira zochiritsira zowopsa komanso zowunikira zomwe zimathandizira kuwongolera ndikuchotsa khansa ma cell amayambitsanso zovuta zambiri, zoyipa komanso nthawi zina zosasinthika. Odwala khansa ndi okondedwa awo nthawi zonse amakhala akuyang'ana kugwiritsa ntchito njira zina zachirengedwe kuti achepetse ndi kuteteza ku zotsatira za chemotherapy, kulimbikitsa chitetezo cha mthupi komanso kukhala ndi thanzi.

Berberine ndi Khansa

Gulu lachilengedwe Berberine, lomwe limapezeka muzitsamba zingapo monga Barberry, Goldenseal ndi ena, lakhala likugwiritsidwa ntchito ku Traditional Chinese Medicine pazinthu zambiri zopindulitsa. Zotsatirazi ndi zina mwazabwino za berberine:

• Itha kukhala ndi zotsutsana ndi zotupa
• Mutha kukhala ndi zotsutsana ndi bakiteriya
• Mutha kukhala ndi zida zowonjezera chitetezo chamthupi
• Zitha kuthandiza kuwongolera shuga wamagazi
• Zitha kuthandiza kuchepetsa cholesterol yoyipa
• Itha kuthandizira pazovuta zam'mimba komanso m'mimba

Komabe, kwa anthu ena, kugwiritsa ntchito kwambiri Berberine kumatha kubweretsa zovuta zina monga kukhumudwa m'mimba, kutsekula m'mimba, kuphulika, kudzimbidwa, ndi kupweteka mutu.

Katundu wa Berberine kuti aziwongolera kuchuluka kwa shuga, gwero lalikulu lamafuta a khansa kupulumuka kwa ma cell, limodzi ndi anti-yotupa komanso kukulitsa chitetezo chamthupi, zimapangitsa kuti chomera ichi chikhale chothandizira anti-cancer adjuvant. Pakhala pali maphunziro khumi m'maselo ambiri a khansa ndi mitundu ya nyama zomwe zatsimikizira zabwino zotsutsana ndi khansa za Berberine.

Njira zama cell zomwe zimayendetsedwa ndi Berberine zimaphatikizapo kupsinjika kwa Oxidative, Signaling TGFB, Kukonza DNA, Angiogenesis ndi Noncoding RNA Signaling. Njira zamaguluzi zimayendetsa mwachindunji kapena mosakonzeka mwanjira zina za khansa monga kukula, kufalikira ndi kufa. Chifukwa cha lamuloli - pakudya zakudya zabwino za khansa, kusankha koyenera kwa zowonjezera monga Berberine payekha kapena kuphatikiza ndichofunikira kupanga. Mukamapanga zisankho pakugwiritsa ntchito mankhwala owonjezera a Berberine a khansa - ganizirani izi ndikufotokozera. Chifukwa monga momwe zimakhalira ndi khansa - kugwiritsa ntchito Berberine sikungakhale kukula kokwanira pamitundu yonse ya khansa.

Chithandizo cha Berberine / Kugwiritsa Ntchito Colorectal Adenoma Kubwereranso (Ma polyps ku Colon - Precursors of Colon Cancer)

Kafukufuku waposachedwa wachipatala wothandizidwa ndi National Natural Science Foundation yaku China adayesa kugwiritsa ntchito Berberine mu chemoprevention of colorectal adenoma (mapangidwe a polyps m'matumbo) ndi colorectal. khansa. Kuyesa kosasinthika, kwakhungu, koyendetsedwa ndi placebo kudachitika m'zipatala 7 m'maboma 6 ku China. (NCT02226185) Anthu omwe adalemba nawo kafukufukuyu adachotsedwapo ma polyps angapo m'matumbo mkati mwa miyezi 6 asanayambe phunzirolo. Adatumizidwa mwachisawawa m'magulu awiri, pomwe anthu 553 adalandira Berberine (0.3 magalamu, kawiri patsiku) ndi anthu 555 omwe adalandira piritsi la placebo. Ophunzira adayenera kutsatira colonoscopy pazaka 1 ndi 2-year timepoints polembetsa. Mapeto a phunziroli anali kuyesa kubwereza kwa ma polyps mu colon mu colonoscopy iliyonse yotsatira. (Chen YX et al, Lancet gastroenterology & Hepatology, 2020)

Zotsatira Zofunikira

Kupeza kwa kafukufukuyu ndikuti anthu 155 (36%) mgulu la Berberine anali ndi ma polyps obwereza pomwe anali mgulu la placebo chiwerengerochi chinali chachikulu kwambiri pomwe anthu 216 (47%) anali ndi ma polyps adenoma). Palibe khansa yoyipa yomwe idapezeka mukamatsata. Chovuta chofala kwambiri chinali kudzimbidwa komwe kumawoneka mu 1% ya odwala mgulu la Berberine ndi 0.5% mgulu la placebo. Panalibe zovuta zoyipa zomwe zidagwiritsidwa ntchito ndi Berberine.

Chofunika kwambiri pofufuza zamankhwala ndikuti magalamu 0.3 a Berberine omwe amatengedwa kawiri tsiku lililonse amapezeka kuti ndi otetezeka komanso othandiza kuti achepetse kuyambiranso kwa ma colorectal adenomas (polyps). Popeza palibe zovuta zoyipa zomwe zimapezeka mu phunziroli mukamamwa mankhwala oyenera, kugwiritsa ntchito Berberine kumatha kukhala njira yodzitetezera khansa kwa anthu omwe ali ndi polypectomy (kuchotsedwa kwa polyps kuchokera m'matumbo).

Pomaliza

Kugwiritsa ntchito Berberine mwa anthu omwe achotsedwa m'matumbo adenoma kungakhale kotetezeka popanda zovuta zoyipa akamwedwa pamlingo woyenera ndipo kungawathandize kuchepetsa kubwereza kwa ma polyp m'matumbo komanso mwayi wa colorectal. khansa. Komabe, kugwiritsa ntchito mwachisawawa zowonjezera za berberine ndi odwala khansa kuyenera kupewedwa. Odwala khansa akuyenera kukaonana ndi akatswiri awo azaumoyo asanayambe kumwa zakudya zopatsa thanzi popanda kuthandizidwa ndi asayansi, chifukwa izi zitha kugwirizana ndi chithandizo chopitilira.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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