Nā Punawai Meaʻai, Nā Pōmaikaʻi a me nā Pilikia o ka Wikamina E i ka maʻi ʻaʻai

o ka Naauao

ʻO ka Vitamin E kahi meaʻai antioxidant e loaʻa iā mākou ma o nā kumu meaʻai a i ʻole nā ​​​​mea hoʻohui. Eia nō naʻe, ua hōʻike ka hoʻohui ʻana i ka Vitamin E i ka hopena ʻokoʻa i nā maʻi maʻi like ʻole. Ua hōʻike ka Vitamin E i ka nui o ka pilikia o ka maʻi prostate a me ka lolo, ʻaʻohe hopena i ka maʻi kanesa a me nā pōmaikaʻi i ka maʻi maʻi Ovarian. Hiki ke hoʻopili ʻia kēia hopena ʻokoʻa i ka hoʻololi genetic i kēlā me kēia kanaka e pili ana i nā ʻano like ʻole o ka hana ʻana o ka Vitamin E i ke kino. ʻO ka hoʻonui ʻana i ka Vitamin E hiki ke hōʻeha ʻia ma muli o ka nui o ke koko a me ka hahau. No laila, ʻoi aku ka maikaʻi o ka hoʻonui ʻana i ka Vitamin E ma o nā kumu meaʻai ma ke ʻano o ka meaʻai olakino a i ʻole ka meaʻai no Ka maʻi 'aʻai, ma mua o ka lawe ʻana i nā mea hoʻohui.

Pākuʻi E Kākoʻo

Manaʻo ka poʻe he nui hiki i ka lawe ʻana i nā wikamina a me nā mea hoʻopihapiha ke kōkua me ka hōʻemi ʻana i ka makaʻu o nā ʻano olakino mau a hoʻomaikaʻi i ko lākou olakino holoʻokoʻa. Eia nō naʻe, nui nā noiʻi hoʻokolohua e hōʻike nei i nā pōmaikaʻi o nā huaora a me nā mea hoʻopihapiha i kikoʻī ka pōʻaiapili a i nā manawa ʻaʻole hāʻawi lākou i kahi pōmaikaʻi a hiki paha ke hōʻeha. ʻO ka wikamina E kekahi mea momona i makemake nui ʻia no nā pōmaikaʻi olakino like ʻole a ʻokoʻa kahi ʻāpana o nā meaʻai a mākou e ʻai ai ma ke ʻāpana o kā mākou papaʻai / meaʻai, lawe ʻia ma ke ʻano he kōkua no kahi waihona a me ka pono i hoʻohui ʻia. E nānā mākou i nā kumuwaiwai, nā pōmaikaʻi a me nā pilikia e pili ana i ka huakino Vitamin E hoʻonui i kaʻai maʻi ʻaʻai / meaʻai.

ʻO ka Vitamin E kahi hui o nā mea momona momona momona momona i loaʻa i nā meaʻai he nui a lawe ʻia hoʻi ma ke ʻano he pākahi a i ʻole ʻāpana o ka hoʻopili vitamina maha, no nā pono olakino he nui. Hana ʻia ka wikamina E o nā hui ʻelua o nā kemika: tocopherols a me tocotrienols. ʻO nā waiwai antioxidant o Wikamina E kōkua i ka pale ʻana i kā mākou mau pūnaewele mai ka hōʻino ʻana i hopena ʻia e nā radical free reactive a me ka stress oxidative. No laila, hāʻawi nā kumuwaiwai a me nā mea hoʻopili o ka Vitamin E i nā pono olakino he nui mai ka mālama ʻana i ka ʻili i ka maikaʻi o ka naʻau a me ka lolo.

Nā Kumuwaiwai o ka Wikamina E

ʻO nā kumuwaiwai waiwai momona ʻo Wikamina E e pili pū ana me ka aila kulina, nā aila mea kanu, ka aila pāma, nā ʻalemona, nā hazelnut, nā pinenuts, nā hua pua sunflower, ʻokoʻa nā hua a me nā mea kanu ʻē aʻe a mākou e ʻai ai i kā mākou papaʻai. ʻO nā Tocopherols nā kumuwaiwai nui o ka Wikamina E i kā mākou papaʻai a me nā mea hoʻopili ke hoʻohālikelike ʻia i nā tocotrienols. ʻO nā meaʻai i loaʻa ka tocotrienol ʻoi aku ka nui o ka raiki, nā ʻoka, ka rai, ka bale a me ka aila pāma.

ʻImi - Hui pū me ke kōkua ʻo Vitamin E me ka maʻi ʻaʻai

Hiki i nā waiwai Antioxidant o ka Vitamin E ke kōkua i ka hōʻemi ʻana i ke kaumaha oxidative pōʻino a me ka pōʻino i loko o kā mākou mau cell. Hoʻemi ka ʻelemakule i ka mana antioxidant inherent o ko mākou kino, no laila kōkua ka Vitamin E me nā hopena anti-aging. Hoʻopili ʻia ia me ka hōʻemi ʻana i ka pilikia o ka maʻi maʻi a me ka ʻelemakule e like me ka cardiovascular, diabetes a me ka loaʻa ʻana o ka hopena anti-cancer. Haʻawina ma Ka maʻi 'aʻai Ua hōʻike ʻia nā mea hoʻohālike a me nā holoholona i ka hopena maikaʻi o ka hoʻohui ʻana i ka Vitamin E i ka pale ʻana i ka maʻi kanesa. Ua loiloi nā hoʻokolohua hoʻokolohua he nui i ka hui ʻana o ka hoʻohana ʻana i ka Vitamin E supplement i nā poʻe maʻi maʻi maʻi a ua hōʻike i nā hopena like ʻole mai ka pōmaikaʻi, ʻaʻohe hopena, i ka pōʻino, i nā maʻi maʻi like ʻole.

Ma kēia blog e hōʻuluʻulu mākou i kekahi o kēia mau noiʻi hoʻokolohua e hōʻike ana i ka hoʻohana ʻia ʻana o ka Vitamin E ma ke ʻano he pono kaʻai / meaʻai i loko o kekahi mau maʻi maʻi ʻoiai e pili ʻia me ka hopena maikaʻi ʻole i nā ʻano maʻi ʻē aʻe. No laila, ʻoi aku ka maikaʻi a me ka makaʻu ʻole o ka hoʻohana ʻana o nā kumuwaiwai E E i kaʻai ʻaʻai / meaʻai he mea pili i ka pōʻaiapili a ʻokoʻa hoʻi me ka maʻi ʻaʻai a me ka lāʻau.

Nā pono o ka Wikamina E i ka maʻi ʻaʻai ʻovarian 

Hana pinepine ʻia ka maʻi ʻōpio ʻo Ovarian i kahi wā ma hope aku, ʻoi aku ka holomua, no ka mea, ʻaʻole hana iki nā ʻōuli o kēia maʻi maʻi i nā ʻōuli. I nā wā ma hope o ka maʻi ʻaʻai ovarian, nā ʻōuli e like me ka pohō kaumaha a me ka ʻeha o ka ʻōpū, ka mea maʻamau ʻole kikoʻī, hoʻomaka e hōʻike a ʻaʻole mau kēia e hoʻāla i ka pīhoihoi. Ma muli o kēia mau kumu i ʻike ʻia ai nā wahine me ka maʻi ʻaʻai ovarian i nā wā hope loa, me kahi helu ola ʻelima mau makahiki o 47% (American Cancer Society). Mālama ʻia nā mea maʻi ʻōkoki ʻo Ovarian me nā lāʻau chemotherapy i pane ʻole ka hapa nui. ʻO kekahi o nā ʻo nā therapies i hoʻomāka ʻia pinepine ʻia hoʻohana ʻia no ka hana ʻana i ka maʻi ʻaʻai ovarian e ka pōloli ʻana i nā hunaola tumo ma o ka pale ʻana i ka ulu ʻana o nā kīʻaha koko he mea nui ia no ka lawe ʻana i nā meaola i ka tumo e ulu wikiwiki ana.  

I loko o ka pōʻaiapili o ka maʻi ʻaʻai ovarian, ua hōʻike ʻo Vitamin E compound tocotrienol i nā pōmaikaʻi ke hoʻohana ʻia me ka maʻamau o ka mālama (SOC) lāʻau (humanized anti-VEGF monoclonal antibody) i nā mea maʻi i kū ʻole i ka chemotherapy. ʻO nā kānaka noiʻi ma ka ʻOihana o Oncology ma ka Halemai ʻo Vejle, Denmark, ua aʻo i ka hopena o ka tocotrienol subgroup o Wikamina E i hui pū ʻia me ka lāʻau SOC i nā mea maʻi maʻi ʻaʻa ovarian i pane ʻole i nā mālama chemotherapy. ʻO 23 mau maʻi ka mea i hoʻopaʻa ʻia. ʻO ka hui pū ʻana o tocotrienol me ka lāʻau SOC i hōʻike i ka haʻahaʻa haʻahaʻa loa i nā mea maʻi a loaʻa iā 70% ka helu stabilization maʻi. ʻO ke ola waena waena i hoʻopaʻa ʻia no kēia hoʻokolohua pae II ʻoi aku ke kiʻekiʻe i hoʻohālikelike ʻia i nā puke i kēia manawa. (Thomsen CB a me al, Pharmacol Res., 2019) Kākoʻo kēia noi i ka hopena anti-cancer o ka delta-tocotrienol subgroup o ka Vitamin E i multiresistant ovarian cancer, akā ʻaʻole hoʻokumu ʻia ka mea like no nā tocopherols.

ʻIke o ka Vitamin E i ka maʻi ʻaʻai Brain

ʻO kahi noiʻi e pili ana i nā neuro oncology a me nā neurosurgery ʻokoʻa ma waena o nā haukapila ʻo US i kālailai ʻia i ka ʻikepili ninaninau ʻia mai nā maʻi 470 i mālama ʻia ma hope o ka ʻike ʻia ʻana o ka maʻi ʻaʻai lolo glioblastoma multiforme (GBM). Ua hōʻike ʻia nā hopena he helu nui loa o kēia mau maʻi (77%) i hōʻike lōkahi me ka hoʻohana ʻana i kekahi ʻano o ke kōkua kōkua e like me nā huaora a i ʻole nā ​​mea hoʻohui kūlohelohe. ʻO ka mea kupaianaha, ʻoi aku ka nui o ka make o nā mea hoʻohana Vitamin E ke hoʻohālikelike ʻia i nā mea i hoʻohana ʻole i nā mea hoʻohui Vitamin E. (Mulphur BH et al, Neurooncol Pract., 2015)

Ma kahi noiʻi ʻē aʻe mai ke Kulanui o Umea, Suède a me ke Kakau Kanesa o Nolewai, ua lawe ka poʻe noiʻi i kahi ala ʻokoʻa i ka hoʻoholo ʻana i nā pilikia no ka maʻi ʻaʻai lolo, glioblastoma. Lawe lākou i nā laikini serum a i 22 mau makahiki ma mua o ka hōʻike glioblastoma a hoʻohālikelike i nā metabolite concentrations o nā laumā serum o nā mea i hoʻomohala i ka maʻi ʻaʻai mai ka poʻe i ʻole. Ua loaʻa iā lākou ka nui o ke kiʻekiʻe o ke kahe o ka Vitamin E isoform alpha-tocopherol a me gamma-tocopherol i nā hihia i ulu i ka glioblastoma. (Bjorkblom B et al, Oncotarget, 2016)

ʻIke o ka Vitamin E i ka Prostate Cancer

ʻO kahi Selenium nui a me ka Vitamin E Cancer Prevent Trial (SELECT) i hana ʻia ma nā pūnaewele 427 ma United States, Canada a me Puerto Rico ma luna o 35,000 mau kāne e loiloi i ka pōʻino-ka pono o ka Vitamin E supplementation. Hana ʻia kēia hoʻokolokolo ma luna o nā kāne he 50 a ʻoi paha makahiki a ʻoi paha nā pae o ka antigen (PSA) haʻahaʻa o 4.0 ng / ml a ʻoi iki paha. Hoʻohālikelike ʻia i ka poʻe i lawe ʻole i nā mea kōkua Vitamin E (Placebo a i ʻole ka hui kūmole), ua loaʻa kahi noiʻi i kahi piʻi loa o ka makaʻu o ka maʻi ʻaʻai prostate i kēlā mau mea e lawe nei i nā huaora E. No laila, ʻo ka supplementation me Vitamin E i ka papaʻai / meaʻai e pili pū ana me ka nui o ka makaʻu o ka maʻi ʻaʻai prostate ma waena o nā kāne olakino. (Klein EA a me al, JAMA, 2011)

ʻAʻohe hopena o ka Wikamina E i ka maʻi ʻaʻai puʻu

I loko o ka alpha-tocopherol, beta-carotene cancer cancer study i hana ʻia i nā kāne puhipaka ma mua o 50 mau makahiki, ʻaʻole i loaʻa iā lākou kahi hōʻemi o ka maʻi ʻaʻa pūhae ma hope o ʻelima a ʻewalu mau makahiki o ka hoʻopiliʻai me alpha-tocopherol. (ʻO New Engl J Med, 1994)

Loaʻa ka pōmaikaʻi / Pilikia o ka Wikamina E i ka maʻi ʻaʻai i nā ʻano loli like ʻole

Ua kālailai ʻia kahi noiʻi hou nei i nā hopena like ʻole o ka hopena Vitamin E ma nā maʻi ʻokoʻa like ʻole, a ua hōʻike ʻia he ʻokoʻa nā hopena pale maʻi ʻaʻai o nā kumuwaiwai E i kēlā me kēia kanaka ma muli o nā ʻokoʻa o ka enzyme e hana i ka Vitamin E i ke kino. ʻO Catechol-o-methyltransferase (COMT) ka enzyme e hana i ka Vitamin E i loko o kā mākou kino. Hiki i kēlā me kēia kanaka ke loaʻa kahi ʻano kikoʻī o ka COMT, me kahi ʻano like me kahi hana kiʻekiʻe loa o COMT, ʻoiai kahi ʻano ʻē aʻe i loaʻa kahi hana haʻahaʻa a hiki i kekahi ke loaʻa i kahi kope o kēlā me kēia a no laila loaʻa ka hana kūpono o COMT.

Ua ʻike ʻia ka haʻawina ʻo ka hoʻohana ʻana i nā kumu Vitamin E kiʻekiʻe i nā poʻe me nā ʻano hana kiʻekiʻe o COMT e kau iā lākou i kahi hemahema no kahi kiʻekiʻe. Ka maʻi 'aʻai pilikia. I nā poʻe me ka ʻano haʻahaʻa haʻahaʻa o COMT i lawe i nā mea hoʻohui Vitamin E, ua pōmaikaʻi ka hoʻohui ʻana i ka Vitamin E a ua hoʻohaʻahaʻa i ko lākou pilikia o ka maʻi kanesa e 15% i hoʻohālikelike ʻia i kā lākou mau hoa me ka ʻano haʻahaʻa haʻahaʻa COMT ʻaʻole i lawe i ka hoʻohui ʻana i ka Vitamin E.

No laila, e like me kēia kaʻanalike, hiki ke hoʻopili ʻia ka loli o ka hopena ʻo ka maʻi ʻaʻai E e pili ana i ka hanauna kūlohelohe o ke kanaka e pili ana i ka hana ʻana o ka Vitamin E i loko o ke kino. (Hale, KT et al, J National Cancer Inst., 2019) Ua ʻike maikaʻi ʻia kēia ʻano hoʻololi i kapa ʻia ʻo pharmacogenetics i nā pane i nā lāʻau like ʻole e pili ana i nā ʻano genetic i loko o kēlā me kēia kanaka. Ua loaʻa kēia i kēia manawa no ka hana ʻana i nā kumu Vitamin E a hiki ke kūpono no nā kumu meaʻai ʻē aʻe i hoʻohana ʻia i loko Ka maʻi 'aʻai meaʻai / meaʻai pū kekahi..

No laila ʻoiai ʻoi aku ka maikaʻi o ka lawe ʻana o Vitamin E no kahi hana pilikino i ka Ovarian Cancer, ʻaʻole ia e kōkua i ka hōʻemi ʻana i ka hopena o nā maʻi ʻē aʻe e like me ka maʻi ʻaʻai Prostate.

kaiapuni e lawe ʻia

ʻO ka lāʻau i koi ʻia i kēlā me kēia lā no ka Wikamina E he 15 mg. Hiki i ka nui o kēia nui ke alakaʻi i nā hopena ʻino e like me ka hoʻonui ʻana o ka kahe ʻana o ke kahe a me ka hahau hemorrhagic, a he ʻokoʻa nā kumu pilikia i luna e pili ana i ka hoʻonui ʻia o ka hui pū ʻana me ka maʻi ʻaʻai prostate a me glioblastoma, e like me ka mea i hōʻike ʻia i loko o nā noiʻi maʻi.

ʻO kahi kumu e hiki ai ke hōʻino i ka nui o ka Vitamin E antioxidant supplementation no ka mea hiki ke hoʻopau i ke koena maikaʻi o ka mālama ʻana i ke kiʻekiʻe kūpono o ke koʻikoʻi oxidative i ko mākou kaiapuni kelepona. ʻO ka nui o ke koʻikoʻi oxidative hiki ke make a me ka degeneration, akā ʻoi aku ka liʻiliʻi o ke koʻikoʻi oxidative hiki ke hoʻopilikia i ka mana antioxidant inherent e alakaʻi i nā loli hopena ʻē aʻe. ʻO kekahi o ia hoʻololi ʻana, ʻo ia ka emi ʻana o kahi ʻano hoʻopaʻi tumor nui i kapa ʻia ʻo P53, i manaʻo ʻia ʻo ia ke kahu o ka genome, no laila e hoʻonui ai i ka hiki ke ulu. Ka maʻi 'aʻai. (Sayin VI et al, Sci Translate Med., 2014)  

No laila, ʻoi aku ka maikaʻi o ka hoʻopili maikaʻi ʻana o ka Vitamin E (ʻoi loa i ka papaʻai no kāu maʻi ʻaʻai). ʻOi aku ka maikaʻi e hoʻonui i kāu lawe ʻana i ka Wikamina E ma o ka ʻai ʻana i nā kumuwaiwai momona ʻo Wikamina E ma mua o ka hoʻohana ʻana i nā mea kōkua Vitamin E kiʻekiʻe, ke ʻole e koi ʻia e kāu kauka.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

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• Ka hopena o ka hoʻoikaika kino a me ka hana kino i ka maʻi ʻaʻai